iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0051992	FBtr0089100	FBpp0088169
FBgn0051992	FBtr0310543	FBpp0302680
FBgn0051992	FBtr0310542	FBpp0302679

Annotation

mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	19295135; 19383769

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	0.0002	21.4	552	586

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGFdreealqaLraannnleaAveyLl 39
            + + lve GF +e++ +aL  an n+e+A+++L 
   Q: 552  KQYRILVENGFKKEDVERALVIANMNIEEAADMLR 586
           566789**************************995 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development.

Protein Sequence
(Fasta)

MREALFSQDG WGCQHVNQDT NWEVPSSPEP ANKDAPGPPM WKPSINNGTD LWESNLRNGG 60
QPAAQQVPKP SWGHTPSSNL GGTWGEDDDG ADSSSVWTGG AVSNAGSGAA VGVNQAGVNV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATAGCCGG ATCAATTCGT ATTTAAGGTT GTATGATGGT TAAAACGGGA AATCGCAGTA 60
ATTTTTATTA TTTAAATAGT AAATTTAAAC TTCAGTAAAA ATATCCTAAA TAATGTGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0943--RNA-mediated gene silencing
KW-0810--Translation regulation

Interpro

IPR019486--Argonaute_hook_dom
IPR033503--GW182
IPR026805--GW182_M_dom
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS50030--UBA

Pfam

PF10427--Ago_hook
PF12938--M_domain
PF00627--UBA

Gene Ontology

GO:0000932--C:P-body
GO:0000166--F:nucleotide binding
GO:0003723--F:RNA binding
GO:0001700--P:embryonic development via the syncytial blastoderm
GO:0035195--P:gene silencing by miRNA
GO:0045475--P:locomotor rhythm
GO:0035278--P:miRNA mediated inhibition of translation
GO:0006402--P:mRNA catabolic process
GO:0032880--P:regulation of protein localization

KEGG

dme:Dmel_CG31992

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001985	Ailuropoda melanoleuca	34.70	2.00e-35	144.00
IUUC-Apl-003191	Anas platyrhynchos	38.71	9.00e-33	135.00
IUUC-Aca-004717	Anolis carolinensis	58.89	5.00e-26	113.00
IUUC-Ame-010681	Astyanax mexicanus	39.58	2.00e-32	134.00
IUUC-Bta-012915	Bos taurus	34.70	1.00e-35	145.00
IUUC-Cel-018193	Caenorhabditis elegans	28.57	2.00e-01	30.40
IUUC-Cja-019614	Callithrix jacchus	41.84	3.00e-32	134.00
IUUC-Cfa-020452	Canis familiaris	34.70	2.00e-35	145.00
IUUC-Cpo-021452	Cavia porcellus	41.53	6.00e-32	133.00
IUUC-Csa-023169	Chlorocebus sabaeus	34.70	2.00e-35	144.00
IUUC-Cho-024655	Choloepus hoffmanni	38.91	8.00e-32	132.00
IUUC-Dre-028059	Danio rerio	39.66	2.00e-28	121.00
IUUC-Dno-029734	Dasypus novemcinctus	34.36	3.00e-33	137.00
IUUC-Dor-030671	Dipodomys ordii	35.13	6.00e-35	143.00
IUUC-Ete-032774	Echinops telfairi	39.75	4.00e-36	147.00
IUUC-Eca-033866	Equus caballus	42.68	3.00e-32	134.00
IUUC-Eeu-034572	Erinaceus europaeus	54.74	1.00e-26	115.00
IUUC-Fal-036856	Ficedula albicollis	37.28	7.00e-30	126.00
IUUC-Gga-040531	Gallus gallus	42.34	5.00e-33	137.00
IUUC-Gac-041681	Gasterosteus aculeatus	41.74	1.00e-35	145.00
IUUC-Ggo-045143	Gorilla gorilla	43.51	4.00e-40	160.00
IUUC-Hsa-045913	Homo sapiens	41.84	5.00e-37	149.00
IUUC-Lch-049619	Latimeria chalumnae	34.46	7.00e-35	142.00
IUUC-Loc-052289	Lepisosteus oculatus	40.51	9.00e-30	125.00
IUUC-Laf-053607	Loxodonta africana	42.28	3.00e-32	134.00
IUUC-Mcc-055342	Macaca mulatta	41.84	4.00e-32	133.00
IUUC-Meu-056275	Macropus eugenii	38.23	5.00e-34	140.00
IUUC-Mga-059241	Meleagris gallopavo	35.45	2.00e-34	141.00
IUUC-Mmr-061348	Microcebus murinus	34.70	2.00e-35	144.00
IUUC-Mdo-062155	Monodelphis domestica	41.53	5.00e-32	133.00
IUUC-Mmu-064259	Mus musculus	35.36	8.00e-36	145.00
IUUC-Mpu-066534	Mustela putorius furo	37.54	4.00e-34	140.00
IUUC-Mlu-067834	Myotis lucifugus	33.92	2.00e-35	144.00
IUUC-Nle-069168	Nomascus leucogenys	34.10	2.00e-32	134.00
IUUC-Opr-070976	Ochotona princeps	56.67	2.00e-26	114.00
IUUC-Ocu-073749	Oryctolagus cuniculus	35.13	3.00e-35	144.00
IUUC-Oba-075778	Oryza barthii	26.67	9.70e-01	27.70
IUUC-Oga-088116	Otolemur garnettii	34.45	7.00e-35	142.00
IUUC-Oar-090041	Ovis aries	34.70	1.00e-35	145.00
IUUC-Ptr-091135	Pan troglodytes	36.67	1.00e-32	135.00
IUUC-Pan-092665	Papio anubis	60.49	2.00e-25	111.00
IUUC-Psi-093057	Pelodiscus sinensis	42.34	3.00e-33	137.00
IUUC-Pfo-097115	Poecilia formosa	57.14	4.00e-04	40.00
IUUC-Pab-097935	Pongo abelii	34.96	1.00e-35	145.00
IUUC-Pca-100481	Procavia capensis	59.09	2.00e-25	111.00
IUUC-Pva-102376	Pteropus vampyrus	56.04	4.00e-26	114.00
IUUC-Rno-105508	Rattus norvegicus	35.90	1.00e-35	145.00
IUUC-Sly-111284	Solanum lycopersicum	54.17	1.70e-02	33.90
IUUC-Stu-112750	Solanum tuberosum	54.17	1.90e-02	33.90
IUUC-Sar-113036	Sorex araneus	55.43	2.00e-26	114.00
IUUC-Ssc-115574	Sus scrofa	42.24	2.00e-30	127.00
IUUC-Tgu-117233	Taeniopygia guttata	42.34	4.00e-33	137.00
IUUC-Tru-117725	Takifugu rubripes	42.56	5.00e-32	133.00
IUUC-Tsy-118786	Tarsius syrichta	55.43	2.00e-26	115.00
IUUC-Tvi-122630	Trichoderma virens	31.82	5.20e-02	31.20
IUUC-Tbe-127551	Tupaia belangeri	37.33	3.00e-34	141.00
IUUC-Ttr-128518	Tursiops truncatus	41.94	1.00e-32	135.00
IUUC-Vpa-130230	Vicugna pacos	50.72	6.00e-15	77.00
IUUC-Xtr-132265	Xenopus tropicalis	41.53	8.00e-35	142.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence