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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Dme-032014
Ensembl Protein ID FBpp0088169
UniProt Accession Q8SY33; Q8MSF0; Q9V4F1; GAWKY_DROME
Genbank Protein ID AAF59322.2; AAF59323.2; AAN06507.2; AAN06508.1; AAN06509.1; AAX52511.2; AAL68245.1; AAM50720.1
Protein Name Protein Gawky
Genbank Nucleotide ID AE014135; AE014135; AE014135; AE014135; AE014135; AE014135; AY075429; AY118860
Gene Name gw; GW182; CG31992
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0051992 FBtr0089100 FBpp0088169
FBgn0051992 FBtr0310543 FBpp0302680
FBgn0051992 FBtr0310542 FBpp0302679
Annotation
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
dbPAFPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 19295135; 19383769
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 0.0002 21.4 552 586
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGFdreealqaLraannnleaAveyLl 39
    + + lve GF +e++ +aL an n+e+A+++L
   Q: 552 KQYRILVENGFKKEDVERALVIANMNIEEAADMLR 586
    566789**************************995 PP
   

Organism Drosophila melanogaster
Functional Description
(View)

Functional Description



     Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development.
Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development.
Protein Sequence
(Fasta)
MREALFSQDG WGCQHVNQDT NWEVPSSPEP ANKDAPGPPM WKPSINNGTD LWESNLRNGG 60
QPAAQQVPKP SWGHTPSSNL GGTWGEDDDG ADSSSVWTGG AVSNAGSGAA VGVNQAGVNV 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Dme-032014|UBD,UBA|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
AAATAGCCGG ATCAATTCGT ATTTAAGGTT GTATGATGGT TAAAACGGGA AATCGCAGTA 60
ATTTTTATTA TTTAAATAGT AAATTTAAAC TTCAGTAAAA ATATCCTAAA TAATGTGAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Dme-032014|UBD,UBA|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0943--RNA-mediated gene silencing
KW-0810--Translation regulation

Interpro

IPR019486--Argonaute_hook_dom
IPR033503--GW182
IPR026805--GW182_M_dom
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS50030--UBA

Pfam

PF10427--Ago_hook
PF12938--M_domain
PF00627--UBA

Gene Ontology

GO:0000932--C:P-body
GO:0000166--F:nucleotide binding
GO:0003723--F:RNA binding
GO:0001700--P:embryonic development via the syncytial blastoderm
GO:0035195--P:gene silencing by miRNA
GO:0045475--P:locomotor rhythm
GO:0035278--P:miRNA mediated inhibition of translation
GO:0006402--P:mRNA catabolic process
GO:0032880--P:regulation of protein localization

KEGG dme:Dmel_CG31992
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001985 Ailuropoda melanoleuca 34.70 2.00e-35 144.00
IUUC-Apl-003191 Anas platyrhynchos 38.71 9.00e-33 135.00
IUUC-Aca-004717 Anolis carolinensis 58.89 5.00e-26 113.00
IUUC-Ame-010681 Astyanax mexicanus 39.58 2.00e-32 134.00
IUUC-Bta-012915 Bos taurus 34.70 1.00e-35 145.00
IUUC-Cel-018193 Caenorhabditis elegans 28.57 2.00e-01 30.40
IUUC-Cja-019614 Callithrix jacchus 41.84 3.00e-32 134.00
IUUC-Cfa-020452 Canis familiaris 34.70 2.00e-35 145.00
IUUC-Cpo-021452 Cavia porcellus 41.53 6.00e-32 133.00
IUUC-Csa-023169 Chlorocebus sabaeus 34.70 2.00e-35 144.00
IUUC-Cho-024655 Choloepus hoffmanni 38.91 8.00e-32 132.00
IUUC-Dre-028059 Danio rerio 39.66 2.00e-28 121.00
IUUC-Dno-029734 Dasypus novemcinctus 34.36 3.00e-33 137.00
IUUC-Dor-030671 Dipodomys ordii 35.13 6.00e-35 143.00
IUUC-Ete-032774 Echinops telfairi 39.75 4.00e-36 147.00
IUUC-Eca-033866 Equus caballus 42.68 3.00e-32 134.00
IUUC-Eeu-034572 Erinaceus europaeus 54.74 1.00e-26 115.00
IUUC-Fal-036856 Ficedula albicollis 37.28 7.00e-30 126.00
IUUC-Gga-040531 Gallus gallus 42.34 5.00e-33 137.00
IUUC-Gac-041681 Gasterosteus aculeatus 41.74 1.00e-35 145.00
IUUC-Ggo-045143 Gorilla gorilla 43.51 4.00e-40 160.00
IUUC-Hsa-045913 Homo sapiens 41.84 5.00e-37 149.00
IUUC-Lch-049619 Latimeria chalumnae 34.46 7.00e-35 142.00
IUUC-Loc-052289 Lepisosteus oculatus 40.51 9.00e-30 125.00
IUUC-Laf-053607 Loxodonta africana 42.28 3.00e-32 134.00
IUUC-Mcc-055342 Macaca mulatta 41.84 4.00e-32 133.00
IUUC-Meu-056275 Macropus eugenii 38.23 5.00e-34 140.00
IUUC-Mga-059241 Meleagris gallopavo 35.45 2.00e-34 141.00
IUUC-Mmr-061348 Microcebus murinus 34.70 2.00e-35 144.00
IUUC-Mdo-062155 Monodelphis domestica 41.53 5.00e-32 133.00
IUUC-Mmu-064259 Mus musculus 35.36 8.00e-36 145.00
IUUC-Mpu-066534 Mustela putorius furo 37.54 4.00e-34 140.00
IUUC-Mlu-067834 Myotis lucifugus 33.92 2.00e-35 144.00
IUUC-Nle-069168 Nomascus leucogenys 34.10 2.00e-32 134.00
IUUC-Opr-070976 Ochotona princeps 56.67 2.00e-26 114.00
IUUC-Ocu-073749 Oryctolagus cuniculus 35.13 3.00e-35 144.00
IUUC-Oba-075778 Oryza barthii 26.67 9.70e-01 27.70
IUUC-Oga-088116 Otolemur garnettii 34.45 7.00e-35 142.00
IUUC-Oar-090041 Ovis aries 34.70 1.00e-35 145.00
IUUC-Ptr-091135 Pan troglodytes 36.67 1.00e-32 135.00
IUUC-Pan-092665 Papio anubis 60.49 2.00e-25 111.00
IUUC-Psi-093057 Pelodiscus sinensis 42.34 3.00e-33 137.00
IUUC-Pfo-097115 Poecilia formosa 57.14 4.00e-04 40.00
IUUC-Pab-097935 Pongo abelii 34.96 1.00e-35 145.00
IUUC-Pca-100481 Procavia capensis 59.09 2.00e-25 111.00
IUUC-Pva-102376 Pteropus vampyrus 56.04 4.00e-26 114.00
IUUC-Rno-105508 Rattus norvegicus 35.90 1.00e-35 145.00
IUUC-Sly-111284 Solanum lycopersicum 54.17 1.70e-02 33.90
IUUC-Stu-112750 Solanum tuberosum 54.17 1.90e-02 33.90
IUUC-Sar-113036 Sorex araneus 55.43 2.00e-26 114.00
IUUC-Ssc-115574 Sus scrofa 42.24 2.00e-30 127.00
IUUC-Tgu-117233 Taeniopygia guttata 42.34 4.00e-33 137.00
IUUC-Tru-117725 Takifugu rubripes 42.56 5.00e-32 133.00
IUUC-Tsy-118786 Tarsius syrichta 55.43 2.00e-26 115.00
IUUC-Tvi-122630 Trichoderma virens 31.82 5.20e-02 31.20
IUUC-Tbe-127551 Tupaia belangeri 37.33 3.00e-34 141.00
IUUC-Ttr-128518 Tursiops truncatus 41.94 1.00e-32 135.00
IUUC-Vpa-130230 Vicugna pacos 50.72 6.00e-15 77.00
IUUC-Xtr-132265 Xenopus tropicalis 41.53 8.00e-35 142.00
Created Date 25-Jun-2017

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