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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045727
UUCD1 version UUC-HoS-00094
Ensembl Protein ID ENSP00000381045.2
UniProt Accession Q05086; A8K8Z9; P78355; Q93066; Q9UEP4; Q9UEP5; Q9UEP6; Q9UEP7; Q9UEP8; Q9UEP9; UBE3A_HUMAN
Genbank Protein ID CAA66653.1; CAA66653.1; CAA66653.1; CAA66653.1; CAA66653.1; CAA66653.1; CAA66653.1; CAA66653.1; CAA66653.1; CAA66653.1; CAA66654.1; CAA66655.1; CAA66656.1; BAF85203.1; EAW57645.1; AAA35542.1; AAB69154.1; AAB69154.1; AAB69154.1; AAB69154.1; AAB69154.1; AAB69154.1; AAB49301.1; CAA04534.1; CAA04535.1; CAA04536.1; CAA04537.1; CAA04538.1; CAA04539.1
Protein Name Ubiquitin-protein ligase E3A; E6AP ubiquitin-protein ligase; HECT-type ubiquitin transferase E3A; Human papillomavirus E6-associated protein; Oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY-REN-54
Genbank Nucleotide ID X98021; X98027; X98022; X98023; X98024; X98025; X98026; X98028; X98029; X98030; X98031; X98032; X98033; AC100774; AC124997; L07557; AF016708; AF016703; AF016704; AF016705; AF016706; AF016707; U84404; AJ001107; AJ001108; AJ001109; AJ001110; AJ001111; AJ001112
Gene Name UBE3A; E6AP; EPVE6AP; HPVE6A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000114062.18 ENST00000637886.1 ENSP00000490258.1
ENSG00000114062.18 ENST00000626176.2 ENSP00000487178.1
ENSG00000114062.18 ENST00000604860.3 ENSP00000473822.2
ENSG00000114062.18 ENST00000397954.6 ENSP00000381045.2
ENSG00000114062.18 ENST00000626068.2 ENSP00000487534.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Drug and target
TTDManually
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 20210701; 19591933; 19664228; 15371341; 19204938; 18298802; 16482544; 20589759; 17131388; 19759827; 17947517; 19164530; 17108031; 16951183; 20559465; 20589759; 19204938; 22645313
Classification
Family E-value Score Start End
E3 activity/HECT 2.40e-107 360.9 548 874
Active Site
Position(s) Description Evidence
843 Glycyl thioester intermediate N/A
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpls 93
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld++++
   Q: 548  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDVHFP 634
           689******************************************998888876.88888....789************************* PP
   S: 94   ksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvveyrlke 184
            ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ +y+l++
   Q: 635  MVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNK 724
           **********************************.7799986.99***9665444************************************* PP
   S: 185  gikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlP 275
           ++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLqF+Tg++r+P
   Q: 725  SVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAP 816
           *****************99934558******************************************************************* PP
   S: 276  lgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 817  VGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 874
           ********...8888866666**************************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).
Protein Sequence
(Fasta)
MEKLHQCYWK SGEPQSDDIE ASRMKRAAAK HLIERYYHQL TEGCGNEACT NEFCASCPTF 60
LRMDNNAAAI KALELYKINA KLCDPHPSKK GASSAYLENS KGAPNNSCSE IKMNKKGARI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045727|E3,HECT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTGCCTGCC GGGATACTCG GCCCGCCCAG CCAGTCCTCC CGTCTTGCGC CGCGGCCGCG 60
AGATCCGTGT GTCTCCCAAG ATGGTGGCGC TGGGCTCGGG GTGACTACAG GAGACGACGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045727|E3,HECT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0945--Host-virus interaction
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A
PROSITE

PS50237--HECT
Pfam

PF16558--AZUL
PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0046872--F:metal ion binding
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0007420--P:brain development
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0006508--P:proteolysis
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process
KEGG hsa:7337
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002214 Ailuropoda melanoleuca 98.24 0.00e+00 1612.00
IUUC-Atr-003144 Amborella trichopoda 45.80 9.00e-96 343.00
IUUC-Apl-003742 Anas platyrhynchos 91.32 0.00e+00 1587.00
IUUC-Aca-004873 Anolis carolinensis 93.30 0.00e+00 1600.00
IUUC-Ame-011166 Astyanax mexicanus 86.83 0.00e+00 1452.00
IUUC-Bta-013286 Bos taurus 97.13 0.00e+00 1583.00
IUUC-Cja-019707 Callithrix jacchus 99.54 0.00e+00 1684.00
IUUC-Cfa-020154 Canis familiaris 97.70 0.00e+00 1620.00
IUUC-Cpo-021292 Cavia porcellus 97.66 0.00e+00 1602.00
IUUC-Cre-022790 Chlamydomonas reinhardtii 49.06 2.00e-82 298.00
IUUC-Csa-023378 Chlorocebus sabaeus 99.65 0.00e+00 1665.00
IUUC-Cho-025059 Choloepus hoffmanni 93.81 0.00e+00 1512.00
IUUC-Cin-025643 Ciona intestinalis 44.91 0.00e+00 714.00
IUUC-Csv-026282 Ciona savignyi 45.10 0.00e+00 673.00
IUUC-Cme-027151 Cyanidioschyzon merolae 44.02 5.00e-101 363.00
IUUC-Dre-027901 Danio rerio 86.23 0.00e+00 1437.00
IUUC-Dno-029320 Dasypus novemcinctus 97.37 0.00e+00 1625.00
IUUC-Dor-030756 Dipodomys ordii 95.41 0.00e+00 744.00
IUUC-Dme-032035 Drosophila melanogaster 42.86 1.00e-165 577.00
IUUC-Eca-033843 Equus caballus 98.01 0.00e+00 1574.00
IUUC-Eeu-035109 Erinaceus europaeus 96.36 0.00e+00 1561.00
IUUC-Fca-036344 Felis catus 95.99 0.00e+00 1618.00
IUUC-Fal-036747 Ficedula albicollis 91.32 0.00e+00 1588.00
IUUC-Gmo-038840 Gadus morhua 63.58 0.00e+00 1103.00
IUUC-Gga-040399 Gallus gallus 91.21 0.00e+00 1586.00
IUUC-Gac-041933 Gasterosteus aculeatus 84.36 0.00e+00 1394.00
IUUC-Ggo-044804 Gorilla gorilla 100.00 0.00e+00 1692.00
IUUC-Itr-048289 Ictidomys tridecemlineatus 94.50 0.00e+00 1519.00
IUUC-Lch-050197 Latimeria chalumnae 91.01 0.00e+00 1548.00
IUUC-Loc-052743 Lepisosteus oculatus 88.63 0.00e+00 1521.00
IUUC-Lma-053245 Leptosphaeria maculans 33.87 5.00e-57 216.00
IUUC-Laf-053615 Loxodonta africana 96.08 0.00e+00 1607.00
IUUC-Mcc-054934 Macaca mulatta 99.20 0.00e+00 1666.00
IUUC-Meu-056061 Macropus eugenii 90.26 0.00e+00 1426.00
IUUC-Mga-059271 Meleagris gallopavo 90.71 0.00e+00 1561.00
IUUC-Mmr-061288 Microcebus murinus 98.40 0.00e+00 1659.00
IUUC-Mdo-062975 Monodelphis domestica 95.54 0.00e+00 1603.00
IUUC-Mmu-063674 Mus musculus 95.40 0.00e+00 1576.00
IUUC-Mpu-066568 Mustela putorius furo 98.05 0.00e+00 1646.00
IUUC-Mlu-067522 Myotis lucifugus 88.95 0.00e+00 1497.00
IUUC-Nle-069505 Nomascus leucogenys 100.00 0.00e+00 1692.00
IUUC-Opr-070570 Ochotona princeps 89.77 0.00e+00 1461.00
IUUC-Ont-071527 Oreochromis niloticus 84.65 0.00e+00 1464.00
IUUC-Oan-073446 Ornithorhynchus anatinus 90.59 0.00e+00 1053.00
IUUC-Ocu-074922 Oryctolagus cuniculus 95.56 0.00e+00 1626.00
IUUC-Ola-086996 Oryzias latipes 85.51 0.00e+00 1466.00
IUUC-Oga-088261 Otolemur garnettii 98.94 0.00e+00 1629.00
IUUC-Oar-090024 Ovis aries 97.13 0.00e+00 1583.00
IUUC-Ptr-090455 Pan troglodytes 100.00 0.00e+00 1692.00
IUUC-Pan-092509 Papio anubis 98.37 0.00e+00 1522.00
IUUC-Psi-092974 Pelodiscus sinensis 91.43 0.00e+00 1555.00
IUUC-Pma-094643 Petromyzon marinus 71.72 0.00e+00 1259.00
IUUC-Pno-094886 Phaeosphaeria nodorum 35.32 9.00e-58 219.00
IUUC-Pfo-096905 Poecilia formosa 85.35 0.00e+00 1461.00
IUUC-Pab-097840 Pongo abelii 97.54 0.00e+00 1597.00
IUUC-Pca-100869 Procavia capensis 96.84 0.00e+00 1590.00
IUUC-Pva-103040 Pteropus vampyrus 97.02 0.00e+00 667.00
IUUC-Rno-105453 Rattus norvegicus 95.63 0.00e+00 1581.00
IUUC-Sha-107651 Sarcophilus harrisii 95.54 0.00e+00 1603.00
IUUC-Smo-108858 Selaginella moellendorffii 49.65 7.00e-116 411.00
IUUC-Sar-113293 Sorex araneus 97.43 0.00e+00 1597.00
IUUC-Ssc-115979 Sus scrofa 97.54 0.00e+00 1598.00
IUUC-Tgu-116901 Taeniopygia guttata 91.32 0.00e+00 1587.00
IUUC-Tru-118368 Takifugu rubripes 86.01 0.00e+00 1462.00
IUUC-Tsy-119516 Tarsius syrichta 94.95 0.00e+00 1518.00
IUUC-Tni-120143 Tetraodon nigroviridis 83.83 0.00e+00 1454.00
IUUC-Tbe-127484 Tupaia belangeri 92.76 0.00e+00 1108.00
IUUC-Ttr-129078 Tursiops truncatus 97.31 0.00e+00 1570.00
IUUC-Vpa-130312 Vicugna pacos 90.05 0.00e+00 1353.00
IUUC-Xtr-132881 Xenopus tropicalis 91.59 0.00e+00 1551.00
Created Date 25-Jun-2017

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