iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-56	193.0	334	855
UBD/Alpha-Helix/UBA	4.20e-18	65.3	725	762

Active Site

Position(s)	Description	Evidence
343	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
818	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 334  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeHKPQQNG 421
           7******************************788777765.79*****************8888888888888877765543388888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 422  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 481
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f++++++++   ++++  ++k+  +
   Q: 482  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayelmrreaetnrrplpelvrakiPFSACLQAFAEPDNVDD---FWSSALQAKSAGV 567
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+s+  ++                                        
   Q: 568  KTSRFASFPEYLVVQIKKFTFGLD-WVPRKFDVSIDMPDLLDISHLRARglqpgeeelpdisppivipddskdrlmnqlidpsdidess 655
           *********************997.*******************999889999999999999999998888888888888888888887 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 656  vmqlaemgfpleacrkavyftgntgaevafnwiivhmeepdfaeplaipgyggagasafgatgldnqppeeivaiitamgfqrsqavqa 744
           77777777777777777777777777777777777777777777777777777777777777776666666666666666666666666 PP
   S: 268  ........peekqke...........................................kkkYeLiavvvHsG.slssGHYvayvknekg 304
                   +     +                                           +  YeL+a ++H+G s+ sGHYv+++k+ +g
   Q: 745  lqatnhnlE-----RaldwifshpefeedsdfviemennananimseakpegprvkdgSGMYELFAFISHMGtSTMSGHYVCHIKK-EG 827
           555555550.....05555555555555555556666666667778888888888888****************************.9* PP
   S: 305  kWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 828  RWVIYNDHKVCAS--ERPPK---DLGYMYFYRR 855
           **********999..78888...99******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaL+a+n nle+A+++++++
   Q: 725  EEIVAIITAMGFQRSQAVQALQATNHNLERALDWIFSH 762
           899*********************************97 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MQRRGALFSV PGGGGKMAAG DLGELLVPHM PTIRVPRSGD RVYKNECAFS YDSPNSEGGL 60
YVCMNTFLAF GREHVERHFR KTGQSVYMHL KRHMREKVRG ASGGALPKRR NSKLFLDLDM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCTCAGCC CGCGCGGCCG CTACGTCCAG GTCCTGCTCT CCCACTGCGC CGCGTTCCTC 60
CCCAGGCCCG CTGCGCTCAG CGGCCATGCA GCGCCGGGGC GCCCTGTTCA GCGTGCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:310306

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	94.76	0.00e+00	1558.00
IUUC-Apl-003712	Anas platyrhynchos	82.74	0.00e+00	1330.00
IUUC-Aca-004634	Anolis carolinensis	82.08	0.00e+00	1365.00
IUUC-Ame-011470	Astyanax mexicanus	73.63	0.00e+00	1261.00
IUUC-Bta-013349	Bos taurus	94.55	0.00e+00	1598.00
IUUC-Cja-019021	Callithrix jacchus	94.08	0.00e+00	1554.00
IUUC-Cfa-020614	Canis familiaris	95.01	0.00e+00	1568.00
IUUC-Cpo-022484	Cavia porcellus	95.45	0.00e+00	1479.00
IUUC-Csa-024078	Chlorocebus sabaeus	95.02	0.00e+00	1568.00
IUUC-Cho-024522	Choloepus hoffmanni	78.93	0.00e+00	1138.00
IUUC-Cme-027335	Cyanidioschyzon merolae	25.45	6.00e-52	199.00
IUUC-Dre-027651	Danio rerio	74.01	0.00e+00	1325.00
IUUC-Dno-028975	Dasypus novemcinctus	95.38	0.00e+00	1571.00
IUUC-Dor-030130	Dipodomys ordii	71.69	0.00e+00	1050.00
IUUC-Ete-032251	Echinops telfairi	80.67	0.00e+00	1248.00
IUUC-Eca-033568	Equus caballus	95.54	0.00e+00	1471.00
IUUC-Eeu-034612	Erinaceus europaeus	77.70	0.00e+00	1129.00
IUUC-Fca-036280	Felis catus	95.41	0.00e+00	1467.00
IUUC-Fal-036610	Ficedula albicollis	83.52	0.00e+00	1310.00
IUUC-Gmo-038906	Gadus morhua	71.85	0.00e+00	1233.00
IUUC-Gga-041215	Gallus gallus	82.50	0.00e+00	1415.00
IUUC-Gac-042441	Gasterosteus aculeatus	71.35	0.00e+00	1243.00
IUUC-Ggo-044446	Gorilla gorilla	94.90	0.00e+00	1572.00
IUUC-Hsa-046546	Homo sapiens	95.25	0.00e+00	1576.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	87.32	0.00e+00	1398.00
IUUC-Lch-050425	Latimeria chalumnae	77.26	0.00e+00	1342.00
IUUC-Loc-052072	Lepisosteus oculatus	76.81	0.00e+00	1285.00
IUUC-Laf-053909	Loxodonta africana	94.34	0.00e+00	1571.00
IUUC-Mcc-054686	Macaca mulatta	95.25	0.00e+00	1573.00
IUUC-Meu-056361	Macropus eugenii	80.02	0.00e+00	1285.00
IUUC-Mga-059972	Meleagris gallopavo	78.15	0.00e+00	1277.00
IUUC-Mmr-060916	Microcebus murinus	94.89	0.00e+00	1576.00
IUUC-Mdo-062302	Monodelphis domestica	88.22	0.00e+00	1472.00
IUUC-Mmu-063639	Mus musculus	98.83	0.00e+00	1626.00
IUUC-Mpu-066533	Mustela putorius furo	95.13	0.00e+00	1570.00
IUUC-Mlu-067786	Myotis lucifugus	88.85	0.00e+00	1435.00
IUUC-Nle-069997	Nomascus leucogenys	95.24	0.00e+00	1454.00
IUUC-Ont-071859	Oreochromis niloticus	71.44	0.00e+00	1245.00
IUUC-Oan-072959	Ornithorhynchus anatinus	87.03	4.00e-125	440.00
IUUC-Ocu-074265	Oryctolagus cuniculus	94.99	0.00e+00	1552.00
IUUC-Ola-087344	Oryzias latipes	70.80	0.00e+00	1257.00
IUUC-Oga-088734	Otolemur garnettii	95.31	0.00e+00	1517.00
IUUC-Oar-089636	Ovis aries	94.80	0.00e+00	1531.00
IUUC-Ptr-090982	Pan troglodytes	95.02	0.00e+00	1572.00
IUUC-Pan-091991	Papio anubis	95.13	0.00e+00	1571.00
IUUC-Psi-093509	Pelodiscus sinensis	85.03	0.00e+00	1424.00
IUUC-Pfo-096029	Poecilia formosa	73.23	0.00e+00	1291.00
IUUC-Pab-098672	Pongo abelii	90.73	0.00e+00	1471.00
IUUC-Pca-100860	Procavia capensis	72.29	0.00e+00	1016.00
IUUC-Pva-102545	Pteropus vampyrus	87.25	0.00e+00	1426.00
IUUC-Sar-113733	Sorex araneus	94.55	0.00e+00	758.00
IUUC-Tgu-116591	Taeniopygia guttata	83.99	0.00e+00	1412.00
IUUC-Tru-118627	Takifugu rubripes	69.47	0.00e+00	1252.00
IUUC-Tsy-119278	Tarsius syrichta	86.62	0.00e+00	1311.00
IUUC-Tni-120804	Tetraodon nigroviridis	72.98	0.00e+00	1283.00
IUUC-Tbe-127699	Tupaia belangeri	77.35	0.00e+00	865.00
IUUC-Ttr-128295	Tursiops truncatus	86.76	0.00e+00	1422.00
IUUC-Vpa-130170	Vicugna pacos	84.62	0.00e+00	1296.00
IUUC-Xtr-132809	Xenopus tropicalis	73.37	0.00e+00	1242.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence