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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064308
Ensembl Protein ID ENSMUSP00000110057.3
UniProt Accession Q8VI24; SATB2_MOUSE
Genbank Protein ID AAL37172.1; BAC98080.1
Protein Name DNA-binding protein SATB2; Special AT-rich sequence-binding protein 2
Genbank Nucleotide ID AF319623; AK129270
Gene Name Satb2; Kiaa1034
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000038331.15 ENSMUST00000042857.13 ENSMUSP00000046067.7
ENSMUSG00000038331.15 ENSMUST00000114415.9 ENSMUSP00000110057.3
ENSMUSG00000038331.15 ENSMUST00000177424.1 ENSMUSP00000135391.1
ENSMUSG00000038331.15 ENSMUST00000176759.1 ENSMUSP00000135163.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UDP/UBQ/UBQ_Other 4.40e-06 27.6 62 148
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_Other
   S: 1    vqvtvksldgs.eltlkvnpsd.tVaeLKeki.....ekk.lgip.peqqrLiykGki.L..eddktLady.glkdgstihllekksg 75
           v+++v++ldgs e++ + ++++ +V+++K+ +     e++ l ++ +++++ + +G+i L  +++ +L+++ +++d++++++l+++++
   Q: 62   VFCVVEQLDGSlEYDNR-EEHAeFVLVRKDVLfsqlvETAlLALGySHSSAAQAQGIIkLgrWNPLPLSYVtDAPDATVADMLQDVYH 148
           689************99.77777*******55555578888****************96599************************98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating Bcl11b expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
 Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating Bcl11b expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
Protein Sequence
(Fasta)
MERRSESPCL RDSPDRRSGS PDVKGPPPVK VARLEQNGSP MGARGRPNGA VAKAVGGLMI 60
PVFCVVEQLD GSLEYDNREE HAEFVLVRKD VLFSQLVETA LLALGYSHSS AAQAQGIIKL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064308|ULD,UBQ_Other|Mus musculus
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Nucleotide Sequence
(Fasta)
AACCAACAAA CCCAATTACT AAGCTTTATT GATACTAAAA GGAAAAGTTC CCCTCGTAAA 60
ATTTCTCTGA GCTTATTAGT TATTTAAATC AGCCCCGGGG CTGGACCTGC GACGCCTAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064308|ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0371--Homeobox
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
Interpro

IPR003350--CUT_dom
IPR032355--CUTL
IPR009057--Homeobox-like
IPR001356--Homeobox_dom
IPR010982--Lambda_DNA-bd_dom
IPR032392--ULD
PROSITE

PS51042--CUT
PS50071--HOMEOBOX_2
Pfam

PF02376--CUT
PF16557--CUTL
PF00046--Homeobox
PF16534--ULD
SMART

SM01109--CUT
SM00389--HOX
Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0000790--C:nuclear chromatin
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0051216--P:cartilage development
GO:0071310--P:cellular response to organic substance
GO:0006338--P:chromatin remodeling
GO:0021902--P:commitment of neuronal cell to specific neuron type in forebrain
GO:0016569--P:covalent chromatin modification
GO:0009880--P:embryonic pattern specification
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001764--P:neuron migration
GO:0002076--P:osteoblast development
GO:0060021--P:palate development
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010468--P:regulation of gene expression
GO:0006351--P:transcription, DNA-templated
KEGG mmu:212712
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001646 Ailuropoda melanoleuca 99.70 0.00e+00 1189.00
IUUC-Apl-004052 Anas platyrhynchos 94.68 0.00e+00 1144.00
IUUC-Aca-004787 Anolis carolinensis 91.63 0.00e+00 1236.00
IUUC-Bta-013408 Bos taurus 99.56 0.00e+00 1204.00
IUUC-Cja-019389 Callithrix jacchus 99.59 0.00e+00 1265.00
IUUC-Cfa-020265 Canis familiaris 99.85 0.00e+00 1209.00
IUUC-Cpo-022536 Cavia porcellus 94.18 0.00e+00 1046.00
IUUC-Csa-023562 Chlorocebus sabaeus 99.59 0.00e+00 1266.00
IUUC-Cho-024887 Choloepus hoffmanni 99.32 0.00e+00 1263.00
IUUC-Dno-029724 Dasypus novemcinctus 99.32 0.00e+00 1228.00
IUUC-Dor-030304 Dipodomys ordii 97.19 0.00e+00 726.00
IUUC-Ete-032494 Echinops telfairi 98.31 2.00e-126 446.00
IUUC-Eca-034263 Equus caballus 98.90 0.00e+00 1234.00
IUUC-Eeu-035070 Erinaceus europaeus 86.22 0.00e+00 1080.00
IUUC-Fca-035798 Felis catus 99.27 0.00e+00 1220.00
IUUC-Fal-037543 Ficedula albicollis 94.81 0.00e+00 1142.00
IUUC-Ggo-045271 Gorilla gorilla 99.59 0.00e+00 1266.00
IUUC-Hsa-046324 Homo sapiens 99.59 0.00e+00 1266.00
IUUC-Laf-053934 Loxodonta africana 99.32 0.00e+00 1263.00
IUUC-Mcc-054634 Macaca mulatta 99.73 0.00e+00 1267.00
IUUC-Meu-056505 Macropus eugenii 98.22 7.00e-134 470.00
IUUC-Mga-060057 Meleagris gallopavo 94.24 0.00e+00 1135.00
IUUC-Mmr-061381 Microcebus murinus 99.56 0.00e+00 1108.00
IUUC-Mdo-061840 Monodelphis domestica 97.68 0.00e+00 1285.00
IUUC-Mpu-066080 Mustela putorius furo 99.85 0.00e+00 1226.00
IUUC-Mlu-066936 Myotis lucifugus 97.00 0.00e+00 1217.00
IUUC-Nle-069956 Nomascus leucogenys 99.73 0.00e+00 1267.00
IUUC-Ocu-073904 Oryctolagus cuniculus 99.05 0.00e+00 1228.00
IUUC-Oga-088311 Otolemur garnettii 99.03 0.00e+00 1234.00
IUUC-Oar-089530 Ovis aries 99.71 0.00e+00 1206.00
IUUC-Ptr-090832 Pan troglodytes 99.59 0.00e+00 1266.00
IUUC-Pan-091847 Papio anubis 99.59 0.00e+00 1265.00
IUUC-Psi-093659 Pelodiscus sinensis 95.36 0.00e+00 1279.00
IUUC-Pab-098649 Pongo abelii 99.59 0.00e+00 1266.00
IUUC-Pca-100908 Procavia capensis 97.96 0.00e+00 1203.00
IUUC-Pva-102867 Pteropus vampyrus 100.00 0.00e+00 1229.00
IUUC-Rno-105849 Rattus norvegicus 99.32 0.00e+00 1272.00
IUUC-Sha-106557 Sarcophilus harrisii 97.27 0.00e+00 1299.00
Created Date 25-Jun-2017

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