iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-087344

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

BAAF04009504

Gene Name

usp13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000005687.1	ENSORLT00000007151.1	ENSORLP00000007150.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.30e-52	177.4	323	865
UBD/Alpha-Helix/UBA	1.20e-18	66.9	733	771

Active Site

Position(s)	Description	Evidence
332	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
828	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG+kNlg +CY+  v+Q L+++p++++++   + +++ + +p +p+++++++++kl + l                       k++++ 
   Q: 323  TGIKNLGDSCYLSTVMQILFSVPDFQRMFVG-NLQRIFDYSPLDPTQDFATQMAKLGHGLlsgqyskppmkselieqvmkeeHKQQQRG 410
           7******************************.7777778889******************9999999999998888876554488899* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDa+Efl ++++ + +                              + + +  sd F++ ++++i+c
   Q: 411  ISPRMFKALVSKGHPEFSSNRQQDAHEFLLHIINLFLQRN----------------------------STGLENPSDSFRFLVEERIQC 471
           **********************************987765............................67888999************* PP
   S: 157  lecdnvs..sreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqe 216
            + ++v   +r +  ++l+ p++  +++  e                            ++ cL++ft++e++ +   ++++  ++k+ 
   Q: 472  CQTRRVRysQRVDYCIQLPAPIEAATNR--EellayeakrkeaeenmgtppepvrariPFTACLQAFTEPENVPD---FWSSALQAKSA 555
           8887776334444444555555554444..3569***************************************97...*********** PP
   S: 217  aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts...................................... 267
            +k+ ++ ++Pe+Li+++k+f+f  + ++++k++  +++p+ Ldls+  ++                                      
   Q: 556  GVKTSRFASFPEYLIVQIKKFTFGVD-WVPKKLDLTIDVPDFLDLSRLRATglqadeeelpdlmppivlpedtrgaceiqfnntcqnvf 643
           ***********************776.*******************9888878888888888888888888888888887777777777 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 644  lnfifshtvapemdetavmqlaemgfpleacrkavyytgnmgpemafnwiiahmeepdfaepltlpslmdpgpstsdgptgatpignsp 732
           77777777777777777777777777777777777777777777777777777766666666666666666666666666666666666 PP
   S: 268  ........................peekqke.................................................kkkYeLiav 283
                                   +     +                                                 + +YeL+a 
   Q: 733  peesiailtsmgfprahsihalkaT-----NnnleraldwifthpeeeetdalsdmadtepndnafssdregsgsrvkdgPGRYELFAF 816
           6666666655555555555555550.....05555555555555555666677777777777788888888888999999********* PP
   S: 284  vvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           ++H G s+ sGHYv+++k+ +g+W+ ++D+kV  +  e+  +   + +Y++fY+r
   Q: 817  ISHIGaSTMSGHYVCHIKK-EGRWVIYNDHKVCLS--ERPPK---DLGYIYFYHR 865
           *******************.9***********988..78888...89******97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
            e+ ++ l++MGF+r + + aL a+nnnle+A+++++++
   Q: 733  PEESIAILTSMGFPRAHSIHALKATNNNLERALDWIFTH 771
           5899*********************************98 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

MAADLGELLV PYMPTIRVPR TGDRVFKSEC AFSFDSPESE GGLYVCMNTF LGFGREHVER 60
HYRKTGQSVY MHLKRHVKEK TTGAAGGAIP RRRNGKVFLD LELNRDFNGE DFEYEDEAKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGCAG ACTTGGGAGA GCTGTTGGTC CCCTACATGC CCACCATCCG AGTCCCCAGA 60
ACCGGAGACA GGGTCTTCAA GAGCGAGTGC GCCTTTTCGT TCGACTCCCC CGTAAGTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	70.47	0.00e+00	1222.00
IUUC-Apl-003712	Anas platyrhynchos	71.82	0.00e+00	1206.00
IUUC-Aca-004634	Anolis carolinensis	72.64	0.00e+00	1239.00
IUUC-Ame-011470	Astyanax mexicanus	80.00	0.00e+00	1414.00
IUUC-Bta-013349	Bos taurus	70.69	0.00e+00	1233.00
IUUC-Cja-019021	Callithrix jacchus	70.31	0.00e+00	1215.00
IUUC-Cfa-020614	Canis familiaris	70.47	0.00e+00	1221.00
IUUC-Cpo-022484	Cavia porcellus	69.29	0.00e+00	1154.00
IUUC-Csa-024078	Chlorocebus sabaeus	70.54	0.00e+00	1224.00
IUUC-Cho-024522	Choloepus hoffmanni	59.06	0.00e+00	900.00
IUUC-Cme-027335	Cyanidioschyzon merolae	25.12	1.00e-51	198.00
IUUC-Dre-027651	Danio rerio	80.82	0.00e+00	1484.00
IUUC-Dno-028975	Dasypus novemcinctus	70.03	0.00e+00	1213.00
IUUC-Dor-030130	Dipodomys ordii	60.00	0.00e+00	689.00
IUUC-Ete-032251	Echinops telfairi	59.42	0.00e+00	947.00
IUUC-Eca-033568	Equus caballus	71.12	0.00e+00	1158.00
IUUC-Fca-036280	Felis catus	70.12	0.00e+00	1156.00
IUUC-Fal-036610	Ficedula albicollis	72.21	0.00e+00	1183.00
IUUC-Gmo-038906	Gadus morhua	82.45	0.00e+00	1453.00
IUUC-Gga-041215	Gallus gallus	71.30	0.00e+00	1255.00
IUUC-Gac-042441	Gasterosteus aculeatus	87.73	0.00e+00	1571.00
IUUC-Ggo-044446	Gorilla gorilla	70.43	0.00e+00	1224.00
IUUC-Hsa-046546	Homo sapiens	70.43	0.00e+00	1225.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	67.56	0.00e+00	1129.00
IUUC-Lch-050425	Latimeria chalumnae	73.83	0.00e+00	1308.00
IUUC-Loc-052072	Lepisosteus oculatus	76.95	0.00e+00	1331.00
IUUC-Laf-053909	Loxodonta africana	69.12	0.00e+00	1205.00
IUUC-Mcc-054686	Macaca mulatta	70.43	0.00e+00	1224.00
IUUC-Meu-056361	Macropus eugenii	73.25	0.00e+00	943.00
IUUC-Mga-059972	Meleagris gallopavo	70.83	0.00e+00	1172.00
IUUC-Mmr-060916	Microcebus murinus	69.97	0.00e+00	1220.00
IUUC-Mdo-062302	Monodelphis domestica	72.56	0.00e+00	1301.00
IUUC-Mmu-063639	Mus musculus	70.06	0.00e+00	1218.00
IUUC-Mac-065634	Musa acuminata	38.35	2.00e-169	589.00
IUUC-Mpu-066533	Mustela putorius furo	70.36	0.00e+00	1221.00
IUUC-Mlu-067786	Myotis lucifugus	68.24	0.00e+00	1160.00
IUUC-Nle-069997	Nomascus leucogenys	69.87	0.00e+00	1145.00
IUUC-Ont-071859	Oreochromis niloticus	88.44	0.00e+00	1595.00
IUUC-Oan-072959	Ornithorhynchus anatinus	76.35	3.00e-110	390.00
IUUC-Ocu-074265	Oryctolagus cuniculus	69.85	0.00e+00	1213.00
IUUC-Oga-088734	Otolemur garnettii	70.40	0.00e+00	1204.00
IUUC-Oar-089636	Ovis aries	71.39	0.00e+00	1196.00
IUUC-Ptr-090982	Pan troglodytes	70.31	0.00e+00	1224.00
IUUC-Pan-091991	Papio anubis	70.54	0.00e+00	1225.00
IUUC-Psi-093509	Pelodiscus sinensis	72.84	0.00e+00	1279.00
IUUC-Pfo-096029	Poecilia formosa	88.34	0.00e+00	1616.00
IUUC-Pab-098672	Pongo abelii	66.97	0.00e+00	1133.00
IUUC-Pva-102545	Pteropus vampyrus	65.90	0.00e+00	1111.00
IUUC-Rno-105210	Rattus norvegicus	69.94	0.00e+00	1211.00
IUUC-Sar-113733	Sorex araneus	74.94	5.00e-178	617.00
IUUC-Tgu-116591	Taeniopygia guttata	72.73	0.00e+00	1269.00
IUUC-Tru-118627	Takifugu rubripes	86.85	0.00e+00	1589.00
IUUC-Tsy-119278	Tarsius syrichta	62.98	0.00e+00	1029.00
IUUC-Tni-120804	Tetraodon nigroviridis	87.39	0.00e+00	1587.00
IUUC-Ttr-128295	Tursiops truncatus	64.10	0.00e+00	1103.00
IUUC-Vpa-130170	Vicugna pacos	61.94	0.00e+00	981.00
IUUC-Xtr-132809	Xenopus tropicalis	67.89	0.00e+00	1198.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence