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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063208
Ensembl Protein ID ENSMUSP00000022682.5
UniProt Accession Q9R1Z8; Q62423; VINEX_MOUSE
Genbank Protein ID AAD32303.1; AAC52642.1
Protein Name Vinexin; SH3 domain-containing protein SH3P3; SH3-containing adapter molecule 1; Sorbin and SH3 domain-containing protein 3
Genbank Nucleotide ID AF064806; U58889
Gene Name Sorbs3; Scam1; Sh3d4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022091.5 ENSMUST00000022682.5 ENSMUSP00000022682.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.90e-38 131.3 680 733
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +++y+y +qn+deL+l++Gd v+v+  ++ d gW +gv+  ++k G fP n+v+ +
   Q: 680  RAMYQYRPQNEDELELREGDRVDVM--QQCDDGWFVGVSRRTQKFGTFPGNYVAPV 733
           699*********************9..88999*********************875 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2, INPPL1/SHIP2 and SRCIN1 (By similarity). Interacts with DLG5 through its third SH3 domain. Interacts with SOCS7 and MAPK1/ERK2. Interacts with FASLG (By similarity).
 Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2, INPPL1/SHIP2 and SRCIN1 (By similarity). Interacts with DLG5 through its third SH3 domain. Interacts with SOCS7 and MAPK1/ERK2. Interacts with FASLG (By similarity).
Protein Sequence
(Fasta)
MARILGVGRS SASSLNNKED NESDVALLSP KDPNRVHTKE QLAHPASSNL DPSMQGLPAG 60
LSLDDFIPGH LRTHIGSSSR GTRVPVIRNG GSNTLNFQFH DPAPRTVCNG CPPPRRDGSL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063208|UBD,SH3|Mus musculus
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Nucleotide Sequence
(Fasta)
GTGAAGGGGG ATGGCCAGGA TTCTTGGAGT GGGAAGATCT TCAGCTTCGT CTTTGAACAA 60
CAAAGAAGAC AATGAAAGTG ATGTAGCCCT TCTTAGTCCC AAGGACCCTA ACAGGTGGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063208|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0130--Cell adhesion
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
Interpro

IPR001452--SH3_domain
IPR003127--SoHo_dom
IPR028510--Vinexin
PROSITE

PS50002--SH3
PS50831--SOHO
Pfam

PF00018--SH3_1
PF14604--SH3_9
PF02208--Sorb
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
SM00459--Sorb
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005925--C:focal adhesion
GO:0005634--C:nucleus
GO:0008134--F:transcription factor binding
GO:0017166--F:vinculin binding
GO:0007015--P:actin filament organization
GO:0031589--P:cell-substrate adhesion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0043410--P:positive regulation of MAPK cascade
GO:0051496--P:positive regulation of stress fiber assembly
KEGG mmu:20410
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001334 Ailuropoda melanoleuca 77.33 0.00e+00 1044.00
IUUC-Aca-004742 Anolis carolinensis 62.72 9.00e-91 326.00
IUUC-Ame-011484 Astyanax mexicanus 65.03 2.00e-54 206.00
IUUC-Bta-013006 Bos taurus 74.22 0.00e+00 960.00
IUUC-Cja-018889 Callithrix jacchus 77.91 0.00e+00 994.00
IUUC-Cfa-020116 Canis familiaris 72.04 0.00e+00 967.00
IUUC-Cpo-022410 Cavia porcellus 74.15 0.00e+00 962.00
IUUC-Csa-023880 Chlorocebus sabaeus 78.14 0.00e+00 1046.00
IUUC-Dre-027897 Danio rerio 42.31 7.00e-68 251.00
IUUC-Dor-031099 Dipodomys ordii 76.56 0.00e+00 976.00
IUUC-Ete-033119 Echinops telfairi 72.15 2.00e-95 343.00
IUUC-Eca-033308 Equus caballus 77.39 0.00e+00 1059.00
IUUC-Eeu-034908 Erinaceus europaeus 65.53 6.00e-169 587.00
IUUC-Fca-035613 Felis catus 73.67 0.00e+00 975.00
IUUC-Fal-036732 Ficedula albicollis 60.27 7.00e-94 338.00
IUUC-Gmo-039474 Gadus morhua 66.67 1.00e-52 201.00
IUUC-Ggo-045404 Gorilla gorilla 78.20 0.00e+00 1088.00
IUUC-Hsa-046435 Homo sapiens 78.92 0.00e+00 976.00
IUUC-Itr-048874 Ictidomys tridecemlineatus 77.21 0.00e+00 1050.00
IUUC-Lch-049463 Latimeria chalumnae 56.49 3.00e-87 314.00
IUUC-Loc-052576 Lepisosteus oculatus 41.19 1.00e-70 260.00
IUUC-Laf-053952 Loxodonta africana 75.64 0.00e+00 1026.00
IUUC-Mcc-055482 Macaca mulatta 79.36 0.00e+00 1016.00
IUUC-Meu-056517 Macropus eugenii 63.68 5.00e-122 431.00
IUUC-Mvi-060304 Microbotryum violaceum 35.81 6.00e-20 92.40
IUUC-Mmr-061231 Microcebus murinus 77.65 0.00e+00 1008.00
IUUC-Mdo-061965 Monodelphis domestica 58.20 0.00e+00 654.00
IUUC-Mpu-066398 Mustela putorius furo 77.49 0.00e+00 1069.00
IUUC-Mlu-067369 Myotis lucifugus 66.13 0.00e+00 852.00
IUUC-Nle-069995 Nomascus leucogenys 78.63 0.00e+00 999.00
IUUC-Opr-070845 Ochotona princeps 76.53 1.00e-83 303.00
IUUC-Ont-071643 Oreochromis niloticus 42.50 5.00e-77 282.00
IUUC-Oan-072838 Ornithorhynchus anatinus 66.46 4.00e-111 395.00
IUUC-Ocu-074532 Oryctolagus cuniculus 75.30 0.00e+00 986.00
IUUC-Ola-086962 Oryzias latipes 39.86 1.00e-61 231.00
IUUC-Oga-089133 Otolemur garnettii 75.67 0.00e+00 1035.00
IUUC-Oar-089690 Ovis aries 73.73 0.00e+00 989.00
IUUC-Ptr-091678 Pan troglodytes 79.51 0.00e+00 1024.00
IUUC-Pan-091746 Papio anubis 78.63 0.00e+00 1076.00
IUUC-Pfo-096778 Poecilia formosa 42.52 3.00e-74 273.00
IUUC-Pab-098678 Pongo abelii 79.22 0.00e+00 1006.00
IUUC-Pca-100286 Procavia capensis 73.44 0.00e+00 934.00
IUUC-Pva-102673 Pteropus vampyrus 76.89 0.00e+00 738.00
IUUC-Rno-105212 Rattus norvegicus 93.32 0.00e+00 1345.00
IUUC-Sha-107072 Sarcophilus harrisii 58.13 0.00e+00 690.00
IUUC-Ssc-116138 Sus scrofa 77.42 0.00e+00 1058.00
IUUC-Tsy-118791 Tarsius syrichta 82.47 9.00e-139 487.00
IUUC-Tbe-127945 Tupaia belangeri 80.99 2.00e-101 363.00
IUUC-Ttr-128675 Tursiops truncatus 83.28 4.00e-141 494.00
Created Date 25-Jun-2017

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