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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063255
Ensembl Protein ID ENSMUSP00000095953.3
UniProt Accession Q6GQT6; Q6A0A6; Q6NS67; Q7TNG7; Q80UI6; SCAP_MOUSE
Genbank Protein ID BAD32190.1; BAE27338.1; BAE29431.1; BAE31252.1; BAE31909.1; AAH51066.1; AAH55472.1; AAH69955.1; AAH70437.1; AAH72633.1
Protein Name Sterol regulatory element-binding protein cleavage-activating protein
Genbank Nucleotide ID AK172912; AK146658; AK150275; AK152478; AK153330; BC051066; BC055472; BC069955; BC070437; BC072633
Gene Name Scap; Kiaa0199
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032485.14 ENSMUST00000198976.4 ENSMUSP00000143369.1
ENSMUSG00000032485.14 ENSMUST00000098350.9 ENSMUSP00000095953.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.00e-15 57.4 1114 1148
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd.tl.lvsGsdDgtikvWDlrtgv 34
           gH++ +t++   d t+ l+sG+ Dg i +WD+ tg 
   Q: 1114 GHSGAITAVYI-DqTMvLASGGQDGAICLWDVLTGS 1148
           8********88.446648*************98885 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway.
 Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway.
Protein Sequence
(Fasta)
MTLTERLREK ISQAFYNHGL LCASYPIPII LFTGLCILAC CYPLLKLPLP GTGPVEFSTP 60
VKGYSPPPAD SDHKQGEPSE QPEWYVGAPV AYIQQIFVKS SVSPWHRNLL AVDVFRSPLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063255|E3,WD_repeat|Mus musculus
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Nucleotide Sequence
(Fasta)
AGACTACGCA TGCGCACGCC GCCGGGAGCA CGTGTGGAGG GCGGCGGAGC GGGAGGGGAA 60
AGGTAGGAGT TGAGAGGTGA AGGGGCGGGG AGCTGCGCGG GCGCCGGGCG GCCGGGAGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063255|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0153--Cholesterol metabolism
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0753--Steroid metabolism
KW-1207--Sterol metabolism
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0853--WD repeat
Interpro

IPR027295--Quinoprotein_ADH-like_fam
IPR030225--SCAP
IPR000731--SSD
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50156--SSD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12349--Sterol-sensing
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0012507--C:ER to Golgi transport vesicle membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0043234--C:protein complex
GO:0015485--F:cholesterol binding
GO:0007568--P:aging
GO:0008203--P:cholesterol metabolic process
GO:0045540--P:regulation of cholesterol biosynthetic process
GO:0042304--P:regulation of fatty acid biosynthetic process
GO:0019217--P:regulation of fatty acid metabolic process
GO:0001666--P:response to hypoxia
GO:0032868--P:response to insulin
GO:0032933--P:SREBP signaling pathway
KEGG mmu:235623
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001802 Ailuropoda melanoleuca 95.36 0.00e+00 1098.00
IUUC-Apl-003294 Anas platyrhynchos 76.76 0.00e+00 1721.00
IUUC-Aca-004424 Anolis carolinensis 69.49 0.00e+00 1503.00
IUUC-Bta-013478 Bos taurus 90.23 0.00e+00 2024.00
IUUC-Cel-018160 Caenorhabditis elegans 30.24 2.00e-67 251.00
IUUC-Cja-019123 Callithrix jacchus 89.21 0.00e+00 2013.00
IUUC-Cfa-021082 Canis familiaris 89.60 0.00e+00 1999.00
IUUC-Cpo-022477 Cavia porcellus 83.83 0.00e+00 1867.00
IUUC-Csa-023176 Chlorocebus sabaeus 89.05 0.00e+00 2009.00
IUUC-Cin-025490 Ciona intestinalis 38.10 3.00e-89 323.00
IUUC-Csv-026115 Ciona savignyi 36.34 6.00e-132 465.00
IUUC-Dre-028008 Danio rerio 67.39 0.00e+00 1517.00
IUUC-Dno-028887 Dasypus novemcinctus 91.06 0.00e+00 1213.00
IUUC-Dor-030467 Dipodomys ordii 93.28 0.00e+00 879.00
IUUC-Dme-032087 Drosophila melanogaster 32.81 5.00e-110 392.00
IUUC-Ete-032372 Echinops telfairi 76.36 0.00e+00 1652.00
IUUC-Eca-033896 Equus caballus 91.32 0.00e+00 2098.00
IUUC-Eeu-035099 Erinaceus europaeus 83.65 0.00e+00 1196.00
IUUC-Fca-035616 Felis catus 93.75 0.00e+00 1100.00
IUUC-Fal-037231 Ficedula albicollis 74.54 0.00e+00 1650.00
IUUC-Gmo-039439 Gadus morhua 73.90 0.00e+00 679.00
IUUC-Gac-041516 Gasterosteus aculeatus 66.90 0.00e+00 1490.00
IUUC-Hsa-046674 Homo sapiens 91.95 0.00e+00 2152.00
IUUC-Itr-048879 Ictidomys tridecemlineatus 91.16 0.00e+00 2106.00
IUUC-Lch-049689 Latimeria chalumnae 70.69 0.00e+00 1627.00
IUUC-Loc-052417 Lepisosteus oculatus 54.04 2.00e-131 462.00
IUUC-Laf-053795 Loxodonta africana 89.42 0.00e+00 2037.00
IUUC-Mcc-055502 Macaca mulatta 91.71 0.00e+00 2104.00
IUUC-Mga-059805 Meleagris gallopavo 77.58 0.00e+00 1724.00
IUUC-Mmr-060997 Microcebus murinus 91.80 0.00e+00 2130.00
IUUC-Mdo-062940 Monodelphis domestica 81.45 0.00e+00 1814.00
IUUC-Mpu-066158 Mustela putorius furo 90.38 0.00e+00 2061.00
IUUC-Mlu-067201 Myotis lucifugus 86.54 0.00e+00 1978.00
IUUC-Nle-069145 Nomascus leucogenys 93.88 0.00e+00 1362.00
IUUC-Opr-070797 Ochotona princeps 86.08 0.00e+00 1917.00
IUUC-Ont-071553 Oreochromis niloticus 66.74 0.00e+00 1486.00
IUUC-Ocu-074598 Oryctolagus cuniculus 91.86 0.00e+00 2062.00
IUUC-Ola-086650 Oryzias latipes 82.87 2.00e-107 381.00
IUUC-Oar-089287 Ovis aries 85.30 0.00e+00 1104.00
IUUC-Pan-092004 Papio anubis 92.19 0.00e+00 2105.00
IUUC-Psi-093028 Pelodiscus sinensis 71.18 0.00e+00 1519.00
IUUC-Pma-094145 Petromyzon marinus 50.29 0.00e+00 1112.00
IUUC-Pfo-096320 Poecilia formosa 67.33 0.00e+00 1490.00
IUUC-Pab-097862 Pongo abelii 92.25 0.00e+00 2158.00
IUUC-Pca-100862 Procavia capensis 76.66 0.00e+00 1606.00
IUUC-Pva-103050 Pteropus vampyrus 90.56 0.00e+00 1326.00
IUUC-Rno-105852 Rattus norvegicus 98.12 0.00e+00 2292.00
IUUC-Sha-107312 Sarcophilus harrisii 81.38 0.00e+00 1823.00
IUUC-Sar-113311 Sorex araneus 84.89 0.00e+00 776.00
IUUC-Ssc-116356 Sus scrofa 90.31 0.00e+00 2097.00
IUUC-Tgu-116896 Taeniopygia guttata 60.58 4.00e-151 529.00
IUUC-Tru-118197 Takifugu rubripes 67.76 0.00e+00 1502.00
IUUC-Tni-119823 Tetraodon nigroviridis 66.03 0.00e+00 1476.00
IUUC-Ttr-129164 Tursiops truncatus 90.00 0.00e+00 2016.00
IUUC-Xtr-132819 Xenopus tropicalis 69.14 0.00e+00 1613.00
Created Date 25-Jun-2017

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