iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18757916

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	7.00e-06	24.9	914	961

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC +++   ++  l++ CgH f+++Cl  +   +ns++   +CP Cr
   Q: 914  CSICTTEPmdlDK-ALFTECGHSFCEKCLFEYIEFQNSKNLGLKCPNCR 961
           9***997756566.667************88866677799999*****8 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with the DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs. Recruits the UBC13-MMS2 dimer to chromatin for DNA repair.

Protein Sequence
(Fasta)

MSHIEQEERK RFFNDDLDTS ETSLNFKSEN KESFLFANSH NDDDDDVVVS VSDTTEGEGD 60
RSIVPVRREI EEEGQNQFIT ELLRIIPEMP KDLVMELNEK FGSQEEGLSL ALSHYFDHNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTCATA TTGAACAGGA AGAAAGGAAG AGGTTTTTTA ACGATGACCT TGACACTTCA 60
GAAACATCGT TAAACTTCAA ATCTGAGAAT AAAGAGTCGT TTTTATTTGC AAATAGTCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR014905--HIRAN
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00271--Helicase_C
PF08797--HIRAN
PF00176--SNF2_N
PF13639--zf-RING_2

SMART

SM00487--DEXDc
SM00490--HELICc
SM00910--HIRAN
SM00184--RING

Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005524--F:ATP binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0000400--F:four-way junction DNA binding
GO:0009378--F:four-way junction helicase activity
GO:0000403--F:Y-form DNA binding
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0042276--P:error-prone translesion synthesis
GO:0010994--P:free ubiquitin chain polymerization
GO:0006301--P:postreplication repair
GO:0000209--P:protein polyubiquitination

KEGG

sce:YLR032W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000167	Aegilops tauschii	30.72	6.00e-112	396.00
IUUC-Atr-003139	Amborella trichopoda	29.20	1.00e-110	392.00
IUUC-Aly-005600	Arabidopsis lyrata	33.29	4.00e-115	407.00
IUUC-Ath-007079	Arabidopsis thaliana	33.25	8.00e-112	396.00
IUUC-Ago-007997	Ashbya gossypii	47.87	0.00e+00	962.00
IUUC-Acl-008022	Aspergillus clavatus	32.58	1.00e-145	508.00
IUUC-Afl-008514	Aspergillus flavus	33.46	3.00e-148	517.00
IUUC-Afu-009055	Aspergillus fumigatus	33.59	6.00e-144	503.00
IUUC-Ani-009340	Aspergillus nidulans	32.77	5.00e-147	513.00
IUUC-Ang-009785	Aspergillus niger	34.01	6.00e-154	536.00
IUUC-Aor-010158	Aspergillus oryzae	33.46	4.00e-148	517.00
IUUC-Ate-010536	Aspergillus terreus	32.30	3.00e-129	454.00
IUUC-Ame-011743	Astyanax mexicanus	30.41	3.00e-71	261.00
IUUC-Bgr-012147	Blumeria graminis	33.82	7.00e-144	503.00
IUUC-Bta-013391	Bos taurus	31.05	1.00e-78	286.00
IUUC-Bci-013741	Botrytis cinerea	33.33	3.00e-147	514.00
IUUC-Bdi-014646	Brachypodium distachyon	30.73	6.00e-112	396.00
IUUC-Bol-015995	Brassica oleracea	34.05	1.00e-114	405.00
IUUC-Bra-017004	Brassica rapa	33.74	5.00e-113	400.00
IUUC-Cpo-021361	Cavia porcellus	30.79	5.00e-69	253.00
IUUC-Cre-022824	Chlamydomonas reinhardtii	23.80	6.00e-42	164.00
IUUC-Cho-024891	Choloepus hoffmanni	31.44	3.00e-53	201.00
IUUC-Cgl-026606	Colletotrichum gloeosporioides	34.21	3.00e-153	534.00
IUUC-Cne-026886	Cryptococcus neoformans	30.61	1.00e-114	405.00
IUUC-Cme-027110	Cyanidioschyzon merolae	30.22	1.00e-93	336.00
IUUC-Dno-029517	Dasypus novemcinctus	31.98	8.00e-72	263.00
IUUC-Dse-031471	Dothistroma septosporum	34.23	2.00e-150	524.00
IUUC-Dme-031815	Drosophila melanogaster	27.81	3.00e-51	195.00
IUUC-Fox-038039	Fusarium oxysporum	34.58	1.00e-152	532.00
IUUC-Fso-038179	Fusarium solani	34.11	7.00e-152	529.00
IUUC-Ggr-039735	Gaeumannomyces graminis	34.29	1.00e-146	511.00
IUUC-Gac-042401	Gasterosteus aculeatus	31.99	2.00e-83	301.00
IUUC-Gma-042995	Glycine max	30.34	2.00e-114	404.00
IUUC-Ggo-045628	Gorilla gorilla	31.83	8.00e-79	286.00
IUUC-Hsa-045930	Homo sapiens	31.83	8.00e-79	286.00
IUUC-Hvu-047747	Hordeum vulgare	31.33	3.00e-114	404.00
IUUC-Kpa-049087	Komagataella pastoris	39.89	0.00e+00	692.00
IUUC-Lch-050617	Latimeria chalumnae	32.43	1.00e-80	292.00
IUUC-Lpe-051123	Leersia perrieri	29.30	2.00e-110	392.00
IUUC-Loc-052785	Lepisosteus oculatus	31.99	4.00e-82	297.00
IUUC-Lma-052956	Leptosphaeria maculans	33.99	9.00e-153	532.00
IUUC-Laf-054309	Loxodonta africana	32.37	1.00e-71	263.00
IUUC-Mor-057210	Magnaporthe oryzae	35.10	6.00e-158	549.00
IUUC-Mpo-057407	Magnaporthe poae	34.17	5.00e-149	520.00
IUUC-Mtr-058194	Medicago truncatula	31.24	4.00e-104	370.00
IUUC-Mla-058867	Melampsora laricipopulina	30.05	3.00e-73	267.00
IUUC-Mvi-060322	Microbotryum violaceum	29.78	4.00e-80	291.00
IUUC-Mmr-061043	Microcebus murinus	31.66	6.00e-72	263.00
IUUC-Mmu-064338	Mus musculus	31.59	3.00e-77	281.00
IUUC-Nfi-068354	Neosartorya fischeri	33.56	1.00e-144	505.00
IUUC-Ncr-068844	Neurospora crassa	33.71	5.00e-151	526.00
IUUC-Oba-075316	Oryza barthii	29.26	8.00e-108	383.00
IUUC-Obr-076403	Oryza brachyantha	33.46	2.00e-108	385.00
IUUC-Ogl-077573	Oryza glaberrima	29.80	2.00e-110	392.00
IUUC-Ogu-078083	Oryza glumaepatula	29.36	3.00e-109	387.00
IUUC-Oin-079146	Oryza indica	29.80	3.00e-110	390.00
IUUC-Olo-080615	Oryza longistaminata	30.15	6.00e-114	403.00
IUUC-Ome-081448	Oryza meridionalis	28.72	4.00e-96	344.00
IUUC-Oni-082773	Oryza nivara	29.64	1.00e-109	389.00
IUUC-Opu-083675	Oryza punctata	29.93	1.00e-113	402.00
IUUC-Oru-084543	Oryza rufipogon	29.64	4.00e-109	387.00
IUUC-Osa-085686	Oryza sativa	32.46	7.00e-106	376.00
IUUC-Oar-089293	Ovis aries	31.32	2.00e-78	285.00
IUUC-Pno-094916	Phaeosphaeria nodorum	35.53	4.00e-153	533.00
IUUC-Ppa-095877	Physcomitrella patens	34.24	2.00e-110	391.00
IUUC-Pfo-096540	Poecilia formosa	30.69	4.00e-81	294.00
IUUC-Pop-099537	Populus trichocarpa	32.55	1.00e-112	398.00
IUUC-Pca-100648	Procavia capensis	31.08	1.00e-77	282.00
IUUC-Ppe-102107	Prunus persica	29.90	2.00e-107	382.00
IUUC-Pgr-103454	Puccinia graminis	28.57	3.00e-79	288.00
IUUC-Ptt-103829	Puccinia triticina	30.33	1.00e-82	300.00
IUUC-Pte-104242	Pyrenophora teres	32.67	1.00e-146	512.00
IUUC-Pyt-104728	Pyrenophora triticirepentis	34.04	3.00e-148	517.00
IUUC-Rno-106130	Rattus norvegicus	31.38	3.00e-79	288.00
IUUC-Sja-107985	Schizosaccharomyces japonicus	36.78	8.00e-155	539.00
IUUC-Spo-108026	Schizosaccharomyces pombe	34.63	1.00e-152	531.00
IUUC-Ssl-108388	Sclerotinia sclerotiorum	33.46	4.00e-148	517.00
IUUC-Smo-109465	Selaginella moellendorffii	27.72	5.00e-76	277.00
IUUC-Sit-110076	Setaria italica	29.94	2.00e-107	381.00
IUUC-Sly-111031	Solanum lycopersicum	33.17	2.00e-113	401.00
IUUC-Stu-112600	Solanum tuberosum	33.17	3.00e-115	407.00
IUUC-Sar-113719	Sorex araneus	32.26	7.00e-80	290.00
IUUC-Sbi-113927	Sorghum bicolor	30.17	3.00e-106	377.00
IUUC-Sre-115131	Sporisorium reilianum	39.02	4.00e-56	211.00
IUUC-Tgu-117188	Taeniopygia guttata	28.28	2.00e-25	110.00
IUUC-Tni-120618	Tetraodon nigroviridis	31.61	8.00e-84	303.00
IUUC-Tca-121146	Theobroma cacao	30.62	2.00e-115	408.00
IUUC-Tre-121896	Trichoderma reesei	33.62	4.00e-148	517.00
IUUC-Tvi-122597	Trichoderma virens	32.30	2.00e-151	528.00
IUUC-Tae-124722	Triticum aestivum	30.54	7.00e-111	393.00
IUUC-Tur-125999	Triticum urartu	34.30	6.00e-110	390.00
IUUC-Tme-126953	Tuber melanosporum	31.81	1.00e-140	491.00
IUUC-Tbe-127642	Tupaia belangeri	33.46	2.00e-33	135.00
IUUC-Uma-129629	Ustilago maydis	29.40	2.00e-116	412.00
IUUC-Vda-129849	Verticillium dahliae	32.55	3.00e-139	487.00
IUUC-Vvi-131508	Vitis vinifera	32.22	2.00e-112	398.00
IUUC-Xma-133384	Xiphophorus maculatus	30.42	7.00e-80	290.00
IUUC-Yli-134588	Yarrowia lipolytica	32.21	5.00e-132	463.00
IUUC-Zma-135801	Zea mays	31.44	2.00e-97	348.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence