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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046320
Ensembl Protein ID ENSP00000260247.5
UniProt Accession Q9BTE7; Q3ZTT2; DCNL5_HUMAN
Genbank Protein ID BAB71336.1; AAH04169.1; AAQ76805.1
Protein Name DCN1-like protein 5; DCUN1 domain-containing protein 5; Defective in cullin neddylation protein 1-like protein 5
Genbank Nucleotide ID AK056993; BC004169; AY364246
Gene Name DCUN1D5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000137692.11 ENST00000527260.5 ENSP00000432027.1
ENSG00000137692.11 ENST00000260247.9 ENSP00000260247.5
ENSG00000137692.11 ENST00000531571.5 ENSP00000433073.1
ENSG00000137692.11 ENST00000531543.1 ENSP00000435035.1
ENSG00000137692.11 ENST00000529281.5 ENSP00000431311.1
ENSG00000137692.11 ENST00000529294.5 ENSP00000433134.1
ENSG00000137692.11 ENST00000527576.5 ENSP00000433344.1
ENSG00000137692.11 ENST00000527779.1 ENSP00000432488.1
ENSG00000137692.11 ENST00000583974.1 ENSP00000463796.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/DCUN1 DCUN1 19617556
Classification
Family E-value Score Start End
E3 activity/DCUN1 6.30e-83 279.1 47 232
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/DCUN1
   S: 2    skkkleelferYkdpqedligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselkdeqk 93
           s+kk+ ++f++Y++p+e ++g eg+ekfced+gv+pe+i++Lvlawklea+++++f++ee+l+g+t+l+cd++eklq+k+++l+s+l+d+++
   Q: 47   SSKKCLAWFYEYAGPDE-VVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEKLQNKFDFLRSQLNDISS 137
           78*************95.************************************************************************** PP
   S: 94   fkdiYrfafnfakdkgqksldldtaialwkLllaerefklldawlkfLeeekkksiskDtWnllLefskviakdlsnYdeegaWPvliDefv 185
           fk+iYr+af+fa+dk+q+sld+dta+++++Lll +r+++l+++++++Le++k+++++kD+W+++Lefs+++++dlsnYde+gaWPvl+Defv
   Q: 138  FKNIYRYAFDFARDKDQRSLDIDTAKSMLALLL-GRTWPLFSVFYQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFV 228
           *********************************.999******************************************************* PP
   S: 186  eylk 189
           e++k
   Q: 229  EWQK 232
           **86 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MPVKKKRKSP GVAAAVAEDG GLKKCKISSY CRSQPPARLI SGEEHFSSKK CLAWFYEYAG 60
PDEVVGPEGM EKFCEDIGVE PENIIMLVLA WKLEAESMGF FTKEEWLKGM TSLQCDCTEK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046320|E3,DCUN1|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATTGCGTCA CTTCCGGGCC TCAGCGATTC GCCTCCGGGT TAGGCTGAGC CTCTTGCTTG 60
CTGTGACTGG TGGAGCTGCC GCGCTGTCCG CGTTATCTCC TCCCGGTGAG AACGAACCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046320|E3,DCUN1|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
PROSITE

PS51229--DCUN1
Pfam

PF03556--Cullin_binding
Gene Ontology

GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation
KEGG hsa:84259
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001567 Ailuropoda melanoleuca 99.58 4.00e-141 493.00
IUUC-Apl-003338 Anas platyrhynchos 87.34 2.00e-123 434.00
IUUC-Aca-004660 Anolis carolinensis 90.30 1.00e-127 448.00
IUUC-Afu-009005 Aspergillus fumigatus 31.07 5.00e-17 80.50
IUUC-Bta-013463 Bos taurus 98.31 1.00e-137 481.00
IUUC-Cja-019665 Callithrix jacchus 100.00 3.00e-141 493.00
IUUC-Cfa-020873 Canis familiaris 98.73 3.00e-140 490.00
IUUC-Csa-023661 Chlorocebus sabaeus 100.00 3.00e-141 493.00
IUUC-Cin-025635 Ciona intestinalis 56.71 3.00e-52 197.00
IUUC-Csv-025976 Ciona savignyi 56.48 1.00e-62 233.00
IUUC-Cme-027199 Cyanidioschyzon merolae 23.31 9.00e-08 50.80
IUUC-Dre-028080 Danio rerio 78.39 1.00e-111 395.00
IUUC-Dno-029984 Dasypus novemcinctus 98.33 2.00e-138 485.00
IUUC-Dor-030556 Dipodomys ordii 97.05 9.00e-137 478.00
IUUC-Eca-034108 Equus caballus 100.00 3.00e-141 493.00
IUUC-Fca-035374 Felis catus 90.68 6.00e-125 439.00
IUUC-Fal-037284 Ficedula albicollis 94.37 1.00e-119 422.00
IUUC-Gga-040330 Gallus gallus 92.41 5.00e-130 456.00
IUUC-Gac-042443 Gasterosteus aculeatus 75.32 2.00e-101 361.00
IUUC-Ggo-044892 Gorilla gorilla 100.00 3.00e-141 493.00
IUUC-Itr-048437 Ictidomys tridecemlineatus 100.00 2.00e-73 267.00
IUUC-Lch-049750 Latimeria chalumnae 87.76 2.00e-123 434.00
IUUC-Loc-052941 Lepisosteus oculatus 84.81 1.00e-119 422.00
IUUC-Laf-054402 Loxodonta africana 99.16 3.00e-140 490.00
IUUC-Mcc-055269 Macaca mulatta 100.00 3.00e-141 493.00
IUUC-Meu-056847 Macropus eugenii 84.47 1.00e-106 379.00
IUUC-Mga-059420 Meleagris gallopavo 94.34 3.00e-118 417.00
IUUC-Mmr-061732 Microcebus murinus 99.58 7.00e-141 492.00
IUUC-Mdo-062269 Monodelphis domestica 97.47 1.00e-128 452.00
IUUC-Mmu-063396 Mus musculus 97.18 2.00e-123 434.00
IUUC-Mpu-066206 Mustela putorius furo 99.40 5.00e-98 349.00
IUUC-Mlu-067871 Myotis lucifugus 99.16 9.00e-140 488.00
IUUC-Nfi-068610 Neosartorya fischeri 31.64 8.00e-18 83.20
IUUC-Nle-069808 Nomascus leucogenys 100.00 3.00e-141 493.00
IUUC-Opr-070404 Ochotona princeps 98.23 1.00e-62 232.00
IUUC-Ont-072416 Oreochromis niloticus 71.79 3.00e-96 344.00
IUUC-Oan-072930 Ornithorhynchus anatinus 88.03 2.00e-120 424.00
IUUC-Ocu-073767 Oryctolagus cuniculus 99.16 3.00e-140 490.00
IUUC-Ola-086378 Oryzias latipes 69.75 8.00e-96 342.00
IUUC-Oga-088583 Otolemur garnettii 100.00 3.00e-141 493.00
IUUC-Oar-089612 Ovis aries 98.09 6.00e-123 432.00
IUUC-Ptr-090753 Pan troglodytes 100.00 3.00e-141 493.00
IUUC-Pan-091951 Papio anubis 100.00 3.00e-141 493.00
IUUC-Psi-093385 Pelodiscus sinensis 94.09 4.00e-124 437.00
IUUC-Pma-094582 Petromyzon marinus 72.15 2.00e-99 355.00
IUUC-Pfo-096222 Poecilia formosa 70.66 2.00e-96 345.00
IUUC-Pab-097692 Pongo abelii 100.00 3.00e-141 493.00
IUUC-Pva-102620 Pteropus vampyrus 99.09 1.00e-128 451.00
IUUC-Rno-105023 Rattus norvegicus 97.65 3.00e-124 437.00
IUUC-Sha-107177 Sarcophilus harrisii 97.47 1.00e-128 452.00
IUUC-Sar-113656 Sorex araneus 87.02 5.00e-103 366.00
IUUC-Ssc-116272 Sus scrofa 99.16 6.00e-140 489.00
IUUC-Tgu-116631 Taeniopygia guttata 92.24 3.00e-118 417.00
IUUC-Tsy-119350 Tarsius syrichta 99.16 3.00e-140 490.00
IUUC-Tbe-127515 Tupaia belangeri 92.80 2.00e-127 448.00
IUUC-Ttr-128784 Tursiops truncatus 75.53 2.00e-95 342.00
IUUC-Vpa-130543 Vicugna pacos 99.58 4.00e-141 493.00
IUUC-Xtr-132448 Xenopus tropicalis 87.71 5.00e-124 436.00
Created Date 25-Jun-2017

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