iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	21205830

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.60e-08	35.9	309	352

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCl+++++g  +++lpC H++h +C+  w     s+ ++ +CP+C+
   Q: 309  CAICLDEYEEGdqLKILPCSHTYHCKCIDPW----FSQAPRRSCPVCK 352
           ********55555******************....9***********7 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830). Could have a role in spermatogenesis (By similarity).

Protein Sequence
(Fasta)

MPLCRPEHLM PRASRVPVAA SLPLSHAVIP TQLPSRPGHR PPGRPRRCPK ASCLPPPVGP 60
SSTQTAKRVT MGWPRPGRAL VAVKALLVLS LLQVPAQAVV RAVLEDNSSS VDFADLPALF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCTGCCAGA AAGGCCACCT GCGCCAGCAC CTCCTGAGAC CGGCCTTCAA AGACACGACG 60
CATGCCGCTC TGCCGTCCGG AGCACTTAAT GCCTAGAGCC AGCAGGGTCC CAGTGGCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF02225--PA
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:148066

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001654	Ailuropoda melanoleuca	71.67	2.00e-137	482.00
IUUC-Bta-012572	Bos taurus	67.63	3.00e-119	421.00
IUUC-Cja-019445	Callithrix jacchus	79.76	1.00e-154	539.00
IUUC-Cfa-020828	Canis familiaris	73.04	1.00e-125	443.00
IUUC-Csa-023281	Chlorocebus sabaeus	91.14	4.00e-179	620.00
IUUC-Dor-030690	Dipodomys ordii	54.23	8.00e-61	226.00
IUUC-Ete-032610	Echinops telfairi	65.79	3.00e-124	438.00
IUUC-Ggo-045531	Gorilla gorilla	95.09	0.00e+00	699.00
IUUC-Itr-048891	Ictidomys tridecemlineatus	75.50	3.00e-113	401.00
IUUC-Laf-053469	Loxodonta africana	68.94	5.00e-123	434.00
IUUC-Mcc-054662	Macaca mulatta	91.38	1.00e-179	622.00
IUUC-Meu-056499	Macropus eugenii	58.54	6.00e-97	347.00
IUUC-Mdo-062468	Monodelphis domestica	53.99	1.00e-101	362.00
IUUC-Mmu-064409	Mus musculus	50.15	8.00e-64	237.00
IUUC-Mpu-066553	Mustela putorius furo	72.58	2.00e-132	465.00
IUUC-Oan-073710	Ornithorhynchus anatinus	51.74	1.00e-68	253.00
IUUC-Ptr-090842	Pan troglodytes	94.61	0.00e+00	665.00
IUUC-Pan-092278	Papio anubis	91.61	0.00e+00	629.00
IUUC-Ppa-095724	Physcomitrella patens	32.71	9.00e-25	107.00
IUUC-Pab-097537	Pongo abelii	92.74	2.00e-179	621.00
IUUC-Rno-104830	Rattus norvegicus	50.47	8.00e-58	217.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence