iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	14732404; 15530417

Classification

Family	E-value	Score	Start	End
E2/UBC	1.30e-53	180.8	8	143

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsvesvl 102
           Rl++++k+l++dpp+g+s  p+++ ++ +we+ i+Gp++tp+e+g+Fkl++ef+e+YP kPP+vkf++k+fhPnvy++G++Cl+il+  ++Wsp+++v+ +l
   Q: 8    RLMRDFKKLQEDPPAGVSGAPTED-NILTWEAIIFGPQETPFEDGTFKLSLEFTEEYPNKPPTVKFISKMFHPNVYADGSICLDILQ--NRWSPTYDVAAIL 106
           9***********************.9************************************************************9..************* PP
   S: 103  lsiqsllaepnpesplneeaaellkknreeykkkvre 139
           +siqsll+epnp+sp+n+ aa+l+++nr+ey+k+v++
   Q: 107  TSIQSLLDEPNPNSPANSLAAQLYQENRREYEKRVQQ 143
           **********************************985 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.

Protein Sequence
(Fasta)

MTTPSRRRLM RDFKKLQEDP PAGVSGAPTE DNILTWEAII FGPQETPFED GTFKLSLEFT 60
EEYPNKPPTV KFISKMFHPN VYADGSICLD ILQNRWSPTY DVAAILTSIQ SLLDEPNPNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGTTAGGTT ATCAATATGA CGACGCCCAG CCGTAGACGT TTGATGAGAG ATTTTAAGAA 60
ACTTCAGGTG AGTTTTGAAA TTTTTGGCCC GAAAATTTGG CTTTCTTTGA ACATTAGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0031371--C:ubiquitin conjugating enzyme complex
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006281--P:DNA repair
GO:0016574--P:histone ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination

KEGG

cel:CELE_C35B1.1

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001001	Aegilops tauschii	73.15	1.00e-68	249.00
IUUC-Aml-002120	Ailuropoda melanoleuca	84.56	5.00e-77	278.00
IUUC-Atr-002862	Amborella trichopoda	73.83	1.00e-69	253.00
IUUC-Apl-004063	Anas platyrhynchos	78.08	5.00e-66	241.00
IUUC-Aca-005001	Anolis carolinensis	84.56	7.00e-77	277.00
IUUC-Aly-005584	Arabidopsis lyrata	73.15	4.00e-69	251.00
IUUC-Ath-007149	Arabidopsis thaliana	73.15	4.00e-69	251.00
IUUC-Ago-007745	Ashbya gossypii	67.11	4.00e-62	229.00
IUUC-Acl-008139	Aspergillus clavatus	69.80	9.00e-65	237.00
IUUC-Afl-008551	Aspergillus flavus	69.80	1.00e-64	237.00
IUUC-Afu-008980	Aspergillus fumigatus	69.80	1.00e-64	237.00
IUUC-Ang-009554	Aspergillus niger	69.80	1.00e-64	237.00
IUUC-Aor-010242	Aspergillus oryzae	69.80	1.00e-64	237.00
IUUC-Ate-010390	Aspergillus terreus	69.80	1.00e-64	237.00
IUUC-Ame-010844	Astyanax mexicanus	85.91	3.00e-78	282.00
IUUC-Bgr-012039	Blumeria graminis	69.40	1.00e-57	213.00
IUUC-Bta-012840	Bos taurus	84.56	5.00e-77	278.00
IUUC-Bci-013919	Botrytis cinerea	69.80	5.00e-65	238.00
IUUC-Bdi-014475	Brachypodium distachyon	73.83	1.00e-69	253.00
IUUC-Bol-016084	Brassica oleracea	74.50	1.00e-69	253.00
IUUC-Bra-016643	Brassica rapa	74.50	1.00e-69	253.00
IUUC-Cja-018783	Callithrix jacchus	85.91	2.00e-78	282.00
IUUC-Cfa-020646	Canis familiaris	85.91	3.00e-78	282.00
IUUC-Cpo-021323	Cavia porcellus	86.58	2.00e-78	283.00
IUUC-Cre-022822	Chlamydomonas reinhardtii	70.67	2.00e-56	209.00
IUUC-Csa-023588	Chlorocebus sabaeus	85.91	2.00e-78	282.00
IUUC-Cho-024773	Choloepus hoffmanni	67.11	2.00e-55	206.00
IUUC-Cin-025537	Ciona intestinalis	78.81	3.00e-61	225.00
IUUC-Csv-025846	Ciona savignyi	79.19	8.00e-66	240.00
IUUC-Cgl-026381	Colletotrichum gloeosporioides	69.80	3.00e-65	239.00
IUUC-Cne-026864	Cryptococcus neoformans	69.80	5.00e-65	238.00
IUUC-Cme-027284	Cyanidioschyzon merolae	69.08	2.00e-57	214.00
IUUC-Dre-028358	Danio rerio	85.91	2.00e-78	282.00
IUUC-Dno-029661	Dasypus novemcinctus	84.56	5.00e-77	278.00
IUUC-Dor-030452	Dipodomys ordii	85.07	2.00e-68	249.00
IUUC-Dse-031487	Dothistroma septosporum	69.80	5.00e-65	238.00
IUUC-Dme-031863	Drosophila melanogaster	80.79	2.00e-75	273.00
IUUC-Ete-032595	Echinops telfairi	82.12	2.00e-75	272.00
IUUC-Eca-033377	Equus caballus	84.56	5.00e-77	278.00
IUUC-Eeu-035191	Erinaceus europaeus	67.55	4.00e-55	205.00
IUUC-Fca-036581	Felis catus	85.91	2.00e-78	282.00
IUUC-Fal-037474	Ficedula albicollis	86.21	4.00e-60	221.00
IUUC-Fox-037808	Fusarium oxysporum	69.80	4.00e-65	238.00
IUUC-Fso-038232	Fusarium solani	69.80	5.00e-65	238.00
IUUC-Gmo-038517	Gadus morhua	85.91	2.00e-78	282.00
IUUC-Ggr-039875	Gaeumannomyces graminis	69.80	4.00e-65	238.00
IUUC-Gga-040588	Gallus gallus	85.91	2.00e-78	282.00
IUUC-Gac-041504	Gasterosteus aculeatus	85.91	7.00e-78	281.00
IUUC-Gma-043883	Glycine max	73.83	1.00e-69	253.00
IUUC-Ggo-044896	Gorilla gorilla	85.91	2.00e-78	282.00
IUUC-Hsa-046383	Homo sapiens	85.91	2.00e-78	282.00
IUUC-Hvu-047054	Hordeum vulgare	73.15	1.00e-68	249.00
IUUC-Itr-048507	Ictidomys tridecemlineatus	85.91	2.00e-78	282.00
IUUC-Kpa-049225	Komagataella pastoris	66.44	5.00e-62	228.00
IUUC-Lch-049964	Latimeria chalumnae	85.91	2.00e-78	282.00
IUUC-Lpe-051301	Leersia perrieri	73.83	2.00e-69	253.00
IUUC-Loc-051731	Lepisosteus oculatus	85.91	2.00e-78	282.00
IUUC-Laf-053680	Loxodonta africana	85.91	2.00e-78	282.00
IUUC-Mcc-055546	Macaca mulatta	85.91	5.00e-78	282.00
IUUC-Meu-056231	Macropus eugenii	85.91	2.00e-78	282.00
IUUC-Mor-057087	Magnaporthe oryzae	70.15	3.00e-57	212.00
IUUC-Mpo-057498	Magnaporthe poae	67.72	4.00e-65	239.00
IUUC-Mtr-058305	Medicago truncatula	73.83	1.00e-69	254.00
IUUC-Mla-058876	Melampsora laricipopulina	71.52	1.00e-58	217.00
IUUC-Mga-059863	Meleagris gallopavo	83.21	8.00e-69	250.00
IUUC-Mvi-060330	Microbotryum violaceum	72.85	4.00e-61	225.00
IUUC-Mmr-060630	Microcebus murinus	84.56	5.00e-77	278.00
IUUC-Mdo-062292	Monodelphis domestica	85.91	2.00e-78	282.00
IUUC-Mmu-063680	Mus musculus	85.91	2.00e-78	282.00
IUUC-Mac-064774	Musa acuminata	75.17	5.00e-70	254.00
IUUC-Mpu-065803	Mustela putorius furo	84.56	5.00e-77	278.00
IUUC-Mlu-067147	Myotis lucifugus	84.56	5.00e-77	278.00
IUUC-Nfi-068580	Neosartorya fischeri	69.80	1.00e-64	237.00
IUUC-Ncr-068913	Neurospora crassa	69.80	2.00e-65	239.00
IUUC-Nle-069121	Nomascus leucogenys	85.91	2.00e-78	282.00
IUUC-Opr-070935	Ochotona princeps	84.56	5.00e-77	278.00
IUUC-Ont-071335	Oreochromis niloticus	85.91	5.00e-78	281.00
IUUC-Oan-072706	Ornithorhynchus anatinus	80.14	3.00e-70	255.00
IUUC-Ocu-074550	Oryctolagus cuniculus	85.91	4.00e-78	282.00
IUUC-Oba-075847	Oryza barthii	73.15	9.00e-69	251.00
IUUC-Obr-076713	Oryza brachyantha	73.83	2.00e-69	253.00
IUUC-Ogl-077116	Oryza glaberrima	73.83	2.00e-69	253.00
IUUC-Ogu-078696	Oryza glumaepatula	73.83	2.00e-69	253.00
IUUC-Oin-079099	Oryza indica	73.83	2.00e-69	253.00
IUUC-Olo-081018	Oryza longistaminata	61.90	5.00e-60	222.00
IUUC-Ome-081285	Oryza meridionalis	73.83	2.00e-69	253.00
IUUC-Oni-082088	Oryza nivara	73.83	2.00e-69	253.00
IUUC-Opu-083310	Oryza punctata	73.83	2.00e-69	253.00
IUUC-Oru-084449	Oryza rufipogon	73.83	2.00e-69	253.00
IUUC-Osa-085923	Oryza sativa	73.83	2.00e-69	253.00
IUUC-Ola-086407	Oryzias latipes	85.91	2.00e-78	282.00
IUUC-Olu-087830	Ostreococcus lucimarinus	73.15	3.00e-59	219.00
IUUC-Oga-088659	Otolemur garnettii	85.91	2.00e-78	282.00
IUUC-Oar-090141	Ovis aries	84.56	5.00e-77	278.00
IUUC-Ptr-091305	Pan troglodytes	85.91	2.00e-78	282.00
IUUC-Pan-092740	Papio anubis	85.91	5.00e-78	282.00
IUUC-Psi-094094	Pelodiscus sinensis	85.91	2.00e-78	282.00
IUUC-Pma-094376	Petromyzon marinus	86.58	3.00e-79	285.00
IUUC-Pno-094935	Phaeosphaeria nodorum	69.80	3.00e-65	239.00
IUUC-Ppa-095689	Physcomitrella patens	76.51	1.00e-60	223.00
IUUC-Pfo-096656	Poecilia formosa	86.58	2.00e-78	283.00
IUUC-Pab-097972	Pongo abelii	85.91	2.00e-78	282.00
IUUC-Pop-099517	Populus trichocarpa	73.83	1.00e-69	253.00
IUUC-Pca-100906	Procavia capensis	80.54	6.00e-72	261.00
IUUC-Ppe-101949	Prunus persica	73.83	3.00e-69	253.00
IUUC-Pva-102380	Pteropus vampyrus	85.23	1.00e-76	276.00
IUUC-Pgr-103611	Puccinia graminis	69.18	7.00e-60	221.00
IUUC-Ptt-103971	Puccinia triticina	69.35	2.00e-44	169.00
IUUC-Pte-104378	Pyrenophora teres	70.47	2.00e-65	239.00
IUUC-Pyt-104757	Pyrenophora triticirepentis	70.47	2.00e-65	239.00
IUUC-Rno-105772	Rattus norvegicus	84.56	3.00e-77	279.00
IUUC-Sce-106283	Saccharomyces cerevisiae	67.11	3.00e-62	229.00
IUUC-Sha-107650	Sarcophilus harrisii	83.89	7.00e-76	274.00
IUUC-Sja-107790	Schizosaccharomyces japonicus	70.47	3.00e-59	219.00
IUUC-Spo-108073	Schizosaccharomyces pombe	70.47	2.00e-59	219.00
IUUC-Ssl-108432	Sclerotinia sclerotiorum	69.80	5.00e-65	238.00
IUUC-Smo-109036	Selaginella moellendorffii	76.51	8.00e-71	257.00
IUUC-Sit-110731	Setaria italica	73.83	2.00e-69	253.00
IUUC-Sly-111506	Solanum lycopersicum	73.15	3.00e-69	252.00
IUUC-Stu-112080	Solanum tuberosum	73.15	3.00e-69	252.00
IUUC-Sar-113429	Sorex araneus	84.56	5.00e-77	278.00
IUUC-Sbi-114289	Sorghum bicolor	73.83	2.00e-69	253.00
IUUC-Sre-115106	Sporisorium reilianum	72.73	3.00e-61	226.00
IUUC-Ssc-116265	Sus scrofa	85.91	2.00e-78	282.00
IUUC-Tgu-117383	Taeniopygia guttata	85.91	2.00e-78	282.00
IUUC-Tru-118576	Takifugu rubripes	82.78	2.00e-76	276.00
IUUC-Tsy-119000	Tarsius syrichta	84.56	5.00e-77	278.00
IUUC-Tni-119745	Tetraodon nigroviridis	83.89	3.00e-76	275.00
IUUC-Tca-121827	Theobroma cacao	74.50	8.00e-70	254.00
IUUC-Tre-122002	Trichoderma reesei	69.80	6.00e-65	238.00
IUUC-Tvi-122331	Trichoderma virens	69.80	6.00e-65	238.00
IUUC-Tae-125807	Triticum aestivum	73.83	2.00e-69	253.00
IUUC-Tur-126866	Triticum urartu	73.83	2.00e-69	253.00
IUUC-Tme-127148	Tuber melanosporum	70.47	2.00e-65	239.00
IUUC-Tbe-127921	Tupaia belangeri	82.55	1.00e-72	263.00
IUUC-Ttr-129121	Tursiops truncatus	84.56	5.00e-77	278.00
IUUC-Uma-129561	Ustilago maydis	72.73	2.00e-61	226.00
IUUC-Vda-129711	Verticillium dahliae	69.80	3.00e-65	239.00
IUUC-Vpa-130570	Vicugna pacos	79.85	6.00e-63	231.00
IUUC-Vvi-131547	Vitis vinifera	73.83	1.00e-69	254.00
IUUC-Xtr-132301	Xenopus tropicalis	85.91	2.00e-78	282.00
IUUC-Xma-133937	Xiphophorus maculatus	85.91	2.00e-78	282.00
IUUC-Yli-134660	Yarrowia lipolytica	68.46	1.00e-64	237.00
IUUC-Zma-135584	Zea mays	71.81	3.00e-68	249.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence