iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046158

UUCD1 version

UUC-HoS-00346

Ensembl Protein ID

ENSP00000302120.5

UniProt Accession

Q9BZR9; A6NI31; Q9C028; TRIM8_HUMAN

Genbank Protein ID

AAG53087.1; AAG53488.1; EAW49680.1; AAH21925.1

Protein Name

Probable E3 ubiquitin-protein ligase TRIM8; Glioblastoma-expressed RING finger protein; RING finger protein 27; RING-type E3 ubiquitin transferase TRIM8; Tripartite motif-containing protein 8

Genbank Nucleotide ID

AF281046; AF220034; AL391121; BC021925

Gene Name

TRIM8; GERP; RNF27

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000171206.13	ENST00000302424.11	ENSP00000302120.5
ENSG00000171206.13	ENST00000462202.2	ENSP00000473428.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM	SZDB
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090; 20516148

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	3.20e-05	25.6	11	78
E3 activity/RING/RING	3.70e-07	32.2	15	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssI.ekwlasggk.tcPvtrqpl.teedlvPnltlrrliqaw 68
           ee++CpI l ++ +Pv lp+ + + r +I e w +++g   cP ++q   ++  l  nl l ++++++
   Q: 11   EELICPICLHVFVEPVQLPCKHNFCRGCIgEAWAKDSGLvRCPECNQAYnQKPGLEKNLKLTNIVEKF 78
           799**************************66788555557*******994455668888888888877 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl  f + p+ lpC+H f++ C+ ++w     + s+  rCP C+
   Q: 15   CPICLHVFVE-PVQLPCKHNFCRGCIgEAW----AKDSGLVRCPECN 56
           ********99.999****************....889*********7 PP

Organism

Homo sapiens

Functional Description
(View)

Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.

Protein Sequence
(Fasta)

MAENWKNCFE EELICPICLH VFVEPVQLPC KHNFCRGCIG EAWAKDSGLV RCPECNQAYN 60
QKPGLEKNLK LTNIVEKFNA LHVEKPPAAL HCVFCRRGPP LPAQKVCLRC EAPCCQSHVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGACCGTC GGGGCCGGCT GGGGCCGGAG CTCGGGGCTC GGTGGGCCTA CAGCGGCTCC 60
GGACGGACCC CCGGGGCTGG GGAGTCGGGG AGGCCTGCCC CGGCCCCCTG CCCGCGGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0016605--C:PML body
GO:0042802--F:identical protein binding
GO:0042803--F:protein homodimerization activity
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0016567--P:protein ubiquitination
GO:0019827--P:stem cell population maintenance

KEGG

hsa:81603

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001258	Ailuropoda melanoleuca	98.55	0.00e+00	1123.00
IUUC-Apl-004223	Anas platyrhynchos	85.69	0.00e+00	986.00
IUUC-Aca-005106	Anolis carolinensis	85.66	0.00e+00	1013.00
IUUC-Ame-011348	Astyanax mexicanus	67.14	0.00e+00	761.00
IUUC-Bta-012787	Bos taurus	99.27	0.00e+00	1132.00
IUUC-Cja-019471	Callithrix jacchus	99.46	0.00e+00	1134.00
IUUC-Cfa-020052	Canis familiaris	98.73	0.00e+00	1127.00
IUUC-Cpo-022491	Cavia porcellus	96.14	0.00e+00	717.00
IUUC-Csa-023544	Chlorocebus sabaeus	99.46	0.00e+00	1134.00
IUUC-Dre-028013	Danio rerio	66.43	0.00e+00	762.00
IUUC-Dno-029676	Dasypus novemcinctus	98.55	0.00e+00	1128.00
IUUC-Dor-030402	Dipodomys ordii	97.82	0.00e+00	1119.00
IUUC-Ete-033188	Echinops telfairi	89.87	0.00e+00	1014.00
IUUC-Eca-033524	Equus caballus	98.01	0.00e+00	1115.00
IUUC-Eeu-034979	Erinaceus europaeus	97.21	1.00e-142	499.00
IUUC-Fca-036362	Felis catus	98.73	0.00e+00	1125.00
IUUC-Fal-036652	Ficedula albicollis	84.26	0.00e+00	967.00
IUUC-Gmo-039405	Gadus morhua	60.64	0.00e+00	649.00
IUUC-Gga-040813	Gallus gallus	85.48	0.00e+00	988.00
IUUC-Gac-041792	Gasterosteus aculeatus	64.12	0.00e+00	657.00
IUUC-Ggo-044962	Gorilla gorilla	99.82	0.00e+00	1138.00
IUUC-Itr-048118	Ictidomys tridecemlineatus	98.91	0.00e+00	1128.00
IUUC-Lch-049433	Latimeria chalumnae	79.64	0.00e+00	871.00
IUUC-Loc-052026	Lepisosteus oculatus	76.48	0.00e+00	880.00
IUUC-Laf-054159	Loxodonta africana	96.33	0.00e+00	906.00
IUUC-Mcc-055490	Macaca mulatta	99.46	0.00e+00	1134.00
IUUC-Meu-056549	Macropus eugenii	89.00	0.00e+00	740.00
IUUC-Mga-059334	Meleagris gallopavo	85.66	0.00e+00	984.00
IUUC-Mmr-061672	Microcebus murinus	99.09	0.00e+00	1131.00
IUUC-Mdo-061849	Monodelphis domestica	89.34	0.00e+00	927.00
IUUC-Mmu-063537	Mus musculus	97.64	0.00e+00	1118.00
IUUC-Mpu-065762	Mustela putorius furo	98.91	0.00e+00	1129.00
IUUC-Mlu-066979	Myotis lucifugus	95.10	0.00e+00	751.00
IUUC-Nle-069419	Nomascus leucogenys	99.82	0.00e+00	1138.00
IUUC-Opr-070981	Ochotona princeps	98.19	0.00e+00	1123.00
IUUC-Ont-072053	Oreochromis niloticus	58.87	2.00e-175	608.00
IUUC-Oan-073608	Ornithorhynchus anatinus	86.75	0.00e+00	830.00
IUUC-Ocu-074694	Oryctolagus cuniculus	98.19	0.00e+00	1082.00
IUUC-Ola-086949	Oryzias latipes	60.21	1.00e-175	609.00
IUUC-Oga-089175	Otolemur garnettii	99.27	0.00e+00	1134.00
IUUC-Oar-089591	Ovis aries	88.89	0.00e+00	887.00
IUUC-Ptr-091309	Pan troglodytes	98.73	0.00e+00	1103.00
IUUC-Pan-091903	Papio anubis	99.46	0.00e+00	1134.00
IUUC-Psi-093293	Pelodiscus sinensis	83.78	0.00e+00	969.00
IUUC-Pfo-097191	Poecilia formosa	60.14	2.00e-172	598.00
IUUC-Pab-098251	Pongo abelii	96.19	0.00e+00	1085.00
IUUC-Pca-100504	Procavia capensis	98.73	0.00e+00	1129.00
IUUC-Pva-102320	Pteropus vampyrus	97.82	0.00e+00	1077.00
IUUC-Rno-105545	Rattus norvegicus	97.82	0.00e+00	1117.00
IUUC-Ssc-116121	Sus scrofa	99.27	0.00e+00	1132.00
IUUC-Tgu-116724	Taeniopygia guttata	85.48	0.00e+00	983.00
IUUC-Tru-118048	Takifugu rubripes	59.52	5.00e-179	620.00
IUUC-Tni-120856	Tetraodon nigroviridis	60.32	2.00e-170	592.00
IUUC-Tbe-127400	Tupaia belangeri	85.56	1.00e-164	572.00
IUUC-Ttr-128233	Tursiops truncatus	98.37	0.00e+00	1108.00
IUUC-Xtr-132578	Xenopus tropicalis	84.03	0.00e+00	967.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence