iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046055

Ensembl Protein ID

ENSP00000353886.3

UniProt Accession

Q9H492; E1P5P4; E1P5P5; Q9BXW5; MLP3A_HUMAN

Genbank Protein ID

AAK35151.1; AAP36120.1; CAD38714.1; CAC14078.1; CAI40290.1; EAW76263.1; EAW76264.1; EAW76265.1; EAW76266.1; AAH15810.1

Protein Name

Microtubule-associated proteins 1A/1B light chain 3A; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; Microtubule-associated protein 1 light chain 3 alpha

Genbank Nucleotide ID

AF276658; BT007452; AL833855; AL118520; AL118520; CH471077; CH471077; CH471077; CH471077; BC015810

Gene Name

MAP1LC3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000101460.12	ENST00000374837.7	ENSP00000363970.3
ENSG00000101460.12	ENST00000360668.7	ENSP00000353886.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UBL/ATG8	ATG8	16325851

Classification

Family	E-value	Score	Start	End
ULD/UBL/ATG8	4.10e-50	169.9	15	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkeki.peldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnn.slvsvsatlaeiyeeekded 90
           +r++ev++ird++p+kiPvi+e++k+ek+ p+ldk+k+lvP+++++++lvkiir+rlql++++a+fllvn+ s+vsvs+++a+iye+ekded
   Q: 15   DRCKEVQQIRDQHPSKIPVIIERYKGEKQlPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQhSMVSVSTPIADIYEQEKDED 106
           69**************************99************************************************************** PP
   S: 91   gflyvayaseetfG 104
           gfly++yas+etfG
   Q: 107  GFLYMVYASQETFG 120
           *************9 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600).

Protein Sequence
(Fasta)

MPSDRPFKQR RSFADRCKEV QQIRDQHPSK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM 60
SELVKIIRRR LQLNPTQAFF LLVNQHSMVS VSTPIADIYE QEKDEDGFLY MVYASQETFG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCCACCTG CCACTCCTGA CTGCATGGAA GCCAGGTGCA AGGAGAAAGG ATTTTGAGGA 60
GGGGTGAGTC ACCAGAACAC ATTTGTTTGC TGCGGAGAGA TCGTAAGGGG CCTCGGAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0044754--C:autolysosome
GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0005829--C:cytosol
GO:0005770--C:late endosome
GO:0005874--C:microtubule
GO:0031090--C:organelle membrane
GO:0008429--F:phosphatidylethanolamine binding
GO:0005543--F:phospholipid binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0000045--P:autophagosome assembly
GO:0097352--P:autophagosome maturation
GO:0034198--P:cellular response to amino acid starvation
GO:0071280--P:cellular response to copper ion
GO:0070301--P:cellular response to hydrogen peroxide
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0010040--P:response to iron(II) ion
GO:0010288--P:response to lead ion
GO:0043278--P:response to morphine

KEGG

hsa:84557

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001444	Ailuropoda melanoleuca	98.18	1.00e-60	223.00
IUUC-Apl-003457	Anas platyrhynchos	87.50	3.00e-59	219.00
IUUC-Aca-004647	Anolis carolinensis	95.04	4.00e-66	242.00
IUUC-Ame-010918	Astyanax mexicanus	95.83	1.00e-65	241.00
IUUC-Bta-012939	Bos taurus	99.17	5.00e-68	248.00
IUUC-Cel-018533	Caenorhabditis elegans	59.65	2.00e-35	140.00
IUUC-Cja-018774	Callithrix jacchus	99.07	4.00e-60	222.00
IUUC-Cfa-020676	Canis familiaris	98.33	7.00e-67	246.00
IUUC-Cpo-022407	Cavia porcellus	100.00	2.00e-68	250.00
IUUC-Csa-023226	Chlorocebus sabaeus	100.00	2.00e-68	250.00
IUUC-Dre-027607	Danio rerio	95.83	1.00e-65	241.00
IUUC-Dno-029031	Dasypus novemcinctus	100.00	2.00e-68	250.00
IUUC-Ete-032915	Echinops telfairi	100.00	6.00e-60	221.00
IUUC-Eca-033844	Equus caballus	98.18	1.00e-60	223.00
IUUC-Eeu-034695	Erinaceus europaeus	99.07	2.00e-59	220.00
IUUC-Fca-035743	Felis catus	95.97	6.00e-66	242.00
IUUC-Fal-036789	Ficedula albicollis	96.30	1.00e-58	218.00
IUUC-Gmo-039473	Gadus morhua	95.00	2.00e-65	240.00
IUUC-Gga-040489	Gallus gallus	95.04	4.00e-66	242.00
IUUC-Gac-041849	Gasterosteus aculeatus	95.00	3.00e-65	239.00
IUUC-Ggo-044780	Gorilla gorilla	100.00	2.00e-60	223.00
IUUC-Itr-048837	Ictidomys tridecemlineatus	100.00	2.00e-68	250.00
IUUC-Lch-050578	Latimeria chalumnae	90.83	2.00e-62	230.00
IUUC-Loc-052008	Lepisosteus oculatus	96.67	3.00e-66	243.00
IUUC-Laf-054392	Loxodonta africana	91.67	3.00e-60	223.00
IUUC-Mcc-055894	Macaca mulatta	100.00	2.00e-60	223.00
IUUC-Mga-059593	Meleagris gallopavo	95.37	1.00e-58	217.00
IUUC-Mmr-061787	Microcebus murinus	100.00	2.00e-68	250.00
IUUC-Mdo-062276	Monodelphis domestica	97.52	3.00e-67	246.00
IUUC-Mmu-063357	Mus musculus	100.00	2.00e-68	250.00
IUUC-Mpu-065740	Mustela putorius furo	98.35	8.00e-68	249.00
IUUC-Mlu-067688	Myotis lucifugus	99.17	4.00e-68	249.00
IUUC-Nle-069441	Nomascus leucogenys	100.00	2.00e-60	223.00
IUUC-Opr-071159	Ochotona princeps	100.00	6.00e-60	221.00
IUUC-Ont-071272	Oreochromis niloticus	95.00	2.00e-65	240.00
IUUC-Oan-073060	Ornithorhynchus anatinus	88.46	4.00e-52	195.00
IUUC-Ola-087353	Oryzias latipes	93.33	2.00e-64	237.00
IUUC-Oga-088213	Otolemur garnettii	100.00	2.00e-68	250.00
IUUC-Oar-089438	Ovis aries	93.28	2.00e-61	226.00
IUUC-Ptr-090906	Pan troglodytes	100.00	2.00e-60	223.00
IUUC-Pan-091989	Papio anubis	100.00	2.00e-60	224.00
IUUC-Psi-093576	Pelodiscus sinensis	90.16	3.00e-59	219.00
IUUC-Pfo-097503	Poecilia formosa	95.00	2.00e-65	240.00
IUUC-Pab-098040	Pongo abelii	100.00	2.00e-68	250.00
IUUC-Rno-104943	Rattus norvegicus	100.00	2.00e-68	250.00
IUUC-Ssc-115937	Sus scrofa	99.17	4.00e-67	245.00
IUUC-Tgu-116715	Taeniopygia guttata	95.41	4.00e-58	216.00
IUUC-Tru-117554	Takifugu rubripes	95.33	2.00e-57	213.00
IUUC-Tni-120190	Tetraodon nigroviridis	91.67	3.00e-63	233.00
IUUC-Vpa-130194	Vicugna pacos	97.20	1.00e-57	214.00
IUUC-Xtr-132257	Xenopus tropicalis	92.50	2.00e-63	233.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence