iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066920

Ensembl Protein ID

ENSMPUP00000013743.1

UniProt Accession

M3YQY4; M3YQY4_MUSPF

Genbank Protein ID

ENSMPUP00000013743

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01051092

Gene Name

USP4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000013846.1	ENSMPUT00000013960.1	ENSMPUP00000013743.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.00e-113	379.0	302	923
ULD/UDP/UBQ/UBQ_Other	5.00e-18	64.8	143	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl NlgNtC+mNS+LQcLsn+ +l++++l+ +++ ++n++np ++kge+++++++l++++w++++++v+pr+++++++++a++fsgy+
   Q: 302  CGLGNLGNTCFMNSALQCLSNTAPLTDYFLKdEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDSHVAPRMFKTQVGRFAPQFSGYQ 390
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ k+kp+ e+++++   ++d      a+e++  +n+s+i+d+F+g +ks+++c+ec++vs++++pf++l
   Q: 391  QQDSQELLAFLLDGLHEDLNRVKKKPYLELKDAN--GRPDAvvakeAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 477
           ******************************8888..5555556777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p k+++ +e                                                                            
   Q: 478  TLPLPLKKDRVMEvflvpadprcrptqyrvvvplmgavsdlcealsrlsgvavenmvvtdvynhrfhkifqmdeglnhimprddifvye 566
           ********99999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 567  vcgtsadgsecvtlpvyfrerksrpsstssgavlygqpllvsvpkhkltleslyqavcerisryikqplpeesggsplepgacngsrgs 655
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 656  cegedeeemehqeegkeqlsetegsgedelsgdhgettqkkvkgqpcpkrlftfslvnsygtadinslatdgkllklnsrstlaidwds 744
           ***************************************************************************************** PP
   S: 186  ................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfsee 242
                                            l+dc+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs++++
   Q: 745  etrslyydeqeseayekhvsmlqpqkkkktavALRDCIELFTTMETLGEHDPWYCPTCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY 833
           ************************************************************************************99885 PP
   S: 243  qksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkne.kgkWllfdDskVtevkeeevleetgst 329
              r k+++ vefp + L++s+f+++ +    +++ Y+Liav +H+G ++ GHY+ay+kn+ +gkW++fdDs+V+  +e+++++   + 
   Q: 834  --WRDKLDTVVEFPVRaLNMSEFVCDLSA---RPYVYDLIAVSNHYGAMGVGHYTAYAKNKlNGKWYYFDDSNVSLASEDQIVT---KA 914
           ..567******************999443...49**************************52666*******************...** PP
   S: 330  aYvlfYkrr 338
           aYvlfY+rr
   Q: 915  AYVLFYQRR 923
           *******96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           ++++d + +l+++++++dt+a++ ++++k+++ip +++ rL++k       + L + d+t++d gl++g+++++++++++
   Q: 143  CENSDPTnVLSCHFSKADTIATIEKEMRKLFNIPaERETRLWNKymsntyEQ-LsKLDNTVQDAGLYQGQVLVIEPQNED 221
           78999999**************************888*****9999977444.46********************99986 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MAEGGGCRER PDAETQKSEL GALMRTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYNVG 60
EHNLFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPTEA WNKLLNWYGC VEGQQPIVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCAGGCGCC CCACTTTTGT GTGTGTGTGT GTGACTTCTT TTTGAGGGCA GGAACTGCTA 60
GCCCAGCTGC TAGCCAGCTG CCCGGTCTCT TCCTTGCTCC GGGCTTACTT CCCACTCCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001597	Ailuropoda melanoleuca	97.61	0.00e+00	1743.00
IUUC-Atr-002991	Amborella trichopoda	35.06	2.00e-142	499.00
IUUC-Apl-004068	Anas platyrhynchos	71.52	0.00e+00	1219.00
IUUC-Aca-004459	Anolis carolinensis	69.76	0.00e+00	1255.00
IUUC-Ath-007343	Arabidopsis thaliana	37.04	3.00e-152	532.00
IUUC-Ago-007911	Ashbya gossypii	38.55	1.00e-62	235.00
IUUC-Ang-009562	Aspergillus niger	45.13	3.00e-55	211.00
IUUC-Ame-011064	Astyanax mexicanus	64.43	0.00e+00	891.00
IUUC-Bta-012929	Bos taurus	94.81	0.00e+00	1771.00
IUUC-Bdi-014013	Brachypodium distachyon	36.04	2.00e-150	526.00
IUUC-Cel-018257	Caenorhabditis elegans	31.56	4.00e-93	336.00
IUUC-Cja-018798	Callithrix jacchus	93.36	0.00e+00	1701.00
IUUC-Cfa-020599	Canis familiaris	98.24	0.00e+00	1784.00
IUUC-Cpo-022144	Cavia porcellus	90.65	0.00e+00	1655.00
IUUC-Csa-023770	Chlorocebus sabaeus	94.83	0.00e+00	1617.00
IUUC-Cho-024595	Choloepus hoffmanni	84.84	0.00e+00	1129.00
IUUC-Cin-025292	Ciona intestinalis	43.61	0.00e+00	749.00
IUUC-Cne-026852	Cryptococcus neoformans	38.58	1.00e-72	268.00
IUUC-Dre-027869	Danio rerio	64.36	0.00e+00	1221.00
IUUC-Dno-029316	Dasypus novemcinctus	92.53	0.00e+00	1758.00
IUUC-Ete-032970	Echinops telfairi	83.20	0.00e+00	1085.00
IUUC-Eca-034012	Equus caballus	95.64	0.00e+00	1751.00
IUUC-Eeu-035158	Erinaceus europaeus	79.40	0.00e+00	817.00
IUUC-Fca-035373	Felis catus	92.74	0.00e+00	1728.00
IUUC-Fal-037634	Ficedula albicollis	75.32	0.00e+00	1313.00
IUUC-Fox-037986	Fusarium oxysporum	42.67	9.00e-65	242.00
IUUC-Fso-038291	Fusarium solani	45.22	1.00e-63	239.00
IUUC-Gmo-038866	Gadus morhua	68.08	0.00e+00	858.00
IUUC-Gga-040729	Gallus gallus	67.95	0.00e+00	1267.00
IUUC-Gac-042631	Gasterosteus aculeatus	67.88	0.00e+00	1261.00
IUUC-Gma-043077	Glycine max	42.90	2.00e-137	483.00
IUUC-Ggo-045337	Gorilla gorilla	93.55	0.00e+00	1549.00
IUUC-Hsa-045669	Homo sapiens	95.02	0.00e+00	1740.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	94.71	0.00e+00	1765.00
IUUC-Lch-050533	Latimeria chalumnae	69.21	0.00e+00	1208.00
IUUC-Lpe-051424	Leersia perrieri	36.89	3.00e-150	525.00
IUUC-Laf-053803	Loxodonta africana	95.02	0.00e+00	1765.00
IUUC-Mcc-055556	Macaca mulatta	91.08	0.00e+00	1628.00
IUUC-Meu-056742	Macropus eugenii	73.27	0.00e+00	1358.00
IUUC-Mor-056985	Magnaporthe oryzae	42.86	5.00e-61	230.00
IUUC-Mpo-057486	Magnaporthe poae	45.09	1.00e-61	232.00
IUUC-Mtr-058138	Medicago truncatula	36.84	6.00e-154	538.00
IUUC-Mga-059300	Meleagris gallopavo	71.05	0.00e+00	1234.00
IUUC-Mdo-061848	Monodelphis domestica	84.81	0.00e+00	1590.00
IUUC-Mmu-063960	Mus musculus	91.08	0.00e+00	1681.00
IUUC-Mac-065239	Musa acuminata	33.09	3.00e-130	459.00
IUUC-Mlu-068088	Myotis lucifugus	93.98	0.00e+00	1740.00
IUUC-Ncr-068879	Neurospora crassa	46.29	1.00e-61	232.00
IUUC-Nle-070010	Nomascus leucogenys	95.12	0.00e+00	1740.00
IUUC-Opr-070740	Ochotona princeps	90.30	0.00e+00	1236.00
IUUC-Ont-072573	Oreochromis niloticus	66.00	0.00e+00	1276.00
IUUC-Oan-073363	Ornithorhynchus anatinus	77.43	0.00e+00	1441.00
IUUC-Ocu-074242	Oryctolagus cuniculus	90.10	0.00e+00	1649.00
IUUC-Oba-075553	Oryza barthii	41.41	2.00e-128	453.00
IUUC-Obr-076902	Oryza brachyantha	35.91	3.00e-147	515.00
IUUC-Ogl-077583	Oryza glaberrima	41.41	2.00e-128	453.00
IUUC-Ogu-077990	Oryza glumaepatula	41.01	1.00e-122	434.00
IUUC-Oin-079300	Oryza indica	41.56	2.00e-129	456.00
IUUC-Olo-080315	Oryza longistaminata	35.95	1.00e-145	510.00
IUUC-Ome-081271	Oryza meridionalis	35.51	3.00e-147	515.00
IUUC-Oni-082303	Oryza nivara	40.77	2.00e-123	436.00
IUUC-Opu-083770	Oryza punctata	41.49	3.00e-126	446.00
IUUC-Oru-085141	Oryza rufipogon	41.18	2.00e-125	444.00
IUUC-Osa-085641	Oryza sativa	41.56	2.00e-129	456.00
IUUC-Ola-086553	Oryzias latipes	67.42	0.00e+00	1293.00
IUUC-Olu-087717	Ostreococcus lucimarinus	40.72	1.00e-124	440.00
IUUC-Oga-088562	Otolemur garnettii	86.94	0.00e+00	1518.00
IUUC-Oar-090439	Ovis aries	94.29	0.00e+00	1740.00
IUUC-Ptr-090801	Pan troglodytes	95.02	0.00e+00	1736.00
IUUC-Pan-092717	Papio anubis	89.95	0.00e+00	1600.00
IUUC-Psi-093942	Pelodiscus sinensis	75.08	0.00e+00	1317.00
IUUC-Pfo-097060	Poecilia formosa	65.73	0.00e+00	1269.00
IUUC-Pab-098522	Pongo abelii	93.21	0.00e+00	1255.00
IUUC-Pop-099801	Populus trichocarpa	37.53	3.00e-150	525.00
IUUC-Pca-100161	Procavia capensis	83.61	0.00e+00	1517.00
IUUC-Ppe-101587	Prunus persica	37.08	8.00e-149	521.00
IUUC-Rno-106081	Rattus norvegicus	90.46	0.00e+00	1699.00
IUUC-Sha-106937	Sarcophilus harrisii	83.40	0.00e+00	1551.00
IUUC-Smo-108736	Selaginella moellendorffii	52.16	4.00e-72	265.00
IUUC-Sit-109948	Setaria italica	36.28	1.00e-141	497.00
IUUC-Sly-111746	Solanum lycopersicum	37.82	2.00e-153	536.00
IUUC-Stu-112671	Solanum tuberosum	37.67	2.00e-151	529.00
IUUC-Sar-113542	Sorex araneus	89.00	0.00e+00	1644.00
IUUC-Sbi-114874	Sorghum bicolor	36.16	5.00e-143	501.00
IUUC-Ssc-115637	Sus scrofa	96.06	0.00e+00	1762.00
IUUC-Tgu-117267	Taeniopygia guttata	73.02	0.00e+00	1309.00
IUUC-Tru-118634	Takifugu rubripes	67.40	0.00e+00	1218.00
IUUC-Tca-121001	Theobroma cacao	36.12	6.00e-155	541.00
IUUC-Tae-125295	Triticum aestivum	35.97	5.00e-150	525.00
IUUC-Tbe-127669	Tupaia belangeri	77.13	0.00e+00	943.00
IUUC-Ttr-128778	Tursiops truncatus	94.81	0.00e+00	1750.00
IUUC-Uma-129498	Ustilago maydis	42.02	1.00e-71	265.00
IUUC-Vda-129781	Verticillium dahliae	30.62	1.00e-69	258.00
IUUC-Vpa-130571	Vicugna pacos	97.10	0.00e+00	1161.00
IUUC-Vvi-131010	Vitis vinifera	38.60	9.00e-153	534.00
IUUC-Xtr-132305	Xenopus tropicalis	69.98	0.00e+00	1294.00
IUUC-Xma-133176	Xiphophorus maculatus	71.60	0.00e+00	844.00
IUUC-Yli-134392	Yarrowia lipolytica	43.66	5.00e-63	236.00
IUUC-Zma-135699	Zea mays	35.73	3.00e-144	505.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence