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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046615
Ensembl Protein ID ENSP00000435726.1
UniProt Accession Q6RFH5; A8K8G5; Q9BRC9; Q9H6X8; Q9NVY2; WDR74_HUMAN
Genbank Protein ID AAS48499.1; BAA91610.1; BAB15122.1; BAF85019.1; AAH06351.1
Protein Name WD repeat-containing protein 74; NOP seven-associated protein 1
Genbank Nucleotide ID AY500828; AK001301; AK025383; AK292330; BC006351
Gene Name WDR74; NSA1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000133316.15 ENST00000536401.1 ENSP00000439541.1
ENSG00000133316.15 ENST00000311713.11 ENSP00000308931.7
ENSG00000133316.15 ENST00000529106.5 ENSP00000435726.1
ENSG00000133316.15 ENST00000542347.5 ENSP00000438700.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.70e-10 41.8 269 297
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 3    tdsvtclaf.sd.tllvsGsdDgtikvWD 29
           ++sv++l+  ++ +ll+s++ D ++++ +
   Q: 269  AGSVRGLQChPSkPLLASCGLDRVLRIHR 297
           5789**9999778************9965 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MAAAAARWNH VWVGTETGIL KGVNLQRKQA ANFTAGGQPR REEAVSALCW GTGGETQMLV 60
GCADRTVKHF STEDGIFQGQ RHCPGGEGMF RGLAQADGTL ITCVDSGILR VWHDKDKDTS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046615|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATCGCTTCTC GGCCTTTTGG CTAAGATCAA GTGTAGTATC TGTTCTTATC AGTTTAATAT 60
CTGATACGTC CTCTATCCGA GGACAATATA TTAAATGGAT TTTTGGAAAT AGGAGATGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046615|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0030687--C:preribosome, large subunit precursor
GO:0042273--P:ribosomal large subunit biogenesis
KEGG hsa:54663
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000787 Aegilops tauschii 32.56 6.00e-25 108.00
IUUC-Aml-001460 Ailuropoda melanoleuca 89.92 0.00e+00 717.00
IUUC-Atr-002657 Amborella trichopoda 36.21 4.00e-25 109.00
IUUC-Aly-006380 Arabidopsis lyrata 34.89 6.00e-28 118.00
IUUC-Ath-007686 Arabidopsis thaliana 39.08 3.00e-26 113.00
IUUC-Ame-011942 Astyanax mexicanus 55.97 1.00e-111 396.00
IUUC-Bta-013382 Bos taurus 92.19 0.00e+00 729.00
IUUC-Bdi-014280 Brachypodium distachyon 35.10 2.00e-29 123.00
IUUC-Bra-017855 Brassica rapa 40.23 5.00e-28 119.00
IUUC-Cja-018933 Callithrix jacchus 95.58 0.00e+00 738.00
IUUC-Cfa-020634 Canis familiaris 90.34 0.00e+00 710.00
IUUC-Cpo-022089 Cavia porcellus 83.55 3.00e-177 614.00
IUUC-Csa-023835 Chlorocebus sabaeus 97.14 0.00e+00 771.00
IUUC-Cho-024385 Choloepus hoffmanni 69.30 8.00e-87 313.00
IUUC-Cin-025691 Ciona intestinalis 43.53 2.00e-74 272.00
IUUC-Dre-028473 Danio rerio 54.75 1.00e-104 373.00
IUUC-Dno-029687 Dasypus novemcinctus 90.26 0.00e+00 704.00
IUUC-Dor-030529 Dipodomys ordii 89.54 4.00e-128 451.00
IUUC-Dme-031982 Drosophila melanogaster 30.72 3.00e-35 142.00
IUUC-Ete-032407 Echinops telfairi 60.88 4.00e-107 381.00
IUUC-Eca-033792 Equus caballus 84.75 2.00e-176 611.00
IUUC-Fca-036584 Felis catus 90.62 0.00e+00 724.00
IUUC-Gmo-039064 Gadus morhua 58.23 3.00e-104 371.00
IUUC-Gac-042170 Gasterosteus aculeatus 54.01 1.00e-100 360.00
IUUC-Gma-044150 Glycine max 31.47 1.00e-26 114.00
IUUC-Ggo-044955 Gorilla gorilla 98.70 0.00e+00 781.00
IUUC-Hvu-047119 Hordeum vulgare 33.86 1.00e-28 120.00
IUUC-Itr-048987 Ictidomys tridecemlineatus 90.13 0.00e+00 704.00
IUUC-Kpa-049188 Komagataella pastoris 29.51 4.00e-19 89.00
IUUC-Lch-050396 Latimeria chalumnae 58.11 1.00e-122 432.00
IUUC-Laf-054015 Loxodonta africana 89.12 0.00e+00 680.00
IUUC-Mcc-055589 Macaca mulatta 97.66 0.00e+00 775.00
IUUC-Meu-056160 Macropus eugenii 61.67 1.00e-119 423.00
IUUC-Mtr-057719 Medicago truncatula 32.63 9.00e-28 118.00
IUUC-Mmr-060801 Microcebus murinus 91.95 0.00e+00 741.00
IUUC-Mdo-062069 Monodelphis domestica 72.77 2.00e-153 535.00
IUUC-Mmu-063586 Mus musculus 89.35 0.00e+00 675.00
IUUC-Mpu-066542 Mustela putorius furo 91.43 0.00e+00 711.00
IUUC-Mlu-067520 Myotis lucifugus 76.35 7.00e-155 540.00
IUUC-Nle-069422 Nomascus leucogenys 97.14 0.00e+00 769.00
IUUC-Opr-070402 Ochotona princeps 75.44 2.00e-94 338.00
IUUC-Ont-072078 Oreochromis niloticus 60.00 4.00e-108 384.00
IUUC-Ocu-073886 Oryctolagus cuniculus 88.95 0.00e+00 674.00
IUUC-Obr-076206 Oryza brachyantha 33.33 6.00e-32 132.00
IUUC-Ogl-077112 Oryza glaberrima 34.24 1.00e-31 130.00
IUUC-Ogu-078172 Oryza glumaepatula 36.23 3.00e-27 116.00
IUUC-Oin-080070 Oryza indica 34.24 2.00e-31 130.00
IUUC-Olo-080534 Oryza longistaminata 31.93 6.00e-29 122.00
IUUC-Ome-081869 Oryza meridionalis 31.93 1.00e-28 120.00
IUUC-Opu-083828 Oryza punctata 33.59 2.00e-29 123.00
IUUC-Oru-084690 Oryza rufipogon 32.96 4.00e-29 122.00
IUUC-Ola-087342 Oryzias latipes 55.41 3.00e-94 338.00
IUUC-Oga-088865 Otolemur garnettii 91.32 0.00e+00 715.00
IUUC-Oar-090030 Ovis aries 91.41 0.00e+00 722.00
IUUC-Pan-092461 Papio anubis 97.66 0.00e+00 773.00
IUUC-Psi-093061 Pelodiscus sinensis 59.84 5.00e-132 464.00
IUUC-Pma-094281 Petromyzon marinus 53.28 9.00e-102 363.00
IUUC-Ppa-095623 Physcomitrella patens 35.37 3.00e-30 126.00
IUUC-Pfo-097074 Poecilia formosa 58.44 7.00e-97 347.00
IUUC-Pab-098290 Pongo abelii 98.96 0.00e+00 781.00
IUUC-Pop-099317 Populus trichocarpa 38.51 8.00e-26 111.00
IUUC-Pca-100383 Procavia capensis 87.01 0.00e+00 655.00
IUUC-Ppe-101867 Prunus persica 35.29 3.00e-26 113.00
IUUC-Pva-103218 Pteropus vampyrus 77.40 2.00e-170 591.00
IUUC-Rno-105494 Rattus norvegicus 89.90 0.00e+00 709.00
IUUC-Sha-107127 Sarcophilus harrisii 72.15 4.00e-155 541.00
IUUC-Sit-110466 Setaria italica 38.30 1.00e-27 117.00
IUUC-Sbi-113854 Sorghum bicolor 39.25 7.00e-28 118.00
IUUC-Ssc-116144 Sus scrofa 90.89 0.00e+00 691.00
IUUC-Tru-118516 Takifugu rubripes 51.43 5.00e-105 374.00
IUUC-Tni-120527 Tetraodon nigroviridis 57.41 1.00e-103 369.00
IUUC-Tae-123391 Triticum aestivum 33.47 3.00e-28 120.00
IUUC-Tur-126054 Triticum urartu 32.81 1.00e-27 118.00
IUUC-Tbe-127232 Tupaia belangeri 71.43 2.00e-143 501.00
IUUC-Ttr-128529 Tursiops truncatus 92.19 0.00e+00 732.00
IUUC-Vpa-130703 Vicugna pacos 92.70 1.00e-93 336.00
IUUC-Vvi-131680 Vitis vinifera 36.84 2.00e-27 116.00
IUUC-Xtr-132802 Xenopus tropicalis 47.26 3.00e-93 335.00
IUUC-Xma-133396 Xiphophorus maculatus 50.47 2.00e-79 289.00
Created Date 25-Jun-2017

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