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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046671
Ensembl Protein ID ENSP00000369213.2
UniProt Accession O95786; A2RU81; Q5HYE1; Q5VYT1; Q9NT04; DDX58_HUMAN
Genbank Protein ID AAD19826.1; CAH71251.1; CAH71251.1; CAH72600.1; CAH72600.1; EAW58548.1; AAI32787.1; AAI36611.1; CAI46068.1; CAB70840.1
Protein Name Probable ATP-dependent RNA helicase DDX58; DEAD box protein 58; RIG-I-like receptor 1; Retinoic acid-inducible gene 1 protein; Retinoic acid-inducible gene I protein
Genbank Nucleotide ID AF038963; AL353671; AL161783; AL161783; AL353671; CH471071; BC132786; BC136610; BX647917; AL137608
Gene Name DDX58
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000107201.9 ENST00000379883.2 ENSP00000369213.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/CARD CARD 20403326
Classification
Family E-value Score Start End
UBD/CARD 6.00e-59 198.2 1 74
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/CARD
   S: 1    tdeeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLktL..vqkegWfrefl 73
           +++e+r++l+++qd++rk+Ld+t++l+ y++++++eee+++i+a++++kg+m+aa+l+Lk+L  +q+egWfr+fl
   Q: 1    MTTEQRRSLQAFQDYIRKTLDPTYILS-YMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLleLQEEGWFRGFL 74
           689************************.*********************************************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.
 Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.
Protein Sequence
(Fasta)
MTTEQRRSLQ AFQDYIRKTL DPTYILSYMA PWFREEEVQY IQAEKNNKGP MEAATLFLKF 60
LLELQEEGWF RGFLDALDHA GYSGLYEAIE SWDFKKIEKL EEYRLLLKRL QPEFKTRIIP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046671|UBD,CARD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TAGTTATTAA AGTTCCTATG CAGCTCCGCC TCGCGTCCGG CCTCATTTCC TCGGAAAATC 60
CCTGCTTTCC CCGCTCGCCA CGCCCTCCTC CTACCCGGCT TTAAAGCTAG TGAGGCACAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046671|UBD,CARD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0067--ATP-binding
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0347--Helicase
KW-0945--Host-virus interaction
KW-0378--Hydrolase
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0796--Tight junction
KW-0832--Ubl conjugation
KW-0862--Zinc
Interpro

IPR031964--CARD_dom
IPR011545--DEAD/DEAH_box_helicase_dom
IPR011029--DEATH-like_dom
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR021673--RLR_CTR
PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51789--RLR_CTR
Pfam

PF16739--CARD_2
PF00270--DEAD
PF00271--Helicase_C
PF11648--RIG-I_C-RD
SMART

SM00487--DEXDc
SM00490--HELICc
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005923--C:bicellular tight junction
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0003690--F:double-stranded DNA binding
GO:0003725--F:double-stranded RNA binding
GO:0004386--F:helicase activity
GO:0042802--F:identical protein binding
GO:0003727--F:single-stranded RNA binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0039528--P:cytoplasmic pattern recognition receptor signaling pathway in response to virus
GO:0009597--P:detection of virus
GO:0045087--P:innate immune response
GO:0032480--P:negative regulation of type I interferon production
GO:0002230--P:positive regulation of defense response to virus by host
GO:0010628--P:positive regulation of gene expression
GO:0032725--P:positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032727--P:positive regulation of interferon-alpha production
GO:0032728--P:positive regulation of interferon-beta production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016579--P:protein deubiquitination
GO:0030334--P:regulation of cell migration
GO:0034344--P:regulation of type III interferon production
GO:0043330--P:response to exogenous dsRNA
GO:0009615--P:response to virus
GO:0039529--P:RIG-I signaling pathway
KEGG hsa:23586
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001898 Ailuropoda melanoleuca 79.70 0.00e+00 1493.00
IUUC-Apl-003966 Anas platyrhynchos 54.52 0.00e+00 927.00
IUUC-Aca-004499 Anolis carolinensis 46.94 0.00e+00 819.00
IUUC-Ame-011950 Astyanax mexicanus 44.17 0.00e+00 705.00
IUUC-Bta-012489 Bos taurus 80.11 0.00e+00 1460.00
IUUC-Cel-018230 Caenorhabditis elegans 29.08 6.00e-71 263.00
IUUC-Cja-018716 Callithrix jacchus 94.27 0.00e+00 1751.00
IUUC-Cfa-020269 Canis familiaris 81.70 0.00e+00 1544.00
IUUC-Cpo-022507 Cavia porcellus 77.23 0.00e+00 1448.00
IUUC-Csa-024209 Chlorocebus sabaeus 96.54 0.00e+00 1799.00
IUUC-Cho-025104 Choloepus hoffmanni 74.37 0.00e+00 1190.00
IUUC-Cin-025792 Ciona intestinalis 31.47 4.00e-79 289.00
IUUC-Cgl-026385 Colletotrichum gloeosporioides 25.42 8.00e-23 103.00
IUUC-Dno-028954 Dasypus novemcinctus 79.08 0.00e+00 1436.00
IUUC-Eca-034039 Equus caballus 82.16 0.00e+00 1541.00
IUUC-Eeu-035009 Erinaceus europaeus 70.02 0.00e+00 930.00
IUUC-Fca-036169 Felis catus 82.49 0.00e+00 1560.00
IUUC-Fal-037579 Ficedula albicollis 54.94 0.00e+00 932.00
IUUC-Fso-038398 Fusarium solani 26.64 6.00e-25 110.00
IUUC-Ggo-045318 Gorilla gorilla 95.85 0.00e+00 1656.00
IUUC-Itr-047996 Ictidomys tridecemlineatus 79.52 0.00e+00 1459.00
IUUC-Lch-050461 Latimeria chalumnae 49.73 0.00e+00 877.00
IUUC-Loc-052582 Lepisosteus oculatus 48.61 0.00e+00 856.00
IUUC-Laf-054324 Loxodonta africana 79.34 0.00e+00 1453.00
IUUC-Mcc-055390 Macaca mulatta 95.78 0.00e+00 1780.00
IUUC-Meu-056365 Macropus eugenii 55.94 0.00e+00 632.00
IUUC-Mpo-057328 Magnaporthe poae 26.67 1.30e+00 29.30
IUUC-Mvi-060497 Microbotryum violaceum 24.57 1.00e-24 109.00
IUUC-Mmr-061407 Microcebus murinus 86.18 0.00e+00 1633.00
IUUC-Mmu-063939 Mus musculus 77.08 0.00e+00 1428.00
IUUC-Mpu-066226 Mustela putorius furo 79.88 0.00e+00 1409.00
IUUC-Mlu-068092 Myotis lucifugus 81.63 0.00e+00 1487.00
IUUC-Nfi-068405 Neosartorya fischeri 25.00 8.00e-27 116.00
IUUC-Opr-070246 Ochotona princeps 69.32 0.00e+00 694.00
IUUC-Oan-072742 Ornithorhynchus anatinus 61.81 0.00e+00 986.00
IUUC-Ocu-073959 Oryctolagus cuniculus 76.78 0.00e+00 1457.00
IUUC-Oga-089173 Otolemur garnettii 84.45 0.00e+00 1567.00
IUUC-Oar-089369 Ovis aries 79.35 0.00e+00 1420.00
IUUC-Ptr-091032 Pan troglodytes 100.00 0.00e+00 1826.00
IUUC-Pan-092383 Papio anubis 96.22 0.00e+00 1784.00
IUUC-Psi-093432 Pelodiscus sinensis 56.47 0.00e+00 1059.00
IUUC-Pma-094367 Petromyzon marinus 42.66 1.00e-117 416.00
IUUC-Pab-098416 Pongo abelii 98.74 0.00e+00 1698.00
IUUC-Pca-101006 Procavia capensis 77.72 0.00e+00 637.00
IUUC-Pva-102966 Pteropus vampyrus 83.33 0.00e+00 1548.00
IUUC-Pgr-103529 Puccinia graminis 27.39 9.00e-29 123.00
IUUC-Rno-105059 Rattus norvegicus 76.35 0.00e+00 913.00
IUUC-Ssl-108450 Sclerotinia sclerotiorum 27.55 1.00e-04 43.90
IUUC-Sar-113202 Sorex araneus 68.54 0.00e+00 1044.00
IUUC-Ssc-116120 Sus scrofa 78.71 0.00e+00 1423.00
IUUC-Tgu-117314 Taeniopygia guttata 53.01 0.00e+00 942.00
IUUC-Tsy-119453 Tarsius syrichta 84.84 0.00e+00 904.00
IUUC-Tre-122194 Trichoderma reesei 27.14 1.00e-20 95.90
IUUC-Ttr-128421 Tursiops truncatus 78.32 0.00e+00 1224.00
IUUC-Vpa-130602 Vicugna pacos 78.88 0.00e+00 1398.00
Created Date 25-Jun-2017

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