iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108371

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 2

Genbank Nucleotide ID

CU329671

Gene Name

uch2; SPBC409.06

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC409.06	SPBC409.06.1	SPBC409.06.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/UCH	UCH	15533439

Classification

Family	E-value	Score	Start	End
DUB/UCH	1.50e-88	295.5	2	292

Active Site

Position(s)	Description	Evidence
83	Nucleophile	ECO:0000250}
159	Proton donor	ECO:0000250}

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsC 99
           +w+++esd+g+ft+l+e++gvk++ +v+elysLd ++l+++  +++g+++lFk+n+k ++ +          ++d+d +++iffakqvi+N+C
   Q: 2    SWTTIESDAGVFTDLIENLGVKDV-EVDELYSLDVDSLRQF-PDIYGIIFLFKWNSKVDKPD---------GTMDYDSMDNIFFAKQVINNAC 83
           7***********************.****************.99****************99.........89******************** PP
   S: 100  atyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlye 192
           at+Allsvlln++d+ +dlGttls++k+++k+  pe k++algn+++++c+hns+ar++++ ++e +++++   ++e++hf++y+nin+ +ye
   Q: 84   ATQALLSVLLNHSDE-IDLGTTLSEFKDFSKTLPPELKGEALGNSEHIRCCHNSFARSDPFISEEVRAATD---EDEVYHFIAYTNINNVFYE 172
           ***************.5***********************************************9998877...9****************** PP
   S: 193  ldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkidkeLlkLlkdieseeekieaqlddeke 285
           ldgl+++P+++g+++++e  +++++v++    ri +++  eirfnl+ i++d++                 +Ll++ + ++e+++a+++ e+e
   Q: 173  LDGLQAAPINHGSCTKEEFAEKAVSVIQ---ARIANYDPAEIRFNLMVICKDKKA----------------SLLTREDLTDEEKAASIAVEDE 246
           ***************9999999999999...*********************995................9********************* PP
   S: 286  krkkfkiddirRtenydeficifikdlaregilrklveetisevre 331
           kr ++k +++ R++n+++ ++++ k l +++i ++++++t+   + 
   Q: 247  KRLRWKRENQLRRHNFVGLFVELSKLLVKDRIDKNTWNSTLETAKA 292
           ****************************************987765 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.

Protein Sequence
(Fasta)

MSWTTIESDA GVFTDLIENL GVKDVEVDEL YSLDVDSLRQ FPDIYGIIFL FKWNSKVDKP 60
DGTMDYDSMD NIFFAKQVIN NACATQALLS VLLNHSDEID LGTTLSEFKD FSKTLPPELK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAATTTTA AAGTAATACC ATCATTTGAT CTCTCATAAA AGTCAGCTTG CATAAGTGCT 60
GTCAAATTCC ATTCTTTCGT TCTTCTGTAA CACACAAGAT GAGTTGGACT ACAATAGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0034399--C:nuclear periphery
GO:0031595--C:nuclear proteasome complex
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination

KEGG

spo:SPBC409.06

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	44.83	2.00e-69	253.00
IUUC-Aml-001866	Ailuropoda melanoleuca	41.58	4.00e-59	219.00
IUUC-Atr-002966	Amborella trichopoda	40.41	3.00e-58	216.00
IUUC-Apl-003306	Anas platyrhynchos	38.34	7.00e-54	202.00
IUUC-Aca-004763	Anolis carolinensis	40.26	3.00e-60	223.00
IUUC-Aly-005581	Arabidopsis lyrata	44.90	1.00e-64	237.00
IUUC-Ath-007283	Arabidopsis thaliana	43.31	8.00e-67	245.00
IUUC-Ago-007999	Ashbya gossypii	35.45	2.00e-39	154.00
IUUC-Acl-008231	Aspergillus clavatus	46.65	1.00e-74	271.00
IUUC-Afl-008557	Aspergillus flavus	49.82	2.00e-74	270.00
IUUC-Afu-008988	Aspergillus fumigatus	46.65	5.00e-74	268.00
IUUC-Ani-009420	Aspergillus nidulans	49.83	1.00e-74	271.00
IUUC-Ang-009859	Aspergillus niger	46.96	5.00e-70	255.00
IUUC-Aor-010145	Aspergillus oryzae	49.82	2.00e-74	270.00
IUUC-Ate-010347	Aspergillus terreus	45.09	2.00e-73	266.00
IUUC-Ame-010791	Astyanax mexicanus	40.12	8.00e-61	225.00
IUUC-Bgr-012298	Blumeria graminis	50.67	2.00e-75	273.00
IUUC-Bta-013251	Bos taurus	42.38	2.00e-59	220.00
IUUC-Bci-013786	Botrytis cinerea	52.16	4.00e-84	302.00
IUUC-Bdi-014132	Brachypodium distachyon	51.09	3.00e-63	233.00
IUUC-Bol-015611	Brassica oleracea	44.68	2.00e-66	243.00
IUUC-Bra-017769	Brassica rapa	44.68	3.00e-66	243.00
IUUC-Cel-018604	Caenorhabditis elegans	42.07	2.00e-53	200.00
IUUC-Cja-019768	Callithrix jacchus	37.76	4.00e-54	202.00
IUUC-Cfa-020207	Canis familiaris	41.58	4.00e-59	219.00
IUUC-Cpo-021925	Cavia porcellus	39.93	3.00e-54	202.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	39.16	6.00e-57	212.00
IUUC-Csa-023958	Chlorocebus sabaeus	42.05	2.00e-59	220.00
IUUC-Cho-024928	Choloepus hoffmanni	60.00	2.00e-19	87.40
IUUC-Cin-025771	Ciona intestinalis	35.80	3.00e-53	200.00
IUUC-Csv-026149	Ciona savignyi	38.28	8.00e-55	205.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	44.17	2.00e-65	240.00
IUUC-Cne-026955	Cryptococcus neoformans	35.40	3.00e-44	170.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.83	5.00e-44	169.00
IUUC-Dre-027409	Danio rerio	39.20	7.00e-60	221.00
IUUC-Dno-028921	Dasypus novemcinctus	41.58	9.00e-59	218.00
IUUC-Dor-030891	Dipodomys ordii	36.97	9.00e-33	133.00
IUUC-Dse-031170	Dothistroma septosporum	49.36	9.00e-79	284.00
IUUC-Dme-031677	Drosophila melanogaster	41.78	5.00e-55	206.00
IUUC-Ete-032646	Echinops telfairi	42.64	9.00e-35	139.00
IUUC-Eca-033776	Equus caballus	40.70	2.00e-52	197.00
IUUC-Eeu-035305	Erinaceus europaeus	39.56	4.00e-31	126.00
IUUC-Fca-035846	Felis catus	38.48	3.00e-55	206.00
IUUC-Fal-037597	Ficedula albicollis	39.65	1.00e-52	197.00
IUUC-Fox-037670	Fusarium oxysporum	51.93	2.00e-75	273.00
IUUC-Fso-038243	Fusarium solani	51.93	6.00e-76	275.00
IUUC-Gmo-038499	Gadus morhua	38.61	1.00e-53	201.00
IUUC-Ggr-039975	Gaeumannomyces graminis	46.98	2.00e-67	247.00
IUUC-Gga-040904	Gallus gallus	41.58	3.00e-61	226.00
IUUC-Gac-042058	Gasterosteus aculeatus	41.20	4.00e-60	222.00
IUUC-Gma-043763	Glycine max	42.94	2.00e-66	244.00
IUUC-Ggo-044699	Gorilla gorilla	47.77	7.00e-57	212.00
IUUC-Hsa-046227	Homo sapiens	41.91	1.00e-59	221.00
IUUC-Hvu-047359	Hordeum vulgare	44.51	8.00e-69	251.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	38.02	3.00e-55	206.00
IUUC-Lch-049829	Latimeria chalumnae	42.57	1.00e-61	227.00
IUUC-Lpe-050899	Leersia perrieri	42.77	1.00e-64	237.00
IUUC-Loc-052264	Lepisosteus oculatus	41.39	2.00e-59	220.00
IUUC-Lma-053110	Leptosphaeria maculans	50.89	3.00e-74	270.00
IUUC-Laf-053639	Loxodonta africana	41.58	4.00e-59	219.00
IUUC-Mcc-055506	Macaca mulatta	42.05	2.00e-59	220.00
IUUC-Meu-056267	Macropus eugenii	40.83	2.00e-40	159.00
IUUC-Mor-057001	Magnaporthe oryzae	45.10	8.00e-66	241.00
IUUC-Mpo-057608	Magnaporthe poae	51.65	1.00e-45	173.00
IUUC-Mtr-057731	Medicago truncatula	42.35	1.00e-68	251.00
IUUC-Mla-059016	Melampsora laricipopulina	41.00	9.00e-41	157.00
IUUC-Mga-060178	Meleagris gallopavo	41.05	1.00e-54	204.00
IUUC-Mvi-060353	Microbotryum violaceum	40.93	3.00e-55	206.00
IUUC-Mmr-060738	Microcebus murinus	41.91	9.00e-60	221.00
IUUC-Mdo-062266	Monodelphis domestica	47.55	3.00e-50	189.00
IUUC-Mmu-063619	Mus musculus	41.58	9.00e-60	221.00
IUUC-Mac-065301	Musa acuminata	46.15	3.00e-72	263.00
IUUC-Mpu-066058	Mustela putorius furo	41.58	1.00e-59	221.00
IUUC-Mlu-067292	Myotis lucifugus	41.06	2.00e-60	223.00
IUUC-Nfi-068275	Neosartorya fischeri	48.56	4.00e-79	285.00
IUUC-Ncr-068713	Neurospora crassa	51.36	7.00e-81	291.00
IUUC-Nle-069013	Nomascus leucogenys	42.05	1.00e-59	221.00
IUUC-Opr-070628	Ochotona princeps	37.58	8.00e-50	188.00
IUUC-Ont-072688	Oreochromis niloticus	40.59	1.00e-58	217.00
IUUC-Oan-073004	Ornithorhynchus anatinus	47.09	3.00e-50	189.00
IUUC-Ocu-074303	Oryctolagus cuniculus	41.86	2.00e-59	221.00
IUUC-Oba-075002	Oryza barthii	42.73	6.00e-66	242.00
IUUC-Obr-076392	Oryza brachyantha	51.98	3.00e-65	239.00
IUUC-Ogl-077271	Oryza glaberrima	42.73	6.00e-66	242.00
IUUC-Ogu-078493	Oryza glumaepatula	42.73	2.00e-66	243.00
IUUC-Oin-080084	Oryza indica	42.73	2.00e-66	243.00
IUUC-Olo-080803	Oryza longistaminata	42.42	9.00e-66	241.00
IUUC-Ome-081146	Oryza meridionalis	42.42	6.00e-66	242.00
IUUC-Oni-082146	Oryza nivara	42.73	2.00e-66	243.00
IUUC-Opu-083633	Oryza punctata	43.41	6.00e-65	238.00
IUUC-Oru-084789	Oryza rufipogon	42.73	2.00e-66	243.00
IUUC-Osa-086196	Oryza sativa	42.73	2.00e-66	243.00
IUUC-Ola-087126	Oryzias latipes	42.52	2.00e-60	223.00
IUUC-Olu-087665	Ostreococcus lucimarinus	43.22	1.00e-61	227.00
IUUC-Oga-089140	Otolemur garnettii	38.79	9.00e-56	208.00
IUUC-Oar-090296	Ovis aries	42.00	7.00e-59	218.00
IUUC-Ptr-090566	Pan troglodytes	41.91	1.00e-59	221.00
IUUC-Pan-092052	Papio anubis	42.05	3.00e-59	220.00
IUUC-Psi-093723	Pelodiscus sinensis	40.00	4.00e-54	202.00
IUUC-Pma-094568	Petromyzon marinus	44.66	7.00e-47	178.00
IUUC-Pno-095120	Phaeosphaeria nodorum	50.33	2.00e-75	273.00
IUUC-Ppa-095761	Physcomitrella patens	41.71	3.00e-63	233.00
IUUC-Pfo-096210	Poecilia formosa	41.53	4.00e-60	222.00
IUUC-Pab-098463	Pongo abelii	41.91	1.00e-59	221.00
IUUC-Pop-099109	Populus trichocarpa	42.06	3.00e-66	243.00
IUUC-Pca-100108	Procavia capensis	46.90	4.00e-54	202.00
IUUC-Ppe-101176	Prunus persica	42.06	1.00e-63	234.00
IUUC-Pva-102629	Pteropus vampyrus	48.21	5.00e-56	209.00
IUUC-Pgr-103419	Puccinia graminis	38.64	3.00e-48	183.00
IUUC-Pte-104207	Pyrenophora teres	54.82	1.00e-46	176.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	49.50	6.00e-82	295.00
IUUC-Rno-105579	Rattus norvegicus	36.48	2.00e-48	184.00
IUUC-Sha-106894	Sarcophilus harrisii	43.13	3.00e-50	189.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	67.36	8.00e-118	414.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	50.00	5.00e-70	255.00
IUUC-Smo-109396	Selaginella moellendorffii	41.82	1.00e-60	224.00
IUUC-Sit-110630	Setaria italica	56.19	3.00e-69	253.00
IUUC-Sly-110972	Solanum lycopersicum	41.46	6.00e-62	228.00
IUUC-Stu-112185	Solanum tuberosum	43.28	2.00e-71	259.00
IUUC-Sar-113294	Sorex araneus	36.25	9.00e-49	185.00
IUUC-Sbi-113951	Sorghum bicolor	55.31	5.00e-68	249.00
IUUC-Ssc-115501	Sus scrofa	40.48	1.00e-54	204.00
IUUC-Tgu-117152	Taeniopygia guttata	39.65	1.00e-52	197.00
IUUC-Tru-118388	Takifugu rubripes	40.92	2.00e-60	223.00
IUUC-Tsy-119109	Tarsius syrichta	41.91	1.00e-59	221.00
IUUC-Tni-120048	Tetraodon nigroviridis	40.92	3.00e-60	223.00
IUUC-Tca-121750	Theobroma cacao	41.64	1.00e-69	254.00
IUUC-Tre-122130	Trichoderma reesei	52.92	4.00e-78	282.00
IUUC-Tvi-122284	Trichoderma virens	51.48	2.00e-74	270.00
IUUC-Tae-124082	Triticum aestivum	44.83	2.00e-69	253.00
IUUC-Tur-126366	Triticum urartu	43.08	4.00e-47	180.00
IUUC-Tme-127187	Tuber melanosporum	52.36	5.00e-85	305.00
IUUC-Tbe-127705	Tupaia belangeri	41.74	6.00e-39	152.00
IUUC-Ttr-128225	Tursiops truncatus	43.93	3.00e-45	174.00
IUUC-Vda-129912	Verticillium dahliae	49.25	9.00e-76	275.00
IUUC-Vpa-130552	Vicugna pacos	47.06	1.00e-49	188.00
IUUC-Vvi-130881	Vitis vinifera	42.69	6.00e-66	242.00
IUUC-Xtr-131934	Xenopus tropicalis	39.20	3.00e-60	223.00
IUUC-Xma-133312	Xiphophorus maculatus	41.53	4.00e-60	222.00
IUUC-Yli-134487	Yarrowia lipolytica	43.81	4.00e-66	242.00
IUUC-Zma-135462	Zea mays	39.46	2.00e-55	207.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence