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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045767
UUCD1 version UUC-HoS-01118
Ensembl Protein ID ENSP00000345216.4
UniProt Accession Q70EL1; A1L4Q4; A3KFK3; A3KFK5; A3KFK6; A3KFK7; A6PVS4; A6PVS5; A6PVS6; A6PVS7; B3KVY1; B9ZVM1; Q5F2F4; Q6P1N6; Q6ZSP1; Q6ZSR1; Q6ZTM0; Q8N1X2; UBP54_HUMAN
Genbank Protein ID CAE47747.1; BAC04393.1; BAG53943.1; BAC86566.1; BAC86886.1; BAC86907.1; CAO03506.1; CAO03507.1; CAO03508.1; CAO03509.1; AAH64967.1; AAI30634.1
Protein Name Inactive ubiquitin carboxyl-terminal hydrolase 54; Inactive ubiquitin-specific peptidase 54
Genbank Nucleotide ID AJ583820; AK094637; AK123711; AK126497; AK127213; AK127267; BX649087; AL359074; AL359074; AL359074; BC064967; BC130633
Gene Name USP54; C10orf29
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000166348.18 ENST00000418501.5 ENSP00000404644.1
ENSG00000166348.18 ENST00000466048.6 ENSP00000473466.1
ENSG00000166348.18 ENST00000424265.5 ENSP00000399972.1
ENSG00000166348.18 ENST00000339859.8 ENSP00000345216.4
ENSG00000166348.18 ENST00000451492.5 ENSP00000402435.1
ENSG00000166348.18 ENST00000422491.6 ENSP00000407368.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 19302785
Classification
Family E-value Score Start End
DUB/USP 4.50e-24 86.9 32 349
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNl..gNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavspre.....llkalkkeaeefsg 86
           Gl+N   +N+C++NS+LQ+L+++  +r+ + + +++k+  +       ++ ++l+ +f++++ +++++v p++     l k++++e+ +f+ 
   Q: 32   GLSNEpgQNSCFLNSALQVLWHLDIFRRSFRQLTTHKCMGD------SCIFCALKGIFNQFQ-CSSEKVLPSDtlrsaLAKTFQDEQ-RFQL 115
           88887668******************************986......59************5.555555555543333555555444.599* PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
               Da E+++ ll +++ ++                    de +e+  + ++++ ++ F ++l +q++c +c+ +s    pf+++   ++ 
   Q: 116  GIMDDAAECFENLLMRIHFHI-------------------ADETKEDICTAQHCISHQKFAMTLFEQCVCTSCGATSDPL-PFIQMVHYIST 187
           *********************...................3455677899*************************99766.9*********9 PP
   S: 179  keetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
            + +++             +++ +  ++ +  g+ +   ++c ++ +  +++   + P+++++ L +   s + +  e +  ++ +   L+l
   Q: 188  TSLCNQAicmlerrekPSPSMFGELLQNASTMGDLRNCPSNCGERIR-IRRVL-MNAPQIITIGLVWD--SDHSDLAEDVIHSLGTC--LKL 273
           99988889999999985556666666677777666667777777664.56655.566**********9..33334444444444444..555 PP
   S: 262  sp..fctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtev..keeevleetg...staYvlfY 335
               f ++ ++  k+++ Y L+++++++G     HY ++  ++k + W++fdD +V+e+  k+++v++++     ++ +l+Y
   Q: 274  GDlfFRVT-DDRAKQSELY-LVGMICYYG----KHYSTFFFQTKIRkWMYFDDAHVKEIgpKWKDVVTKCIkghYQPLLLLY 349
           55213333.3333335555.*********....9*****99987767************76689998865555555556666 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Weakly expressed in a few tissues.
 Weakly expressed in a few tissues.
Protein Sequence
(Fasta)
MSWKRNYFSG GRGSVQGMFA PRSSTSIAPS KGLSNEPGQN SCFLNSALQV LWHLDIFRRS 60
FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR SALAKTFQDE QRFQLGIMDD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045767|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCGGCGCC AGGAGCTGTG AGTGCGACAC CCTCAGGGGG GCGGGGCCGG GGGTAACGGG 60
GTGCAGGGGG TAGCGCCTGG GGAGGGGGTG CGGGGAAGGT TAGGTCGCGG GAGGAATGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045767|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR001394--Peptidase_C19_UCH
IPR028889--USP_dom
PROSITE

PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
KEGG hsa:159195
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000820 Aegilops tauschii 29.76 2.00e-18 87.00
IUUC-Aml-001414 Ailuropoda melanoleuca 87.18 0.00e+00 2586.00
IUUC-Apl-004044 Anas platyrhynchos 79.68 0.00e+00 1233.00
IUUC-Aca-004351 Anolis carolinensis 58.60 0.00e+00 1551.00
IUUC-Aly-005468 Arabidopsis lyrata 32.78 3.00e-43 171.00
IUUC-Ath-007147 Arabidopsis thaliana 32.65 4.00e-42 167.00
IUUC-Ame-011525 Astyanax mexicanus 61.18 0.00e+00 979.00
IUUC-Bta-013344 Bos taurus 85.12 0.00e+00 2542.00
IUUC-Bdi-015058 Brachypodium distachyon 32.13 5.00e-41 164.00
IUUC-Bol-015670 Brassica oleracea 31.78 1.00e-39 158.00
IUUC-Bra-016731 Brassica rapa 32.36 7.00e-42 167.00
IUUC-Cja-018724 Callithrix jacchus 94.77 0.00e+00 2846.00
IUUC-Cfa-021222 Canis familiaris 86.92 0.00e+00 2644.00
IUUC-Cpo-021795 Cavia porcellus 85.33 0.00e+00 2093.00
IUUC-Csa-023262 Chlorocebus sabaeus 96.56 0.00e+00 2984.00
IUUC-Cho-024422 Choloepus hoffmanni 83.78 0.00e+00 2052.00
IUUC-Cin-025752 Ciona intestinalis 68.60 7.00e-48 182.00
IUUC-Csv-026063 Ciona savignyi 56.10 6.00e-112 397.00
IUUC-Dre-028046 Danio rerio 64.38 0.00e+00 962.00
IUUC-Dno-029417 Dasypus novemcinctus 81.60 0.00e+00 2370.00
IUUC-Dor-030653 Dipodomys ordii 74.30 0.00e+00 1010.00
IUUC-Dme-032071 Drosophila melanogaster 53.82 2.00e-104 374.00
IUUC-Ete-032692 Echinops telfairi 66.09 0.00e+00 756.00
IUUC-Eca-033235 Equus caballus 86.87 0.00e+00 2277.00
IUUC-Eeu-034975 Erinaceus europaeus 65.77 0.00e+00 922.00
IUUC-Fca-036070 Felis catus 86.01 0.00e+00 2632.00
IUUC-Fal-037089 Ficedula albicollis 60.29 0.00e+00 1665.00
IUUC-Gmo-038653 Gadus morhua 74.93 1.00e-173 602.00
IUUC-Gga-041241 Gallus gallus 60.98 0.00e+00 1667.00
IUUC-Gac-042157 Gasterosteus aculeatus 80.20 0.00e+00 682.00
IUUC-Gma-043273 Glycine max 31.20 2.00e-37 152.00
IUUC-Ggo-045626 Gorilla gorilla 99.35 0.00e+00 3051.00
IUUC-Hvu-047657 Hordeum vulgare 31.67 6.00e-42 167.00
IUUC-Itr-048187 Ictidomys tridecemlineatus 76.66 0.00e+00 2357.00
IUUC-Lch-049712 Latimeria chalumnae 87.79 0.00e+00 717.00
IUUC-Lpe-051572 Leersia perrieri 32.05 7.00e-39 157.00
IUUC-Loc-052615 Lepisosteus oculatus 66.45 0.00e+00 1023.00
IUUC-Laf-054578 Loxodonta africana 74.98 0.00e+00 1560.00
IUUC-Mcc-054696 Macaca mulatta 96.80 0.00e+00 2947.00
IUUC-Meu-056841 Macropus eugenii 54.92 0.00e+00 684.00
IUUC-Mga-059519 Meleagris gallopavo 49.06 0.00e+00 1138.00
IUUC-Mmr-060701 Microcebus murinus 88.13 0.00e+00 2570.00
IUUC-Mdo-062433 Monodelphis domestica 69.16 0.00e+00 1969.00
IUUC-Mmu-063480 Mus musculus 71.05 0.00e+00 1468.00
IUUC-Mac-064469 Musa acuminata 31.89 4.00e-19 90.90
IUUC-Mpu-066404 Mustela putorius furo 86.96 0.00e+00 2675.00
IUUC-Mlu-067841 Myotis lucifugus 76.88 0.00e+00 1562.00
IUUC-Nle-070110 Nomascus leucogenys 98.68 0.00e+00 2607.00
IUUC-Opr-070676 Ochotona princeps 85.53 0.00e+00 1365.00
IUUC-Ont-072289 Oreochromis niloticus 71.10 0.00e+00 712.00
IUUC-Oan-073551 Ornithorhynchus anatinus 66.30 0.00e+00 1665.00
IUUC-Ocu-074729 Oryctolagus cuniculus 86.89 0.00e+00 2608.00
IUUC-Obr-076268 Oryza brachyantha 33.24 3.00e-42 167.00
IUUC-Ogl-077138 Oryza glaberrima 32.35 2.00e-39 158.00
IUUC-Oin-079125 Oryza indica 32.35 3.00e-39 157.00
IUUC-Opu-083823 Oryza punctata 32.94 6.00e-40 160.00
IUUC-Ola-086742 Oryzias latipes 80.43 0.00e+00 648.00
IUUC-Oga-088920 Otolemur garnettii 90.14 0.00e+00 2227.00
IUUC-Oar-089644 Ovis aries 85.06 0.00e+00 2533.00
IUUC-Ptr-091530 Pan troglodytes 99.51 0.00e+00 2632.00
IUUC-Pan-092190 Papio anubis 99.00 0.00e+00 1725.00
IUUC-Psi-094022 Pelodiscus sinensis 60.24 0.00e+00 1646.00
IUUC-Pma-094745 Petromyzon marinus 59.89 2.00e-134 472.00
IUUC-Pfo-096072 Poecilia formosa 79.23 0.00e+00 699.00
IUUC-Pab-097979 Pongo abelii 98.82 0.00e+00 2396.00
IUUC-Pop-099539 Populus trichocarpa 31.69 1.00e-37 152.00
IUUC-Pca-101005 Procavia capensis 71.88 0.00e+00 2020.00
IUUC-Ppe-101918 Prunus persica 30.90 9.00e-39 156.00
IUUC-Pva-103125 Pteropus vampyrus 85.35 0.00e+00 2491.00
IUUC-Rno-105463 Rattus norvegicus 76.99 0.00e+00 2280.00
IUUC-Sha-107164 Sarcophilus harrisii 69.28 0.00e+00 1885.00
IUUC-Sit-110021 Setaria italica 32.26 2.00e-37 152.00
IUUC-Sly-110975 Solanum lycopersicum 31.34 4.00e-39 157.00
IUUC-Stu-112904 Solanum tuberosum 31.40 2.00e-37 152.00
IUUC-Sar-113423 Sorex araneus 64.66 0.00e+00 894.00
IUUC-Sbi-114345 Sorghum bicolor 32.84 2.00e-41 165.00
IUUC-Ssc-116206 Sus scrofa 85.17 0.00e+00 2506.00
IUUC-Tgu-116521 Taeniopygia guttata 94.50 0.00e+00 795.00
IUUC-Tru-118155 Takifugu rubripes 70.20 2.00e-172 598.00
IUUC-Tsy-118998 Tarsius syrichta 85.24 0.00e+00 2334.00
IUUC-Tni-120257 Tetraodon nigroviridis 80.36 0.00e+00 664.00
IUUC-Tca-121692 Theobroma cacao 31.87 2.00e-38 155.00
IUUC-Tae-125619 Triticum aestivum 31.94 9.00e-43 169.00
IUUC-Tur-126027 Triticum urartu 31.67 2.00e-42 169.00
IUUC-Tbe-128072 Tupaia belangeri 68.75 4.00e-163 568.00
IUUC-Ttr-128290 Tursiops truncatus 85.49 0.00e+00 1994.00
IUUC-Vpa-130213 Vicugna pacos 84.00 0.00e+00 2137.00
IUUC-Vvi-131652 Vitis vinifera 31.20 1.00e-38 156.00
IUUC-Xtr-131831 Xenopus tropicalis 53.47 0.00e+00 1431.00
IUUC-Xma-133409 Xiphophorus maculatus 60.31 0.00e+00 847.00
Created Date 25-Jun-2017

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