iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000085982.13	ENST00000450940.5	ENSP00000407696.1
ENSG00000085982.13	ENST00000454354.1	ENSP00000394133.1
ENSG00000085982.13	ENST00000430158.5	ENSP00000388121.1
ENSG00000085982.13	ENST00000409945.1	ENSP00000386664.1
ENSG00000085982.13	ENST00000452724.1	ENSP00000408853.1
ENSG00000085982.13	ENST00000443711.2	ENSP00000394154.2
ENSG00000085982.13	ENST00000450966.5	ENSP00000415434.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
AREsite	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	20302855

Classification

Family	E-value	Score	Start	End
DUB/USP	5.30e-78	264.2	54	493

Active Site

Position(s)	Description	Evidence
50	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
305	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkg....ellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           G++N+g tCY+NS+LQ+L+++pe+re+l++  +e+l   ++k++       +  +lq+lf++l+  +++a s+ +l+++++++++e  +++q
   Q: 54   GIRNQGGTCYLNSLLQTLHFTPEFREALFSLGPEELGLFEDKDKPDakvrIIPLQLQRLFAQLLLLDQEAASTADLTDSFGWTSNE--EMRQ 143
           9*****************************888888765543322234448999******************************98..**** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkee 181
           +D+qE+ ++l+++le++l                            +++++li +l++g++ +qi+c+ec+nvs+r+e+fldl+++v++ + 
   Q: 144  HDVQELNRILFSALETSL--------------------------VGTSGHDLIYRLYHGTIVNQIVCKECKNVSERQEDFLDLTVAVKNVS- 208
           ******************..........................789********************************************. PP
   S: 182  tkkeslqdcL.esftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekq 272
                l+d+L +++++ee ++++n y+c +c+++++a k+ kl+klP++L++ L Rf+f+  ++ r k +++++fpl+++l+pfc+++e ++
   Q: 209  ----GLEDALwNMYVEEEVFDCDNLYHCGTCDRLVKAAKSAKLRKLPPFLTVSLLRFNFDFVKCERYKETSCYTFPLRINLKPFCEQSELDD 296
           ....9**********************************************************************************99998 PP
   S: 273  kekkkYeLiavvvHsGslssGHYvayvkn............................................................... 301
             +++Y+L++v++H+G++ +GHY++y+k+                                                               
   Q: 297  L-EYIYDLFSVIIHKGGCYGGHYHVYIKDvdhlgnwqfqeekskpdvnlkdlqseeeidhplmilkailleennlipvdqlgqkllkkigis 387
           7.9***************************************************************************************** PP
   S: 302  .................................................................ekgk.....WllfdDskVtevkeeevl 323
                                                                            +  +     W+ ++DskV++++e++++
   Q: 388  wnkkyrkqhgplrkflqlhsqifllssdestvrllknsslqaesdfqrndqqifkmlppespglnN--SiscphWFDINDSKVQPIREKDIE 477
           ******************************************999999999999999888887651..234567****************** PP
   S: 324  eetg..staYvlfYkr 337
           ++ +  ++aY+lfY++
   Q: 478  QQFQgkESAYMLFYRK 493
           *9889*********98 PP

Organism

Homo sapiens

Functional Description
(View)

Broadly expressed.

Protein Sequence
(Fasta)

MSLFLRVVFS FTMFGDLFEE EYSTVSNNQY GKGKKLKTKA LEPPAPREFT NLSGIRNQGG 60
TCYLNSLLQT LHFTPEFREA LFSLGPEELG LFEDKDKPDA KVRIIPLQLQ RLFAQLLLLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTTCTGGA GACCCGCCCT CGCCAACATG GCGGCGCCCA GTTGGGGCGG GTTCGTTCGC 60
TTCGCGTTTT GGCCAGGGCG GGGGTCTGGG CTTTAGGCAG TAAGTGCGGC TGGCGCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:55230

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001216	Ailuropoda melanoleuca	84.63	0.00e+00	1979.00
IUUC-Apl-004105	Anas platyrhynchos	64.25	0.00e+00	1545.00
IUUC-Aca-004715	Anolis carolinensis	62.75	0.00e+00	1489.00
IUUC-Ame-011073	Astyanax mexicanus	47.77	0.00e+00	1032.00
IUUC-Bta-012487	Bos taurus	83.74	0.00e+00	2036.00
IUUC-Cja-018937	Callithrix jacchus	94.50	0.00e+00	2324.00
IUUC-Cfa-020645	Canis familiaris	80.21	0.00e+00	1274.00
IUUC-Cpo-022160	Cavia porcellus	80.21	0.00e+00	1966.00
IUUC-Csa-023078	Chlorocebus sabaeus	95.87	0.00e+00	2401.00
IUUC-Cho-025013	Choloepus hoffmanni	67.35	0.00e+00	848.00
IUUC-Csv-026193	Ciona savignyi	56.47	8.00e-59	219.00
IUUC-Dre-027416	Danio rerio	48.42	0.00e+00	1132.00
IUUC-Dno-029639	Dasypus novemcinctus	81.11	0.00e+00	1694.00
IUUC-Dor-030624	Dipodomys ordii	90.67	3.00e-154	539.00
IUUC-Ete-032626	Echinops telfairi	64.07	0.00e+00	756.00
IUUC-Eca-034208	Equus caballus	86.40	0.00e+00	2137.00
IUUC-Eeu-035340	Erinaceus europaeus	46.82	1.00e-94	341.00
IUUC-Fca-035886	Felis catus	74.66	0.00e+00	788.00
IUUC-Fal-036925	Ficedula albicollis	64.05	0.00e+00	1451.00
IUUC-Gmo-038597	Gadus morhua	45.95	0.00e+00	893.00
IUUC-Gga-041171	Gallus gallus	64.10	0.00e+00	1547.00
IUUC-Gac-041362	Gasterosteus aculeatus	45.84	0.00e+00	946.00
IUUC-Ggo-045069	Gorilla gorilla	97.18	0.00e+00	2232.00
IUUC-Itr-049006	Ictidomys tridecemlineatus	82.34	0.00e+00	1983.00
IUUC-Lch-050182	Latimeria chalumnae	52.82	0.00e+00	1168.00
IUUC-Loc-052705	Lepisosteus oculatus	54.47	0.00e+00	1266.00
IUUC-Laf-054132	Loxodonta africana	81.73	0.00e+00	2034.00
IUUC-Mcc-055734	Macaca mulatta	96.30	0.00e+00	2428.00
IUUC-Meu-056135	Macropus eugenii	85.84	8.00e-114	405.00
IUUC-Mga-060092	Meleagris gallopavo	63.88	0.00e+00	1513.00
IUUC-Mmr-061546	Microcebus murinus	85.29	0.00e+00	2099.00
IUUC-Mdo-061935	Monodelphis domestica	62.01	0.00e+00	1512.00
IUUC-Mmu-063630	Mus musculus	79.71	0.00e+00	1970.00
IUUC-Mpu-066579	Mustela putorius furo	80.58	0.00e+00	2025.00
IUUC-Mlu-068034	Myotis lucifugus	84.80	0.00e+00	2024.00
IUUC-Nle-069082	Nomascus leucogenys	97.38	0.00e+00	2034.00
IUUC-Opr-070953	Ochotona princeps	72.74	0.00e+00	998.00
IUUC-Ont-072435	Oreochromis niloticus	47.38	0.00e+00	1083.00
IUUC-Oan-073339	Ornithorhynchus anatinus	67.14	0.00e+00	1565.00
IUUC-Ocu-073760	Oryctolagus cuniculus	82.28	0.00e+00	2026.00
IUUC-Ola-087015	Oryzias latipes	47.01	0.00e+00	917.00
IUUC-Oga-088960	Otolemur garnettii	86.81	0.00e+00	2130.00
IUUC-Oar-089853	Ovis aries	84.09	0.00e+00	2063.00
IUUC-Ptr-091093	Pan troglodytes	99.20	0.00e+00	2479.00
IUUC-Pan-091962	Papio anubis	95.31	0.00e+00	2382.00
IUUC-Psi-093691	Pelodiscus sinensis	66.13	0.00e+00	1592.00
IUUC-Pma-094428	Petromyzon marinus	65.11	3.00e-91	328.00
IUUC-Pfo-096983	Poecilia formosa	47.56	0.00e+00	1013.00
IUUC-Pab-097860	Pongo abelii	97.77	0.00e+00	2260.00
IUUC-Pca-100514	Procavia capensis	79.95	0.00e+00	664.00
IUUC-Pva-102771	Pteropus vampyrus	84.58	0.00e+00	1945.00
IUUC-Rno-105405	Rattus norvegicus	78.58	0.00e+00	1912.00
IUUC-Sha-107376	Sarcophilus harrisii	64.27	0.00e+00	1472.00
IUUC-Ssc-115819	Sus scrofa	79.75	0.00e+00	1413.00
IUUC-Tgu-117262	Taeniopygia guttata	63.13	0.00e+00	1517.00
IUUC-Tru-117601	Takifugu rubripes	48.18	0.00e+00	1093.00
IUUC-Tsy-118996	Tarsius syrichta	76.95	0.00e+00	1685.00
IUUC-Tni-120682	Tetraodon nigroviridis	42.92	0.00e+00	863.00
IUUC-Tbe-127616	Tupaia belangeri	67.31	0.00e+00	1162.00
IUUC-Ttr-129075	Tursiops truncatus	81.92	0.00e+00	1910.00
IUUC-Vpa-130108	Vicugna pacos	83.99	0.00e+00	1835.00
IUUC-Xtr-132623	Xenopus tropicalis	52.88	0.00e+00	1211.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence