iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cja-019021

UUCD1 version

UUC-CaJ-01142

Ensembl Protein ID

ENSCJAP00000023868.2

UniProt Accession

F7H7I8; F7H7I8_CALJA

Genbank Protein ID

JAB13363.1; JAB24813.1; JAB42976.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ACFV01110581; GAMR01009119; GAMP01009779

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000012999.2	ENSCJAT00000025251.2	ENSCJAP00000023868.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.00e-57	195.9	333	857
UBD/Alpha-Helix/UBA	1.40e-17	64.1	727	764

Active Site

Position(s)	Description	Evidence
342	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
820	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 333  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeHKPQHNG 420
           7******************************788777765.79*****************8888888888887777765543377777* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 421  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 480
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++e++++   ++++  ++k+  +
   Q: 481  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaevnrrplpelvrakiPFSACLQAFSEPENVDD---FWSSALQAKSAGV 566
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 567  KTSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRARglqpgeeelpdisppivipddskdrlmnqlidpsdidess 654
           *********************997.*******************998888999999999999999998888888888888888887777 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 655  vmqlaemgfpleacrkavyftgnmgaevafnwiivhmeepdfaepltmpgyggaasagasvfgaagldnqppeeiisiitsmgfqrnqa 743
           77777777777777777777777777777777777777777777777777777777777777776666666666666666666666666 PP
   S: 268  ...................peekqke...................................kkkYeLiavvvHsG.slssGHYvayvkn 301
                              +     +                                   + +YeL+a ++H+G s+ sGHY++++k+
   Q: 744  iqalratnhsleraldwifS-----HpefeedsdfviemennananiiseakpegprvkdgPGTYELFAFISHMGtSTMSGHYICHIKK 827
           65555555555555555550.....055555555556666666667788888888888888**************************** PP
   S: 302  ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 828  -EGRWVIYNDHKVCAS--ERPPK---DLGYMYFYRR 857
           .9***********999..78888...99******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+++  +++MGF r++a+qaLra+n +le+A+++++++
   Q: 727  EEIISIITSMGFQRNQAIQALRATNHSLERALDWIFSH 764
           899999******************************97 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MQRRGALLGM PGGRKMAAGD LGELLVPHMP AIRVPRSGDR VYKSECAFSF DSPNSEGGLY 60
ICMNTFLAFG REHVERHFRK TGQSVYMHLK RHVREKVRGA SGGALPKRRN SKLFLDLDTD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCGCCCGC CGGCCGCGCG CACTCGGCTC CCGCGGCTCC GCTCCGCTCC GGCTGCAGCT 60
GCGTCCTCGC TCGCTCGGGG CGGCCATGCA GCGCCGGGGC GCCCTGCTGG GGATGCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cjc:100397458

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	96.16	0.00e+00	1576.00
IUUC-Apl-003712	Anas platyrhynchos	83.35	0.00e+00	1352.00
IUUC-Aca-004634	Anolis carolinensis	82.62	0.00e+00	1389.00
IUUC-Ame-011470	Astyanax mexicanus	74.33	0.00e+00	1282.00
IUUC-Bta-013349	Bos taurus	96.52	0.00e+00	1627.00
IUUC-Cfa-020614	Canis familiaris	96.40	0.00e+00	1585.00
IUUC-Cpo-022484	Cavia porcellus	96.93	0.00e+00	1496.00
IUUC-Csa-024078	Chlorocebus sabaeus	97.33	0.00e+00	1597.00
IUUC-Cho-024522	Choloepus hoffmanni	80.55	0.00e+00	1169.00
IUUC-Cme-027335	Cyanidioschyzon merolae	25.94	3.00e-54	206.00
IUUC-Dre-027651	Danio rerio	74.71	0.00e+00	1342.00
IUUC-Dno-028975	Dasypus novemcinctus	96.53	0.00e+00	1589.00
IUUC-Dor-030130	Dipodomys ordii	72.67	0.00e+00	1058.00
IUUC-Ete-032251	Echinops telfairi	81.78	0.00e+00	1269.00
IUUC-Eca-033568	Equus caballus	97.52	0.00e+00	1494.00
IUUC-Eeu-034612	Erinaceus europaeus	78.93	0.00e+00	1133.00
IUUC-Fca-036280	Felis catus	97.39	0.00e+00	1491.00
IUUC-Fal-036610	Ficedula albicollis	84.39	0.00e+00	1327.00
IUUC-Gmo-038906	Gadus morhua	72.28	0.00e+00	1242.00
IUUC-Gga-041215	Gallus gallus	83.06	0.00e+00	1420.00
IUUC-Gac-042441	Gasterosteus aculeatus	72.48	0.00e+00	1262.00
IUUC-Ggo-044446	Gorilla gorilla	97.22	0.00e+00	1598.00
IUUC-Hsa-046546	Homo sapiens	97.45	0.00e+00	1597.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	88.38	0.00e+00	1415.00
IUUC-Lch-050425	Latimeria chalumnae	77.97	0.00e+00	1350.00
IUUC-Loc-052072	Lepisosteus oculatus	77.31	0.00e+00	1298.00
IUUC-Laf-053909	Loxodonta africana	94.80	0.00e+00	1580.00
IUUC-Mcc-054686	Macaca mulatta	97.33	0.00e+00	1598.00
IUUC-Meu-056361	Macropus eugenii	79.62	0.00e+00	1289.00
IUUC-Mga-059972	Meleagris gallopavo	78.87	0.00e+00	1291.00
IUUC-Mmr-060916	Microcebus murinus	96.18	0.00e+00	1588.00
IUUC-Mdo-062302	Monodelphis domestica	88.34	0.00e+00	1494.00
IUUC-Mmu-063639	Mus musculus	93.50	0.00e+00	1583.00
IUUC-Mpu-066533	Mustela putorius furo	96.52	0.00e+00	1588.00
IUUC-Mlu-067786	Myotis lucifugus	90.49	0.00e+00	1452.00
IUUC-Nle-069997	Nomascus leucogenys	98.25	0.00e+00	1488.00
IUUC-Ont-071859	Oreochromis niloticus	72.70	0.00e+00	1268.00
IUUC-Oan-072959	Ornithorhynchus anatinus	89.12	6.00e-129	452.00
IUUC-Ocu-074265	Oryctolagus cuniculus	96.48	0.00e+00	1570.00
IUUC-Ola-087344	Oryzias latipes	71.49	0.00e+00	1267.00
IUUC-Oga-088734	Otolemur garnettii	97.12	0.00e+00	1541.00
IUUC-Oar-089636	Ovis aries	97.15	0.00e+00	1562.00
IUUC-Ptr-090982	Pan troglodytes	97.45	0.00e+00	1601.00
IUUC-Pan-091991	Papio anubis	97.45	0.00e+00	1599.00
IUUC-Psi-093509	Pelodiscus sinensis	85.71	0.00e+00	1446.00
IUUC-Pfo-096029	Poecilia formosa	74.16	0.00e+00	1311.00
IUUC-Pab-098672	Pongo abelii	93.16	0.00e+00	1499.00
IUUC-Pca-100860	Procavia capensis	73.66	0.00e+00	1036.00
IUUC-Pva-102545	Pteropus vampyrus	88.64	0.00e+00	1449.00
IUUC-Rno-105210	Rattus norvegicus	93.03	0.00e+00	1564.00
IUUC-Sha-106805	Sarcophilus harrisii	88.06	0.00e+00	731.00
IUUC-Sar-113733	Sorex araneus	95.05	0.00e+00	763.00
IUUC-Tgu-116591	Taeniopygia guttata	84.36	0.00e+00	1423.00
IUUC-Tru-118627	Takifugu rubripes	71.06	0.00e+00	1276.00
IUUC-Tsy-119278	Tarsius syrichta	88.72	0.00e+00	1339.00
IUUC-Tni-120804	Tetraodon nigroviridis	73.90	0.00e+00	1301.00
IUUC-Tbe-127699	Tupaia belangeri	78.69	0.00e+00	869.00
IUUC-Ttr-128295	Tursiops truncatus	88.43	0.00e+00	1441.00
IUUC-Vpa-130170	Vicugna pacos	86.37	0.00e+00	1321.00
IUUC-Xtr-132809	Xenopus tropicalis	73.29	0.00e+00	1252.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence