iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000101557.14	ENST00000582707.5	ENSP00000464447.1
ENSG00000101557.14	ENST00000400266.7	ENSP00000383125.3
ENSG00000101557.14	ENST00000383589.6	ENSP00000373083.2
ENSG00000101557.14	ENST00000261601.7	ENSP00000261601.6
ENSG00000101557.14	ENST00000583119.5	ENSP00000473563.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
GRAC	PDTD	Manually
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	16211010; 19615732
UBD/Other/Other	UBD/Other/Other	16211010
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	16211010

Classification

Family	E-value	Score	Start	End
DUB/USP	1.80e-65	223.1	105	480
ULD/UDP/UBQ/UBQ_Other	4.00e-09	37.9	5	74

Active Site

Position(s)	Description	Evidence
114	Nucleophile	{ECO:0000305\|PubMed:16211010}
435	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs......g 86
           +Gl+NlgNtCYmN+++Qc+ ++pel+++l++ +  +l+++ +  + + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f       +
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPELKDALKR-YAGALRASGEMASAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekgeqgQ 194
           7******************************.****************************.99999******************999*9999 PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           y qqDa+E++ +++  l+++l+  ++ +++e+        s++a+  +++k+ksli++ F++++++++kc e +++ +++ + ++l+l+   
   Q: 195  YLQQDANECWIQMMRVLQQKLEAIEDDSVKETD-------SSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFI 279
           *********************664444444443.......33478899**************************999999888888888887 PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts... 267
           ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+ + ct    
   Q: 280  NQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPelq 364
           7754..58999999999999998.....58899999999**************************************************666 PP
   S: 268  .....................peekqke...........................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfd 310
                                p     +                           +  Y+L av+ H+G s+ssGHYv++vk ++++W++fd
   Q: 365  ekmvsfrskfkdledkkvnqqP-----NtsdkksspqkevkyepfsfaddigsnnCGYYDLQAVLTHQGrSSSSGHYVSWVKRKQDEWIKFD 451
           6666666666666665555551.....0555556666677777777777777777************************************* PP
   S: 311  DskVtevkeeevleetg....staYvlfY 335
           D+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 452  DDKVSIVTPEDILRLSGggdwHIAYVLLY 480
           **************988************ PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           +vtvk+ + +  ++++n +++  ++K +++ ++g++p++q+ ++kG  L+dd ++++ ++k+g+t++++ +
   Q: 5    SVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDD-DWGNIKIKNGMTLLMMGS 74
           69********99*************************************999.9**************965 PP

Organism

Homo sapiens

Functional Description
(View)

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).

Protein Sequence
(Fasta)

MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 60
IKIKNGMTLL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTCACTTG CTCCCTCCTT CCTTCCCGCC ACCCCTCCAC CGCCTTCCCC CTCCTCCCTC 60
CTCTCGCCAC CTCTAGGCCC CGCCCCGGTC CTGCCGCCCA GTCTCCTCGC TGCAGTCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0000502--C:proteasome complex
GO:0045202--C:synapse
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004866--F:endopeptidase inhibitor activity
GO:0070628--F:proteasome binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008193--F:tRNA guanylyltransferase activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:9097

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	43.96	2.00e-38	153.00
IUUC-Aml-002053	Ailuropoda melanoleuca	98.98	0.00e+00	935.00
IUUC-Atr-002725	Amborella trichopoda	42.03	1.00e-102	367.00
IUUC-Apl-004031	Anas platyrhynchos	91.26	0.00e+00	892.00
IUUC-Aca-004361	Anolis carolinensis	89.29	0.00e+00	913.00
IUUC-Aly-006078	Arabidopsis lyrata	42.20	3.00e-112	399.00
IUUC-Ath-007623	Arabidopsis thaliana	42.18	1.00e-112	400.00
IUUC-Ago-007796	Ashbya gossypii	32.22	2.00e-58	220.00
IUUC-Acl-008258	Aspergillus clavatus	36.52	8.00e-65	241.00
IUUC-Afl-008732	Aspergillus flavus	33.33	5.00e-72	265.00
IUUC-Afu-008755	Aspergillus fumigatus	34.83	1.00e-79	290.00
IUUC-Ani-009148	Aspergillus nidulans	37.90	3.00e-70	259.00
IUUC-Ang-009878	Aspergillus niger	37.32	3.00e-65	243.00
IUUC-Aor-010239	Aspergillus oryzae	33.33	6.00e-72	265.00
IUUC-Ate-010243	Aspergillus terreus	33.74	1.00e-70	261.00
IUUC-Ame-011327	Astyanax mexicanus	51.00	3.00e-127	448.00
IUUC-Bgr-012231	Blumeria graminis	34.15	3.00e-79	289.00
IUUC-Bta-012553	Bos taurus	97.57	0.00e+00	949.00
IUUC-Bci-013606	Botrytis cinerea	39.95	7.00e-70	258.00
IUUC-Bdi-014567	Brachypodium distachyon	42.91	4.00e-112	398.00
IUUC-Bol-016127	Brassica oleracea	42.60	3.00e-114	405.00
IUUC-Bra-017501	Brassica rapa	42.40	2.00e-113	402.00
IUUC-Cel-018140	Caenorhabditis elegans	41.55	3.00e-100	358.00
IUUC-Cja-019516	Callithrix jacchus	98.99	0.00e+00	965.00
IUUC-Cfa-020808	Canis familiaris	99.19	0.00e+00	961.00
IUUC-Cpo-021688	Cavia porcellus	96.96	0.00e+00	941.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	37.78	8.00e-83	301.00
IUUC-Csa-023429	Chlorocebus sabaeus	99.80	0.00e+00	946.00
IUUC-Cho-024347	Choloepus hoffmanni	97.77	0.00e+00	954.00
IUUC-Cin-025198	Ciona intestinalis	54.38	6.00e-151	527.00
IUUC-Csv-026007	Ciona savignyi	53.01	4.00e-153	534.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	38.44	1.00e-63	237.00
IUUC-Cne-026963	Cryptococcus neoformans	34.68	2.00e-76	279.00
IUUC-Cme-027240	Cyanidioschyzon merolae	30.62	7.00e-60	224.00
IUUC-Dre-027647	Danio rerio	82.45	0.00e+00	831.00
IUUC-Dno-029967	Dasypus novemcinctus	97.98	0.00e+00	936.00
IUUC-Dor-030886	Dipodomys ordii	92.27	0.00e+00	765.00
IUUC-Dse-031466	Dothistroma septosporum	35.03	8.00e-57	214.00
IUUC-Dme-032079	Drosophila melanogaster	55.35	4.00e-159	554.00
IUUC-Ete-032351	Echinops telfairi	86.23	0.00e+00	860.00
IUUC-Eca-033461	Equus caballus	97.98	0.00e+00	994.00
IUUC-Eeu-035220	Erinaceus europaeus	74.18	0.00e+00	689.00
IUUC-Fca-036210	Felis catus	99.39	0.00e+00	963.00
IUUC-Fal-037528	Ficedula albicollis	90.67	0.00e+00	875.00
IUUC-Fox-037805	Fusarium oxysporum	39.90	1.00e-70	260.00
IUUC-Fso-038177	Fusarium solani	37.82	1.00e-67	250.00
IUUC-Gmo-038953	Gadus morhua	78.21	0.00e+00	767.00
IUUC-Ggr-039972	Gaeumannomyces graminis	34.48	7.00e-75	275.00
IUUC-Gga-040462	Gallus gallus	90.28	0.00e+00	886.00
IUUC-Gac-041312	Gasterosteus aculeatus	81.72	0.00e+00	802.00
IUUC-Gma-043255	Glycine max	42.43	6.00e-109	387.00
IUUC-Ggo-045458	Gorilla gorilla	82.63	0.00e+00	788.00
IUUC-Hvu-047821	Hordeum vulgare	46.76	1.00e-57	216.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	97.98	0.00e+00	961.00
IUUC-Lch-050464	Latimeria chalumnae	82.45	0.00e+00	822.00
IUUC-Lpe-051419	Leersia perrieri	42.71	4.00e-108	384.00
IUUC-Loc-052732	Lepisosteus oculatus	80.85	0.00e+00	841.00
IUUC-Lma-053177	Leptosphaeria maculans	40.51	1.00e-70	260.00
IUUC-Laf-053822	Loxodonta africana	97.97	0.00e+00	949.00
IUUC-Mcc-055893	Macaca mulatta	100.00	0.00e+00	947.00
IUUC-Meu-056307	Macropus eugenii	82.45	0.00e+00	795.00
IUUC-Mor-057171	Magnaporthe oryzae	38.42	8.00e-68	251.00
IUUC-Mpo-057415	Magnaporthe poae	38.83	1.00e-69	257.00
IUUC-Mtr-057901	Medicago truncatula	43.00	1.00e-111	397.00
IUUC-Mla-058897	Melampsora laricipopulina	39.63	1.00e-75	277.00
IUUC-Mga-060016	Meleagris gallopavo	90.85	0.00e+00	890.00
IUUC-Mvi-060562	Microbotryum violaceum	38.77	4.00e-67	249.00
IUUC-Mmr-060624	Microcebus murinus	97.98	0.00e+00	999.00
IUUC-Mdo-061809	Monodelphis domestica	93.15	0.00e+00	902.00
IUUC-Mmu-063869	Mus musculus	96.76	0.00e+00	941.00
IUUC-Mac-064876	Musa acuminata	39.68	1.00e-96	347.00
IUUC-Mpu-066480	Mustela putorius furo	98.79	0.00e+00	958.00
IUUC-Mlu-067866	Myotis lucifugus	97.37	0.00e+00	957.00
IUUC-Nfi-068393	Neosartorya fischeri	36.38	4.00e-65	242.00
IUUC-Ncr-068815	Neurospora crassa	35.66	8.00e-82	298.00
IUUC-Nle-070121	Nomascus leucogenys	100.00	5.00e-141	493.00
IUUC-Opr-070712	Ochotona princeps	77.39	9.00e-174	603.00
IUUC-Ont-071544	Oreochromis niloticus	81.87	0.00e+00	769.00
IUUC-Oan-073635	Ornithorhynchus anatinus	91.59	0.00e+00	746.00
IUUC-Ocu-074926	Oryctolagus cuniculus	97.17	0.00e+00	932.00
IUUC-Oba-075633	Oryza barthii	42.18	2.00e-108	385.00
IUUC-Obr-076423	Oryza brachyantha	42.86	3.00e-110	392.00
IUUC-Ogl-077913	Oryza glaberrima	42.02	6.00e-111	394.00
IUUC-Ogu-078435	Oryza glumaepatula	42.18	2.00e-108	385.00
IUUC-Oin-080072	Oryza indica	42.15	2.00e-108	386.00
IUUC-Olo-080535	Oryza longistaminata	39.00	6.00e-93	334.00
IUUC-Ome-081309	Oryza meridionalis	42.18	2.00e-108	385.00
IUUC-Oni-083113	Oryza nivara	42.18	2.00e-108	385.00
IUUC-Opu-083168	Oryza punctata	41.24	1.00e-102	366.00
IUUC-Oru-084253	Oryza rufipogon	42.18	2.00e-108	385.00
IUUC-Osa-085554	Oryza sativa	42.02	5.00e-111	394.00
IUUC-Ola-086998	Oryzias latipes	81.14	0.00e+00	794.00
IUUC-Olu-087818	Ostreococcus lucimarinus	36.09	6.00e-71	261.00
IUUC-Oga-088571	Otolemur garnettii	97.98	0.00e+00	949.00
IUUC-Oar-089526	Ovis aries	97.36	0.00e+00	942.00
IUUC-Ptr-091433	Pan troglodytes	100.00	0.00e+00	947.00
IUUC-Pan-091966	Papio anubis	99.80	0.00e+00	946.00
IUUC-Psi-093458	Pelodiscus sinensis	89.22	0.00e+00	851.00
IUUC-Pma-094343	Petromyzon marinus	68.86	5.00e-121	427.00
IUUC-Pno-095109	Phaeosphaeria nodorum	39.65	1.00e-65	244.00
IUUC-Ppa-095756	Physcomitrella patens	43.90	3.00e-111	395.00
IUUC-Pfo-096514	Poecilia formosa	82.28	0.00e+00	785.00
IUUC-Pab-098477	Pongo abelii	87.45	0.00e+00	748.00
IUUC-Pop-099221	Populus trichocarpa	41.16	4.00e-103	368.00
IUUC-Pca-100791	Procavia capensis	81.59	7.00e-180	623.00
IUUC-Ppe-101812	Prunus persica	41.77	1.00e-107	383.00
IUUC-Pva-102462	Pteropus vampyrus	93.24	0.00e+00	768.00
IUUC-Pgr-103623	Puccinia graminis	40.69	6.00e-75	275.00
IUUC-Ptt-103767	Puccinia triticina	39.40	4.00e-68	252.00
IUUC-Pte-104109	Pyrenophora teres	38.94	1.00e-69	257.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	40.56	4.00e-70	259.00
IUUC-Rno-105351	Rattus norvegicus	96.56	0.00e+00	904.00
IUUC-Sce-106168	Saccharomyces cerevisiae	32.41	1.00e-62	234.00
IUUC-Sha-107491	Sarcophilus harrisii	92.93	0.00e+00	914.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	33.92	3.00e-78	285.00
IUUC-Spo-108174	Schizosaccharomyces pombe	37.63	8.00e-81	294.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	34.74	4.00e-84	305.00
IUUC-Smo-108805	Selaginella moellendorffii	43.27	7.00e-110	390.00
IUUC-Sit-110361	Setaria italica	42.34	5.00e-113	401.00
IUUC-Sly-110965	Solanum lycopersicum	40.35	2.00e-108	386.00
IUUC-Sar-113355	Sorex araneus	84.62	0.00e+00	663.00
IUUC-Sbi-114778	Sorghum bicolor	43.03	3.00e-112	398.00
IUUC-Sre-115011	Sporisorium reilianum	36.06	1.00e-61	231.00
IUUC-Ssc-116273	Sus scrofa	97.56	0.00e+00	934.00
IUUC-Tgu-117063	Taeniopygia guttata	90.04	0.00e+00	873.00
IUUC-Tru-118381	Takifugu rubripes	78.86	0.00e+00	790.00
IUUC-Tsy-119076	Tarsius syrichta	82.61	5.00e-120	424.00
IUUC-Tni-119941	Tetraodon nigroviridis	81.02	0.00e+00	781.00
IUUC-Tca-121246	Theobroma cacao	41.49	2.00e-109	389.00
IUUC-Tre-121969	Trichoderma reesei	34.49	2.00e-75	276.00
IUUC-Tvi-122543	Trichoderma virens	34.87	2.00e-77	283.00
IUUC-Tae-125484	Triticum aestivum	41.88	6.00e-109	387.00
IUUC-Tur-126128	Triticum urartu	41.87	2.00e-39	156.00
IUUC-Tbe-128030	Tupaia belangeri	91.19	0.00e+00	853.00
IUUC-Ttr-128701	Tursiops truncatus	96.70	0.00e+00	769.00
IUUC-Uma-129657	Ustilago maydis	36.80	7.00e-65	241.00
IUUC-Vda-129723	Verticillium dahliae	32.31	3.00e-71	263.00
IUUC-Vpa-130284	Vicugna pacos	70.70	0.00e+00	633.00
IUUC-Vvi-131037	Vitis vinifera	42.55	2.00e-108	385.00
IUUC-Xtr-132235	Xenopus tropicalis	86.09	0.00e+00	878.00
IUUC-Xma-133840	Xiphophorus maculatus	82.28	0.00e+00	810.00
IUUC-Yli-134453	Yarrowia lipolytica	36.78	2.00e-82	299.00
IUUC-Zma-135669	Zea mays	36.27	8.00e-94	337.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence