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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046498
UUCD1 version UUC-HoS-01176
Ensembl Protein ID ENSP00000333266.3
UniProt Accession P41226; Q9BRB2; UBA7_HUMAN
Genbank Protein ID AAA75388.1; AAG49557.1; AAP35672.1; EAW65023.1; AAH06378.1
Protein Name Ubiquitin-like modifier-activating enzyme 7; D8; Ubiquitin-activating enzyme E1 homolog
Genbank Nucleotide ID L13852; AF294032; BT007026; CH471055; BC006378
Gene Name UBA7; UBE1L; UBE2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000182179.11 ENST00000333486.3 ENSP00000333266.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
TRANSFACTargetScanRepTarmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E1 E1_ThiF 20133869
Classification
Family E-value Score Start End
E1 8.60e-222 738.3 415 890
Active Site
Position(s) Description Evidence
599 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU10132}
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpd 87
           YD+Qi+++G+  qekl+++++llvGag++GcEllK ++l+G+     g +tvvDmd++e snl+rqFLfr +dvg++KAevaa+a++ lnpd
   Q: 415  YDGQIAVFGAGFQEKLRRQHYLLVGAGAIGCELLKVFALVGLgagnsGGLTVVDMDHIERSNLSRQFLFRSQDVGRPKAEVAAAAARGLNPD 506
           ******************************************************************************************** PP
   S: 88   vnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPf 173
            +v + ++++++++e+i+   Ff+++d+V++ald+++arr+v+ +c+++ +pl+e+gt G++G ++v+++++te+y+++     +++  +P+
   Q: 507  LQVIPLTYPLDPTTEHIYgdnFFSRVDGVAAALDSFQARRYVAARCTHYLKPLLEAGTSGTWGSATVFMPHVTEAYRAPAsaaASEDAPYPV 598
           *********************************************************************************999******** PP
   S: 174  ctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqll 257
           ct++ +p++aeht++wa        +l ++++++++++++ l+++d+ ++++ +++v   l+  +++n+++++++a+ +++ +++++ikqll
   Q: 599  CTVRYFPSTAEHTLQWArhefeelfRLSAETINHHQQAHTSLADMDEPQTLTLLKPVLGVLRV-RPQNWQDCVAWALGHWKLCFHYGIKQLL 689
           *************************9*******************************888777.6*************************** PP
   S: 258  ksfecdivtkskspfwv................................................sfcsnaealqvpekvekdeevvkasap 301
           ++f++++v ++++pfw+                                                ++ ++ + +q+ +  +++ e  +asa+
   Q: 690  RHFPPNKVLEDGTPFWSgpkqcpqplefdtnqdthllyvlaaanlyaqmhglpgsqdwtalrellKLLPQPDPQQMAPIFASNLELASASAE 781
           *******************************************************************************************9 PP
   S: 302  .....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviK 386
                ++ l +ale ++  + +kp  l+fekddds  +vd+v aaa+lr++++gi+p +++ + k+i+g+iipaiatt+a+v+Gl+ +E++K
   Q: 782  fgpeqQKELNKALEVWSVGPPLKP--LMFEKDDDSnfHVDFVVAAASLRCQNYGIPP-VNRAQSKRIVGQIIPAIATTTAAVAGLLGLELYK 870
           ***********************9..*******************************.********************************** PP
   S: 387  vvsg..kfeplknfflfdae 404
           vvsg  + +++++ +l++ae
   Q: 871  VVSGprPRSAFRHSYLHLAE 890
           ****8777889998888775 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.
 Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.
Protein Sequence
(Fasta)
MDALDASKLL DEELYSRQLY VLGSPAMQRI QGARVLVSGL QGLGAEVAKN LVLMGVGSLT 60
LHDPHPTCWS DLAAQFLLSE QDLERSRAEA SQELLAQLNR AVQVVVHTGD ITEDLLLDFQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046498|E1,E1_ThiF|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCAGGAAGAG AGCTGTGACC AGCAGCGTCC CTTATTCGCT TGGCCTTGGT TCCTGTTTGC 60
ACTGGCTACA GCAGGGCACT GGCCCCTACT GTCACCGCCA CCTACACAAA GACCCTATCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046498|E1,E1_ThiF|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like
PROSITE

PS00865--UBIQUITIN_ACTIVAT_2
Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys
PRINTS

PR01849--UBIQUITINACT
SMART

SM00985--UBA_e1_C
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process
GO:0032480--P:negative regulation of type I interferon production
GO:0019985--P:translesion synthesis
KEGG hsa:7318
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001816 Ailuropoda melanoleuca 79.58 0.00e+00 1461.00
IUUC-Bta-012665 Bos taurus 76.19 0.00e+00 1357.00
IUUC-Cja-019047 Callithrix jacchus 90.02 0.00e+00 1703.00
IUUC-Cfa-021225 Canis familiaris 80.83 0.00e+00 1536.00
IUUC-Cpo-022336 Cavia porcellus 71.32 0.00e+00 1320.00
IUUC-Csa-023462 Chlorocebus sabaeus 96.05 0.00e+00 1746.00
IUUC-Cho-024436 Choloepus hoffmanni 76.37 4.00e-93 336.00
IUUC-Dno-029347 Dasypus novemcinctus 79.84 0.00e+00 1477.00
IUUC-Dor-030997 Dipodomys ordii 75.00 0.00e+00 1366.00
IUUC-Ete-033124 Echinops telfairi 73.82 0.00e+00 926.00
IUUC-Eca-033929 Equus caballus 81.92 0.00e+00 1559.00
IUUC-Eeu-034717 Erinaceus europaeus 68.64 0.00e+00 944.00
IUUC-Fca-036564 Felis catus 81.95 0.00e+00 1506.00
IUUC-Ggo-044480 Gorilla gorilla 98.50 0.00e+00 1811.00
IUUC-Itr-048657 Ictidomys tridecemlineatus 78.34 0.00e+00 1439.00
IUUC-Laf-054119 Loxodonta africana 78.75 0.00e+00 1502.00
IUUC-Mcc-055597 Macaca mulatta 93.98 0.00e+00 1678.00
IUUC-Meu-056534 Macropus eugenii 49.35 0.00e+00 877.00
IUUC-Mdo-063058 Monodelphis domestica 56.85 0.00e+00 1017.00
IUUC-Mmu-063578 Mus musculus 73.43 0.00e+00 1393.00
IUUC-Mpu-066255 Mustela putorius furo 79.68 0.00e+00 1501.00
IUUC-Mlu-067814 Myotis lucifugus 76.32 0.00e+00 1357.00
IUUC-Nle-069193 Nomascus leucogenys 95.95 0.00e+00 1768.00
IUUC-Opr-070715 Ochotona princeps 73.42 0.00e+00 1382.00
IUUC-Ocu-074162 Oryctolagus cuniculus 77.89 0.00e+00 1455.00
IUUC-Oga-088895 Otolemur garnettii 80.04 0.00e+00 1475.00
IUUC-Oar-089579 Ovis aries 75.79 0.00e+00 1347.00
IUUC-Ptr-090581 Pan troglodytes 99.19 0.00e+00 1790.00
IUUC-Pan-092458 Papio anubis 96.15 0.00e+00 1743.00
IUUC-Pab-098653 Pongo abelii 91.30 0.00e+00 1658.00
IUUC-Pca-100578 Procavia capensis 76.02 0.00e+00 878.00
IUUC-Pva-102914 Pteropus vampyrus 79.31 0.00e+00 1176.00
IUUC-Rno-106066 Rattus norvegicus 73.21 0.00e+00 1404.00
IUUC-Sha-107368 Sarcophilus harrisii 59.62 0.00e+00 1103.00
IUUC-Ssc-115743 Sus scrofa 81.72 0.00e+00 1504.00
IUUC-Tbe-127587 Tupaia belangeri 74.25 0.00e+00 1204.00
Created Date 25-Jun-2017

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