iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Cel-018686

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase rpm-1; Pam/highwire/rpm-1 protein; RING-type E3 ubiquitin transferase rpm-1; Regulator of presynaptic morphology protein 1; Synapse defective protein 3

Genbank Nucleotide ID

FO080217

Gene Name

rpm-1; syd-3; C01B7.6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00004457	C01B7.6	C01B7.6

Annotation

mRNA Expression
GEO
DNA & RNA Element
microRNA	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20592256; 19172179

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00014	22.6	3517	3567

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplv.lpCgHvfhadCl.....qkwpglknssskefrCPlC 45
           C iC+++      p++ l+CgH+fh++C+      +w + ++   ++ +CPlC
   Q: 3517 CVICFTERlgAA-PCIrLGCGHMFHFHCVrmileRRW-NGPRIVFRFMQCPLC 3567
           ****99665544.554499*********766789999.88888999999**** PP

Organism

Caenorhabditis elegans

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1 (PubMed:10839353, PubMed:15707898). Negatively regulates a p38 MAP kinase pathway composed of dlk-1, mkk-4, and pmk-3 that functions presynaptically to regulate synaptic architecture (PubMed:15707898). Has a role during synaptogenesis; regulates neuronal morphology, specifically presynaptic differentiation. May regulate the spatial arrangement of presynaptic terminals or restrict their development (PubMed:10839354, PubMed:15208641, PubMed:15707898, PubMed:21968191). By targeting both dlk-1 and mlk-1 for degradation, may negatively regulate mlk-1/mek-1/kgb-1 and dlk-1/mkk-4/pmk-3 pathways which are involved in axon regeneration after injury (PubMed:21670305). Regulates axon termination in PLM and ALM neurons (PubMed:21968191).

Protein Sequence
(Fasta)

MSFFLREIDG ERVCSTSTET SIPEDRKSAR RLRKLLYKCA ENTCKPDILR VPAHCGKLDK 60
EEEKSKTPLD QQQQINFHDI LNSKFVVGPP SPFALVAIAK SILARFGNPE EVSEKEDGSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGTTCT TCTTGCGAGA AATTGATGGT GAACGAGTGT GTTCCACGAG CACCGAAACG 60
TCGATTCCTG AAGATAGGAA AAGTGCACGA AGACTGAGAA AATTGCTATA CAAATGTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0966--Cell projection
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR008979--Galactose-bd-like
IPR013783--Ig-like_fold
IPR012983--PHR
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51284--DOC
PS00626--RCC1_2
PS50012--RCC1_3
PS50119--ZF_BBOX
PS50089--ZF_RING_2

Pfam

PF03256--ANAPC10
PF08005--PHR
PF00415--RCC1
PF00643--zf-B_box
PF13639--zf-RING_2

SMART

SM01337--APC10
SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0030424--C:axon
GO:0031594--C:neuromuscular junction
GO:0005634--C:nucleus
GO:0036062--C:presynaptic periactive zone
GO:0045202--C:synapse
GO:0031435--F:mitogen-activated protein kinase kinase kinase binding
GO:0019903--F:protein phosphatase binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0010171--P:body morphogenesis
GO:0033563--P:dorsal/ventral axon guidance
GO:0040011--P:locomotion
GO:1905869--P:negative regulation of 3'-UTR-mediated mRNA stabilization
GO:0030517--P:negative regulation of axon extension
GO:0048843--P:negative regulation of axon extension involved in axon guidance
GO:0048692--P:negative regulation of axon extension involved in regeneration
GO:0048681--P:negative regulation of axon regeneration
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0043409--P:negative regulation of MAPK cascade
GO:1905490--P:negative regulation of sensory neuron axon guidance
GO:0018991--P:oviposition
GO:1905608--P:positive regulation of presynapse assembly
GO:0051965--P:positive regulation of synapse assembly
GO:1905868--P:regulation of 3'-UTR-mediated mRNA stabilization
GO:0048841--P:regulation of axon extension involved in axon guidance
GO:1905815--P:regulation of dorsal/ventral axon guidance
GO:1905812--P:regulation of motor neuron axon guidance
GO:1905606--P:regulation of presynapse assembly
GO:0031647--P:regulation of protein stability
GO:1905489--P:regulation of sensory neuron axon guidance
GO:0050807--P:regulation of synapse organization
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

cel:CELE_C01B7.6

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001951	Ailuropoda melanoleuca	32.18	0.00e+00	641.00
IUUC-Apl-003625	Anas platyrhynchos	31.56	4.00e-166	579.00
IUUC-Aca-005207	Anolis carolinensis	32.06	9.00e-174	605.00
IUUC-Aor-010074	Aspergillus oryzae	35.97	9.00e-13	66.20
IUUC-Ame-010649	Astyanax mexicanus	32.33	1.00e-177	617.00
IUUC-Bta-012670	Bos taurus	32.31	0.00e+00	639.00
IUUC-Cja-019910	Callithrix jacchus	32.23	0.00e+00	639.00
IUUC-Cfa-020184	Canis familiaris	32.39	0.00e+00	641.00
IUUC-Cpo-021334	Cavia porcellus	41.94	1.00e-140	495.00
IUUC-Csa-023291	Chlorocebus sabaeus	32.31	0.00e+00	642.00
IUUC-Cho-024927	Choloepus hoffmanni	28.16	6.00e-50	193.00
IUUC-Cin-025345	Ciona intestinalis	32.65	1.00e-140	493.00
IUUC-Csv-026264	Ciona savignyi	29.73	4.00e-149	521.00
IUUC-Dre-028645	Danio rerio	32.56	1.00e-178	621.00
IUUC-Dno-029670	Dasypus novemcinctus	32.31	0.00e+00	640.00
IUUC-Dor-030993	Dipodomys ordii	30.40	2.00e-163	570.00
IUUC-Dme-031777	Drosophila melanogaster	38.91	7.00e-122	432.00
IUUC-Ete-032613	Echinops telfairi	45.24	4.00e-133	469.00
IUUC-Eca-034364	Equus caballus	32.14	0.00e+00	639.00
IUUC-Eeu-035200	Erinaceus europaeus	35.56	5.00e-142	499.00
IUUC-Fca-036054	Felis catus	32.31	0.00e+00	639.00
IUUC-Fal-036991	Ficedula albicollis	32.23	9.00e-176	611.00
IUUC-Gmo-038487	Gadus morhua	32.19	0.00e+00	652.00
IUUC-Gga-041035	Gallus gallus	32.47	3.00e-176	613.00
IUUC-Gac-041637	Gasterosteus aculeatus	31.78	4.00e-177	616.00
IUUC-Ggo-045091	Gorilla gorilla	27.30	2.00e-143	503.00
IUUC-Hsa-046977	Homo sapiens	32.31	0.00e+00	642.00
IUUC-Itr-048995	Ictidomys tridecemlineatus	26.92	1.00e-42	167.00
IUUC-Lch-050171	Latimeria chalumnae	39.36	3.00e-114	407.00
IUUC-Loc-052822	Lepisosteus oculatus	32.03	7.00e-178	619.00
IUUC-Laf-054065	Loxodonta africana	32.14	0.00e+00	640.00
IUUC-Mcc-054947	Macaca mulatta	32.31	0.00e+00	642.00
IUUC-Meu-056600	Macropus eugenii	45.87	5.00e-118	419.00
IUUC-Mga-059559	Meleagris gallopavo	32.14	2.00e-173	603.00
IUUC-Mmr-060973	Microcebus murinus	32.31	0.00e+00	641.00
IUUC-Mdo-061938	Monodelphis domestica	32.17	7.00e-176	612.00
IUUC-Mmu-063569	Mus musculus	32.14	0.00e+00	640.00
IUUC-Mpu-066457	Mustela putorius furo	31.53	4.00e-168	586.00
IUUC-Mlu-067165	Myotis lucifugus	27.19	7.00e-144	505.00
IUUC-Nle-069042	Nomascus leucogenys	32.06	3.00e-180	627.00
IUUC-Opr-070201	Ochotona princeps	27.72	3.00e-85	311.00
IUUC-Ont-072263	Oreochromis niloticus	32.37	1.00e-179	624.00
IUUC-Oan-073108	Ornithorhynchus anatinus	27.46	3.00e-138	486.00
IUUC-Ocu-074359	Oryctolagus cuniculus	32.23	0.00e+00	647.00
IUUC-Ola-087074	Oryzias latipes	28.15	4.00e-141	496.00
IUUC-Oga-088322	Otolemur garnettii	32.31	0.00e+00	640.00
IUUC-Oar-089244	Ovis aries	32.39	0.00e+00	642.00
IUUC-Ptr-091449	Pan troglodytes	32.31	0.00e+00	640.00
IUUC-Pan-091756	Papio anubis	32.23	0.00e+00	639.00
IUUC-Psi-093387	Pelodiscus sinensis	32.05	2.00e-171	597.00
IUUC-Pma-094327	Petromyzon marinus	26.49	2.00e-23	101.00
IUUC-Ppa-095276	Physcomitrella patens	38.10	6.00e-50	191.00
IUUC-Pfo-097372	Poecilia formosa	31.94	8.00e-177	615.00
IUUC-Pab-097572	Pongo abelii	32.39	0.00e+00	641.00
IUUC-Pca-101007	Procavia capensis	25.32	5.00e-127	449.00
IUUC-Pva-102217	Pteropus vampyrus	43.13	4.00e-137	483.00
IUUC-Rno-105422	Rattus norvegicus	32.14	0.00e+00	642.00
IUUC-Sha-107119	Sarcophilus harrisii	32.64	2.00e-175	609.00
IUUC-Smo-108712	Selaginella moellendorffii	37.25	1.00e-51	195.00
IUUC-Sar-113595	Sorex araneus	38.42	2.00e-120	427.00
IUUC-Ssc-115690	Sus scrofa	24.68	7.00e-152	532.00
IUUC-Tgu-116555	Taeniopygia guttata	32.23	5.00e-176	612.00
IUUC-Tru-117796	Takifugu rubripes	32.04	9.00e-180	625.00
IUUC-Tsy-118924	Tarsius syrichta	40.26	4.00e-132	466.00
IUUC-Tni-120759	Tetraodon nigroviridis	32.50	1.00e-180	627.00
IUUC-Tre-122202	Trichoderma reesei	52.94	4.00e-05	43.50
IUUC-Tvi-122439	Trichoderma virens	50.00	2.00e-04	41.20
IUUC-Ttr-128814	Tursiops truncatus	32.31	0.00e+00	640.00
IUUC-Uma-129630	Ustilago maydis	26.46	6.00e-09	54.70
IUUC-Vpa-130430	Vicugna pacos	29.58	8.00e-147	515.00
IUUC-Xtr-131898	Xenopus tropicalis	35.01	3.00e-62	232.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence