iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000111671.9	ENST00000523102.5	ENSP00000430872.1
ENSG00000111671.9	ENST00000519357.1	ENSP00000431037.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA
DNA & RNA Element
UTRdb	circBase	CircNet	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	20603330

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.50e-15	58.4	219	263

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 6    llrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           ++r ep+SL hL+Rl++r+ lg++rl ++++LPLP+++k+YLly+
   Q: 219  ERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ 263
           7899****************************************8 PP

Organism

Homo sapiens

Functional Description
(View)

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MGQTALAGGS SSTPTPQALY PDLSCPEGLE ELLSAPPPDL GAQRRHGWNP KDCSENIEVK 60
EGGLYFERRP VAQSTDGARG KRGYSRGLHA WEISWPLEQR GTHAVVGVAT ALAPLQTDHY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAAAAAAAA GAAAAATTAC TGGTGAAAAG GCCATCTTCC AGAATACCAT GAGGTTAGTG 60
GTTGCTATCT TCTGGGGAAA GATGCCCAAC TGCATTTAAT ATTTCCAAAC TAGAAACACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001496--SOCS_box
IPR003877--SPRY_dom

PROSITE

PS50188--B302_SPRY
PS50225--SOCS

Pfam

PF07525--SOCS_box
PF00622--SPRY

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

hsa:84727

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001366	Ailuropoda melanoleuca	94.68	9.00e-133	466.00
IUUC-Cja-019350	Callithrix jacchus	96.96	3.00e-147	513.00
IUUC-Cfa-020542	Canis familiaris	95.44	5.00e-144	503.00
IUUC-Cpo-021754	Cavia porcellus	92.78	1.00e-139	488.00
IUUC-Cho-024374	Choloepus hoffmanni	91.37	1.00e-66	244.00
IUUC-Dno-029997	Dasypus novemcinctus	94.30	8.00e-116	409.00
IUUC-Eeu-034632	Erinaceus europaeus	90.87	1.00e-134	471.00
IUUC-Fca-035539	Felis catus	94.51	1.00e-126	445.00
IUUC-Gma-042785	Glycine max	43.33	5.30e-02	29.30
IUUC-Ggo-044949	Gorilla gorilla	99.62	1.00e-151	528.00
IUUC-Itr-048113	Ictidomys tridecemlineatus	95.45	2.00e-143	501.00
IUUC-Laf-053755	Loxodonta africana	95.82	2.00e-137	481.00
IUUC-Mcc-055467	Macaca mulatta	85.55	1.00e-122	432.00
IUUC-Meu-056625	Macropus eugenii	85.28	2.00e-114	404.00
IUUC-Mmr-061190	Microcebus murinus	97.34	1.00e-138	485.00
IUUC-Mmu-063210	Mus musculus	90.53	9.00e-136	475.00
IUUC-Mpu-066662	Mustela putorius furo	94.30	2.00e-142	497.00
IUUC-Nle-069267	Nomascus leucogenys	98.86	8.00e-151	525.00
IUUC-Opr-070650	Ochotona princeps	84.79	3.00e-111	394.00
IUUC-Ocu-073993	Oryctolagus cuniculus	95.06	3.00e-143	500.00
IUUC-Oga-089049	Otolemur garnettii	94.30	5.00e-135	473.00
IUUC-Pab-098113	Pongo abelii	99.24	4.00e-151	526.00
IUUC-Pca-100149	Procavia capensis	96.83	2.00e-122	431.00
IUUC-Pva-102664	Pteropus vampyrus	95.44	5.00e-135	473.00
IUUC-Rno-105741	Rattus norvegicus	91.29	6.00e-126	443.00
IUUC-Sha-107519	Sarcophilus harrisii	84.21	2.00e-111	394.00
IUUC-Ssc-115687	Sus scrofa	94.68	2.00e-142	498.00
IUUC-Tsy-119519	Tarsius syrichta	69.07	1.00e-82	299.00
IUUC-Tur-126737	Triticum urartu	26.14	4.00e-01	29.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence