iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000033178.12	ENST00000322244.9	ENSP00000313454.4
ENSG00000033178.12	ENST00000514261.1	ENSP00000425091.1
ENSG00000033178.12	ENST00000505673.2	ENSP00000421984.2
ENSG00000033178.12	ENST00000420827.2	ENSP00000399234.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	HINT	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E1	E1_ThiF	20075161

Classification

Family	E-value	Score	Start	End
E1	4.70e-228	758.9	443	930

Active Site

Position(s)	Description	Evidence
625	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv......gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnp 86
           YD +++++G++ ++kl++ +++lvG+g++GcE+lKn++l+Gv      g+itv+D d +e+snlnrqFLfr+++++k+K+ +aa+a  ++n+
   Q: 443  YDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVgtskekGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINS 534
           9******************************************************************************************* PP
   S: 87   dvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfct 175
           +++++ah +++++++e+i+   F++k dv+++aldn+earr+v+++cl++ +pl++sgt+G++G+++vi+++lte+y++++dpp+++iPfct
   Q: 535  QIKIDAHLNKVCPTTETIYndeFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCT 626
           ******************************************************************************************** PP
   S: 176  lketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikq 255
           lk++p+a+ehti+wa            +lfnk++++++++eevl+k++s +++eg+++v  +l s++++n+++++e+a+ +f+k++++++ q
   Q: 627  LKSFPAAIEHTIQWArdkfessfshkpSLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQV-IKLLSRRPRNWSQCVELARLKFEKYFNHKALQ 717
           ***********************************************************.999***************************** PP
   S: 256  llksfecdivtkskspfwv.........................................................sfcsnaealqvpekve 290
           ll++f+ di+ k++s fw+                                                         +f++ ++ +q++e++ 
   Q: 718  LLHCFPLDIRLKDGSLFWQspkrppspikfdlneplhlsflqnaaklyatvycipfaeedlsadallnilsevkiqEFKPSNKVVQTDETAR 809
           ******************************************************************************************** PP
   S: 291  kdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnav 375
           k+ +v  +s++     ++l++++l++ ++k+++++++lsfekddd+  ++d++taa+nlra++++iep +d++++k+iag+iipaiatt+a+
   Q: 810  KPDHVPISSEDernaiFQLEKAILSNEATKSDLQMAVLSFEKDDDHngHIDFITAASNLRAKMYSIEP-ADRFKTKRIAGKIIPAIATTTAT 900
           ******999999********************************************************.*********************** PP
   S: 376  vgGlaaqEviKvvsg.kfeplknfflfdae 404
           v+Gl+a+E+iKv+ g +fe++kn+fl++a+
   Q: 901  VSGLVALEMIKVTGGyPFEAYKNCFLNLAI 930
           **************************9886 PP

Organism

Homo sapiens

Functional Description
(View)

Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.

Protein Sequence
(Fasta)

MEGSEPVAAH QGEEASCSSW GTGSTNKNLP IMSTASVEID DALYSRQRYV LGDTAMQKMA 60
KSHVFLSGMG GLGLEIAKNL VLAGIKAVTI HDTEKCQAWD LGTNFFLSED DVVNKRNRAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCCCACGG TCCCGCCCCT TCCTACCTTC CAGTAGCCGG CGGCGGTGTC TCAGGCGGCA 60
ATGGAAGGAT CCGAGCCTGT GGCCGCCCAT CAGGGGGAAG AGGCGTCCTG TTCTTCCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR000011--UBQ/SUMO-activ_enz_E1-like

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0019780--F:FAT10 activating enzyme activity
GO:0004839--F:ubiquitin activating enzyme activity
GO:0021764--P:amygdala development
GO:0060996--P:dendritic spine development
GO:0021766--P:hippocampus development
GO:0007612--P:learning
GO:0007626--P:locomotory behavior
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:55236

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001608	Ailuropoda melanoleuca	92.40	0.00e+00	2037.00
IUUC-Apl-004158	Anas platyrhynchos	79.90	0.00e+00	1736.00
IUUC-Aca-005349	Anolis carolinensis	80.31	0.00e+00	1762.00
IUUC-Bta-012696	Bos taurus	92.11	0.00e+00	2033.00
IUUC-Cja-019563	Callithrix jacchus	97.15	0.00e+00	2097.00
IUUC-Cfa-020951	Canis familiaris	92.02	0.00e+00	2036.00
IUUC-Cpo-022307	Cavia porcellus	88.34	0.00e+00	1927.00
IUUC-Csa-023647	Chlorocebus sabaeus	98.19	0.00e+00	2133.00
IUUC-Cho-024682	Choloepus hoffmanni	77.25	0.00e+00	942.00
IUUC-Dre-028022	Danio rerio	66.73	0.00e+00	1468.00
IUUC-Dno-029796	Dasypus novemcinctus	90.56	0.00e+00	1947.00
IUUC-Dor-030981	Dipodomys ordii	75.89	0.00e+00	1519.00
IUUC-Ete-032514	Echinops telfairi	77.60	0.00e+00	1143.00
IUUC-Eca-033697	Equus caballus	92.61	0.00e+00	2003.00
IUUC-Eeu-035323	Erinaceus europaeus	84.15	0.00e+00	1367.00
IUUC-Fca-035858	Felis catus	93.59	0.00e+00	2021.00
IUUC-Fal-036848	Ficedula albicollis	80.12	0.00e+00	1731.00
IUUC-Gmo-039326	Gadus morhua	65.95	0.00e+00	1384.00
IUUC-Gga-040747	Gallus gallus	80.22	0.00e+00	1718.00
IUUC-Gac-041406	Gasterosteus aculeatus	66.63	0.00e+00	1389.00
IUUC-Ggo-044577	Gorilla gorilla	99.43	0.00e+00	2157.00
IUUC-Itr-048191	Ictidomys tridecemlineatus	95.51	0.00e+00	1074.00
IUUC-Lch-049992	Latimeria chalumnae	73.18	0.00e+00	1541.00
IUUC-Loc-051899	Lepisosteus oculatus	68.33	0.00e+00	1485.00
IUUC-Laf-054413	Loxodonta africana	91.90	0.00e+00	1870.00
IUUC-Mcc-054656	Macaca mulatta	98.38	0.00e+00	2136.00
IUUC-Meu-056463	Macropus eugenii	71.31	0.00e+00	1423.00
IUUC-Mga-059721	Meleagris gallopavo	78.54	0.00e+00	1628.00
IUUC-Mmr-060908	Microcebus murinus	91.35	0.00e+00	2004.00
IUUC-Mdo-062096	Monodelphis domestica	84.30	0.00e+00	1893.00
IUUC-Mmu-064114	Mus musculus	89.07	0.00e+00	1955.00
IUUC-Mpu-066017	Mustela putorius furo	92.21	0.00e+00	2043.00
IUUC-Mlu-068037	Myotis lucifugus	90.17	0.00e+00	1963.00
IUUC-Nle-069494	Nomascus leucogenys	98.29	0.00e+00	2132.00
IUUC-Opr-070910	Ochotona princeps	67.09	2.00e-174	606.00
IUUC-Ont-071592	Oreochromis niloticus	68.27	0.00e+00	1450.00
IUUC-Oan-073268	Ornithorhynchus anatinus	80.59	0.00e+00	1609.00
IUUC-Ocu-074296	Oryctolagus cuniculus	93.06	0.00e+00	2036.00
IUUC-Ola-086376	Oryzias latipes	68.27	0.00e+00	1400.00
IUUC-Oga-088186	Otolemur garnettii	93.44	0.00e+00	2043.00
IUUC-Oar-089307	Ovis aries	92.21	0.00e+00	2033.00
IUUC-Ptr-090609	Pan troglodytes	99.52	0.00e+00	2149.00
IUUC-Pan-092905	Papio anubis	98.22	0.00e+00	2034.00
IUUC-Psi-093489	Pelodiscus sinensis	81.35	0.00e+00	1750.00
IUUC-Pma-094203	Petromyzon marinus	64.86	1.00e-56	211.00
IUUC-Pfo-096670	Poecilia formosa	68.59	0.00e+00	1456.00
IUUC-Pab-098418	Pongo abelii	98.57	0.00e+00	2133.00
IUUC-Pca-100889	Procavia capensis	75.29	0.00e+00	1589.00
IUUC-Pva-103144	Pteropus vampyrus	81.75	0.00e+00	1761.00
IUUC-Rno-105612	Rattus norvegicus	89.35	0.00e+00	1960.00
IUUC-Sha-107388	Sarcophilus harrisii	86.02	0.00e+00	1877.00
IUUC-Sar-113128	Sorex araneus	88.51	0.00e+00	1926.00
IUUC-Ssc-116117	Sus scrofa	92.88	0.00e+00	2050.00
IUUC-Tgu-116565	Taeniopygia guttata	80.53	0.00e+00	1744.00
IUUC-Tru-118591	Takifugu rubripes	66.76	0.00e+00	1413.00
IUUC-Tsy-119436	Tarsius syrichta	82.22	0.00e+00	1762.00
IUUC-Tni-120880	Tetraodon nigroviridis	66.34	0.00e+00	1400.00
IUUC-Tbe-127714	Tupaia belangeri	79.66	0.00e+00	1410.00
IUUC-Ttr-129159	Tursiops truncatus	80.32	0.00e+00	1710.00
IUUC-Vpa-130716	Vicugna pacos	90.07	0.00e+00	1895.00
IUUC-Xtr-132947	Xenopus tropicalis	70.05	0.00e+00	1529.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence