iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000100284.20	ENST00000456128.5	ENSP00000393714.1
ENSG00000100284.20	ENST00000449058.6	ENSP00000394466.2
ENSG00000100284.20	ENST00000404284.6	ENSP00000385906.2
ENSG00000100284.20	ENST00000439512.5	ENSP00000394944.1
ENSG00000100284.20	ENST00000424387.5	ENSP00000397492.1
ENSG00000100284.20	ENST00000395736.7	ENSP00000379085.3
ENSG00000100284.20	ENST00000449508.1	ENSP00000390429.1
ENSG00000100284.20	ENST00000411850.5	ENSP00000413697.1
ENSG00000100284.20	ENST00000425375.5	ENSP00000394924.1
ENSG00000100284.20	ENST00000382034.9	ENSP00000371465.6

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRecords
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/GAT	GAT	23781020
UBD/Alpha-Helix/VHS	VHS	14563850; 16199040

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/VHS	3.50e-51	174.3	20	152
UBD/Alpha-Helix/GAT	2.50e-28	100.3	215	302

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/VHS

   S: 1    atselvtsedwelileicdliqetkegakdalralrkri.nnknphvalraLtlLdscvsnCgkkfhvevaskdllee..lrell.knenep 88
           at+ +++sedw+l++eicd+i+et+eg+kdalra++kri +nkn+h++++aLt+L++cv+nCg++fhv+vas+d++e+  +r++l kn++++
   Q: 20   ATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIvGNKNFHEVMLALTVLETCVKNCGHRFHVLVASQDFVESvlVRTILpKNNPPT 111
           68999*********************************99**************************************999*********** PP
   S: 89   kvieKlkalivsWadelknepalslivaliktlkeeGlefp 129
            v++K+++li+sWad+++++p+l+++v+++++l+++Glefp
   Q: 112  IVHDKVLNLIQSWADAFRSSPDLTGVVTIYEDLRRKGLEFP 152
           ****************************************8 PP

UBD/Alpha-Helix/GAT

   S: 39   ekikkliseleevksnvkllnemlselspegeepednellqelyetckaarpkllklieeeedndellaellkanDelnqvlnkykqlk 127
           e+i+kl+sele+v++nv++++eml+el+p+++ep+d ellqel++tc+a+++++l+li +   n++l++ell +nD+ln+v++++++++
   Q: 215  EQIGKLRSELEMVSGNVRVMSEMLTELVPTQAEPADLELLQELNRTCRAMQQRVLELIPQ-IANEQLTEELLIVNDNLNNVFLRHERFE 302
           89**********************************************************.*************************997 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with ZFYVE16; interaction is required to target it to endosomes.

Protein Sequence
(Fasta)

MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA LRAVKKRIVG 60
NKNFHEVMLA LTVLETCVKN CGHRFHVLVA SQDFVESVLV RTILPKNNPP TIVHDKVLNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTTTTGCC ATCCTGGGCG CTAGAGGGAA TTGCGCTGCA ATTCATTAAA TTGCCTCTCA 60
GTCTCAACAG ATGACAAACC CCTTGCCCTT GCCTCTGATT TAAGGTAAGA TAATTTGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport

Interpro

IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR014645--TOM1
IPR002014--VHS_dom

PROSITE

PS50909--GAT
PS50179--VHS

Pfam

PF03127--GAT
PF00790--VHS

SMART

SM00288--VHS

Gene Ontology

GO:0035577--C:azurophil granule membrane
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0035579--C:specific granule membrane
GO:0030276--F:clathrin binding
GO:0006897--P:endocytosis
GO:0016197--P:endosomal transport
GO:0006886--P:intracellular protein transport
GO:0043312--P:neutrophil degranulation
GO:0015031--P:protein transport

KEGG

hsa:10043

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001372	Ailuropoda melanoleuca	90.22	0.00e+00	884.00
IUUC-Apl-004197	Anas platyrhynchos	73.81	0.00e+00	687.00
IUUC-Aca-005277	Anolis carolinensis	72.07	0.00e+00	656.00
IUUC-Bta-013410	Bos taurus	92.48	0.00e+00	902.00
IUUC-Cja-018944	Callithrix jacchus	92.79	0.00e+00	893.00
IUUC-Cfa-021024	Canis familiaris	91.46	0.00e+00	879.00
IUUC-Cpo-021418	Cavia porcellus	83.77	0.00e+00	815.00
IUUC-Csa-023653	Chlorocebus sabaeus	94.71	0.00e+00	943.00
IUUC-Cin-025779	Ciona intestinalis	42.38	2.00e-71	262.00
IUUC-Cne-026931	Cryptococcus neoformans	25.82	6.00e-15	75.90
IUUC-Dno-029610	Dasypus novemcinctus	89.00	0.00e+00	712.00
IUUC-Dor-030925	Dipodomys ordii	77.85	0.00e+00	743.00
IUUC-Eca-034207	Equus caballus	93.09	0.00e+00	888.00
IUUC-Eeu-035025	Erinaceus europaeus	73.00	3.00e-122	432.00
IUUC-Fca-036407	Felis catus	91.72	0.00e+00	817.00
IUUC-Fal-036809	Ficedula albicollis	73.96	0.00e+00	690.00
IUUC-Gga-040357	Gallus gallus	73.27	0.00e+00	726.00
IUUC-Gma-043377	Glycine max	31.36	8.00e-33	135.00
IUUC-Ggo-044454	Gorilla gorilla	97.60	0.00e+00	954.00
IUUC-Itr-049028	Ictidomys tridecemlineatus	86.82	0.00e+00	877.00
IUUC-Lch-049918	Latimeria chalumnae	61.52	1.00e-156	546.00
IUUC-Laf-054231	Loxodonta africana	88.86	0.00e+00	682.00
IUUC-Mcc-055475	Macaca mulatta	98.37	0.00e+00	957.00
IUUC-Meu-056002	Macropus eugenii	65.89	4.00e-155	541.00
IUUC-Mla-058817	Melampsora laricipopulina	25.65	5.00e-19	89.00
IUUC-Mga-059199	Meleagris gallopavo	69.73	0.00e+00	668.00
IUUC-Mvi-060415	Microbotryum violaceum	24.72	2.00e-15	77.80
IUUC-Mmr-061193	Microcebus murinus	93.51	0.00e+00	860.00
IUUC-Mdo-062456	Monodelphis domestica	80.79	0.00e+00	726.00
IUUC-Mmu-063746	Mus musculus	89.43	0.00e+00	888.00
IUUC-Mpu-066772	Mustela putorius furo	90.87	0.00e+00	884.00
IUUC-Mlu-067475	Myotis lucifugus	84.75	0.00e+00	684.00
IUUC-Nle-068998	Nomascus leucogenys	96.21	0.00e+00	935.00
IUUC-Oan-073103	Ornithorhynchus anatinus	75.10	0.00e+00	736.00
IUUC-Ocu-073922	Oryctolagus cuniculus	84.93	0.00e+00	789.00
IUUC-Olo-080980	Oryza longistaminata	31.79	2.00e-30	127.00
IUUC-Olu-087840	Ostreococcus lucimarinus	24.63	4.00e-16	79.70
IUUC-Oga-089050	Otolemur garnettii	81.71	0.00e+00	768.00
IUUC-Oar-090246	Ovis aries	88.13	0.00e+00	845.00
IUUC-Ptr-090714	Pan troglodytes	99.39	0.00e+00	959.00
IUUC-Pan-092875	Papio anubis	98.37	0.00e+00	957.00
IUUC-Psi-094051	Pelodiscus sinensis	72.88	0.00e+00	707.00
IUUC-Pab-098291	Pongo abelii	99.13	0.00e+00	893.00
IUUC-Pca-100907	Procavia capensis	82.32	0.00e+00	743.00
IUUC-Pva-102610	Pteropus vampyrus	83.33	0.00e+00	800.00
IUUC-Pgr-103677	Puccinia graminis	27.22	1.00e-20	94.40
IUUC-Rno-105809	Rattus norvegicus	88.82	0.00e+00	877.00
IUUC-Sha-107255	Sarcophilus harrisii	83.18	0.00e+00	719.00
IUUC-Ssl-108413	Sclerotinia sclerotiorum	39.04	7.00e-22	96.30
IUUC-Sre-115232	Sporisorium reilianum	25.58	2.00e-19	90.50
IUUC-Tgu-117517	Taeniopygia guttata	75.00	0.00e+00	730.00
IUUC-Tni-120701	Tetraodon nigroviridis	54.01	4.00e-144	504.00
IUUC-Ttr-128710	Tursiops truncatus	83.77	0.00e+00	771.00
IUUC-Uma-129380	Ustilago maydis	26.63	4.00e-15	76.60
IUUC-Vpa-130381	Vicugna pacos	71.88	6.00e-107	380.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence