iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000104093.13	ENST00000251076.9	ENSP00000251076.5
ENSG00000104093.13	ENST00000560891.5	ENSP00000453267.1
ENSG00000104093.13	ENST00000543779.6	ENSP00000441858.2
ENSG00000104093.13	ENST00000449909.7	ENSP00000400855.3
ENSG00000104093.13	ENST00000559059.1	ENSP00000453570.1
ENSG00000104093.13	ENST00000559498.1	ENSP00000453454.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.30e-14	52.8	2942	2979

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           H + + +la+ +   ++ +Gs  g+ikvW+l+ + l++
   Q: 2942 HDSAIKALALdPYeEYFTTGSAEGNIKVWRLTGHGLIH 2979
           9999******97779***************98776665 PP

Organism

Homo sapiens

Functional Description
(View)

May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity).

Protein Sequence
(Fasta)

MHLHQVLTGA VNPGDNCYSV GSVGDVPFTA YGSGCDIVIL ANDFECVQII PGAKHGNIQV 60
SCVECSNQQG RIAASYGNAV CIFEPLGINS HKRNCQLKCQ WLKTGQFFLS SVTYNLAWDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAAGCACCC TTGCCCTCCC GCATTTGTGC GCCGGTGCAG CAGGCAGTGG GAACATCCGG 60
GCATTTCCGC AGCTGAGCGG CGACCCGGGC GGCGGCGGCG GTCGAGGAGC TCCCATGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0219--Diabetes mellitus
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-1016--Hypogonadotropic hypogonadism
KW-0472--Membrane
KW-0622--Neuropathy
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0853--WD repeat

Interpro

IPR022033--Rav1p_C
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12234--Rav1p_C
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0030054--C:cell junction
GO:0005615--C:extracellular space
GO:0043291--C:RAVE complex
GO:0008021--C:synaptic vesicle
GO:0030672--C:synaptic vesicle membrane
GO:0017137--F:Rab GTPase binding
GO:0007035--P:vacuolar acidification
GO:0070072--P:vacuolar proton-transporting V-type ATPase complex assembly

KEGG

hsa:23312

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001296	Ailuropoda melanoleuca	94.54	0.00e+00	5786.00
IUUC-Apl-003695	Anas platyrhynchos	82.87	0.00e+00	4958.00
IUUC-Aca-004516	Anolis carolinensis	80.24	0.00e+00	4833.00
IUUC-Afu-009077	Aspergillus fumigatus	33.55	2.00e-37	151.00
IUUC-Ani-009437	Aspergillus nidulans	29.35	3.00e-42	167.00
IUUC-Bol-016375	Brassica oleracea	29.49	2.00e-30	129.00
IUUC-Bra-016630	Brassica rapa	29.78	4.00e-30	128.00
IUUC-Cel-018537	Caenorhabditis elegans	30.28	0.00e+00	1344.00
IUUC-Cja-018770	Callithrix jacchus	97.76	0.00e+00	5973.00
IUUC-Cfa-021089	Canis familiaris	94.48	0.00e+00	5795.00
IUUC-Cpo-022459	Cavia porcellus	89.94	0.00e+00	5040.00
IUUC-Csa-023972	Chlorocebus sabaeus	98.01	0.00e+00	5991.00
IUUC-Cho-024762	Choloepus hoffmanni	90.55	0.00e+00	2335.00
IUUC-Dre-028673	Danio rerio	70.20	0.00e+00	4179.00
IUUC-Dno-029855	Dasypus novemcinctus	90.99	0.00e+00	5539.00
IUUC-Dor-030221	Dipodomys ordii	92.35	0.00e+00	2028.00
IUUC-Dme-031825	Drosophila melanogaster	39.96	0.00e+00	1154.00
IUUC-Ete-033176	Echinops telfairi	87.40	0.00e+00	2866.00
IUUC-Eca-033386	Equus caballus	95.13	0.00e+00	5752.00
IUUC-Fca-036411	Felis catus	87.49	0.00e+00	5181.00
IUUC-Fal-036643	Ficedula albicollis	82.03	0.00e+00	4773.00
IUUC-Gmo-038514	Gadus morhua	68.36	0.00e+00	2185.00
IUUC-Gga-040765	Gallus gallus	83.79	0.00e+00	5033.00
IUUC-Gac-042017	Gasterosteus aculeatus	68.35	0.00e+00	4007.00
IUUC-Gma-044099	Glycine max	34.45	5.00e-35	144.00
IUUC-Ggo-045379	Gorilla gorilla	96.94	0.00e+00	5841.00
IUUC-Hvu-047213	Hordeum vulgare	26.27	4.00e-15	75.50
IUUC-Itr-047982	Ictidomys tridecemlineatus	93.46	0.00e+00	5663.00
IUUC-Lch-049469	Latimeria chalumnae	75.14	0.00e+00	4377.00
IUUC-Loc-052786	Lepisosteus oculatus	73.18	0.00e+00	4341.00
IUUC-Laf-054102	Loxodonta africana	93.16	0.00e+00	5681.00
IUUC-Mcc-055533	Macaca mulatta	98.81	0.00e+00	6014.00
IUUC-Meu-056132	Macropus eugenii	82.99	0.00e+00	1291.00
IUUC-Mga-059386	Meleagris gallopavo	83.38	0.00e+00	4970.00
IUUC-Mmr-061082	Microcebus murinus	95.53	0.00e+00	5799.00
IUUC-Mdo-062837	Monodelphis domestica	85.80	0.00e+00	5120.00
IUUC-Mmu-063696	Mus musculus	91.77	0.00e+00	5519.00
IUUC-Mac-065224	Musa acuminata	30.06	1.00e-27	120.00
IUUC-Mpu-066054	Mustela putorius furo	94.80	0.00e+00	5796.00
IUUC-Mlu-068235	Myotis lucifugus	92.12	0.00e+00	5531.00
IUUC-Nfi-068420	Neosartorya fischeri	29.31	7.00e-38	153.00
IUUC-Nle-069401	Nomascus leucogenys	98.56	0.00e+00	5977.00
IUUC-Opr-070543	Ochotona princeps	93.61	0.00e+00	2363.00
IUUC-Ont-071790	Oreochromis niloticus	69.51	0.00e+00	4113.00
IUUC-Oan-072796	Ornithorhynchus anatinus	83.25	2.00e-95	340.00
IUUC-Ocu-074711	Oryctolagus cuniculus	92.81	0.00e+00	5655.00
IUUC-Ola-087560	Oryzias latipes	68.23	0.00e+00	4116.00
IUUC-Oga-088868	Otolemur garnettii	94.61	0.00e+00	5624.00
IUUC-Oar-090063	Ovis aries	92.94	0.00e+00	5693.00
IUUC-Ptr-091058	Pan troglodytes	99.57	0.00e+00	6062.00
IUUC-Ppa-095505	Physcomitrella patens	29.79	5.00e-42	167.00
IUUC-Pfo-097521	Poecilia formosa	67.33	0.00e+00	3974.00
IUUC-Pab-098507	Pongo abelii	98.58	0.00e+00	5524.00
IUUC-Pca-100419	Procavia capensis	86.19	0.00e+00	1657.00
IUUC-Pva-102432	Pteropus vampyrus	92.23	0.00e+00	5096.00
IUUC-Rno-104981	Rattus norvegicus	91.93	0.00e+00	5524.00
IUUC-Sha-106955	Sarcophilus harrisii	83.56	0.00e+00	4946.00
IUUC-Smo-109573	Selaginella moellendorffii	22.87	8.00e-15	75.10
IUUC-Sit-109981	Setaria italica	31.34	3.00e-11	65.10
IUUC-Sly-110968	Solanum lycopersicum	31.47	2.00e-36	149.00
IUUC-Sar-112928	Sorex araneus	86.76	0.00e+00	1960.00
IUUC-Tgu-117271	Taeniopygia guttata	83.65	0.00e+00	4984.00
IUUC-Tru-118349	Takifugu rubripes	68.87	0.00e+00	4158.00
IUUC-Tni-119924	Tetraodon nigroviridis	67.71	0.00e+00	4066.00
IUUC-Tbe-127760	Tupaia belangeri	91.02	0.00e+00	3689.00
IUUC-Ttr-128323	Tursiops truncatus	86.20	0.00e+00	3949.00
IUUC-Vpa-130118	Vicugna pacos	92.53	0.00e+00	1923.00
IUUC-Vvi-131584	Vitis vinifera	28.88	3.00e-37	151.00
IUUC-Xtr-132638	Xenopus tropicalis	75.02	0.00e+00	4385.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence