iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074861

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAGW02051581

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000003582.3	ENSOCUT00000003583.3	ENSOCUP00000003104.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.60e-64	216.0	359	865
UBD/Alpha-Helix/UBA	1.10e-22	79.5	735	772

Active Site

Position(s)	Description	Evidence
368	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
828	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 359  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGHGLlsgeyskpapesgdgeqapeQKEVQDGIA 446
           7******************************.99999999********************66666666666666555443355666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 447  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 506
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekk 220
            ++v+ ++   + ++lpvp++   +ke                            +++cLe++ ++e++++   ++++  ++k+ a+k+
   Q: 507  TEKVKYTQRVDYIMQLPVPMDAALNKEelveyeekkrqaeeekmplpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVKT 592
           **********************999989*****************************************97...*************** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.......................................... 267
           +++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+                                              
   Q: 593  TRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGAglqpgeeelpdiapplvtpdepkapmldesviiqlvemgfpm 680
           *******************997.*******************98888788888888888888888888888777777777777777777 PP
   S: 268  ..........................................................peekqke........................ 274
                                                                     +     +                        
   Q: 681  dacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaaepppedcvT-----Tivsmgfsrdqalkalratnnsler 764
           77777777777777777777777776666666666666666666655555555555550.....0555555555555555566666666 PP
   S: 275  ...........................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevke 319
                                                      + kY+L+a ++H+G s+ +GHYv+++k+ +g+W+ ++D+kV ++  
   Q: 765  avdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYVCHIKK-EGRWVIYNDQKVCAS-- 850
           6777777777777777777777777777888888888888888****************************.9***********999.. PP
   S: 320  eevleetgstaYvlfYkr 337
           e+  +   + +Y++fY+r
   Q: 851  EKPPK---DLGYIYFYQR 865
           78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 735  EDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 772
           889999******************************97 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MRLTSSVHWT GRVGGGVQGA VGAAVCGGAA AGVMAELSEE ALLSVLPTIR VPKAGDRVHK 60
DECAFSFDTP ESEGGLYICM NTFLGFGKQY VERHFNKTGQ RVYLHLRRTR HPREEDTTAG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGCCTAA CGAGCAGCGT TCATTGGACG GGGAGAGTAG GGGGTGGGGT ACAGGGAGCG 60
GTGGGAGCCG CTGTGTGTGG AGGAGCTGCT GCCGGTGTCA TGGCGGAGCT GAGTGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	45.70	0.00e+00	672.00
IUUC-Aml-002104	Ailuropoda melanoleuca	95.05	0.00e+00	1585.00
IUUC-Atr-002580	Amborella trichopoda	46.95	0.00e+00	754.00
IUUC-Apl-003774	Anas platyrhynchos	88.37	0.00e+00	1481.00
IUUC-Aca-005368	Anolis carolinensis	88.38	0.00e+00	1535.00
IUUC-Aly-005727	Arabidopsis lyrata	48.51	0.00e+00	755.00
IUUC-Ath-006974	Arabidopsis thaliana	48.92	0.00e+00	756.00
IUUC-Ago-007890	Ashbya gossypii	29.12	1.00e-82	301.00
IUUC-Acl-008057	Aspergillus clavatus	34.88	2.00e-126	446.00
IUUC-Afl-008547	Aspergillus flavus	37.07	1.00e-119	423.00
IUUC-Afu-008805	Aspergillus fumigatus	34.56	3.00e-116	412.00
IUUC-Ani-009441	Aspergillus nidulans	33.55	3.00e-102	365.00
IUUC-Ang-009720	Aspergillus niger	34.56	4.00e-121	429.00
IUUC-Aor-010111	Aspergillus oryzae	34.80	3.00e-129	456.00
IUUC-Ate-010531	Aspergillus terreus	32.27	3.00e-105	375.00
IUUC-Ame-011893	Astyanax mexicanus	68.02	0.00e+00	1018.00
IUUC-Bgr-012183	Blumeria graminis	34.73	2.00e-125	442.00
IUUC-Bta-013179	Bos taurus	95.16	0.00e+00	1590.00
IUUC-Bci-013858	Botrytis cinerea	35.40	3.00e-132	466.00
IUUC-Bdi-014904	Brachypodium distachyon	48.57	0.00e+00	738.00
IUUC-Bol-015536	Brassica oleracea	48.81	0.00e+00	767.00
IUUC-Bra-017939	Brassica rapa	49.46	0.00e+00	773.00
IUUC-Cel-018625	Caenorhabditis elegans	35.65	3.00e-138	485.00
IUUC-Cja-019063	Callithrix jacchus	94.12	0.00e+00	1565.00
IUUC-Cfa-020976	Canis familiaris	97.81	0.00e+00	1625.00
IUUC-Cpo-022265	Cavia porcellus	98.55	0.00e+00	1611.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	40.96	2.00e-118	419.00
IUUC-Csa-024177	Chlorocebus sabaeus	97.91	0.00e+00	1472.00
IUUC-Cho-024702	Choloepus hoffmanni	85.41	0.00e+00	937.00
IUUC-Cin-025411	Ciona intestinalis	51.52	0.00e+00	852.00
IUUC-Csv-026347	Ciona savignyi	47.32	0.00e+00	807.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	35.10	2.00e-116	412.00
IUUC-Cne-026831	Cryptococcus neoformans	36.37	7.00e-133	468.00
IUUC-Cme-027335	Cyanidioschyzon merolae	26.49	2.00e-62	234.00
IUUC-Dre-027982	Danio rerio	65.70	0.00e+00	1092.00
IUUC-Dno-029034	Dasypus novemcinctus	95.16	0.00e+00	1603.00
IUUC-Dor-030479	Dipodomys ordii	92.78	0.00e+00	668.00
IUUC-Dse-031467	Dothistroma septosporum	37.19	4.00e-135	475.00
IUUC-Dme-032075	Drosophila melanogaster	50.47	0.00e+00	828.00
IUUC-Ete-032865	Echinops telfairi	84.15	0.00e+00	1404.00
IUUC-Eca-034059	Equus caballus	95.21	0.00e+00	1602.00
IUUC-Eeu-035304	Erinaceus europaeus	89.49	0.00e+00	1441.00
IUUC-Fca-035515	Felis catus	95.40	0.00e+00	1594.00
IUUC-Fal-037271	Ficedula albicollis	90.49	0.00e+00	1461.00
IUUC-Fox-037745	Fusarium oxysporum	36.16	7.00e-131	461.00
IUUC-Fso-038158	Fusarium solani	36.82	4.00e-130	458.00
IUUC-Gmo-039071	Gadus morhua	64.71	0.00e+00	1085.00
IUUC-Ggr-040098	Gaeumannomyces graminis	35.24	6.00e-123	434.00
IUUC-Gga-040635	Gallus gallus	88.23	0.00e+00	1551.00
IUUC-Gac-042528	Gasterosteus aculeatus	65.13	0.00e+00	1104.00
IUUC-Gma-043614	Glycine max	48.02	0.00e+00	723.00
IUUC-Ggo-044602	Gorilla gorilla	95.28	0.00e+00	1588.00
IUUC-Hsa-045959	Homo sapiens	95.28	0.00e+00	1588.00
IUUC-Hvu-047563	Hordeum vulgare	49.32	3.00e-177	614.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	95.52	0.00e+00	1595.00
IUUC-Kpa-049156	Komagataella pastoris	34.20	2.00e-118	420.00
IUUC-Lch-049648	Latimeria chalumnae	84.31	0.00e+00	1414.00
IUUC-Lpe-051523	Leersia perrieri	48.05	0.00e+00	742.00
IUUC-Lma-053216	Leptosphaeria maculans	35.04	5.00e-116	413.00
IUUC-Laf-054327	Loxodonta africana	94.81	0.00e+00	1585.00
IUUC-Mcc-055443	Macaca mulatta	95.16	0.00e+00	1585.00
IUUC-Meu-056298	Macropus eugenii	93.40	0.00e+00	1071.00
IUUC-Mor-057106	Magnaporthe oryzae	36.46	2.00e-132	466.00
IUUC-Mpo-057589	Magnaporthe poae	36.00	1.00e-127	450.00
IUUC-Mtr-058680	Medicago truncatula	49.52	0.00e+00	759.00
IUUC-Mla-058903	Melampsora laricipopulina	32.98	5.00e-122	432.00
IUUC-Mga-059669	Meleagris gallopavo	87.39	0.00e+00	1470.00
IUUC-Mvi-060476	Microbotryum violaceum	35.31	4.00e-123	435.00
IUUC-Mmr-060575	Microcebus murinus	95.75	0.00e+00	1596.00
IUUC-Mdo-062183	Monodelphis domestica	92.35	0.00e+00	1545.00
IUUC-Mmu-063592	Mus musculus	95.51	0.00e+00	1594.00
IUUC-Mac-065634	Musa acuminata	44.01	0.00e+00	709.00
IUUC-Mpu-066082	Mustela putorius furo	94.60	0.00e+00	1605.00
IUUC-Mlu-067345	Myotis lucifugus	92.94	0.00e+00	1552.00
IUUC-Nfi-068558	Neosartorya fischeri	35.49	6.00e-125	441.00
IUUC-Ncr-068960	Neurospora crassa	35.51	6.00e-119	421.00
IUUC-Nle-070173	Nomascus leucogenys	98.18	0.00e+00	1605.00
IUUC-Opr-070556	Ochotona princeps	95.16	0.00e+00	1603.00
IUUC-Ont-071502	Oreochromis niloticus	67.14	0.00e+00	1110.00
IUUC-Oba-075109	Oryza barthii	48.13	0.00e+00	745.00
IUUC-Obr-076292	Oryza brachyantha	49.10	0.00e+00	741.00
IUUC-Ogl-077065	Oryza glaberrima	49.46	0.00e+00	775.00
IUUC-Ogu-078776	Oryza glumaepatula	48.13	0.00e+00	757.00
IUUC-Oin-080048	Oryza indica	48.98	0.00e+00	768.00
IUUC-Olo-080711	Oryza longistaminata	46.30	0.00e+00	687.00
IUUC-Ome-081506	Oryza meridionalis	47.41	0.00e+00	699.00
IUUC-Oni-082320	Oryza nivara	47.53	0.00e+00	743.00
IUUC-Opu-083801	Oryza punctata	48.32	0.00e+00	737.00
IUUC-Oru-085139	Oryza rufipogon	47.53	0.00e+00	744.00
IUUC-Osa-085713	Oryza sativa	49.58	0.00e+00	778.00
IUUC-Ola-086951	Oryzias latipes	64.60	0.00e+00	1065.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.59	0.00e+00	627.00
IUUC-Oga-088625	Otolemur garnettii	95.05	0.00e+00	1579.00
IUUC-Oar-089995	Ovis aries	93.76	0.00e+00	1561.00
IUUC-Ptr-090640	Pan troglodytes	92.68	0.00e+00	1577.00
IUUC-Pan-091974	Papio anubis	94.24	0.00e+00	1567.00
IUUC-Psi-093957	Pelodiscus sinensis	87.09	0.00e+00	1564.00
IUUC-Pma-094242	Petromyzon marinus	72.18	2.00e-171	595.00
IUUC-Pno-094835	Phaeosphaeria nodorum	35.54	2.00e-109	389.00
IUUC-Ppa-095901	Physcomitrella patens	50.41	0.00e+00	808.00
IUUC-Pfo-097148	Poecilia formosa	68.55	0.00e+00	1122.00
IUUC-Pab-098068	Pongo abelii	87.60	0.00e+00	1409.00
IUUC-Pop-098943	Populus trichocarpa	48.38	0.00e+00	742.00
IUUC-Pca-100738	Procavia capensis	93.84	0.00e+00	1087.00
IUUC-Ppe-101315	Prunus persica	48.86	0.00e+00	749.00
IUUC-Pva-102154	Pteropus vampyrus	93.74	0.00e+00	1562.00
IUUC-Pgr-103343	Puccinia graminis	35.14	1.00e-112	400.00
IUUC-Ptt-103928	Puccinia triticina	30.93	3.00e-109	389.00
IUUC-Pte-104306	Pyrenophora teres	33.10	8.00e-107	381.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	34.37	4.00e-110	392.00
IUUC-Rno-105801	Rattus norvegicus	95.16	0.00e+00	1591.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.37	5.00e-75	275.00
IUUC-Sha-107635	Sarcophilus harrisii	94.66	0.00e+00	1565.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.93	3.00e-112	399.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.63	3.00e-116	412.00
IUUC-Smo-108848	Selaginella moellendorffii	49.46	0.00e+00	760.00
IUUC-Sit-110728	Setaria italica	49.94	0.00e+00	799.00
IUUC-Sly-111523	Solanum lycopersicum	48.63	0.00e+00	786.00
IUUC-Sbi-114419	Sorghum bicolor	49.28	0.00e+00	780.00
IUUC-Sre-115225	Sporisorium reilianum	35.86	6.00e-130	458.00
IUUC-Ssc-115686	Sus scrofa	94.46	0.00e+00	1583.00
IUUC-Tgu-117346	Taeniopygia guttata	87.89	0.00e+00	1522.00
IUUC-Tru-118350	Takifugu rubripes	63.18	0.00e+00	1097.00
IUUC-Tni-120658	Tetraodon nigroviridis	64.28	0.00e+00	1082.00
IUUC-Tca-121585	Theobroma cacao	48.75	0.00e+00	747.00
IUUC-Tre-122043	Trichoderma reesei	36.16	3.00e-123	435.00
IUUC-Tvi-122303	Trichoderma virens	36.04	4.00e-128	452.00
IUUC-Tae-125686	Triticum aestivum	48.62	0.00e+00	754.00
IUUC-Tur-126732	Triticum urartu	46.08	0.00e+00	709.00
IUUC-Tme-126909	Tuber melanosporum	34.82	6.00e-122	431.00
IUUC-Tbe-127261	Tupaia belangeri	87.35	0.00e+00	980.00
IUUC-Uma-129599	Ustilago maydis	34.53	9.00e-132	464.00
IUUC-Vda-129688	Verticillium dahliae	35.26	2.00e-124	440.00
IUUC-Vvi-131116	Vitis vinifera	48.46	0.00e+00	724.00
IUUC-Xtr-131953	Xenopus tropicalis	77.17	0.00e+00	1320.00
IUUC-Xma-133837	Xiphophorus maculatus	68.53	0.00e+00	1125.00
IUUC-Yli-134510	Yarrowia lipolytica	35.87	6.00e-131	461.00
IUUC-Zma-135786	Zea mays	49.04	0.00e+00	744.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence