iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000100365.14	ENST00000248899.10	ENSP00000248899.6
ENSG00000100365.14	ENST00000397147.6	ENSP00000380334.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
DrugBank
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/PB1	PB1	17726178

Classification

Family	E-value	Score	Start	End
UBD/SH3	1.40e-10	42.7	175	228
ULD/UDP/UFD/PB1	4.70e-21	76.4	237	329

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            ++l+d++++++ eL++k+Gdv++++     +++Wl+g  + +g  G+fP  Fv+ l+
   Q: 175  AEALFDFTGNSKLELNFKAGDVIFLL--SRINKDWLEG--TVRGATGIFPLSFVKILK 228
           689***********************..999*******..8*************9776 PP

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirs......faldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavslla...skksll..rlli 81
           t++++++y+++++s      +++dl+++++++dLl+++r+  e++++++al+Y+D++GDlv+l sDed++ +v++++   s+k+l+  +l+i
   Q: 237  TNWLRCYYYEDTIStikdiaVEEDLSSTPLLKDLLELTRR--EFQREDIALNYRDAEGDLVRLLSDEDVALMVRQARglpSQKRLFpwKLHI 326
           589**********9**************************..************************************************** PP
   S: 82   qkk 84
           ++k
   Q: 327  TQK 329
           985 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.

Protein Sequence
(Fasta)

MAVAQQLRAE SDFEQLPDDV AISANIADIE EKRGFTSHFV FVIEVKTKGG SKYLIYRRYR 60
QFHALQSKLE ERFGPDSKSS ALACTLPTLP AKVYVGVKQE IAEMRIPALN AYMKSLLSLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGAGGAG CCTCTGCCAG ACTGGAGAGA AGCAGGCCTG AGCCTCCCCA AAGGCAGCTC 60
CTGGGGACTC CCAGGACCAC AGGCTGAGAC GAGACGCAGG GTGGCTGGAG GAAGTGAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0161--Chronic granulomatous disease
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000919--NCF_P40
IPR000270--PB1_dom
IPR001683--Phox
IPR001452--SH3_domain

PROSITE

PS51745--PB1
PS50195--PX
PS50002--SH3

Pfam

PF00564--PB1
PF00787--PX
PF00018--SH3_1

PRINTS

PR00497--P40PHOX

SMART

SM00666--PB1
SM00312--PX
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0016020--C:membrane
GO:0043020--C:NADPH oxidase complex
GO:0032010--C:phagolysosome
GO:0005802--C:trans-Golgi network
GO:0005086--F:ARF guanyl-nucleotide exchange factor activity
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0046983--F:protein dimerization activity
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0045454--P:cell redox homeostasis
GO:0006955--P:immune response
GO:0055114--P:oxidation-reduction process
GO:0000302--P:response to reactive oxygen species
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0016192--P:vesicle-mediated transport

KEGG

hsa:4689

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001675	Ailuropoda melanoleuca	89.09	2.00e-180	624.00
IUUC-Apl-003431	Anas platyrhynchos	67.55	1.00e-135	475.00
IUUC-Aca-005176	Anolis carolinensis	71.13	7.00e-139	486.00
IUUC-Ame-011492	Astyanax mexicanus	57.46	9.00e-114	403.00
IUUC-Bta-013434	Bos taurus	89.68	7.00e-169	586.00
IUUC-Cja-019788	Callithrix jacchus	94.99	0.00e+00	665.00
IUUC-Cfa-021039	Canis familiaris	89.97	1.00e-176	612.00
IUUC-Cpo-021848	Cavia porcellus	88.50	1.00e-175	608.00
IUUC-Csa-023733	Chlorocebus sabaeus	98.30	2.00e-172	598.00
IUUC-Dre-027732	Danio rerio	52.53	2.00e-97	349.00
IUUC-Dno-029154	Dasypus novemcinctus	80.12	6.00e-157	546.00
IUUC-Eca-034062	Equus caballus	91.74	2.00e-179	621.00
IUUC-Fca-036402	Felis catus	90.86	0.00e+00	637.00
IUUC-Fal-037105	Ficedula albicollis	67.26	4.00e-134	471.00
IUUC-Gmo-039144	Gadus morhua	47.95	1.00e-36	145.00
IUUC-Gga-040526	Gallus gallus	68.14	2.00e-135	475.00
IUUC-Itr-048385	Ictidomys tridecemlineatus	70.51	6.00e-132	463.00
IUUC-Lch-050264	Latimeria chalumnae	53.26	9.00e-115	406.00
IUUC-Loc-051887	Lepisosteus oculatus	54.24	2.00e-104	372.00
IUUC-Laf-054411	Loxodonta africana	82.73	2.00e-156	545.00
IUUC-Mcc-055835	Macaca mulatta	97.56	0.00e+00	662.00
IUUC-Meu-056875	Macropus eugenii	81.82	8.00e-94	336.00
IUUC-Mga-059737	Meleagris gallopavo	67.55	3.00e-134	471.00
IUUC-Mdo-062598	Monodelphis domestica	81.18	6.00e-158	550.00
IUUC-Mmu-063643	Mus musculus	86.73	7.00e-177	612.00
IUUC-Mpu-066142	Mustela putorius furo	90.56	0.00e+00	641.00
IUUC-Mlu-067898	Myotis lucifugus	91.11	5.00e-46	175.00
IUUC-Nle-069935	Nomascus leucogenys	85.04	3.00e-160	557.00
IUUC-Ont-072261	Oreochromis niloticus	54.29	1.00e-104	373.00
IUUC-Oan-072846	Ornithorhynchus anatinus	79.62	3.00e-73	266.00
IUUC-Ocu-074683	Oryctolagus cuniculus	90.88	0.00e+00	640.00
IUUC-Ola-086700	Oryzias latipes	54.73	2.00e-97	348.00
IUUC-Oga-087992	Otolemur garnettii	92.49	0.00e+00	634.00
IUUC-Oar-089828	Ovis aries	88.56	4.00e-166	577.00
IUUC-Pan-092264	Papio anubis	96.76	0.00e+00	677.00
IUUC-Psi-093800	Pelodiscus sinensis	69.03	3.00e-134	471.00
IUUC-Pfo-096677	Poecilia formosa	51.97	8.00e-88	317.00
IUUC-Pab-097920	Pongo abelii	98.53	0.00e+00	687.00
IUUC-Rno-105777	Rattus norvegicus	87.32	5.00e-178	616.00
IUUC-Sha-106666	Sarcophilus harrisii	80.59	5.00e-165	573.00
IUUC-Ssc-116056	Sus scrofa	88.79	0.00e+00	631.00
IUUC-Tgu-116797	Taeniopygia guttata	67.85	8.00e-137	479.00
IUUC-Tru-117860	Takifugu rubripes	53.60	7.00e-98	350.00
IUUC-Tni-119946	Tetraodon nigroviridis	55.11	4.00e-100	358.00
IUUC-Ttr-129026	Tursiops truncatus	89.47	3.00e-110	391.00
IUUC-Xtr-131910	Xenopus tropicalis	53.39	2.00e-108	385.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence