iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-068088

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02055491

Gene Name

USP4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000013894.2	ENSMLUT00000013905.2	ENSMLUP00000012651.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.10e-114	381.0	302	923
ULD/UDP/UBQ/UBQ_Other	3.10e-16	59.1	143	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl NlgNtC+mNS+LQcLsn+ +l++++l+ +++ ++n++np ++kge+++++++l++++w++++ +v+pr+++++++++a++fsgy+
   Q: 302  CGLGNLGNTCFMNSALQCLSNTAPLTDYFLKdEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQ 390
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ k+kp+ e+++++   ++d      a+e++  +n+s+i+d+F+g +ks+++c+ec++vs++++pf++l
   Q: 391  QQDSQELLAFLLDGLHEDLNRVKKKPYLELQDAN--GRPDAvvakeAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 477
           ******************************8888..5555566777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p k+++ +e                                                                            
   Q: 478  TLPLPLKKDRVMEvflvpadprcrpvqyrvtvplmgavsdlcealsrlsgvaaenmvvtdvynhrfhkifqmdeglnhimprddifvye 566
           ********99999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 567  vcstcadgsecvtlpvyfrerksrpsspssgavlygqpllvsvpkhtltleslyqavcerisryikqplpeevgssplepgacngsrgs 655
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 656  cegedeeemehleegreqlsepegswedelgsdrgettqrkspgrpcpqrlftfslvnaygtadinslatdgnllklssrstlaidwdt 744
           ***************************************************************************************** PP
   S: 186  ................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfsee 242
                                            l+dc+e ft+ e+l +++ +yc++ck++q+a+kk++l++lP++L++hLkRfs+s++
   Q: 745  etrslyydeqeseafekhvsmlqpqkkkktamALRDCIELFTTMETLGEHDPWYCPNCKRHQQATKKFDLWSLPKILVVHLKRFSYSRY 833
           ************************************************************************************99885 PP
   S: 243  qksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkne.kgkWllfdDskVtevkeeevleetgst 329
              r k+++ vefp + L++s+f+++p+     ++ Y+Liav +H+G ++ GHY+ay+kn+ +gkW++fdDs+V+  +e+++++   + 
   Q: 834  --WRDKLDTVVEFPVRgLNMSEFVCDPSAR---PYVYDLIAVSNHYGAMGVGHYTAYAKNKlNGKWYYFDDSNVSLASEDQIVT---KA 914
           ..556*********************8866...9**************************52666*******************...** PP
   S: 330  aYvlfYkrr 338
           aYvlfY+rr
   Q: 915  AYVLFYQRR 923
           *******96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           ++++d +  l+++++++dt+a++ ++++k+++ip +++ rL++k       + L + d+t++d gl++g+++++++++++
   Q: 143  CENSDPTnMLSCHFSKADTIATIEKEMRKLFNIPaERETRLWNKymsntyEQ-LsKLDNTVQDAGLYQGQVLVIEPQNED 221
           67888888899***********************888*****9999977444.46********************99986 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MAEGGGSGER PDAETQKSEL GALLRTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDVYNVG 60
EHNMFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPTEA WNKLINWYGC VEGQQPIVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAAG GCGGGGGCTC CGGGGAGCGA CCAGATGCGG AGACCCAGAA ATCCGAACTC 60
GGGGCCTTGC TGAGGACCAC GCTCCAGCGA GGGGCGCAGT GGTGAGCGCC GGGCTCCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001597	Ailuropoda melanoleuca	92.95	0.00e+00	1659.00
IUUC-Atr-002991	Amborella trichopoda	35.28	6.00e-142	498.00
IUUC-Apl-004068	Anas platyrhynchos	70.86	0.00e+00	1206.00
IUUC-Aca-004459	Anolis carolinensis	69.65	0.00e+00	1237.00
IUUC-Ath-007343	Arabidopsis thaliana	37.19	1.00e-151	530.00
IUUC-Ago-007911	Ashbya gossypii	38.26	1.00e-62	235.00
IUUC-Ang-009562	Aspergillus niger	45.16	7.00e-56	213.00
IUUC-Ame-011064	Astyanax mexicanus	64.10	0.00e+00	889.00
IUUC-Bta-012929	Bos taurus	93.15	0.00e+00	1728.00
IUUC-Bdi-014013	Brachypodium distachyon	35.81	2.00e-149	523.00
IUUC-Bol-015244	Brassica oleracea	37.17	6.00e-153	535.00
IUUC-Bra-016885	Brassica rapa	36.44	3.00e-150	525.00
IUUC-Cja-018798	Callithrix jacchus	90.66	0.00e+00	1649.00
IUUC-Cfa-020599	Canis familiaris	93.88	0.00e+00	1699.00
IUUC-Cpo-022144	Cavia porcellus	89.14	0.00e+00	1620.00
IUUC-Csa-023770	Chlorocebus sabaeus	92.63	0.00e+00	1583.00
IUUC-Cho-024595	Choloepus hoffmanni	82.79	0.00e+00	1086.00
IUUC-Cin-025292	Ciona intestinalis	42.87	0.00e+00	738.00
IUUC-Cne-026852	Cryptococcus neoformans	38.32	2.00e-72	268.00
IUUC-Dre-027869	Danio rerio	63.16	0.00e+00	1204.00
IUUC-Dno-029316	Dasypus novemcinctus	90.77	0.00e+00	1699.00
IUUC-Ete-032970	Echinops telfairi	81.69	0.00e+00	1050.00
IUUC-Eca-034012	Equus caballus	92.95	0.00e+00	1702.00
IUUC-Eeu-035158	Erinaceus europaeus	76.37	0.00e+00	788.00
IUUC-Fca-035373	Felis catus	89.21	0.00e+00	1648.00
IUUC-Fal-037634	Ficedula albicollis	74.68	0.00e+00	1296.00
IUUC-Fox-037986	Fusarium oxysporum	45.22	1.00e-64	241.00
IUUC-Fso-038291	Fusarium solani	45.22	3.00e-64	241.00
IUUC-Ggr-039740	Gaeumannomyces graminis	44.69	8.00e-63	236.00
IUUC-Gga-040729	Gallus gallus	67.89	0.00e+00	1261.00
IUUC-Gac-042631	Gasterosteus aculeatus	67.08	0.00e+00	1246.00
IUUC-Ggo-045337	Gorilla gorilla	91.01	0.00e+00	1510.00
IUUC-Hsa-045669	Homo sapiens	92.63	0.00e+00	1691.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	92.74	0.00e+00	1715.00
IUUC-Lpe-051424	Leersia perrieri	36.81	9.00e-148	517.00
IUUC-Laf-053803	Loxodonta africana	92.01	0.00e+00	1703.00
IUUC-Mcc-055556	Macaca mulatta	89.32	0.00e+00	1600.00
IUUC-Meu-056742	Macropus eugenii	71.35	0.00e+00	1321.00
IUUC-Mor-056985	Magnaporthe oryzae	43.59	3.00e-62	234.00
IUUC-Mpo-057486	Magnaporthe poae	45.42	7.00e-63	236.00
IUUC-Mga-059300	Meleagris gallopavo	70.77	0.00e+00	1225.00
IUUC-Mdo-061848	Monodelphis domestica	83.57	0.00e+00	1559.00
IUUC-Mmu-063960	Mus musculus	88.80	0.00e+00	1634.00
IUUC-Mac-065239	Musa acuminata	33.23	3.00e-131	462.00
IUUC-Mpu-066920	Mustela putorius furo	93.98	0.00e+00	1701.00
IUUC-Ncr-068879	Neurospora crassa	32.13	1.00e-67	251.00
IUUC-Nle-070010	Nomascus leucogenys	93.05	0.00e+00	1696.00
IUUC-Opr-070740	Ochotona princeps	88.80	0.00e+00	1201.00
IUUC-Oan-073363	Ornithorhynchus anatinus	75.28	0.00e+00	1405.00
IUUC-Ocu-074242	Oryctolagus cuniculus	88.56	0.00e+00	1610.00
IUUC-Olu-087717	Ostreococcus lucimarinus	40.45	8.00e-125	441.00
IUUC-Oga-088562	Otolemur garnettii	84.74	0.00e+00	1466.00
IUUC-Oar-090439	Ovis aries	92.84	0.00e+00	1692.00
IUUC-Ptr-090801	Pan troglodytes	92.84	0.00e+00	1690.00
IUUC-Pan-092717	Papio anubis	88.19	0.00e+00	1563.00
IUUC-Psi-093942	Pelodiscus sinensis	73.71	0.00e+00	1294.00
IUUC-Pab-098522	Pongo abelii	91.44	0.00e+00	1226.00
IUUC-Pca-100161	Procavia capensis	82.16	0.00e+00	1470.00
IUUC-Rno-106081	Rattus norvegicus	89.00	0.00e+00	1662.00
IUUC-Sha-106937	Sarcophilus harrisii	82.20	0.00e+00	1516.00
IUUC-Sly-111746	Solanum lycopersicum	37.85	1.00e-154	540.00
IUUC-Stu-112671	Solanum tuberosum	37.43	3.00e-152	532.00
IUUC-Sar-113542	Sorex araneus	86.20	0.00e+00	1585.00
IUUC-Sbi-114874	Sorghum bicolor	36.09	1.00e-141	497.00
IUUC-Ssc-115637	Sus scrofa	93.67	0.00e+00	1696.00
IUUC-Tgu-117267	Taeniopygia guttata	71.47	0.00e+00	1290.00
IUUC-Tru-118634	Takifugu rubripes	69.78	0.00e+00	863.00
IUUC-Tae-125295	Triticum aestivum	35.78	2.00e-147	516.00
IUUC-Tbe-127669	Tupaia belangeri	74.96	0.00e+00	898.00
IUUC-Ttr-128778	Tursiops truncatus	92.12	0.00e+00	1681.00
IUUC-Uma-129498	Ustilago maydis	41.46	9.00e-70	259.00
IUUC-Vda-129781	Verticillium dahliae	29.97	6.00e-68	253.00
IUUC-Vpa-130571	Vicugna pacos	96.30	0.00e+00	1132.00
IUUC-Xtr-132305	Xenopus tropicalis	69.39	0.00e+00	1277.00
IUUC-Yli-134392	Yarrowia lipolytica	43.53	7.00e-62	233.00
IUUC-Zma-135699	Zea mays	35.69	1.00e-142	500.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence