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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046152
Ensembl Protein ID ENSP00000262803.4
UniProt Accession Q92900; O00239; O43343; Q86Z25; Q92842; RENT1_HUMAN
Genbank Protein ID AAC50771.1; AAC51140.1; BAA19664.2; AAC26788.1; AAB94785.1; AAH39817.1
Protein Name Regulator of nonsense transcripts 1; ATP-dependent helicase RENT1; Nonsense mRNA reducing factor 1; Up-frameshift suppressor 1 homolog
Genbank Nucleotide ID U65533; U59323; D86988; AF074016; AC003972; BC039817
Gene Name UPF1; KIAA0221; RENT1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000005007.12 ENST00000262803.9 ENSP00000262803.4
ENSG00000005007.12 ENST00000599848.5 ENSP00000470142.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 55.98 0.00e+00 969.00 IUUC-Sce-106206
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability.
 RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability.
Protein Sequence
(Fasta)
MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFEFTDFTL PSQTQTPPGG PGGPGGGGAG 60
GPGGAGAGAA AGQLDAQVGP EGILQNGAVD DSVAKTSQLL AELNFEEDEE DTYYTKDLPI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046152|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGACGGCG GCGGTGGCGG CAGTTCCTGC TCTAGGCTGC GAGCGGCTGG CGGCTTCGAG 60
GGGAGCTGAG GCGCGGAGGG GCTCGGCGGC AGCGGCGGCG GCTCGGCACT GTTACCTCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046152|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0488--Methylation
KW-0866--Nonsense-mediated mRNA decay
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006935--Helicase/UvrB_N
IPR027417--P-loop_NTPase
IPR018999--RNA-helicase_UPF1_UPF2-interct
Pfam

PF04851--ResIII
PF09416--UPF1_Zn_bind
Gene Ontology

GO:0000785--C:chromatin
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0035145--C:exon-exon junction complex
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0044530--C:supraspliceosomal complex
GO:0005524--F:ATP binding
GO:0004004--F:ATP-dependent RNA helicase activity
GO:0003682--F:chromatin binding
GO:0004386--F:helicase activity
GO:0003723--F:RNA binding
GO:0042162--F:telomeric DNA binding
GO:0008270--F:zinc ion binding
GO:0061158--P:3'-UTR-mediated mRNA destabilization
GO:0071347--P:cellular response to interleukin-1
GO:0071222--P:cellular response to lipopolysaccharide
GO:0006281--P:DNA repair
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0071044--P:histone mRNA catabolic process
GO:0006406--P:mRNA export from nucleus
GO:0000956--P:nuclear-transcribed mRNA catabolic process
GO:0000294--P:nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
GO:0000184--P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0061014--P:positive regulation of mRNA catabolic process
GO:0006449--P:regulation of translational termination
GO:0000723--P:telomere maintenance
GO:0032201--P:telomere maintenance via semi-conservative replication
KEGG hsa:5976
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000680 Aegilops tauschii 71.47 0.00e+00 1178.00
IUUC-Aml-002008 Ailuropoda melanoleuca 97.26 0.00e+00 2118.00
IUUC-Atr-002632 Amborella trichopoda 67.32 0.00e+00 1271.00
IUUC-Apl-003997 Anas platyrhynchos 97.91 0.00e+00 2017.00
IUUC-Aca-004322 Anolis carolinensis 31.55 7.00e-54 206.00
IUUC-Aly-006521 Arabidopsis lyrata 71.81 0.00e+00 1254.00
IUUC-Ath-007059 Arabidopsis thaliana 71.57 0.00e+00 1253.00
IUUC-Ago-007801 Ashbya gossypii 55.70 0.00e+00 952.00
IUUC-Acl-008312 Aspergillus clavatus 69.06 0.00e+00 1196.00
IUUC-Afl-008429 Aspergillus flavus 68.18 0.00e+00 1194.00
IUUC-Afu-009092 Aspergillus fumigatus 68.37 0.00e+00 1193.00
IUUC-Ani-009317 Aspergillus nidulans 69.06 0.00e+00 1196.00
IUUC-Ang-009783 Aspergillus niger 59.92 0.00e+00 1195.00
IUUC-Aor-010178 Aspergillus oryzae 68.18 0.00e+00 1194.00
IUUC-Ate-010294 Aspergillus terreus 60.26 0.00e+00 1202.00
IUUC-Ame-010774 Astyanax mexicanus 74.07 0.00e+00 1218.00
IUUC-Bgr-012293 Blumeria graminis 67.41 0.00e+00 1187.00
IUUC-Bta-012382 Bos taurus 97.52 0.00e+00 2126.00
IUUC-Bci-013937 Botrytis cinerea 67.66 0.00e+00 1182.00
IUUC-Bdi-014612 Brachypodium distachyon 71.21 0.00e+00 1264.00
IUUC-Bol-015145 Brassica oleracea 70.74 0.00e+00 1244.00
IUUC-Bra-017370 Brassica rapa 69.30 0.00e+00 1209.00
IUUC-Cel-018240 Caenorhabditis elegans 59.06 0.00e+00 997.00
IUUC-Cja-019892 Callithrix jacchus 100.00 0.00e+00 2064.00
IUUC-Cfa-020700 Canis familiaris 98.67 0.00e+00 2130.00
IUUC-Cpo-021510 Cavia porcellus 96.99 0.00e+00 2155.00
IUUC-Cre-022731 Chlamydomonas reinhardtii 59.35 0.00e+00 995.00
IUUC-Csa-023665 Chlorocebus sabaeus 99.91 0.00e+00 2147.00
IUUC-Cin-025798 Ciona intestinalis 83.93 0.00e+00 1352.00
IUUC-Csv-025901 Ciona savignyi 71.97 0.00e+00 1612.00
IUUC-Cgl-026653 Colletotrichum gloeosporioides 64.59 0.00e+00 1157.00
IUUC-Cne-027014 Cryptococcus neoformans 63.51 0.00e+00 1201.00
IUUC-Dre-028705 Danio rerio 92.69 0.00e+00 2045.00
IUUC-Dor-030369 Dipodomys ordii 96.45 0.00e+00 1995.00
IUUC-Dme-031767 Drosophila melanogaster 70.94 0.00e+00 1407.00
IUUC-Ete-032800 Echinops telfairi 33.80 3.00e-53 203.00
IUUC-Eca-033840 Equus caballus 99.71 0.00e+00 2048.00
IUUC-Fca-035466 Felis catus 98.11 0.00e+00 2038.00
IUUC-Fal-037548 Ficedula albicollis 98.37 0.00e+00 1996.00
IUUC-Fox-038023 Fusarium oxysporum 63.83 0.00e+00 1144.00
IUUC-Gmo-039285 Gadus morhua 90.99 0.00e+00 1983.00
IUUC-Ggr-039810 Gaeumannomyces graminis 66.50 0.00e+00 1178.00
IUUC-Gga-040972 Gallus gallus 97.05 0.00e+00 2098.00
IUUC-Gac-042075 Gasterosteus aculeatus 91.09 0.00e+00 2013.00
IUUC-Gma-042713 Glycine max 72.53 0.00e+00 1298.00
IUUC-Ggo-045398 Gorilla gorilla 100.00 0.00e+00 2052.00
IUUC-Hvu-047555 Hordeum vulgare 73.03 0.00e+00 735.00
IUUC-Itr-048247 Ictidomys tridecemlineatus 98.51 0.00e+00 2002.00
IUUC-Kpa-049205 Komagataella pastoris 49.22 0.00e+00 776.00
IUUC-Lch-049587 Latimeria chalumnae 97.27 0.00e+00 1319.00
IUUC-Lpe-051059 Leersia perrieri 73.16 0.00e+00 1271.00
IUUC-Loc-051911 Lepisosteus oculatus 93.48 0.00e+00 2044.00
IUUC-Lma-053007 Leptosphaeria maculans 61.43 0.00e+00 1163.00
IUUC-Laf-054234 Loxodonta africana 97.70 0.00e+00 2107.00
IUUC-Mcc-054762 Macaca mulatta 97.96 0.00e+00 2132.00
IUUC-Meu-056677 Macropus eugenii 94.31 0.00e+00 888.00
IUUC-Mor-057147 Magnaporthe oryzae 67.04 0.00e+00 1170.00
IUUC-Mpo-057314 Magnaporthe poae 66.50 0.00e+00 1179.00
IUUC-Mtr-058329 Medicago truncatula 72.41 0.00e+00 1296.00
IUUC-Mla-059094 Melampsora laricipopulina 67.49 0.00e+00 681.00
IUUC-Mga-060126 Meleagris gallopavo 97.43 0.00e+00 2001.00
IUUC-Mvi-060373 Microbotryum violaceum 67.34 0.00e+00 1272.00
IUUC-Mmr-060628 Microcebus murinus 97.61 0.00e+00 2127.00
IUUC-Mdo-061858 Monodelphis domestica 99.04 0.00e+00 2032.00
IUUC-Mmu-064116 Mus musculus 97.94 0.00e+00 2126.00
IUUC-Mac-065136 Musa acuminata 71.57 0.00e+00 1262.00
IUUC-Mpu-066463 Mustela putorius furo 99.64 0.00e+00 2141.00
IUUC-Mlu-068098 Myotis lucifugus 99.19 0.00e+00 2126.00
IUUC-Nfi-068370 Neosartorya fischeri 68.37 0.00e+00 1193.00
IUUC-Ncr-068792 Neurospora crassa 61.23 0.00e+00 1167.00
IUUC-Nle-070102 Nomascus leucogenys 99.90 0.00e+00 2047.00
IUUC-Opr-070620 Ochotona princeps 91.55 0.00e+00 1872.00
IUUC-Ont-072685 Oreochromis niloticus 91.96 0.00e+00 2011.00
IUUC-Oan-073665 Ornithorhynchus anatinus 95.94 0.00e+00 2094.00
IUUC-Ocu-074154 Oryctolagus cuniculus 33.41 3.00e-55 210.00
IUUC-Oba-075075 Oryza barthii 63.68 0.00e+00 1018.00
IUUC-Obr-076183 Oryza brachyantha 67.04 0.00e+00 1097.00
IUUC-Ogl-077691 Oryza glaberrima 68.47 0.00e+00 1273.00
IUUC-Ogu-078423 Oryza glumaepatula 68.47 0.00e+00 1271.00
IUUC-Oin-080107 Oryza indica 68.47 0.00e+00 1271.00
IUUC-Olo-080269 Oryza longistaminata 67.89 0.00e+00 1198.00
IUUC-Ome-081779 Oryza meridionalis 68.47 0.00e+00 1271.00
IUUC-Oni-082366 Oryza nivara 68.47 0.00e+00 1272.00
IUUC-Opu-083958 Oryza punctata 64.35 0.00e+00 1273.00
IUUC-Oru-084182 Oryza rufipogon 68.47 0.00e+00 1270.00
IUUC-Osa-085285 Oryza sativa 68.28 0.00e+00 1271.00
IUUC-Ola-086954 Oryzias latipes 89.26 0.00e+00 1983.00
IUUC-Olu-087685 Ostreococcus lucimarinus 57.59 0.00e+00 951.00
IUUC-Oga-088591 Otolemur garnettii 99.91 0.00e+00 2146.00
IUUC-Oar-089417 Ovis aries 95.95 0.00e+00 1979.00
IUUC-Ptr-091510 Pan troglodytes 99.16 0.00e+00 1874.00
IUUC-Pan-091886 Papio anubis 100.00 0.00e+00 2147.00
IUUC-Psi-093755 Pelodiscus sinensis 97.91 0.00e+00 1429.00
IUUC-Pma-094470 Petromyzon marinus 86.21 0.00e+00 1891.00
IUUC-Pno-094963 Phaeosphaeria nodorum 66.79 0.00e+00 1163.00
IUUC-Ppa-095479 Physcomitrella patens 72.52 0.00e+00 1299.00
IUUC-Pfo-097456 Poecilia formosa 92.05 0.00e+00 2021.00
IUUC-Pab-098075 Pongo abelii 92.56 0.00e+00 1951.00
IUUC-Pop-099557 Populus trichocarpa 62.44 0.00e+00 1286.00
IUUC-Pca-100717 Procavia capensis 100.00 4.00e-176 612.00
IUUC-Ppe-101675 Prunus persica 63.01 0.00e+00 1302.00
IUUC-Pva-103029 Pteropus vampyrus 99.18 0.00e+00 1393.00
IUUC-Pgr-103318 Puccinia graminis 64.19 0.00e+00 1212.00
IUUC-Ptt-103956 Puccinia triticina 63.17 0.00e+00 1211.00
IUUC-Pte-104399 Pyrenophora teres 62.25 0.00e+00 1176.00
IUUC-Pyt-104749 Pyrenophora triticirepentis 62.03 0.00e+00 1174.00
IUUC-Rno-105784 Rattus norvegicus 97.94 0.00e+00 2163.00
IUUC-Sce-106206 Saccharomyces cerevisiae 55.96 0.00e+00 940.00
IUUC-Sha-106566 Sarcophilus harrisii 97.82 0.00e+00 2023.00
IUUC-Sja-107721 Schizosaccharomyces japonicus 62.40 0.00e+00 1100.00
IUUC-Spo-108258 Schizosaccharomyces pombe 59.47 0.00e+00 1052.00
IUUC-Ssl-108640 Sclerotinia sclerotiorum 64.31 0.00e+00 1044.00
IUUC-Smo-109676 Selaginella moellendorffii 22.33 1.40e+00 28.50
IUUC-Sit-109760 Setaria italica 63.56 0.00e+00 1269.00
IUUC-Sly-111807 Solanum lycopersicum 73.04 0.00e+00 1302.00
IUUC-Stu-112869 Solanum tuberosum 67.36 0.00e+00 1295.00
IUUC-Sar-112950 Sorex araneus 38.31 2.00e-43 171.00
IUUC-Sbi-114863 Sorghum bicolor 63.58 0.00e+00 1268.00
IUUC-Sre-115092 Sporisorium reilianum 66.93 0.00e+00 1259.00
IUUC-Tgu-117214 Taeniopygia guttata 89.70 0.00e+00 1656.00
IUUC-Tru-118386 Takifugu rubripes 86.67 0.00e+00 1977.00
IUUC-Tsy-119550 Tarsius syrichta 99.65 7.00e-168 584.00
IUUC-Tni-120212 Tetraodon nigroviridis 89.23 0.00e+00 1912.00
IUUC-Tca-121353 Theobroma cacao 71.83 0.00e+00 1293.00
IUUC-Tre-122245 Trichoderma reesei 34.94 8.00e-53 203.00
IUUC-Tvi-122452 Trichoderma virens 57.70 0.00e+00 1113.00
IUUC-Tae-123692 Triticum aestivum 73.20 0.00e+00 1263.00
IUUC-Tur-126770 Triticum urartu 61.32 0.00e+00 1078.00
IUUC-Tme-126956 Tuber melanosporum 69.27 0.00e+00 1201.00
IUUC-Tbe-127873 Tupaia belangeri 33.89 3.00e-50 193.00
IUUC-Ttr-128212 Tursiops truncatus 94.73 0.00e+00 2013.00
IUUC-Uma-129327 Ustilago maydis 66.25 0.00e+00 1252.00
IUUC-Vda-129858 Verticillium dahliae 65.66 0.00e+00 1134.00
IUUC-Vpa-130743 Vicugna pacos 33.89 4.00e-51 196.00
IUUC-Vvi-131222 Vitis vinifera 72.53 0.00e+00 1274.00
IUUC-Xtr-131800 Xenopus tropicalis 82.20 0.00e+00 1738.00
IUUC-Xma-133216 Xiphophorus maculatus 91.87 0.00e+00 2018.00
IUUC-Yli-134482 Yarrowia lipolytica 54.14 0.00e+00 897.00
IUUC-Zma-134802 Zea mays 72.42 0.00e+00 1272.00
Created Date 25-Jun-2017

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