iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074926

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 14; Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14

Genbank Nucleotide ID

L37420

Gene Name

USP14; TGT

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000011595.3	ENSOCUT00000029186.2	ENSOCUP00000015687.1

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	14536023

Classification

Family	E-value	Score	Start	End
DUB/USP	4.60e-65	220.1	105	479
ULD/UDP/UBQ/UBQ_Other	2.60e-10	40.1	5	74

Active Site

Position(s)	Description	Evidence
114	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
434	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.... 85
           +Gl+NlgNtCYmN+++Qc+ ++pel+++l++ +  +l+++ +  + + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f     
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPELKDALKR-YAGALRASGEMASAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekge 191
           7******************************.****************************.99999******************999*9 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             +y qqDa+E++ +++  l+++l+          e+++ +e++++a    ++k+ksli++ F++++++++kc e +++ +++ + ++l
   Q: 192  qgQYLQQDANECWIQMMRVLQQKLEA--------IEDDSVKETDSSAAAVAPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQL 272
           999*********************44........334444455666788899*************************999999888888 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+   ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+
   Q: 273  QLSCFINQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDV 354
           8888877754..58999999999999998.....58899999999******************************************** PP
   S: 262  spfcts........................peekqke...........................kkkYeLiavvvHsG.slssGHYvay 298
            + ct                         p     +                           +  Y+L av+ H+G s+ssGHYv++
   Q: 355  YELCTPelqekmvsfrskfkdiedkkvnqqP-----NasdkksspqkevryepfsfaddigsnnCGYYDLQAVLTHQGrSSSSGHYVSW 438
           ******6666666666666666555555551.....0555556666677777777777777777************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetg....staYvlfY 335
           vk ++++W++fdD+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 439  VKRKHDEWIKFDDDKVSIVTPEDILRLSGggdwHIAYVLLY 479
           **************************988************ PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           +vtvk+ + + +++++n +++  ++K +++ ++g++p++qr ++kG  L+dd ++++ ++k+g+ti+++ +
   Q: 5    SVTVKWGKEKFGGVELNTDEPPMVFKAQLFALTGVQPARQRVMVKGGTLKDD-DWGNIKIKNGMTILMMGS 74
           69***********************************************999.9**************975 PP

Organism

Oryctolagus cuniculus

Functional Description
(View)

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity).

Protein Sequence
(Fasta)

MPLYSVTVKW GKEKFGGVEL NTDEPPMVFK AQLFALTGVQ PARQRVMVKG GTLKDDDWGN 60
IKIKNGMTIL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCGCGCAC CTGCTCGGGG CGCTCGGGCC GCGTGCTGGC CCGCGCCTCC TCCTCCCTGC 60
TCCTGCCGCG CTCTCGCCCC GCCTGCTCCT GCCGCGCCTT CCCCGCCCTT CCTCTCGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0000502--C:proteasome complex
GO:0045202--C:synapse
GO:0004866--F:endopeptidase inhibitor activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ocu:100009078

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	29.67	3.00e-64	239.00
IUUC-Aml-002053	Ailuropoda melanoleuca	95.93	0.00e+00	923.00
IUUC-Atr-002725	Amborella trichopoda	42.02	2.00e-102	365.00
IUUC-Apl-004031	Anas platyrhynchos	90.63	0.00e+00	893.00
IUUC-Aca-004361	Anolis carolinensis	88.48	0.00e+00	909.00
IUUC-Aly-006078	Arabidopsis lyrata	41.68	1.00e-110	392.00
IUUC-Ath-007623	Arabidopsis thaliana	41.87	4.00e-111	394.00
IUUC-Ago-007796	Ashbya gossypii	32.49	1.00e-59	223.00
IUUC-Acl-008258	Aspergillus clavatus	37.63	2.00e-66	246.00
IUUC-Afl-008732	Aspergillus flavus	33.15	3.00e-78	286.00
IUUC-Afu-008755	Aspergillus fumigatus	34.84	1.00e-79	290.00
IUUC-Ani-009148	Aspergillus nidulans	39.13	5.00e-71	261.00
IUUC-Ang-009878	Aspergillus niger	38.21	6.00e-66	245.00
IUUC-Aor-010239	Aspergillus oryzae	33.15	3.00e-78	286.00
IUUC-Ate-010243	Aspergillus terreus	33.75	1.00e-71	263.00
IUUC-Ame-011327	Astyanax mexicanus	50.60	9.00e-128	450.00
IUUC-Bgr-012231	Blumeria graminis	33.27	5.00e-71	261.00
IUUC-Bta-012553	Bos taurus	96.15	0.00e+00	947.00
IUUC-Bci-013606	Botrytis cinerea	40.27	4.00e-70	258.00
IUUC-Bdi-014567	Brachypodium distachyon	42.80	7.00e-113	400.00
IUUC-Bol-016127	Brassica oleracea	42.28	9.00e-113	400.00
IUUC-Bra-017501	Brassica rapa	42.08	6.00e-112	397.00
IUUC-Cel-018140	Caenorhabditis elegans	41.24	1.00e-100	360.00
IUUC-Cja-019516	Callithrix jacchus	96.37	0.00e+00	949.00
IUUC-Cfa-020808	Canis familiaris	97.37	0.00e+00	956.00
IUUC-Cpo-021688	Cavia porcellus	96.55	0.00e+00	946.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	37.85	6.00e-83	301.00
IUUC-Csa-023429	Chlorocebus sabaeus	97.16	0.00e+00	930.00
IUUC-Cho-024347	Choloepus hoffmanni	96.35	0.00e+00	947.00
IUUC-Cin-025198	Ciona intestinalis	55.03	4.00e-152	531.00
IUUC-Csv-026007	Ciona savignyi	52.92	2.00e-154	538.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	38.96	6.00e-64	238.00
IUUC-Cne-026963	Cryptococcus neoformans	34.54	4.00e-76	278.00
IUUC-Cme-027240	Cyanidioschyzon merolae	31.07	3.00e-60	226.00
IUUC-Dre-027647	Danio rerio	82.00	0.00e+00	835.00
IUUC-Dno-029967	Dasypus novemcinctus	96.56	0.00e+00	926.00
IUUC-Dor-030886	Dipodomys ordii	90.23	0.00e+00	760.00
IUUC-Dse-031466	Dothistroma septosporum	35.92	2.00e-58	220.00
IUUC-Dme-032079	Drosophila melanogaster	54.64	1.00e-159	555.00
IUUC-Ete-032351	Echinops telfairi	85.19	0.00e+00	853.00
IUUC-Eca-033461	Equus caballus	96.15	0.00e+00	989.00
IUUC-Eeu-035220	Erinaceus europaeus	73.16	0.00e+00	684.00
IUUC-Fca-036210	Felis catus	97.57	0.00e+00	958.00
IUUC-Fal-037528	Ficedula albicollis	90.45	0.00e+00	873.00
IUUC-Fox-037805	Fusarium oxysporum	40.00	6.00e-71	261.00
IUUC-Fso-038177	Fusarium solani	38.44	4.00e-68	252.00
IUUC-Gmo-038953	Gadus morhua	78.21	0.00e+00	775.00
IUUC-Ggr-039972	Gaeumannomyces graminis	39.30	1.00e-64	240.00
IUUC-Gga-040462	Gallus gallus	89.86	0.00e+00	887.00
IUUC-Gac-041312	Gasterosteus aculeatus	81.28	0.00e+00	806.00
IUUC-Gma-043255	Glycine max	42.71	4.00e-109	388.00
IUUC-Ggo-045458	Gorilla gorilla	81.21	0.00e+00	785.00
IUUC-Hsa-045706	Homo sapiens	97.37	0.00e+00	933.00
IUUC-Hvu-047821	Hordeum vulgare	45.83	4.00e-57	214.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	94.94	0.00e+00	949.00
IUUC-Lch-050464	Latimeria chalumnae	82.00	0.00e+00	823.00
IUUC-Lpe-051419	Leersia perrieri	41.98	4.00e-109	387.00
IUUC-Loc-052732	Lepisosteus oculatus	80.65	0.00e+00	845.00
IUUC-Lma-053177	Leptosphaeria maculans	41.13	2.00e-70	259.00
IUUC-Laf-053822	Loxodonta africana	96.35	0.00e+00	946.00
IUUC-Mcc-055893	Macaca mulatta	97.36	0.00e+00	931.00
IUUC-Meu-056307	Macropus eugenii	82.04	0.00e+00	792.00
IUUC-Mor-057171	Magnaporthe oryzae	38.46	7.00e-69	254.00
IUUC-Mpo-057415	Magnaporthe poae	39.53	7.00e-71	261.00
IUUC-Mtr-057901	Medicago truncatula	43.08	8.00e-112	397.00
IUUC-Mla-058897	Melampsora laricipopulina	39.47	3.00e-75	275.00
IUUC-Mga-060016	Meleagris gallopavo	90.22	0.00e+00	889.00
IUUC-Mvi-060562	Microbotryum violaceum	39.14	6.00e-68	251.00
IUUC-Mmr-060624	Microcebus murinus	96.76	0.00e+00	998.00
IUUC-Mdo-061809	Monodelphis domestica	92.34	0.00e+00	896.00
IUUC-Mmu-063869	Mus musculus	95.75	0.00e+00	940.00
IUUC-Mac-064876	Musa acuminata	39.36	1.00e-96	347.00
IUUC-Mpu-066480	Mustela putorius furo	96.96	0.00e+00	954.00
IUUC-Mlu-067866	Myotis lucifugus	95.75	0.00e+00	952.00
IUUC-Nfi-068393	Neosartorya fischeri	36.64	2.00e-65	243.00
IUUC-Ncr-068815	Neurospora crassa	38.61	2.00e-70	259.00
IUUC-Nle-070121	Nomascus leucogenys	97.23	9.00e-139	485.00
IUUC-Opr-070712	Ochotona princeps	78.97	2.00e-180	625.00
IUUC-Ont-071544	Oreochromis niloticus	81.63	0.00e+00	774.00
IUUC-Oan-073635	Ornithorhynchus anatinus	91.10	0.00e+00	754.00
IUUC-Oba-075633	Oryza barthii	41.68	2.00e-108	385.00
IUUC-Obr-076423	Oryza brachyantha	41.90	6.00e-112	397.00
IUUC-Ogl-077913	Oryza glaberrima	41.70	5.00e-111	394.00
IUUC-Ogu-078435	Oryza glumaepatula	41.68	2.00e-108	385.00
IUUC-Oin-080072	Oryza indica	41.86	1.00e-108	386.00
IUUC-Olo-080535	Oryza longistaminata	39.08	3.00e-93	335.00
IUUC-Ome-081309	Oryza meridionalis	41.68	2.00e-108	385.00
IUUC-Oni-083113	Oryza nivara	41.68	2.00e-108	385.00
IUUC-Opu-083168	Oryza punctata	40.74	8.00e-103	367.00
IUUC-Oru-084253	Oryza rufipogon	41.68	2.00e-108	385.00
IUUC-Osa-085554	Oryza sativa	41.70	4.00e-111	394.00
IUUC-Ola-086998	Oryzias latipes	80.89	0.00e+00	797.00
IUUC-Olu-087818	Ostreococcus lucimarinus	36.36	3.00e-71	262.00
IUUC-Oga-088571	Otolemur garnettii	96.75	0.00e+00	956.00
IUUC-Oar-089526	Ovis aries	95.93	0.00e+00	941.00
IUUC-Ptr-091433	Pan troglodytes	97.36	0.00e+00	931.00
IUUC-Pan-091966	Papio anubis	97.16	0.00e+00	930.00
IUUC-Psi-093458	Pelodiscus sinensis	88.98	0.00e+00	848.00
IUUC-Pma-094343	Petromyzon marinus	68.17	1.00e-119	422.00
IUUC-Pno-095109	Phaeosphaeria nodorum	39.43	7.00e-66	244.00
IUUC-Ppa-095756	Physcomitrella patens	43.98	4.00e-112	398.00
IUUC-Pfo-096514	Poecilia formosa	82.04	0.00e+00	789.00
IUUC-Pab-098477	Pongo abelii	85.11	0.00e+00	736.00
IUUC-Pop-099221	Populus trichocarpa	41.25	4.00e-103	368.00
IUUC-Pca-100791	Procavia capensis	80.42	2.00e-180	624.00
IUUC-Ppe-101812	Prunus persica	41.25	7.00e-107	380.00
IUUC-Pva-102462	Pteropus vampyrus	91.84	0.00e+00	768.00
IUUC-Pgr-103623	Puccinia graminis	40.52	1.00e-74	273.00
IUUC-Ptt-103767	Puccinia triticina	39.52	1.00e-68	253.00
IUUC-Pte-104109	Pyrenophora teres	40.58	6.00e-70	258.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	40.96	6.00e-70	258.00
IUUC-Rno-105351	Rattus norvegicus	94.53	0.00e+00	899.00
IUUC-Sce-106168	Saccharomyces cerevisiae	32.47	5.00e-63	234.00
IUUC-Sha-107491	Sarcophilus harrisii	92.32	0.00e+00	915.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	34.52	2.00e-78	286.00
IUUC-Spo-108174	Schizosaccharomyces pombe	37.25	5.00e-81	294.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	34.81	1.00e-84	306.00
IUUC-Smo-108805	Selaginella moellendorffii	43.15	6.00e-110	390.00
IUUC-Sit-110361	Setaria italica	42.83	7.00e-114	404.00
IUUC-Sly-110965	Solanum lycopersicum	41.12	5.00e-108	384.00
IUUC-Sar-113355	Sorex araneus	84.11	0.00e+00	664.00
IUUC-Sbi-114778	Sorghum bicolor	43.72	9.00e-115	407.00
IUUC-Sre-115011	Sporisorium reilianum	36.72	3.00e-62	232.00
IUUC-Ssc-116273	Sus scrofa	96.13	0.00e+00	932.00
IUUC-Tgu-117063	Taeniopygia guttata	89.82	0.00e+00	870.00
IUUC-Tru-118381	Takifugu rubripes	79.07	0.00e+00	798.00
IUUC-Tsy-119076	Tarsius syrichta	80.24	9.00e-118	416.00
IUUC-Tni-119941	Tetraodon nigroviridis	80.37	0.00e+00	790.00
IUUC-Tca-121246	Theobroma cacao	41.37	6.00e-109	387.00
IUUC-Tre-121969	Trichoderma reesei	34.90	2.00e-76	280.00
IUUC-Tvi-122543	Trichoderma virens	34.04	9.00e-75	274.00
IUUC-Tae-125484	Triticum aestivum	42.14	1.00e-109	390.00
IUUC-Tur-126128	Triticum urartu	31.57	9.00e-67	247.00
IUUC-Tbe-128030	Tupaia belangeri	89.34	0.00e+00	848.00
IUUC-Ttr-128701	Tursiops truncatus	95.52	0.00e+00	768.00
IUUC-Uma-129657	Ustilago maydis	37.18	4.00e-65	242.00
IUUC-Vda-129723	Verticillium dahliae	32.17	5.00e-72	265.00
IUUC-Vpa-130284	Vicugna pacos	69.06	0.00e+00	628.00
IUUC-Vvi-131037	Vitis vinifera	42.32	1.00e-108	386.00
IUUC-Xtr-132235	Xenopus tropicalis	86.26	0.00e+00	888.00
IUUC-Xma-133840	Xiphophorus maculatus	82.04	0.00e+00	814.00
IUUC-Yli-134453	Yarrowia lipolytica	37.05	2.00e-82	299.00
IUUC-Zma-135669	Zea mays	36.38	7.00e-96	344.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence