iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	OMIM
Drug and target
TTD	DrugBank	KPID	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	24061540

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	0.008	17.9	305	341

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLl 39
           de++l  ++  G dr++ ++ L+++++n  aA++yLl
   Q: 305  DEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLL 341
           7899999*****************************9 PP

Organism

Homo sapiens

Functional Description
(View)

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).

Protein Sequence
(Fasta)

MVIMSEFSAD PAGQGQGQQK PLRVGFYDIE RTLGKGNFAV VKLARHRVTK TQVAIKIIDK 60
TRLDSSNLEK IYREVQLMKL LNHPHIIKLY QVMETKDMLY IVTEFAKNGE MFDYLTSNGH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGGCGCG GCCCCGGAGG CAGCAGCAGC GGCGGCGGCA GCCGGAGCAG TAGGCACCCG 60
AGCAGCGCCA GCGGCCGAGC GGGCGGCTTC CTGGCCTGGG CGCTCCGGTG GCGGCGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0090--Biological rhythms
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0887--Epilepsy
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0043--Tumor suppressor

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR017090--Ser/Thr_kinase_SIK1/2
IPR034672--SIK
IPR015940--UBA

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0071889--F:14-3-3 protein binding
GO:0005524--F:ATP binding
GO:0008140--F:cAMP response element binding protein binding
GO:0000287--F:magnesium ion binding
GO:0019901--F:protein kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0055007--P:cardiac muscle cell differentiation
GO:0007049--P:cell cycle
GO:0032870--P:cellular response to hormone stimulus
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0035556--P:intracellular signal transduction
GO:0032792--P:negative regulation of CREB transcription factor activity
GO:0045721--P:negative regulation of gluconeogenesis
GO:0010868--P:negative regulation of triglyceride biosynthetic process
GO:2000210--P:positive regulation of anoikis
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0045595--P:regulation of cell differentiation
GO:0007346--P:regulation of mitotic cell cycle
GO:0010830--P:regulation of myotube differentiation
GO:0002028--P:regulation of sodium ion transport
GO:0048511--P:rhythmic process

KEGG

hsa:102724428; hsa:150094

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001538	Ailuropoda melanoleuca	46.80	3.00e-125	442.00
IUUC-Aca-004739	Anolis carolinensis	65.14	0.00e+00	925.00
IUUC-Ame-011603	Astyanax mexicanus	66.17	0.00e+00	768.00
IUUC-Cja-019873	Callithrix jacchus	93.39	0.00e+00	1325.00
IUUC-Cfa-020801	Canis familiaris	74.31	0.00e+00	985.00
IUUC-Cpo-022296	Cavia porcellus	78.27	0.00e+00	1008.00
IUUC-Csa-023676	Chlorocebus sabaeus	95.41	0.00e+00	1317.00
IUUC-Cho-025021	Choloepus hoffmanni	76.80	4.00e-159	555.00
IUUC-Cin-025762	Ciona intestinalis	61.90	8.00e-125	441.00
IUUC-Dre-028021	Danio rerio	64.45	0.00e+00	749.00
IUUC-Dno-029103	Dasypus novemcinctus	76.52	0.00e+00	801.00
IUUC-Dme-031957	Drosophila melanogaster	63.80	3.00e-130	460.00
IUUC-Ete-033190	Echinops telfairi	83.79	0.00e+00	732.00
IUUC-Gmo-039423	Gadus morhua	61.95	0.00e+00	747.00
IUUC-Gga-040174	Gallus gallus	65.38	0.00e+00	895.00
IUUC-Gac-041875	Gasterosteus aculeatus	50.52	7.00e-170	591.00
IUUC-Ggo-045090	Gorilla gorilla	98.60	0.00e+00	1392.00
IUUC-Itr-048715	Ictidomys tridecemlineatus	81.93	0.00e+00	1106.00
IUUC-Lch-049933	Latimeria chalumnae	57.89	0.00e+00	801.00
IUUC-Loc-052048	Lepisosteus oculatus	66.72	0.00e+00	776.00
IUUC-Laf-054466	Loxodonta africana	78.95	0.00e+00	1098.00
IUUC-Mcc-054655	Macaca mulatta	96.69	0.00e+00	1333.00
IUUC-Meu-056705	Macropus eugenii	75.00	0.00e+00	806.00
IUUC-Mmr-061419	Microcebus murinus	83.86	0.00e+00	1120.00
IUUC-Mdo-062854	Monodelphis domestica	69.15	0.00e+00	894.00
IUUC-Mmu-064252	Mus musculus	78.86	0.00e+00	1185.00
IUUC-Nle-069329	Nomascus leucogenys	93.49	0.00e+00	1302.00
IUUC-Opr-071101	Ochotona princeps	64.47	0.00e+00	675.00
IUUC-Ont-071887	Oreochromis niloticus	61.09	0.00e+00	703.00
IUUC-Oan-073050	Ornithorhynchus anatinus	75.23	0.00e+00	892.00
IUUC-Oga-088220	Otolemur garnettii	84.06	0.00e+00	1152.00
IUUC-Oar-089420	Ovis aries	74.39	0.00e+00	928.00
IUUC-Ptr-091258	Pan troglodytes	99.62	0.00e+00	1370.00
IUUC-Pan-092031	Papio anubis	96.56	0.00e+00	1332.00
IUUC-Pfo-097451	Poecilia formosa	63.86	0.00e+00	705.00
IUUC-Pab-097806	Pongo abelii	98.60	0.00e+00	1355.00
IUUC-Pva-102182	Pteropus vampyrus	76.74	0.00e+00	760.00
IUUC-Sha-107262	Sarcophilus harrisii	68.22	0.00e+00	969.00
IUUC-Ssc-115584	Sus scrofa	95.97	4.00e-145	507.00
IUUC-Tgu-116973	Taeniopygia guttata	64.86	0.00e+00	910.00
IUUC-Tsy-119567	Tarsius syrichta	44.96	2.00e-116	413.00
IUUC-Ttr-128365	Tursiops truncatus	81.82	0.00e+00	857.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence