iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000022552.15	ENSMUST00000023211.15	ENSMUSP00000023211.9
ENSMUSG00000022552.15	ENSMUST00000159429.1	ENSMUSP00000124755.1
ENSMUSG00000022552.15	ENSMUST00000160560.1	ENSMUSP00000125382.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/NZF	NZF	21455181
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	21455181

Classification

Family	E-value	Score	Start	End
UBD/ZnF/NZF	5.40e-12	46.1	342	370
ULD/UDP/UBQ/UBQ_Other	1.50e-11	45.1	232	287

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           +++W+C++CTf+N++++++CemCs++R+c
   Q: 342  QPGWSCPSCTFINASNRPGCEMCSTQRPC 370
           689*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 9    dgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkd 63
            +s + +lk++p++++a L++++++++g+pp+ qr+++ G++L  + ++La+yg+ +
   Q: 232  SSSaHVSLKIHPHCSIAALQDQVFSEFGFPPAVQRWVI-GRCLcMPERSLASYGVSQ 287
           3333778889****************************.**************8843 PP

Organism

Mus musculus

Functional Description
(View)

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.

Protein Sequence
(Fasta)

MSPPAGGAAV AADPASPVVL LAVHAAVRPL GAGQDAEAQP RKLQLIADPE RPGRFRLGLL 60
GTEPGAVSLE WPLEAICYTV RGPNQHELQP PPGGPGTFSV HFLDPEEAQQ WAALVRDATA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTCTTCCT AGAGTGGTCC ACGGTTACGA AGAGCCTCTG CTGTGCTTAT GTGTGTTTGT 60
GTGCATTGGT GCCTGGTTCC TTCCGGGAAC TGGTATTGTC TTGTGTAGGG CAGCAGCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0071797--C:LUBAC complex
GO:0014069--C:postsynaptic density
GO:0031593--F:polyubiquitin binding
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0007420--P:brain development
GO:0008544--P:epidermis development
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

KEGG

mmu:106025

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001223	Ailuropoda melanoleuca	69.66	5.00e-111	394.00
IUUC-Apl-004151	Anas platyrhynchos	63.83	3.00e-16	75.90
IUUC-Acl-008308	Aspergillus clavatus	44.00	2.20e-02	33.50
IUUC-Afl-008658	Aspergillus flavus	44.00	3.40e-02	32.70
IUUC-Afu-008913	Aspergillus fumigatus	44.00	2.70e-02	33.10
IUUC-Aor-009946	Aspergillus oryzae	44.00	3.40e-02	32.70
IUUC-Bta-012948	Bos taurus	72.96	3.00e-118	418.00
IUUC-Cja-019031	Callithrix jacchus	67.41	8.00e-106	377.00
IUUC-Cfa-020863	Canis familiaris	67.21	2.00e-94	338.00
IUUC-Cpo-022499	Cavia porcellus	69.21	1.00e-108	386.00
IUUC-Csa-023641	Chlorocebus sabaeus	71.63	1.00e-108	386.00
IUUC-Dre-027612	Danio rerio	38.26	1.00e-38	154.00
IUUC-Dno-029459	Dasypus novemcinctus	66.46	5.00e-45	174.00
IUUC-Dor-030914	Dipodomys ordii	60.33	1.00e-77	283.00
IUUC-Ete-032940	Echinops telfairi	61.34	1.00e-77	283.00
IUUC-Eca-033537	Equus caballus	70.45	2.00e-114	405.00
IUUC-Eeu-035176	Erinaceus europaeus	58.85	6.00e-46	177.00
IUUC-Fca-035971	Felis catus	66.20	2.00e-104	372.00
IUUC-Gmo-039219	Gadus morhua	35.87	2.00e-45	176.00
IUUC-Gac-041562	Gasterosteus aculeatus	37.87	2.00e-34	139.00
IUUC-Ggo-044678	Gorilla gorilla	70.60	3.00e-108	384.00
IUUC-Hsa-046578	Homo sapiens	72.98	3.00e-114	404.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	69.51	3.00e-110	391.00
IUUC-Mcc-055686	Macaca mulatta	67.04	1.00e-114	406.00
IUUC-Meu-055912	Macropus eugenii	48.76	2.00e-52	199.00
IUUC-Mmr-060584	Microcebus murinus	70.68	2.00e-116	411.00
IUUC-Mdo-062191	Monodelphis domestica	49.41	1.00e-67	250.00
IUUC-Mpu-066878	Mustela putorius furo	66.95	1.00e-94	340.00
IUUC-Mlu-067878	Myotis lucifugus	71.93	2.00e-116	411.00
IUUC-Nfi-068513	Neosartorya fischeri	44.00	2.80e-02	33.10
IUUC-Nle-069748	Nomascus leucogenys	70.92	8.00e-104	370.00
IUUC-Ont-072270	Oreochromis niloticus	35.05	2.00e-41	163.00
IUUC-Oga-088300	Otolemur garnettii	70.78	3.00e-119	421.00
IUUC-Oar-089549	Ovis aries	72.75	4.00e-122	431.00
IUUC-Ptr-090961	Pan troglodytes	71.28	1.00e-100	359.00
IUUC-Pan-092687	Papio anubis	71.23	1.00e-110	392.00
IUUC-Pfo-096865	Poecilia formosa	33.50	3.00e-35	142.00
IUUC-Pab-097872	Pongo abelii	71.71	4.00e-100	358.00
IUUC-Pca-100363	Procavia capensis	62.12	3.00e-51	195.00
IUUC-Pva-102595	Pteropus vampyrus	68.79	3.00e-95	342.00
IUUC-Rno-105856	Rattus norvegicus	88.54	2.00e-139	489.00
IUUC-Sha-106838	Sarcophilus harrisii	49.27	7.00e-58	218.00
IUUC-Sar-113611	Sorex araneus	72.84	2.00e-23	103.00
IUUC-Ssc-116263	Sus scrofa	70.92	6.00e-111	394.00
IUUC-Tru-118089	Takifugu rubripes	37.81	2.00e-47	183.00
IUUC-Tni-120004	Tetraodon nigroviridis	37.81	4.00e-38	152.00
IUUC-Tbe-127471	Tupaia belangeri	67.45	7.00e-91	327.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence