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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031746
Ensembl Protein ID FBpp0071028
UniProt Accession O17468; O46105; O77144; Q5U0S5; Q8T0C3; Q9W3Q3; HIRA_DROME
Genbank Protein ID AAC48360.1; CAA10954.1; AAC64041.1; AAF46267.1; AAL39559.1; AAV37052.1
Protein Name Protein HIRA homolog; Protein sesame; dHIRA
Genbank Nucleotide ID AF031081; AJ222709; AF071881; AE014298; AY069414; BT016167
Gene Name Hira; Dhh; ssm; CG12153
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0022786 FBtr0071070 FBpp0071028
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINA
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.30e-26 91.5 127 157
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWD 29
           gH ++v +la+  +d +l+s+s D+t+ +WD
   Q: 127  GHDGDVLDLAWspNDVYLASCSIDNTVIIWD 157
           8***********666**************** PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Required for replication-independent chromatin assembly. Promotes remodeling of sperm chromatin following fertilization via the incorporation of histone H3.3 and histone H4.
 Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Required for replication-independent chromatin assembly. Promotes remodeling of sperm chromatin following fertilization via the incorporation of histone H3.3 and histone H4.
Protein Sequence
(Fasta)
MRLLKPAWVH HDDKQIFSVD IHKDCTKFAT GGQGSDCGRV VIWNLLPVLS DKAEFDADVP 60
KMLCQMDQHL ACVNCVRWSQ NGQNLASGSD DKLIMIWRKS AGSSGVFGTG GMQKNHESWK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031746|E3,WD_repeat|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TACCGATATA GCGGTAGTTT ATCAACAATC TCAGTCGTAA AATAATCTTA ACTTTATCTT 60
AACTTAATTG CACTGAAAAG ATAATACCTA TAAGTAAATC GTAAATGCGG CTCCTTAAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031746|E3,WD_repeat|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0042585--C:germinal vesicle
GO:0001673--C:male germ cell nucleus
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0031491--F:nucleosome binding
GO:0003714--F:transcription corepressor activity
GO:0006338--P:chromatin remodeling
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0035042--P:fertilization, exchange of chromosomal proteins
GO:0031935--P:regulation of chromatin silencing
GO:0035041--P:sperm chromatin decondensation
GO:0006351--P:transcription, DNA-templated
KEGG dme:Dmel_CG12153
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001039 Aegilops tauschii 37.53 6.00e-83 301.00
IUUC-Aml-001723 Ailuropoda melanoleuca 52.73 1.00e-148 520.00
IUUC-Atr-003132 Amborella trichopoda 37.41 1.00e-84 307.00
IUUC-Apl-003197 Anas platyrhynchos 53.67 9.00e-148 516.00
IUUC-Aca-004733 Anolis carolinensis 55.46 1.00e-156 546.00
IUUC-Aly-005446 Arabidopsis lyrata 28.64 1.00e-79 290.00
IUUC-Ath-007627 Arabidopsis thaliana 38.54 9.00e-83 301.00
IUUC-Ago-007766 Ashbya gossypii 31.81 1.00e-56 214.00
IUUC-Acl-008104 Aspergillus clavatus 31.78 1.00e-59 224.00
IUUC-Afl-008591 Aspergillus flavus 31.54 5.00e-59 222.00
IUUC-Afu-008781 Aspergillus fumigatus 32.27 3.00e-56 213.00
IUUC-Ani-009272 Aspergillus nidulans 28.57 7.00e-51 195.00
IUUC-Ang-009655 Aspergillus niger 32.33 9.00e-59 221.00
IUUC-Aor-010119 Aspergillus oryzae 31.54 6.00e-59 222.00
IUUC-Ate-010530 Aspergillus terreus 28.70 1.00e-49 190.00
IUUC-Ame-011147 Astyanax mexicanus 69.31 5.00e-42 161.00
IUUC-Bgr-012237 Blumeria graminis 33.66 2.00e-59 223.00
IUUC-Bta-013320 Bos taurus 52.93 1.00e-148 520.00
IUUC-Bci-013795 Botrytis cinerea 29.10 2.00e-62 233.00
IUUC-Bdi-014075 Brachypodium distachyon 40.00 3.00e-86 312.00
IUUC-Bol-016440 Brassica oleracea 38.20 3.00e-82 299.00
IUUC-Bra-016651 Brassica rapa 37.96 4.00e-82 299.00
IUUC-Cel-018692 Caenorhabditis elegans 37.43 4.00e-74 272.00
IUUC-Cja-018987 Callithrix jacchus 53.29 8.00e-135 473.00
IUUC-Cfa-020132 Canis familiaris 51.77 1.00e-148 519.00
IUUC-Cpo-021484 Cavia porcellus 54.21 2.00e-154 539.00
IUUC-Cre-022846 Chlamydomonas reinhardtii 35.43 3.00e-61 229.00
IUUC-Csa-023081 Chlorocebus sabaeus 55.03 5.00e-156 544.00
IUUC-Cin-025182 Ciona intestinalis 51.49 3.00e-138 485.00
IUUC-Csv-026154 Ciona savignyi 51.60 1.00e-134 473.00
IUUC-Cgl-026655 Colletotrichum gloeosporioides 32.91 1.00e-64 240.00
IUUC-Cne-026891 Cryptococcus neoformans 37.84 2.00e-83 303.00
IUUC-Cme-027349 Cyanidioschyzon merolae 30.62 1.00e-48 187.00
IUUC-Dre-027655 Danio rerio 55.81 6.00e-158 550.00
IUUC-Dno-029557 Dasypus novemcinctus 48.16 7.00e-123 434.00
IUUC-Dor-030687 Dipodomys ordii 47.78 2.00e-125 442.00
IUUC-Dse-031334 Dothistroma septosporum 30.37 4.00e-61 229.00
IUUC-Ete-032384 Echinops telfairi 48.73 3.00e-123 435.00
IUUC-Eca-033430 Equus caballus 54.64 5.00e-149 521.00
IUUC-Fca-036121 Felis catus 52.19 2.00e-149 522.00
IUUC-Fal-036817 Ficedula albicollis 54.45 6.00e-148 517.00
IUUC-Fox-037906 Fusarium oxysporum 34.23 2.00e-63 236.00
IUUC-Fso-038409 Fusarium solani 34.04 3.00e-64 239.00
IUUC-Gmo-039151 Gadus morhua 52.78 3.00e-145 508.00
IUUC-Ggr-040016 Gaeumannomyces graminis 33.58 2.00e-63 236.00
IUUC-Gga-040936 Gallus gallus 51.50 2.00e-154 539.00
IUUC-Gac-041405 Gasterosteus aculeatus 50.50 3.00e-144 505.00
IUUC-Gma-044252 Glycine max 29.35 5.00e-87 315.00
IUUC-Ggo-045430 Gorilla gorilla 55.03 5.00e-156 544.00
IUUC-Hsa-046442 Homo sapiens 55.03 5.00e-156 544.00
IUUC-Hvu-047587 Hordeum vulgare 35.59 2.00e-75 276.00
IUUC-Itr-048910 Ictidomys tridecemlineatus 65.55 7.00e-119 419.00
IUUC-Kpa-049145 Komagataella pastoris 30.52 9.00e-58 218.00
IUUC-Lch-050474 Latimeria chalumnae 53.93 3.00e-147 514.00
IUUC-Lpe-051209 Leersia perrieri 38.80 3.00e-78 285.00
IUUC-Loc-052119 Lepisosteus oculatus 54.80 3.00e-151 528.00
IUUC-Lma-053237 Leptosphaeria maculans 32.61 8.00e-61 228.00
IUUC-Laf-053718 Loxodonta africana 54.96 7.00e-156 543.00
IUUC-Mcc-055621 Macaca mulatta 53.17 1.00e-134 473.00
IUUC-Meu-055914 Macropus eugenii 57.05 5.00e-109 388.00
IUUC-Mor-057090 Magnaporthe oryzae 34.24 5.00e-63 235.00
IUUC-Mpo-057364 Magnaporthe poae 33.25 2.00e-63 236.00
IUUC-Mtr-057744 Medicago truncatula 36.58 2.00e-84 306.00
IUUC-Mla-058914 Melampsora laricipopulina 30.96 3.00e-91 328.00
IUUC-Mga-060181 Meleagris gallopavo 51.25 2.00e-148 519.00
IUUC-Mvi-060432 Microbotryum violaceum 37.56 2.00e-72 266.00
IUUC-Mmr-060871 Microcebus murinus 55.44 2.00e-157 548.00
IUUC-Mdo-062301 Monodelphis domestica 54.93 1.00e-154 540.00
IUUC-Mmu-063888 Mus musculus 55.51 7.00e-156 543.00
IUUC-Mac-065137 Musa acuminata 28.48 2.00e-90 326.00
IUUC-Mpu-066732 Mustela putorius furo 52.73 1.00e-148 520.00
IUUC-Mlu-067542 Myotis lucifugus 54.78 5.00e-151 527.00
IUUC-Nfi-068396 Neosartorya fischeri 32.42 4.00e-56 212.00
IUUC-Ncr-068842 Neurospora crassa 31.64 4.00e-63 236.00
IUUC-Nle-070156 Nomascus leucogenys 55.24 8.00e-156 543.00
IUUC-Opr-070808 Ochotona princeps 51.41 8.00e-100 357.00
IUUC-Ont-072105 Oreochromis niloticus 49.37 3.00e-150 525.00
IUUC-Ocu-074962 Oryctolagus cuniculus 52.25 1.00e-149 523.00
IUUC-Oba-075178 Oryza barthii 39.28 2.00e-84 306.00
IUUC-Obr-076399 Oryza brachyantha 39.13 7.00e-85 308.00
IUUC-Ogu-078797 Oryza glumaepatula 39.28 2.00e-84 306.00
IUUC-Oin-080085 Oryza indica 39.83 2.00e-74 273.00
IUUC-Olo-081048 Oryza longistaminata 39.09 3.00e-64 240.00
IUUC-Ome-081324 Oryza meridionalis 39.28 2.00e-84 306.00
IUUC-Oni-082548 Oryza nivara 39.28 1.00e-84 306.00
IUUC-Opu-084008 Oryza punctata 39.28 2.00e-84 306.00
IUUC-Oru-084339 Oryza rufipogon 39.04 5.00e-84 305.00
IUUC-Osa-085782 Oryza sativa 39.04 5.00e-84 305.00
IUUC-Ola-087302 Oryzias latipes 50.11 3.00e-136 478.00
IUUC-Olu-087611 Ostreococcus lucimarinus 36.90 5.00e-85 308.00
IUUC-Oga-087935 Otolemur garnettii 54.95 3.00e-150 525.00
IUUC-Oar-089229 Ovis aries 48.97 2.00e-121 429.00
IUUC-Ptr-090715 Pan troglodytes 55.03 5.00e-156 544.00
IUUC-Pan-092318 Papio anubis 54.85 8.00e-150 523.00
IUUC-Psi-094053 Pelodiscus sinensis 52.74 4.00e-147 514.00
IUUC-Pno-094985 Phaeosphaeria nodorum 31.09 1.00e-53 204.00
IUUC-Ppa-095819 Physcomitrella patens 40.05 1.00e-85 310.00
IUUC-Pfo-096857 Poecilia formosa 53.68 3.00e-147 515.00
IUUC-Pab-098047 Pongo abelii 55.03 6.00e-156 544.00
IUUC-Pop-099587 Populus trichocarpa 38.97 1.00e-82 301.00
IUUC-Pca-100558 Procavia capensis 62.44 2.00e-81 296.00
IUUC-Ppe-101261 Prunus persica 34.85 9.00e-85 307.00
IUUC-Pva-102683 Pteropus vampyrus 54.83 2.00e-152 532.00
IUUC-Pgr-103660 Puccinia graminis 27.91 3.00e-76 278.00
IUUC-Ptt-103900 Puccinia triticina 36.35 1.00e-76 280.00
IUUC-Pte-104209 Pyrenophora teres 33.02 2.00e-61 230.00
IUUC-Pyt-104802 Pyrenophora triticirepentis 33.02 2.00e-61 230.00
IUUC-Rno-105566 Rattus norvegicus 55.51 7.00e-156 543.00
IUUC-Sce-106291 Saccharomyces cerevisiae 32.02 1.00e-61 230.00
IUUC-Sha-107514 Sarcophilus harrisii 50.85 3.00e-133 468.00
IUUC-Sja-107833 Schizosaccharomyces japonicus 28.28 1.00e-78 286.00
IUUC-Spo-108162 Schizosaccharomyces pombe 37.73 2.00e-73 269.00
IUUC-Smo-109533 Selaginella moellendorffii 37.42 4.00e-88 318.00
IUUC-Sit-109980 Setaria italica 28.85 6.00e-93 334.00
IUUC-Sly-111547 Solanum lycopersicum 40.26 1.00e-84 307.00
IUUC-Stu-112705 Solanum tuberosum 40.26 5.00e-85 308.00
IUUC-Sar-113222 Sorex araneus 52.23 1.00e-137 483.00
IUUC-Sbi-114272 Sorghum bicolor 36.29 6.00e-89 321.00
IUUC-Sre-115061 Sporisorium reilianum 35.27 4.00e-78 285.00
IUUC-Ssc-116364 Sus scrofa 53.22 9.00e-150 523.00
IUUC-Tgu-116645 Taeniopygia guttata 54.45 2.00e-148 519.00
IUUC-Tru-117590 Takifugu rubripes 50.19 3.00e-153 535.00
IUUC-Tsy-119212 Tarsius syrichta 51.27 7.00e-135 474.00
IUUC-Tni-119915 Tetraodon nigroviridis 51.67 4.00e-156 545.00
IUUC-Tca-121765 Theobroma cacao 39.61 3.00e-85 309.00
IUUC-Tre-121887 Trichoderma reesei 33.80 4.00e-58 219.00
IUUC-Tvi-122262 Trichoderma virens 33.58 2.00e-57 217.00
IUUC-Tur-126483 Triticum urartu 40.24 9.00e-87 314.00
IUUC-Tme-127202 Tuber melanosporum 28.00 9.00e-52 197.00
IUUC-Tbe-127350 Tupaia belangeri 50.43 1.00e-98 353.00
IUUC-Ttr-129077 Tursiops truncatus 50.52 1.00e-135 476.00
IUUC-Uma-129465 Ustilago maydis 35.27 8.00e-77 281.00
IUUC-Vda-129844 Verticillium dahliae 34.58 6.00e-65 241.00
IUUC-Vvi-131397 Vitis vinifera 38.18 2.00e-86 313.00
IUUC-Xtr-132057 Xenopus tropicalis 52.12 8.00e-155 540.00
IUUC-Xma-134139 Xiphophorus maculatus 51.28 2.00e-126 446.00
IUUC-Yli-134424 Yarrowia lipolytica 32.26 5.00e-61 229.00
IUUC-Zma-135506 Zea mays 28.37 2.00e-89 323.00
Created Date 25-Jun-2017

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