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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105451
UUCD1 version UUC-RaN-00677
Ensembl Protein ID ENSRNOP00000007963.5
UniProt Accession Q4V8A2; CDC27_RAT
Genbank Protein ID AAH97475.1
Protein Name Cell division cycle protein 27 homolog
Genbank Nucleotide ID BC097475
Gene Name Cdc27
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000005904.5 ENSRNOT00000007963.5 ENSRNOP00000007963.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 40.80 5.00e-63 237.00 IUUC-Sce-106187
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Protein Sequence
(Fasta)
MTVLQEPVQA AIWQALNHYA YRDAVFLAER LYAEVHSEEA LFLLATCYYR SGKAYKAYRL 60
LKGHSCTTPQ CKYLLAKCCV DLSKLAEGEQ ILSGGVFNKQ KSHDDLVTEF GDSACFTLSL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105451|E3,APC_C|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
GCCGGGGCTG GCCGGGCTGG AGCTGCTACG GGGGGGGCCT GAGGCACTGC AGAAAGTGGG 60
TCTGAGCCTC GAGGATGACG GTGCTGCAGG AACCTGTCCA GGTAATGCTA ACCCCTGCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105451|E3,APC_C|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR001440--TPR_1
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
Pfam

PF00515--TPR_1
PF13181--TPR_8
SMART

SM00028--TPR
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005876--C:spindle microtubule
GO:0007091--P:metaphase/anaphase transition of mitotic cell cycle
GO:0070979--P:protein K11-linked ubiquitination
KEGG rno:360643
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000478 Aegilops tauschii 48.40 2.00e-89 323.00
IUUC-Aml-002123 Ailuropoda melanoleuca 96.97 0.00e+00 1632.00
IUUC-Atr-002921 Amborella trichopoda 47.80 2.00e-96 347.00
IUUC-Apl-003652 Anas platyrhynchos 93.73 0.00e+00 1587.00
IUUC-Aca-004797 Anolis carolinensis 91.40 0.00e+00 1458.00
IUUC-Aly-006146 Arabidopsis lyrata 41.78 1.00e-84 307.00
IUUC-Ath-007523 Arabidopsis thaliana 46.08 6.00e-94 338.00
IUUC-Ago-007939 Ashbya gossypii 39.18 4.00e-64 239.00
IUUC-Acl-008169 Aspergillus clavatus 43.10 1.00e-84 307.00
IUUC-Afl-008631 Aspergillus flavus 37.41 1.00e-77 284.00
IUUC-Afu-008990 Aspergillus fumigatus 36.82 4.00e-85 309.00
IUUC-Ani-009208 Aspergillus nidulans 30.48 5.00e-65 242.00
IUUC-Ang-009561 Aspergillus niger 44.81 4.00e-85 309.00
IUUC-Aor-009958 Aspergillus oryzae 37.41 2.00e-77 283.00
IUUC-Ate-010597 Aspergillus terreus 39.49 9.00e-86 311.00
IUUC-Ame-010734 Astyanax mexicanus 78.30 0.00e+00 675.00
IUUC-Bgr-012282 Blumeria graminis 31.55 9.00e-95 341.00
IUUC-Bta-013499 Bos taurus 97.82 0.00e+00 1647.00
IUUC-Bci-013946 Botrytis cinerea 30.50 1.00e-93 337.00
IUUC-Bdi-014213 Brachypodium distachyon 47.76 2.00e-88 320.00
IUUC-Bol-016307 Brassica oleracea 45.87 1.00e-93 337.00
IUUC-Bra-017042 Brassica rapa 45.78 6.00e-94 338.00
IUUC-Cel-018481 Caenorhabditis elegans 40.19 5.00e-76 279.00
IUUC-Cja-019393 Callithrix jacchus 96.90 0.00e+00 1457.00
IUUC-Cfa-020221 Canis familiaris 97.70 0.00e+00 1646.00
IUUC-Cpo-021792 Cavia porcellus 97.33 0.00e+00 1619.00
IUUC-Csa-023091 Chlorocebus sabaeus 97.33 0.00e+00 1635.00
IUUC-Cin-025231 Ciona intestinalis 47.50 0.00e+00 667.00
IUUC-Csv-025983 Ciona savignyi 44.31 0.00e+00 672.00
IUUC-Cgl-026436 Colletotrichum gloeosporioides 42.77 3.00e-72 266.00
IUUC-Cne-026779 Cryptococcus neoformans 40.19 3.00e-63 236.00
IUUC-Cme-027126 Cyanidioschyzon merolae 36.47 5.00e-62 232.00
IUUC-Dre-028038 Danio rerio 78.99 0.00e+00 1256.00
IUUC-Dno-029681 Dasypus novemcinctus 97.45 0.00e+00 1635.00
IUUC-Dor-030742 Dipodomys ordii 76.10 4.00e-151 528.00
IUUC-Dse-031468 Dothistroma septosporum 35.51 8.00e-65 241.00
IUUC-Dme-031900 Drosophila melanogaster 39.93 9.00e-159 554.00
IUUC-Ete-032396 Echinops telfairi 87.52 0.00e+00 1449.00
IUUC-Eca-034414 Equus caballus 97.70 0.00e+00 1647.00
IUUC-Eeu-034864 Erinaceus europaeus 85.19 0.00e+00 762.00
IUUC-Fca-036459 Felis catus 97.31 0.00e+00 1625.00
IUUC-Fox-037700 Fusarium oxysporum 43.05 9.00e-68 249.00
IUUC-Fso-038112 Fusarium solani 30.62 1.00e-89 324.00
IUUC-Gmo-038876 Gadus morhua 72.66 0.00e+00 1169.00
IUUC-Ggr-039822 Gaeumannomyces graminis 44.05 7.00e-74 272.00
IUUC-Gga-040585 Gallus gallus 93.55 0.00e+00 1571.00
IUUC-Gac-042126 Gasterosteus aculeatus 74.55 0.00e+00 1220.00
IUUC-Gma-044263 Glycine max 32.34 2.00e-111 396.00
IUUC-Ggo-045272 Gorilla gorilla 85.19 0.00e+00 986.00
IUUC-Hsa-045682 Homo sapiens 97.45 0.00e+00 1640.00
IUUC-Hvu-047421 Hordeum vulgare 49.80 2.00e-70 258.00
IUUC-Itr-048133 Ictidomys tridecemlineatus 98.41 0.00e+00 999.00
IUUC-Kpa-049367 Komagataella pastoris 30.09 1.00e-86 314.00
IUUC-Lch-049755 Latimeria chalumnae 84.15 0.00e+00 1419.00
IUUC-Lpe-051689 Leersia perrieri 32.74 3.00e-104 372.00
IUUC-Loc-052907 Lepisosteus oculatus 84.36 0.00e+00 1332.00
IUUC-Lma-053272 Leptosphaeria maculans 43.71 7.00e-73 268.00
IUUC-Laf-054312 Loxodonta africana 96.75 0.00e+00 1637.00
IUUC-Mcc-055312 Macaca mulatta 97.33 0.00e+00 1635.00
IUUC-Meu-056290 Macropus eugenii 84.24 0.00e+00 1417.00
IUUC-Mor-057118 Magnaporthe oryzae 43.57 1.00e-74 274.00
IUUC-Mpo-057620 Magnaporthe poae 44.05 1.00e-74 275.00
IUUC-Mtr-058302 Medicago truncatula 32.85 1.00e-115 410.00
IUUC-Mla-058835 Melampsora laricipopulina 36.54 2.00e-60 226.00
IUUC-Mga-060010 Meleagris gallopavo 93.05 0.00e+00 1581.00
IUUC-Mvi-060340 Microbotryum violaceum 39.26 1.00e-60 228.00
IUUC-Mmr-060610 Microcebus murinus 96.51 0.00e+00 1607.00
IUUC-Mdo-062216 Monodelphis domestica 94.72 0.00e+00 1612.00
IUUC-Mmu-063476 Mus musculus 98.18 0.00e+00 1652.00
IUUC-Mac-065409 Musa acuminata 45.43 5.00e-94 338.00
IUUC-Mpu-066213 Mustela putorius furo 97.70 0.00e+00 1646.00
IUUC-Mlu-067540 Myotis lucifugus 97.43 0.00e+00 1628.00
IUUC-Nfi-068437 Neosartorya fischeri 38.43 7.00e-86 311.00
IUUC-Ncr-068882 Neurospora crassa 42.56 3.00e-76 280.00
IUUC-Nle-068976 Nomascus leucogenys 96.63 0.00e+00 1628.00
IUUC-Opr-071171 Ochotona princeps 91.89 0.00e+00 771.00
IUUC-Ont-071295 Oreochromis niloticus 73.68 0.00e+00 1208.00
IUUC-Oan-072896 Ornithorhynchus anatinus 94.44 0.00e+00 711.00
IUUC-Ocu-074828 Oryctolagus cuniculus 98.06 0.00e+00 1687.00
IUUC-Oba-075176 Oryza barthii 35.28 8.00e-80 291.00
IUUC-Obr-076622 Oryza brachyantha 33.59 3.00e-114 405.00
IUUC-Ogu-078158 Oryza glumaepatula 32.99 1.00e-107 383.00
IUUC-Oin-079840 Oryza indica 34.01 3.00e-116 412.00
IUUC-Olo-080632 Oryza longistaminata 48.86 3.00e-92 332.00
IUUC-Ome-081193 Oryza meridionalis 33.76 5.00e-116 412.00
IUUC-Oni-082335 Oryza nivara 41.59 3.00e-77 283.00
IUUC-Opu-083857 Oryza punctata 48.43 8.00e-84 304.00
IUUC-Oru-085165 Oryza rufipogon 30.58 1.00e-93 337.00
IUUC-Osa-085529 Oryza sativa 48.32 6.00e-97 347.00
IUUC-Olu-087803 Ostreococcus lucimarinus 46.85 5.00e-87 314.00
IUUC-Oga-088851 Otolemur garnettii 96.95 0.00e+00 1620.00
IUUC-Oar-089794 Ovis aries 97.94 0.00e+00 1652.00
IUUC-Ptr-091588 Pan troglodytes 97.45 0.00e+00 1637.00
IUUC-Pan-092083 Papio anubis 91.76 0.00e+00 1526.00
IUUC-Psi-093368 Pelodiscus sinensis 94.43 0.00e+00 1585.00
IUUC-Pma-094306 Petromyzon marinus 64.68 0.00e+00 1046.00
IUUC-Pno-094898 Phaeosphaeria nodorum 30.43 9.00e-81 294.00
IUUC-Ppa-095288 Physcomitrella patens 48.19 2.00e-104 373.00
IUUC-Pfo-097263 Poecilia formosa 72.05 0.00e+00 1145.00
IUUC-Pab-097782 Pongo abelii 97.09 0.00e+00 1632.00
IUUC-Pca-100771 Procavia capensis 82.93 0.00e+00 1283.00
IUUC-Ppe-102042 Prunus persica 39.95 8.00e-98 351.00
IUUC-Pva-103207 Pteropus vampyrus 97.45 0.00e+00 1642.00
IUUC-Pgr-103352 Puccinia graminis 37.88 2.00e-52 200.00
IUUC-Ptt-103992 Puccinia triticina 39.62 2.00e-28 121.00
IUUC-Pte-104138 Pyrenophora teres 42.41 2.00e-75 276.00
IUUC-Pyt-104652 Pyrenophora triticirepentis 42.72 7.00e-76 278.00
IUUC-Sce-106187 Saccharomyces cerevisiae 40.80 2.00e-63 237.00
IUUC-Sha-107398 Sarcophilus harrisii 71.45 0.00e+00 1142.00
IUUC-Sja-107984 Schizosaccharomyces japonicus 43.56 2.00e-74 273.00
IUUC-Spo-108274 Schizosaccharomyces pombe 45.16 4.00e-83 302.00
IUUC-Smo-109678 Selaginella moellendorffii 54.97 3.00e-112 399.00
IUUC-Sit-110813 Setaria italica 33.03 7.00e-109 388.00
IUUC-Sly-111637 Solanum lycopersicum 46.33 3.00e-100 359.00
IUUC-Stu-112086 Solanum tuberosum 46.44 9.00e-98 351.00
IUUC-Sar-113214 Sorex araneus 97.21 0.00e+00 1598.00
IUUC-Sre-114904 Sporisorium reilianum 35.34 2.00e-33 138.00
IUUC-Ssc-115692 Sus scrofa 96.45 0.00e+00 1333.00
IUUC-Tgu-116466 Taeniopygia guttata 93.23 0.00e+00 1562.00
IUUC-Tru-118417 Takifugu rubripes 73.53 0.00e+00 1179.00
IUUC-Tsy-118796 Tarsius syrichta 92.91 0.00e+00 1517.00
IUUC-Tni-120331 Tetraodon nigroviridis 85.71 0.00e+00 660.00
IUUC-Tca-121321 Theobroma cacao 47.85 1.00e-94 340.00
IUUC-Tre-122083 Trichoderma reesei 41.10 6.00e-73 268.00
IUUC-Tvi-122558 Trichoderma virens 41.10 9.00e-74 271.00
IUUC-Tae-125209 Triticum aestivum 48.40 7.00e-90 325.00
IUUC-Tur-126187 Triticum urartu 42.63 7.00e-70 258.00
IUUC-Tme-127012 Tuber melanosporum 40.36 8.00e-87 315.00
IUUC-Tbe-127774 Tupaia belangeri 84.97 0.00e+00 1361.00
IUUC-Ttr-128605 Tursiops truncatus 94.42 0.00e+00 1580.00
IUUC-Uma-129576 Ustilago maydis 34.01 8.00e-33 136.00
IUUC-Vda-129996 Verticillium dahliae 43.08 2.00e-57 215.00
IUUC-Vpa-130122 Vicugna pacos 97.57 0.00e+00 1640.00
IUUC-Vvi-131580 Vitis vinifera 45.94 5.00e-100 358.00
IUUC-Xtr-131756 Xenopus tropicalis 89.33 0.00e+00 1449.00
IUUC-Xma-133214 Xiphophorus maculatus 72.05 0.00e+00 1181.00
IUUC-Yli-134473 Yarrowia lipolytica 42.77 3.00e-74 273.00
IUUC-Zma-135179 Zea mays 33.08 3.00e-113 402.00
Created Date 25-Jun-2017

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