iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000027777.9	ENSDART00000147959.1	ENSDARP00000123481.1
ENSDARG00000027777.9	ENSDART00000033528.7	ENSDARP00000032728.6

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.20e-33	116.5	97	264
UBD/ZnF/ZnF_A20	3.40e-14	53.4	729	761

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepeakg 77
           ++l t+gDGnCLl+A+sq+llgv+d+d+ l++al+ +L+e+ +  +    q e  + +ef +++        e+e+  + ++++p + +
   Q: 97   VPLRTNGDGNCLLHAASQYLLGVQDTDLvLRKALHAVLKETDTTDFltrfQTELLHSQEFTQTGlrystlnwEEEWVKIVDMASPVSSS 185
           7899************************************9888777998999999999999999********************9765 PP
   S: 78   ........eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
                   e ihif+L++iL+rpiiv++++ l+s          +vggi+lpl++p+ + +k+pivL+Y+s H+ +L++
   Q: 186  nglqfdslEDIHIFVLSNILRRPIIVIADQVLRSmksgssfsplNVGGIYLPLHWPPGEcYKYPIVLGYDSQHFAPLIT 264
           56*******************************9******************************************986 PP

UBD/ZnF/ZnF_A20

   S: 3    skllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           sk++Ck+ gC++Y n e +gyC++C  +++ +r
   Q: 729  SKQRCKTqGCDHYANQEKQGYCNECDHFKQIYR 761
           89***********************99998776 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MSQGQNFLPK FLFVSNLLKA VKIRERVPND VVKPSAGGSL IHHLRSMHRY TLEMIRMSQF 60
PQAFREVIQA AILDRAMQSS LEQEKRLNWC REVKKLVPLR TNGDGNCLLH AASQYLLGVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTGAAAGG AAAGTACCTT ATGGAAATCC CCTACTGGCT TTTATGTACA GCTAACAATC 60
GGGCTGGTTT GACTAGAGAG CGTGTTGTGG AGGCGAGCAG AGAAATCCAG CGGCTCTCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006955--P:immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0016567--P:protein ubiquitination
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response

KEGG

dre:564497

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	49.13	0.00e+00	742.00
IUUC-Apl-003501	Anas platyrhynchos	48.57	0.00e+00	721.00
IUUC-Aca-004245	Anolis carolinensis	48.83	0.00e+00	740.00
IUUC-Ame-011789	Astyanax mexicanus	82.79	0.00e+00	1261.00
IUUC-Bta-012664	Bos taurus	49.56	0.00e+00	737.00
IUUC-Cja-019895	Callithrix jacchus	48.58	0.00e+00	731.00
IUUC-Cfa-020754	Canis familiaris	49.50	0.00e+00	746.00
IUUC-Cpo-021780	Cavia porcellus	48.14	0.00e+00	723.00
IUUC-Csa-023568	Chlorocebus sabaeus	48.26	0.00e+00	731.00
IUUC-Cho-024300	Choloepus hoffmanni	61.76	1.00e-125	444.00
IUUC-Dno-029382	Dasypus novemcinctus	50.25	0.00e+00	739.00
IUUC-Dor-030874	Dipodomys ordii	47.22	0.00e+00	701.00
IUUC-Ete-032721	Echinops telfairi	60.14	6.00e-150	525.00
IUUC-Eca-033596	Equus caballus	48.32	0.00e+00	712.00
IUUC-Eeu-035159	Erinaceus europaeus	45.37	2.00e-148	519.00
IUUC-Fca-035847	Felis catus	48.82	0.00e+00	741.00
IUUC-Fal-036681	Ficedula albicollis	47.84	0.00e+00	728.00
IUUC-Gmo-038521	Gadus morhua	88.15	0.00e+00	727.00
IUUC-Gga-040975	Gallus gallus	48.16	0.00e+00	733.00
IUUC-Gac-042216	Gasterosteus aculeatus	73.91	0.00e+00	1070.00
IUUC-Ggo-045258	Gorilla gorilla	47.71	0.00e+00	726.00
IUUC-Hsa-046071	Homo sapiens	48.20	0.00e+00	732.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	48.51	0.00e+00	733.00
IUUC-Lch-050326	Latimeria chalumnae	52.21	0.00e+00	795.00
IUUC-Loc-051945	Lepisosteus oculatus	59.19	0.00e+00	806.00
IUUC-Laf-053722	Loxodonta africana	47.71	0.00e+00	724.00
IUUC-Mcc-055503	Macaca mulatta	48.13	0.00e+00	729.00
IUUC-Meu-056481	Macropus eugenii	45.11	0.00e+00	642.00
IUUC-Mga-059690	Meleagris gallopavo	46.79	0.00e+00	679.00
IUUC-Mmr-061233	Microcebus murinus	48.70	0.00e+00	731.00
IUUC-Mdo-062446	Monodelphis domestica	48.88	0.00e+00	736.00
IUUC-Mmu-063436	Mus musculus	48.50	0.00e+00	732.00
IUUC-Mpu-066808	Mustela putorius furo	49.38	0.00e+00	749.00
IUUC-Mlu-067339	Myotis lucifugus	48.94	0.00e+00	733.00
IUUC-Nle-069888	Nomascus leucogenys	47.96	0.00e+00	728.00
IUUC-Opr-070303	Ochotona princeps	48.95	0.00e+00	737.00
IUUC-Ont-072283	Oreochromis niloticus	86.71	0.00e+00	726.00
IUUC-Oan-072925	Ornithorhynchus anatinus	50.50	0.00e+00	761.00
IUUC-Ocu-073889	Oryctolagus cuniculus	48.44	0.00e+00	730.00
IUUC-Ola-087417	Oryzias latipes	86.92	0.00e+00	723.00
IUUC-Oga-088708	Otolemur garnettii	48.56	0.00e+00	694.00
IUUC-Oar-089271	Ovis aries	48.87	0.00e+00	733.00
IUUC-Ptr-091296	Pan troglodytes	48.20	0.00e+00	732.00
IUUC-Pan-092474	Papio anubis	48.01	0.00e+00	728.00
IUUC-Psi-093447	Pelodiscus sinensis	49.07	0.00e+00	752.00
IUUC-Pfo-096511	Poecilia formosa	71.72	0.00e+00	1077.00
IUUC-Pab-098700	Pongo abelii	48.08	0.00e+00	728.00
IUUC-Pca-100246	Procavia capensis	46.59	7.00e-138	484.00
IUUC-Pva-102606	Pteropus vampyrus	50.90	2.00e-112	400.00
IUUC-Rno-105818	Rattus norvegicus	49.62	0.00e+00	745.00
IUUC-Sha-106559	Sarcophilus harrisii	47.74	0.00e+00	723.00
IUUC-Sar-113454	Sorex araneus	63.83	7.00e-128	451.00
IUUC-Ssc-116064	Sus scrofa	49.37	0.00e+00	736.00
IUUC-Tgu-117212	Taeniopygia guttata	47.49	0.00e+00	717.00
IUUC-Tru-118230	Takifugu rubripes	87.83	0.00e+00	742.00
IUUC-Tsy-119066	Tarsius syrichta	50.06	0.00e+00	748.00
IUUC-Tni-119825	Tetraodon nigroviridis	75.22	0.00e+00	1097.00
IUUC-Tbe-127601	Tupaia belangeri	63.83	8.00e-127	447.00
IUUC-Ttr-128930	Tursiops truncatus	49.38	0.00e+00	731.00
IUUC-Vpa-130450	Vicugna pacos	62.22	6.00e-147	514.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence