iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048147

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGTP01061910

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000002367.2	ENSSTOT00000002374.2	ENSSTOP00000002124.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.30e-57	192.7	327	864
UBD/Alpha-Helix/UBA	1.00e-20	73.2	734	771

Active Site

Position(s)	Description	Evidence
336	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
827	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel.......................wkskkk 66
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       ++ +++
   Q: 327  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppgipdhrnwpwtsmrTQPQQN 414
           7******************************788877765.79*****************99999999999999998755544388888 PP
   S: 67   avsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqik 155
            +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+
   Q: 415  GISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVHLVERNR-----------------------------IGSENPSDVFRFLVEERIQ 474
           *************************************9998.............................788899************* PP
   S: 156  clecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqea 217
           c + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++e++++   ++++  ++k+  
   Q: 475  CCQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaeanrrplpelvrakiPFSACLQAFSEPENVDD---FWSSALQAKSAG 560
           *******9999999999999999998887799****************************************97...************ PP
   S: 218  ekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts....................................... 267
           +k+ ++ ++P++L++++k+f+f  + ++++k++ ++++p+ Ld+s+  ++                                       
   Q: 561  VKTSRFASFPDYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDISHLRARglqpgeeelpdisppivipddskgsrtlgihnsedcsgl 648
           **********************997.*******************99988999999999999999999988888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 649  cgalrasdidessvmqlaemgfpleacrkavyftgnmgaevafnwiivhmeepdfaepltipgyggaasagaslfgatgldnqppeeiv 737
           88888888888888888888887777777777777777777777777777777777777777777777777777777777777766666 PP
   S: 268  .......................peekqke............................................kkkYeLiavvvHsG. 288
                                        e                                            +  YeL+a ++H+G 
   Q: 738  aiitsmgfqrnqavqalratnnnL-----EraldwifshpefeedsdfviemennananiiseakpegprvkdgSGMYELFAFISHMGt 821
           666666666666666665555550.....055555555555555556666666666677788888888888888*************** PP
   S: 289  slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           s+ sGHYv+++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 822  STMSGHYVCHIKK-EGRWVIYNDHKVCAS--ERPPK---DLGYLYFYRR 864
           *************.9***********999..78888...89******97 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaLra+nnnle+A+++++++
   Q: 734  EEIVAIITSMGFQRNQAVQALRATNNNLERALDWIFSH 771
           899*********************************97 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

LTGVSEVCFF VIGGLVFIEK NAKQNYKDEN TYKQLAVNSE GGLYVCMNTF LAFGREHVER 60
HFRKTGQSVY MHLKRHVREE WRSKEKVRGA SGGALPKRRN SKIFLDLDTD DDLNSDDYEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGACAGGTG TTTCAGAAGT CTGTTTTTTT GTTATCGGAG GGGTGAGATT AACAGAAGCT 60
TAATGAAATC CACTTCCTTG GAGGAAAGGT GTCTGCTTTC ATAGCTTGTG TTTATAGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	89.07	0.00e+00	1426.00
IUUC-Apl-003712	Anas platyrhynchos	78.90	0.00e+00	1286.00
IUUC-Aca-004634	Anolis carolinensis	79.42	0.00e+00	1276.00
IUUC-Ame-011470	Astyanax mexicanus	69.17	0.00e+00	1165.00
IUUC-Bta-013349	Bos taurus	88.50	0.00e+00	1458.00
IUUC-Cja-019021	Callithrix jacchus	88.03	0.00e+00	1414.00
IUUC-Cfa-020614	Canis familiaris	89.19	0.00e+00	1431.00
IUUC-Cpo-022484	Cavia porcellus	91.45	0.00e+00	1429.00
IUUC-Csa-024078	Chlorocebus sabaeus	89.32	0.00e+00	1432.00
IUUC-Cho-024522	Choloepus hoffmanni	77.23	0.00e+00	1119.00
IUUC-Cme-027335	Cyanidioschyzon merolae	25.90	6.00e-52	199.00
IUUC-Dre-027651	Danio rerio	69.63	0.00e+00	1234.00
IUUC-Dno-028975	Dasypus novemcinctus	89.11	0.00e+00	1430.00
IUUC-Dor-030130	Dipodomys ordii	73.28	0.00e+00	805.00
IUUC-Ete-032251	Echinops telfairi	75.90	0.00e+00	1199.00
IUUC-Eca-033568	Equus caballus	91.57	0.00e+00	1431.00
IUUC-Fca-036280	Felis catus	91.31	0.00e+00	1427.00
IUUC-Fal-036610	Ficedula albicollis	80.58	0.00e+00	1265.00
IUUC-Gmo-038906	Gadus morhua	67.71	0.00e+00	1138.00
IUUC-Gga-041215	Gallus gallus	78.04	0.00e+00	1285.00
IUUC-Gac-042441	Gasterosteus aculeatus	67.33	0.00e+00	1157.00
IUUC-Ggo-044446	Gorilla gorilla	89.20	0.00e+00	1434.00
IUUC-Hsa-046546	Homo sapiens	89.32	0.00e+00	1433.00
IUUC-Lch-050425	Latimeria chalumnae	73.01	0.00e+00	1236.00
IUUC-Loc-052072	Lepisosteus oculatus	72.20	0.00e+00	1179.00
IUUC-Laf-053909	Loxodonta africana	87.95	0.00e+00	1422.00
IUUC-Mcc-054686	Macaca mulatta	89.32	0.00e+00	1434.00
IUUC-Meu-056361	Macropus eugenii	80.60	0.00e+00	970.00
IUUC-Mga-059972	Meleagris gallopavo	78.80	0.00e+00	1267.00
IUUC-Mmr-060916	Microcebus murinus	88.38	0.00e+00	1424.00
IUUC-Mdo-062302	Monodelphis domestica	82.46	0.00e+00	1362.00
IUUC-Mmu-063639	Mus musculus	87.44	0.00e+00	1459.00
IUUC-Mpu-066533	Mustela putorius furo	89.42	0.00e+00	1433.00
IUUC-Mlu-067786	Myotis lucifugus	86.64	0.00e+00	1375.00
IUUC-Nle-069997	Nomascus leucogenys	92.69	0.00e+00	1411.00
IUUC-Ont-071859	Oreochromis niloticus	68.66	0.00e+00	1197.00
IUUC-Oan-072959	Ornithorhynchus anatinus	88.39	1.00e-120	424.00
IUUC-Ocu-074265	Oryctolagus cuniculus	89.55	0.00e+00	1436.00
IUUC-Ola-087344	Oryzias latipes	67.94	0.00e+00	1184.00
IUUC-Oga-088734	Otolemur garnettii	88.85	0.00e+00	1422.00
IUUC-Oar-089636	Ovis aries	91.93	0.00e+00	1487.00
IUUC-Ptr-090982	Pan troglodytes	89.32	0.00e+00	1436.00
IUUC-Pan-091991	Papio anubis	89.44	0.00e+00	1435.00
IUUC-Psi-093509	Pelodiscus sinensis	81.17	0.00e+00	1314.00
IUUC-Pfo-096029	Poecilia formosa	69.00	0.00e+00	1206.00
IUUC-Pab-098672	Pongo abelii	85.56	0.00e+00	1347.00
IUUC-Pva-102545	Pteropus vampyrus	81.69	0.00e+00	1299.00
IUUC-Rno-105210	Rattus norvegicus	86.74	0.00e+00	1436.00
IUUC-Sar-113733	Sorex araneus	89.88	0.00e+00	720.00
IUUC-Tgu-116591	Taeniopygia guttata	79.65	0.00e+00	1296.00
IUUC-Tru-118627	Takifugu rubripes	67.78	0.00e+00	1192.00
IUUC-Tsy-119278	Tarsius syrichta	82.53	0.00e+00	1272.00
IUUC-Tni-120804	Tetraodon nigroviridis	68.55	0.00e+00	1191.00
IUUC-Ttr-128295	Tursiops truncatus	82.11	0.00e+00	1283.00
IUUC-Vpa-130170	Vicugna pacos	80.12	0.00e+00	1249.00
IUUC-Xtr-132809	Xenopus tropicalis	69.17	0.00e+00	1143.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence