iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000006043.3	ENSOCUT00000033606.1	ENSOCUP00000026651.1
ENSOCUG00000006043.3	ENSOCUT00000006045.2	ENSOCUP00000005236.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-56	192.1	332	856
UBD/Alpha-Helix/UBA	7.40e-20	70.5	726	763

Active Site

Position(s)	Description	Evidence
341	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
819	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                      +k +++ 
   Q: 332  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeQKPHQNG 419
           7******************************788777765.79*****************8888888888877777765543477777* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 420  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 479
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f++++++++   ++++  ++k+  +
   Q: 480  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaeanrrplpelvrakiPFSACLQAFSEPDNVDD---FWSSALQAKSAGV 565
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 566  KTSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRARglqpgeeelpdisppivipddskdrlmnqlidpsdidess 653
           *********************997.*******************999889999999999999999998888888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 654  vmqlaemgfpleacrkavyftgnmgaevafnwiivhmeepdfaepltmpgyggaasagasifgatgldnqppeeivaiitsmgfqrnqa 742
           88777777777777777777777777777777777777777777777777777777777777777777776666666666666666666 PP
   S: 268  ..........peekqke............................................kkkYeLiavvvHsG.slssGHYvayvkn 301
                           e                                            +  YeL+a ++H+G s+ sGHYv+++k+
   Q: 743  vqalratsnnL-----EraldwifshpefeedsdfviemennananiiseakpegprvkdgSGMYELFAFISHMGtSTMSGHYVCHIKK 826
           66655555550.....055555555555555555666666666677788888888888888**************************** PP
   S: 302  ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 827  -EGRWVIYNDHKVCAS--ERPPK---DLGYMYFYRR 856
           .9***********999..78888...99******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaLra++nnle+A+++++++
   Q: 726  EEIVAIITSMGFQRNQAVQALRATSNNLERALDWIFSH 763
           899*********************************97 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

GAPVRHPGGS GGRKMAAGDI GELLVPLMPT IRVPRSGDRV YKNECAFSYD SPNSEGGLYV 60
CMNTFLAFGR EHVERHFRKT GQSVYMHLKR HVREKVRGAS GGALPKRRNS KIFLDLDTDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGCGCCGG GGCACCTGTT CGGCATCCGG GCGGCAGCGG TGGCAGGAAG ATGGCTGCAG 60
GAGACATCGG CGAGCTGCTT GTACCGCTCA TGCCCACGAT CCGCGTGCCC CGCTCCGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	97.67	0.00e+00	1594.00
IUUC-Apl-003712	Anas platyrhynchos	83.48	0.00e+00	1351.00
IUUC-Aca-004634	Anolis carolinensis	84.41	0.00e+00	1401.00
IUUC-Ame-011470	Astyanax mexicanus	74.10	0.00e+00	1281.00
IUUC-Bta-013349	Bos taurus	96.97	0.00e+00	1625.00
IUUC-Cja-019021	Callithrix jacchus	96.48	0.00e+00	1569.00
IUUC-Cfa-020614	Canis familiaris	97.79	0.00e+00	1599.00
IUUC-Cpo-022484	Cavia porcellus	98.28	0.00e+00	1511.00
IUUC-Csa-024078	Chlorocebus sabaeus	98.02	0.00e+00	1600.00
IUUC-Cho-024522	Choloepus hoffmanni	81.04	0.00e+00	1177.00
IUUC-Dre-027651	Danio rerio	74.36	0.00e+00	1342.00
IUUC-Dno-028975	Dasypus novemcinctus	97.56	0.00e+00	1597.00
IUUC-Dor-030130	Dipodomys ordii	73.65	0.00e+00	1068.00
IUUC-Ete-032251	Echinops telfairi	82.40	0.00e+00	1277.00
IUUC-Eca-033568	Equus caballus	98.64	0.00e+00	1511.00
IUUC-Eeu-034612	Erinaceus europaeus	79.43	0.00e+00	1148.00
IUUC-Fca-036280	Felis catus	98.51	0.00e+00	1506.00
IUUC-Fal-036610	Ficedula albicollis	84.27	0.00e+00	1328.00
IUUC-Gmo-038906	Gadus morhua	71.89	0.00e+00	1251.00
IUUC-Gga-041215	Gallus gallus	83.51	0.00e+00	1423.00
IUUC-Gac-042441	Gasterosteus aculeatus	71.02	0.00e+00	1263.00
IUUC-Ggo-044446	Gorilla gorilla	97.79	0.00e+00	1602.00
IUUC-Hsa-046546	Homo sapiens	98.02	0.00e+00	1602.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	89.91	0.00e+00	1436.00
IUUC-Lch-050425	Latimeria chalumnae	77.51	0.00e+00	1350.00
IUUC-Loc-052072	Lepisosteus oculatus	77.36	0.00e+00	1306.00
IUUC-Laf-053909	Loxodonta africana	95.94	0.00e+00	1580.00
IUUC-Mcc-054686	Macaca mulatta	98.25	0.00e+00	1605.00
IUUC-Meu-056361	Macropus eugenii	80.45	0.00e+00	1303.00
IUUC-Mga-059972	Meleagris gallopavo	78.87	0.00e+00	1294.00
IUUC-Mmr-060916	Microcebus murinus	97.21	0.00e+00	1593.00
IUUC-Mdo-062302	Monodelphis domestica	89.52	0.00e+00	1512.00
IUUC-Mmu-063639	Mus musculus	96.30	0.00e+00	1593.00
IUUC-Mpu-066533	Mustela putorius furo	98.02	0.00e+00	1599.00
IUUC-Mlu-067786	Myotis lucifugus	91.43	0.00e+00	1469.00
IUUC-Nle-069997	Nomascus leucogenys	98.37	0.00e+00	1494.00
IUUC-Ont-071859	Oreochromis niloticus	72.24	0.00e+00	1267.00
IUUC-Oan-072959	Ornithorhynchus anatinus	88.28	3.00e-128	450.00
IUUC-Ola-087344	Oryzias latipes	71.03	0.00e+00	1266.00
IUUC-Oga-088734	Otolemur garnettii	98.08	0.00e+00	1551.00
IUUC-Oar-089636	Ovis aries	97.52	0.00e+00	1569.00
IUUC-Ptr-090982	Pan troglodytes	98.02	0.00e+00	1605.00
IUUC-Pan-091991	Papio anubis	98.14	0.00e+00	1603.00
IUUC-Psi-093509	Pelodiscus sinensis	86.78	0.00e+00	1450.00
IUUC-Pfo-096029	Poecilia formosa	73.81	0.00e+00	1314.00
IUUC-Pab-098672	Pongo abelii	93.83	0.00e+00	1504.00
IUUC-Pca-100860	Procavia capensis	74.62	0.00e+00	1045.00
IUUC-Pva-102545	Pteropus vampyrus	90.50	0.00e+00	1457.00
IUUC-Rno-105210	Rattus norvegicus	95.58	0.00e+00	1570.00
IUUC-Sar-113733	Sorex araneus	95.54	0.00e+00	768.00
IUUC-Tgu-116591	Taeniopygia guttata	84.88	0.00e+00	1422.00
IUUC-Tru-118627	Takifugu rubripes	70.60	0.00e+00	1280.00
IUUC-Tsy-119278	Tarsius syrichta	89.47	0.00e+00	1352.00
IUUC-Tni-120804	Tetraodon nigroviridis	72.65	0.00e+00	1305.00
IUUC-Tbe-127699	Tupaia belangeri	79.03	0.00e+00	875.00
IUUC-Ttr-128295	Tursiops truncatus	89.19	0.00e+00	1449.00
IUUC-Vpa-130170	Vicugna pacos	86.74	0.00e+00	1330.00
IUUC-Xtr-132809	Xenopus tropicalis	73.78	0.00e+00	1263.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence