iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000116525.13	ENST00000291416.9	ENSP00000291416.5
ENSG00000116525.13	ENST00000543586.1	ENSP00000441173.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090; 23402750

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	2.30e-06	29.2	6	76
E3 activity/RING/RING	7.30e-08	34.5	11	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwl....asggktcPvtrqplteedlvPnltlrrliqawc 69
            +e+lC+I l + +dPv l + + + r++I ++     a+g + cP +r++++e  l P+l l ++++++ 
   Q: 6    KDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWvrqeAQGARDCPECRRTFAEPALAPSLKLANIVERYS 76
           689***************************9888455444444*******************999998875 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+ ++d p++l+C H f++ C+ ++w+ +   ++++  CP Cr
   Q: 11   CSICLSIYQD-PVSLGCEHYFCRRCItEHWVRQE--AQGARDCPECR 54
           **********.*******************5555..**********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.

Protein Sequence
(Fasta)

MACSLKDELL CSICLSIYQD PVSLGCEHYF CRRCITEHWV RQEAQGARDC PECRRTFAEP 60
ALAPSLKLAN IVERYSSFPL DAILNARRAA RPCQAHDKVK LFCLTDRALL CFFCDEPALH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGATTCGGCT GGTTCCGGGT TGAGAGGCTG CGCTGGACCG AAGCGGTGGC TGCTAAGCTC 60
GCGGGGGTAA GGGGTCGCGC TGGGCCAGGG TTTGGGGCCG GGATCCGGCA GCTGAGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0010719--P:negative regulation of epithelial to mesenchymal transition
GO:0032897--P:negative regulation of viral transcription
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046596--P:regulation of viral entry into host cell
GO:1902186--P:regulation of viral release from host cell

KEGG

hsa:55223

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002199	Ailuropoda melanoleuca	99.37	0.00e+00	954.00
IUUC-Apl-003767	Anas platyrhynchos	87.58	0.00e+00	797.00
IUUC-Aca-004412	Anolis carolinensis	83.92	0.00e+00	816.00
IUUC-Ame-010927	Astyanax mexicanus	82.53	0.00e+00	847.00
IUUC-Bta-012927	Bos taurus	99.16	0.00e+00	953.00
IUUC-Cja-019317	Callithrix jacchus	92.84	0.00e+00	864.00
IUUC-Cfa-020292	Canis familiaris	99.41	0.00e+00	700.00
IUUC-Cpo-022274	Cavia porcellus	99.41	0.00e+00	705.00
IUUC-Csa-023042	Chlorocebus sabaeus	99.37	0.00e+00	954.00
IUUC-Dre-028493	Danio rerio	81.26	0.00e+00	839.00
IUUC-Dno-030029	Dasypus novemcinctus	94.74	0.00e+00	894.00
IUUC-Dor-031051	Dipodomys ordii	96.70	0.00e+00	904.00
IUUC-Ete-032752	Echinops telfairi	98.35	2.00e-108	386.00
IUUC-Eca-033898	Equus caballus	79.33	0.00e+00	827.00
IUUC-Eeu-034659	Erinaceus europaeus	99.36	3.00e-84	304.00
IUUC-Fca-035492	Felis catus	90.97	0.00e+00	886.00
IUUC-Fal-036867	Ficedula albicollis	87.53	0.00e+00	853.00
IUUC-Gmo-038916	Gadus morhua	81.89	0.00e+00	816.00
IUUC-Gga-040360	Gallus gallus	89.89	0.00e+00	877.00
IUUC-Gac-041871	Gasterosteus aculeatus	82.53	0.00e+00	849.00
IUUC-Ggo-044411	Gorilla gorilla	92.87	0.00e+00	880.00
IUUC-Itr-047905	Ictidomys tridecemlineatus	99.37	0.00e+00	954.00
IUUC-Loc-052114	Lepisosteus oculatus	84.00	0.00e+00	861.00
IUUC-Laf-054359	Loxodonta africana	93.63	0.00e+00	675.00
IUUC-Mcc-055563	Macaca mulatta	99.37	0.00e+00	954.00
IUUC-Meu-056027	Macropus eugenii	75.58	0.00e+00	724.00
IUUC-Mga-060146	Meleagris gallopavo	82.56	1.00e-74	271.00
IUUC-Mmr-060822	Microcebus murinus	99.16	0.00e+00	952.00
IUUC-Mdo-062117	Monodelphis domestica	77.99	0.00e+00	643.00
IUUC-Mmu-064086	Mus musculus	99.16	0.00e+00	954.00
IUUC-Mpu-066378	Mustela putorius furo	99.37	0.00e+00	954.00
IUUC-Mlu-067155	Myotis lucifugus	98.30	0.00e+00	962.00
IUUC-Nle-069464	Nomascus leucogenys	98.95	0.00e+00	951.00
IUUC-Opr-071058	Ochotona princeps	98.64	2.00e-133	468.00
IUUC-Ont-071253	Oreochromis niloticus	74.48	0.00e+00	727.00
IUUC-Oan-073614	Ornithorhynchus anatinus	93.67	1.00e-94	337.00
IUUC-Ola-086794	Oryzias latipes	82.74	0.00e+00	844.00
IUUC-Oga-088889	Otolemur garnettii	98.74	0.00e+00	951.00
IUUC-Oar-089203	Ovis aries	95.55	0.00e+00	841.00
IUUC-Ptr-090795	Pan troglodytes	99.37	0.00e+00	984.00
IUUC-Pfo-096942	Poecilia formosa	82.11	0.00e+00	838.00
IUUC-Pab-097936	Pongo abelii	85.83	0.00e+00	632.00
IUUC-Pca-100397	Procavia capensis	97.89	0.00e+00	942.00
IUUC-Ppe-101916	Prunus persica	30.97	3.00e-10	61.20
IUUC-Pva-102293	Pteropus vampyrus	99.12	0.00e+00	687.00
IUUC-Rno-105551	Rattus norvegicus	98.95	0.00e+00	949.00
IUUC-Ssc-115983	Sus scrofa	99.37	0.00e+00	954.00
IUUC-Tgu-117279	Taeniopygia guttata	74.39	0.00e+00	654.00
IUUC-Tru-118238	Takifugu rubripes	82.32	0.00e+00	843.00
IUUC-Tni-119788	Tetraodon nigroviridis	60.71	4.00e-157	547.00
IUUC-Xtr-132768	Xenopus tropicalis	74.65	0.00e+00	729.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence