iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	85.71	2.00e-57	218.00	IUUC-Hsa-046518
UBD/Alpha-Helix/UIM	85.71	2.00e-57	218.00	IUUC-Hsa-046518

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation.

Protein Sequence
(Fasta)

MKSEYQNCAE CGTLVCLSDM RAHIRTCEKY IDKYGPLLEL GDTTARCVCP FCQRELDEDC 60
LLDHCIIHHR SERRPVFCPL CHSRPDESPS TFNGSLIRHL QVSHTLFYDD FIDFDIIEEA 120

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Nucleotide Sequence
(Fasta)

AGCCTTTGGC TCAGAGACCC CTCTGCCCTG CTGCAGAGGA CTGAGATTTA AGGTGGTGGC 60
CAACATGGCC ACCTTTTACT CTTCCCCTCA CTGTCAAATG CCTCTGTCCA CTCCTTCGTC 120

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Sequence Source

Ensembl

Keyword

KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0391--Immunity
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0000139--C:Golgi membrane
GO:0005622--C:intracellular
GO:0043231--C:intracellular membrane-bounded organelle
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002250--P:adaptive immune response
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:67664

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001992	Ailuropoda melanoleuca	81.43	6.00e-66	243.00
IUUC-Aca-004839	Anolis carolinensis	57.04	1.00e-44	171.00
IUUC-Bta-012827	Bos taurus	81.43	5.00e-65	240.00
IUUC-Bol-015340	Brassica oleracea	38.24	7.40e-01	26.20
IUUC-Cja-018794	Callithrix jacchus	84.29	1.00e-67	249.00
IUUC-Cfa-021234	Canis familiaris	82.86	4.00e-66	244.00
IUUC-Cpo-022412	Cavia porcellus	79.29	1.00e-63	236.00
IUUC-Csa-023406	Chlorocebus sabaeus	86.43	1.00e-68	252.00
IUUC-Cho-024427	Choloepus hoffmanni	67.86	1.00e-48	185.00
IUUC-Dno-030085	Dasypus novemcinctus	85.00	2.00e-68	251.00
IUUC-Dor-030911	Dipodomys ordii	84.13	2.00e-47	181.00
IUUC-Ete-032469	Echinops telfairi	80.71	2.00e-64	238.00
IUUC-Eca-034352	Equus caballus	82.14	8.00e-67	246.00
IUUC-Eeu-034889	Erinaceus europaeus	62.86	3.00e-44	171.00
IUUC-Fca-036116	Felis catus	82.86	3.00e-66	244.00
IUUC-Hsa-046518	Homo sapiens	85.71	1.00e-67	249.00
IUUC-Itr-048344	Ictidomys tridecemlineatus	86.43	4.00e-69	253.00
IUUC-Laf-053363	Loxodonta africana	82.39	1.00e-65	242.00
IUUC-Meu-056101	Macropus eugenii	70.71	6.00e-53	200.00
IUUC-Mdo-062046	Monodelphis domestica	70.71	1.00e-55	209.00
IUUC-Mpu-065708	Mustela putorius furo	82.14	1.00e-65	242.00
IUUC-Mlu-067561	Myotis lucifugus	82.86	1.00e-66	245.00
IUUC-Nle-069665	Nomascus leucogenys	81.15	4.00e-56	210.00
IUUC-Opr-070301	Ochotona princeps	65.71	1.00e-46	179.00
IUUC-Ocu-074562	Oryctolagus cuniculus	83.33	4.00e-59	219.00
IUUC-Oga-088958	Otolemur garnettii	86.43	5.00e-69	253.00
IUUC-Oar-089541	Ovis aries	82.86	1.00e-66	245.00
IUUC-Ptr-090989	Pan troglodytes	86.43	1.00e-68	252.00
IUUC-Pan-092372	Papio anubis	86.43	5.00e-69	253.00
IUUC-Pab-098718	Pongo abelii	64.29	5.00e-44	170.00
IUUC-Pca-100453	Procavia capensis	82.14	6.00e-65	240.00
IUUC-Pva-102931	Pteropus vampyrus	83.57	3.00e-66	244.00
IUUC-Rno-105771	Rattus norvegicus	95.71	1.00e-66	245.00
IUUC-Sha-107557	Sarcophilus harrisii	69.29	8.00e-57	213.00
IUUC-Sar-113435	Sorex araneus	81.75	1.00e-58	218.00
IUUC-Ssc-116388	Sus scrofa	82.14	2.00e-66	245.00
IUUC-Tsy-119439	Tarsius syrichta	85.00	1.00e-68	251.00
IUUC-Tbe-127417	Tupaia belangeri	59.82	7.00e-32	130.00
IUUC-Ttr-129212	Tursiops truncatus	82.86	7.00e-67	246.00
IUUC-Vpa-130153	Vicugna pacos	84.29	6.00e-67	246.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence