iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000038058.14	ENSMUST00000168172.3	ENSMUSP00000130487.1
ENSMUSG00000038058.14	ENSMUST00000203076.1	ENSMUSP00000145123.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/CARD	81.63	0.00e+00	1496.00	IUUC-Hsa-046886

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Recruits NLRP10 to the cell membrane following bacterial infection (By similarity).

Protein Sequence
(Fasta)

MEEHGHHEME GTPLGCHSHI KLLKINREHL VTNIRNTQCL VDNLLENGYF SAEDAEIVCA 60
CPTKPDKVRK ILDLVQSKGE EVSEFFLYVL QQLEDAYVDL RLWLSEIGFS PSQLIRTKTI 120

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Nucleotide Sequence
(Fasta)

GGTGTCACCC CTGGGCGAAC TGCGAGGCCT GCCCACTCCC ACTGCGCAGT GGCCGCTCGT 60
CCGATGCAGT GTGCGGCGGC TCCTTCCCGG GAAACGAGAC AGGGGGGCAG CGCTACGGAT 120

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Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR007109--Brix
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase

PROSITE

PS50209--CARD
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0016323--C:basolateral plasma membrane
GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0050700--F:CARD domain binding
GO:0042802--F:identical protein binding
GO:0042803--F:protein homodimerization activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915--P:apoptotic process
GO:0071225--P:cellular response to muramyl dipeptide
GO:0042742--P:defense response to bacterium
GO:0050830--P:defense response to Gram-positive bacterium
GO:0016045--P:detection of bacterium
GO:0045087--P:innate immune response
GO:0042228--P:interleukin-8 biosynthetic process
GO:0035556--P:intracellular signal transduction
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002606--P:positive regulation of dendritic cell antigen processing and presentation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032731--P:positive regulation of interleukin-1 beta production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0051000--P:positive regulation of nitric-oxide synthase activity
GO:0032874--P:positive regulation of stress-activated MAPK cascade
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:1904417--P:positive regulation of xenophagy

KEGG

mmu:107607

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001299	Ailuropoda melanoleuca	77.59	0.00e+00	1298.00
IUUC-Apl-003908	Anas platyrhynchos	60.34	0.00e+00	1120.00
IUUC-Aca-005144	Anolis carolinensis	59.45	0.00e+00	1100.00
IUUC-Ame-010829	Astyanax mexicanus	51.47	0.00e+00	896.00
IUUC-Bta-013358	Bos taurus	78.43	0.00e+00	1384.00
IUUC-Cja-019392	Callithrix jacchus	80.82	0.00e+00	1434.00
IUUC-Cfa-020776	Canis familiaris	78.85	0.00e+00	1375.00
IUUC-Cpo-021393	Cavia porcellus	79.87	0.00e+00	1439.00
IUUC-Csa-023872	Chlorocebus sabaeus	81.76	0.00e+00	1482.00
IUUC-Cho-024569	Choloepus hoffmanni	69.32	4.00e-168	585.00
IUUC-Dre-027478	Danio rerio	50.21	0.00e+00	866.00
IUUC-Dno-029231	Dasypus novemcinctus	78.09	0.00e+00	1403.00
IUUC-Dor-030251	Dipodomys ordii	58.56	1.00e-158	553.00
IUUC-Ete-032484	Echinops telfairi	68.72	0.00e+00	702.00
IUUC-Eca-033564	Equus caballus	79.73	0.00e+00	1423.00
IUUC-Eeu-034456	Erinaceus europaeus	67.49	2.00e-138	486.00
IUUC-Fca-036372	Felis catus	77.80	0.00e+00	1375.00
IUUC-Fal-037418	Ficedula albicollis	60.26	0.00e+00	1115.00
IUUC-Gmo-038740	Gadus morhua	50.32	0.00e+00	886.00
IUUC-Gga-040775	Gallus gallus	60.55	0.00e+00	1151.00
IUUC-Gac-041612	Gasterosteus aculeatus	49.58	0.00e+00	885.00
IUUC-Ggo-045161	Gorilla gorilla	81.20	0.00e+00	1233.00
IUUC-Hsa-046886	Homo sapiens	81.45	0.00e+00	1469.00
IUUC-Itr-048414	Ictidomys tridecemlineatus	83.49	0.00e+00	1561.00
IUUC-Lch-049764	Latimeria chalumnae	57.52	0.00e+00	994.00
IUUC-Loc-052143	Lepisosteus oculatus	54.55	0.00e+00	988.00
IUUC-Laf-053503	Loxodonta africana	77.78	0.00e+00	1407.00
IUUC-Mcc-054992	Macaca mulatta	81.55	0.00e+00	1474.00
IUUC-Meu-056406	Macropus eugenii	61.51	0.00e+00	1054.00
IUUC-Mga-059351	Meleagris gallopavo	59.41	0.00e+00	1140.00
IUUC-Mmr-061537	Microcebus murinus	80.71	0.00e+00	1368.00
IUUC-Mdo-061832	Monodelphis domestica	64.48	0.00e+00	1060.00
IUUC-Mpu-066399	Mustela putorius furo	78.53	0.00e+00	1391.00
IUUC-Mlu-067265	Myotis lucifugus	77.75	0.00e+00	1349.00
IUUC-Nle-069078	Nomascus leucogenys	80.92	0.00e+00	1464.00
IUUC-Opr-070946	Ochotona princeps	72.37	0.00e+00	1299.00
IUUC-Ont-071355	Oreochromis niloticus	48.66	0.00e+00	877.00
IUUC-Oan-072937	Ornithorhynchus anatinus	70.76	0.00e+00	1295.00
IUUC-Ocu-073815	Oryctolagus cuniculus	79.04	0.00e+00	1460.00
IUUC-Ola-087381	Oryzias latipes	49.46	0.00e+00	869.00
IUUC-Oga-088725	Otolemur garnettii	79.66	0.00e+00	1432.00
IUUC-Oar-090401	Ovis aries	76.65	0.00e+00	1399.00
IUUC-Ptr-090590	Pan troglodytes	81.34	0.00e+00	1468.00
IUUC-Pan-091765	Papio anubis	81.55	0.00e+00	1475.00
IUUC-Psi-093182	Pelodiscus sinensis	60.85	0.00e+00	1133.00
IUUC-Pfo-097422	Poecilia formosa	48.25	0.00e+00	863.00
IUUC-Pab-098289	Pongo abelii	81.13	0.00e+00	1457.00
IUUC-Pca-100165	Procavia capensis	69.61	0.00e+00	951.00
IUUC-Pva-102943	Pteropus vampyrus	79.04	0.00e+00	1420.00
IUUC-Rno-104930	Rattus norvegicus	95.28	0.00e+00	1739.00
IUUC-Sha-106800	Sarcophilus harrisii	46.93	0.00e+00	636.00
IUUC-Sar-113205	Sorex araneus	70.06	0.00e+00	953.00
IUUC-Ssc-115910	Sus scrofa	79.55	0.00e+00	1243.00
IUUC-Tgu-117179	Taeniopygia guttata	61.30	0.00e+00	1134.00
IUUC-Tru-118220	Takifugu rubripes	48.88	0.00e+00	855.00
IUUC-Tsy-119418	Tarsius syrichta	73.38	0.00e+00	1184.00
IUUC-Tni-120033	Tetraodon nigroviridis	52.71	5.00e-71	260.00
IUUC-Tbe-127308	Tupaia belangeri	82.29	6.00e-176	611.00
IUUC-Ttr-129233	Tursiops truncatus	78.72	0.00e+00	1405.00
IUUC-Vpa-130620	Vicugna pacos	77.38	6.00e-105	375.00
IUUC-Xtr-132075	Xenopus tropicalis	53.26	0.00e+00	993.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence