iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044446

UUCD1 version

UUC-GoG-01133

Ensembl Protein ID

ENSGGOP00000028581.1

UniProt Accession

G3SKD8; G3SKD8_GORGO

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000034809.1	ENSGGOT00000041035.1	ENSGGOP00000028581.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-57	195.8	336	860
UBD/Alpha-Helix/UBA	1.90e-20	72.7	730	767

Active Site

Position(s)	Description	Evidence
345	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
823	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 336  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeHKPQQNG 423
           7******************************788777765.79*****************8888888888888877765543388888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 424  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 483
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++e++++   ++++  ++k+  +
   Q: 484  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaeanrrplpelvrakiPFSACLQAFSEPENVDD---FWSSALQAKSAGV 569
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 570  KTSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRARglqpgeeelpdisppivipddskdrlmnqlidpsdidess 657
           *********************997.*******************999889999999999999999998888888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 658  vmqlaemgfpleacrkavyftgnmgaevafnwiivhmeepdfaepltvpryggaasagasvfgasgldnqppeeivaiitsmgfqrnqa 746
           87777777777777777777777777777777777777777777777777777777777777777776666666666666666666666 PP
   S: 268  ...........peekqke...........................................kkkYeLiavvvHsG.slssGHYvayvkn 301
                      +     +                                           + +YeL+a ++H+G s+ sGHY++++k+
   Q: 747  iqalratnnnlE-----RaldwifshpefeedsdfviemennananiiseakpegprvkdgSGTYELFAFISHMGtSTMSGHYICHIKK 830
           666665555550.....05555555555555555666666666677788888888888888**************************** PP
   S: 302  ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 831  -EGRWVIYNDHKVCAS--ERPPK---DLGYMYFYRR 860
           .9***********999..78888...99******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaLra+nnnle+A+++++++
   Q: 730  EEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSH 767
           899*********************************97 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MQRRGALFGM PGGSGGRKMA AGDIGELLVP HMPTIRVPRS GDRVYKNECA FSYDSPNSEG 60
GLYVCMNTFL AFGREHVERH FRKTGQSVYM HLKRHVREKV RGASGGALPK RRNSKIFLDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCGCTGGC GCCGCCGCCG CCGGCAGACC CCGCGCTCCG GCTCCGGCTC GGCTCGCTCG 60
GCTCTGGTGC GCGCTGAGGC CATGCAGCGC CGGGGCGCCC TGTTCGGCAT GCCGGGCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	98.25	0.00e+00	1618.00
IUUC-Apl-003712	Anas platyrhynchos	83.97	0.00e+00	1362.00
IUUC-Aca-004634	Anolis carolinensis	83.55	0.00e+00	1423.00
IUUC-Ame-011470	Astyanax mexicanus	74.56	0.00e+00	1294.00
IUUC-Bta-013349	Bos taurus	97.80	0.00e+00	1654.00
IUUC-Cja-019021	Callithrix jacchus	97.22	0.00e+00	1600.00
IUUC-Cfa-020614	Canis familiaris	98.26	0.00e+00	1623.00
IUUC-Cpo-022484	Cavia porcellus	97.79	0.00e+00	1512.00
IUUC-Csa-024078	Chlorocebus sabaeus	99.30	0.00e+00	1637.00
IUUC-Cho-024522	Choloepus hoffmanni	81.29	0.00e+00	1204.00
IUUC-Cme-027335	Cyanidioschyzon merolae	25.58	4.00e-53	203.00
IUUC-Dre-027651	Danio rerio	75.17	0.00e+00	1360.00
IUUC-Dno-028975	Dasypus novemcinctus	98.03	0.00e+00	1623.00
IUUC-Dor-030130	Dipodomys ordii	73.41	0.00e+00	1070.00
IUUC-Ete-032251	Echinops telfairi	82.65	0.00e+00	1284.00
IUUC-Eca-033568	Equus caballus	98.64	0.00e+00	1513.00
IUUC-Eeu-034612	Erinaceus europaeus	79.68	0.00e+00	1153.00
IUUC-Fca-036280	Felis catus	98.51	0.00e+00	1511.00
IUUC-Fal-036610	Ficedula albicollis	84.64	0.00e+00	1340.00
IUUC-Gmo-038906	Gadus morhua	72.87	0.00e+00	1254.00
IUUC-Gga-041215	Gallus gallus	83.47	0.00e+00	1437.00
IUUC-Gac-042441	Gasterosteus aculeatus	72.48	0.00e+00	1276.00
IUUC-Hsa-046546	Homo sapiens	99.54	0.00e+00	1640.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	89.55	0.00e+00	1441.00
IUUC-Lch-050425	Latimeria chalumnae	77.92	0.00e+00	1370.00
IUUC-Loc-052072	Lepisosteus oculatus	77.71	0.00e+00	1326.00
IUUC-Laf-053909	Loxodonta africana	96.30	0.00e+00	1611.00
IUUC-Mcc-054686	Macaca mulatta	99.30	0.00e+00	1638.00
IUUC-Meu-056361	Macropus eugenii	80.45	0.00e+00	1313.00
IUUC-Mga-059972	Meleagris gallopavo	79.35	0.00e+00	1303.00
IUUC-Mmr-060916	Microcebus murinus	97.57	0.00e+00	1615.00
IUUC-Mdo-062302	Monodelphis domestica	89.52	0.00e+00	1534.00
IUUC-Mmu-063639	Mus musculus	95.71	0.00e+00	1622.00
IUUC-Mpu-066533	Mustela putorius furo	98.38	0.00e+00	1625.00
IUUC-Mlu-067786	Myotis lucifugus	91.43	0.00e+00	1471.00
IUUC-Nle-069997	Nomascus leucogenys	99.37	0.00e+00	1507.00
IUUC-Ont-071859	Oreochromis niloticus	72.81	0.00e+00	1286.00
IUUC-Oan-072959	Ornithorhynchus anatinus	89.54	5.00e-130	456.00
IUUC-Ocu-074265	Oryctolagus cuniculus	97.79	0.00e+00	1604.00
IUUC-Ola-087344	Oryzias latipes	71.67	0.00e+00	1284.00
IUUC-Oga-088734	Otolemur garnettii	98.08	0.00e+00	1559.00
IUUC-Oar-089636	Ovis aries	97.77	0.00e+00	1574.00
IUUC-Ptr-090982	Pan troglodytes	99.54	0.00e+00	1643.00
IUUC-Pan-091991	Papio anubis	99.42	0.00e+00	1639.00
IUUC-Psi-093509	Pelodiscus sinensis	86.37	0.00e+00	1481.00
IUUC-Pfo-096029	Poecilia formosa	74.39	0.00e+00	1328.00
IUUC-Pab-098672	Pongo abelii	95.25	0.00e+00	1540.00
IUUC-Pca-100860	Procavia capensis	74.21	0.00e+00	1046.00
IUUC-Pva-102545	Pteropus vampyrus	89.92	0.00e+00	1476.00
IUUC-Rno-105210	Rattus norvegicus	94.55	0.00e+00	1586.00
IUUC-Sar-113733	Sorex araneus	96.29	0.00e+00	773.00
IUUC-Tgu-116591	Taeniopygia guttata	84.61	0.00e+00	1439.00
IUUC-Tru-118627	Takifugu rubripes	71.06	0.00e+00	1293.00
IUUC-Tsy-119278	Tarsius syrichta	89.71	0.00e+00	1355.00
IUUC-Tni-120804	Tetraodon nigroviridis	74.13	0.00e+00	1318.00
IUUC-Tbe-127699	Tupaia belangeri	78.86	0.00e+00	874.00
IUUC-Ttr-128295	Tursiops truncatus	89.70	0.00e+00	1476.00
IUUC-Vpa-130170	Vicugna pacos	87.61	0.00e+00	1338.00
IUUC-Xtr-132809	Xenopus tropicalis	74.13	0.00e+00	1284.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence