iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023508

Ensembl Protein ID

ENSCSAP00000006112.1

UniProt Accession

A0A0D9RBX3; A0A0D9RBX3_CHLSB

Genbank Protein ID

ENSCSAP00000006112

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AQIB01151941

Gene Name

BTK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000009872.1	ENSCSAT00000007953.1	ENSCSAP00000006112.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.50e-14	51.6	54	111

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++kv +lydy++ n ++L+l+kGd  +++  ee +  W+++ ++ +g++G +P+n+v+++e
   Q: 54   LKKVVALYDYMPMNANDLQLRKGDEYFIL--EESNLPWWRA-RDKNGQEGYIPSNYVTEAE 111
           689*************************9..9999******.6***************987 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MGCQILENRN GSLKPGSSHR KTKKPLPPTP EEDQILKKPL PPEPAAAPVS TSELKKVVAL 60
YDYMPMNAND LQLRKGDEYF ILEESNLPWW RARDKNGQEG YIPSNYVTEA EDSIEMYEWY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTCCTTTT TTTCTGAATC CTAACCGCAG AAGTCTGTGT TTTCATTGAT CCAGGTTGTA 60
TATGATGAAG GGCCTCTCTA CGTCTTCTCC CCAACTGAAG AACTAAGGAA GCGGTGGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0002344--P:B cell affinity maturation
GO:0048469--P:cell maturation
GO:0098761--P:cellular response to interleukin-7
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0030889--P:negative regulation of B cell proliferation
GO:0001818--P:negative regulation of cytokine production

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001365	Ailuropoda melanoleuca	98.99	0.00e+00	980.00
IUUC-Apl-003907	Anas platyrhynchos	84.48	0.00e+00	845.00
IUUC-Aca-004978	Anolis carolinensis	74.50	0.00e+00	770.00
IUUC-Ame-010694	Astyanax mexicanus	55.70	1.00e-151	529.00
IUUC-Bta-012467	Bos taurus	98.79	0.00e+00	979.00
IUUC-Cja-018841	Callithrix jacchus	98.59	0.00e+00	974.00
IUUC-Cfa-020983	Canis familiaris	98.79	0.00e+00	965.00
IUUC-Cpo-021307	Cavia porcellus	98.79	0.00e+00	981.00
IUUC-Dre-028544	Danio rerio	57.96	1.00e-148	519.00
IUUC-Dno-029828	Dasypus novemcinctus	98.39	0.00e+00	972.00
IUUC-Dor-030102	Dipodomys ordii	94.97	0.00e+00	920.00
IUUC-Ete-032981	Echinops telfairi	87.73	0.00e+00	845.00
IUUC-Eca-033594	Equus caballus	99.40	0.00e+00	985.00
IUUC-Eeu-035281	Erinaceus europaeus	91.60	0.00e+00	676.00
IUUC-Fca-035495	Felis catus	98.59	0.00e+00	963.00
IUUC-Fal-036719	Ficedula albicollis	84.31	0.00e+00	846.00
IUUC-Gga-041193	Gallus gallus	83.90	0.00e+00	843.00
IUUC-Gac-042383	Gasterosteus aculeatus	47.93	2.00e-127	449.00
IUUC-Hsa-045931	Homo sapiens	100.00	0.00e+00	981.00
IUUC-Itr-048061	Ictidomys tridecemlineatus	98.59	0.00e+00	976.00
IUUC-Lch-049868	Latimeria chalumnae	74.55	0.00e+00	807.00
IUUC-Loc-052730	Lepisosteus oculatus	57.75	1.00e-164	572.00
IUUC-Laf-053516	Loxodonta africana	98.99	0.00e+00	984.00
IUUC-Mcc-054795	Macaca mulatta	100.00	0.00e+00	982.00
IUUC-Meu-056157	Macropus eugenii	86.72	0.00e+00	844.00
IUUC-Mga-059529	Meleagris gallopavo	84.10	0.00e+00	845.00
IUUC-Mmr-060824	Microcebus murinus	99.20	0.00e+00	976.00
IUUC-Mdo-063036	Monodelphis domestica	94.13	0.00e+00	908.00
IUUC-Mmu-064047	Mus musculus	97.99	0.00e+00	977.00
IUUC-Mpu-066810	Mustela putorius furo	98.39	0.00e+00	977.00
IUUC-Mlu-067671	Myotis lucifugus	98.59	0.00e+00	951.00
IUUC-Nle-069108	Nomascus leucogenys	100.00	0.00e+00	982.00
IUUC-Opr-070505	Ochotona princeps	75.00	0.00e+00	674.00
IUUC-Ont-072585	Oreochromis niloticus	58.37	2.00e-161	561.00
IUUC-Oan-073495	Ornithorhynchus anatinus	92.76	0.00e+00	950.00
IUUC-Ocu-074416	Oryctolagus cuniculus	99.20	0.00e+00	984.00
IUUC-Ola-086938	Oryzias latipes	59.07	9.00e-157	546.00
IUUC-Oga-088995	Otolemur garnettii	98.79	0.00e+00	973.00
IUUC-Oar-089632	Ovis aries	98.79	0.00e+00	980.00
IUUC-Ptr-090941	Pan troglodytes	99.80	0.00e+00	981.00
IUUC-Pan-091900	Papio anubis	95.98	0.00e+00	931.00
IUUC-Psi-093048	Pelodiscus sinensis	81.68	0.00e+00	863.00
IUUC-Pfo-096955	Poecilia formosa	60.05	5.00e-164	570.00
IUUC-Pab-097587	Pongo abelii	99.80	0.00e+00	982.00
IUUC-Pva-102583	Pteropus vampyrus	98.39	0.00e+00	951.00
IUUC-Rno-104868	Rattus norvegicus	95.98	0.00e+00	947.00
IUUC-Sha-106744	Sarcophilus harrisii	92.35	0.00e+00	929.00
IUUC-Sar-113041	Sorex araneus	98.10	0.00e+00	912.00
IUUC-Ssc-115294	Sus scrofa	99.20	0.00e+00	984.00
IUUC-Tgu-116458	Taeniopygia guttata	60.77	2.00e-170	592.00
IUUC-Tsy-118945	Tarsius syrichta	97.65	0.00e+00	871.00
IUUC-Ttr-128769	Tursiops truncatus	92.16	0.00e+00	873.00
IUUC-Vpa-130517	Vicugna pacos	89.13	7.00e-106	378.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence