iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-045034

Ensembl Protein ID

ENSGGOP00000014363.2

UniProt Accession

G3RFJ6; G3RFJ6_GORGO

Protein Name

Uncharacterized protein

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000014718.2	ENSGGOT00000014774.2	ENSGGOP00000014363.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	3.50e-20	72.1	456	505

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 11   LkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkas 60
           L+ Q+e+Y++DF+aERa+RE+++eeke+L+ q+++l+k++++++d++++s
   Q: 456  LQDQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQS 505
           889*********************************************98 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MSHQPLSCLT EKEDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL 60
NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCCATC AACCTCTCAG CTGCCTCACT GAAAAGGAGG ACAGCCCCAG TGAAAGCACA 60
GGAAATGGAC CCCCCCACCT GGCCCACCCA AACCTGGACA CGTTCACCCC GGAGGAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0005802--C:trans-Golgi network
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	71.79	0.00e+00	714.00
IUUC-Apl-003812	Anas platyrhynchos	50.17	3.00e-127	448.00
IUUC-Aca-004625	Anolis carolinensis	50.35	2.00e-122	432.00
IUUC-Ame-011116	Astyanax mexicanus	34.70	9.00e-61	228.00
IUUC-Bta-013240	Bos taurus	75.39	0.00e+00	781.00
IUUC-Cja-019911	Callithrix jacchus	82.67	0.00e+00	848.00
IUUC-Cfa-020330	Canis familiaris	76.48	0.00e+00	738.00
IUUC-Cpo-021753	Cavia porcellus	73.61	0.00e+00	729.00
IUUC-Csa-023662	Chlorocebus sabaeus	86.14	0.00e+00	863.00
IUUC-Cho-024574	Choloepus hoffmanni	69.43	3.00e-69	255.00
IUUC-Cme-027299	Cyanidioschyzon merolae	35.96	1.00e-03	37.70
IUUC-Dre-027720	Danio rerio	38.19	3.00e-72	265.00
IUUC-Dno-029079	Dasypus novemcinctus	72.65	0.00e+00	669.00
IUUC-Dor-030890	Dipodomys ordii	72.15	0.00e+00	696.00
IUUC-Ete-032568	Echinops telfairi	70.61	8.00e-179	619.00
IUUC-Eca-033528	Equus caballus	75.56	0.00e+00	748.00
IUUC-Eeu-035219	Erinaceus europaeus	69.69	0.00e+00	731.00
IUUC-Fca-035852	Felis catus	75.94	0.00e+00	738.00
IUUC-Fal-036862	Ficedula albicollis	51.15	6.00e-125	441.00
IUUC-Gmo-038735	Gadus morhua	44.44	3.00e-46	179.00
IUUC-Gga-040939	Gallus gallus	52.81	2.00e-127	449.00
IUUC-Gac-041580	Gasterosteus aculeatus	39.15	8.00e-83	301.00
IUUC-Hsa-046624	Homo sapiens	88.39	0.00e+00	927.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	68.38	0.00e+00	665.00
IUUC-Lch-049720	Latimeria chalumnae	48.09	2.00e-74	272.00
IUUC-Loc-052185	Lepisosteus oculatus	41.58	3.00e-83	302.00
IUUC-Laf-054079	Loxodonta africana	74.83	0.00e+00	729.00
IUUC-Mcc-055674	Macaca mulatta	87.22	0.00e+00	860.00
IUUC-Meu-056769	Macropus eugenii	50.60	1.00e-60	227.00
IUUC-Mga-060203	Meleagris gallopavo	53.16	2.00e-125	442.00
IUUC-Mmr-061492	Microcebus murinus	78.22	0.00e+00	743.00
IUUC-Mdo-063051	Monodelphis domestica	66.67	0.00e+00	661.00
IUUC-Mmu-063409	Mus musculus	69.23	0.00e+00	735.00
IUUC-Mpu-065907	Mustela putorius furo	70.07	0.00e+00	694.00
IUUC-Mlu-066957	Myotis lucifugus	74.39	0.00e+00	684.00
IUUC-Nle-069973	Nomascus leucogenys	86.14	0.00e+00	890.00
IUUC-Opr-071049	Ochotona princeps	70.42	0.00e+00	642.00
IUUC-Ont-071915	Oreochromis niloticus	40.30	4.00e-77	281.00
IUUC-Oan-072965	Ornithorhynchus anatinus	65.45	0.00e+00	645.00
IUUC-Ocu-074029	Oryctolagus cuniculus	69.98	0.00e+00	631.00
IUUC-Ola-087019	Oryzias latipes	39.17	4.00e-76	278.00
IUUC-Oga-088613	Otolemur garnettii	78.31	0.00e+00	775.00
IUUC-Oar-090386	Ovis aries	75.04	0.00e+00	773.00
IUUC-Ptr-091619	Pan troglodytes	88.21	0.00e+00	924.00
IUUC-Pan-092178	Papio anubis	85.00	0.00e+00	841.00
IUUC-Psi-093214	Pelodiscus sinensis	56.27	7.00e-144	503.00
IUUC-Pfo-096901	Poecilia formosa	38.97	1.00e-67	250.00
IUUC-Pab-097560	Pongo abelii	77.99	0.00e+00	770.00
IUUC-Pca-100853	Procavia capensis	70.48	2.00e-111	396.00
IUUC-Pva-102255	Pteropus vampyrus	74.96	0.00e+00	677.00
IUUC-Rno-105812	Rattus norvegicus	71.33	0.00e+00	727.00
IUUC-Sha-107225	Sarcophilus harrisii	66.04	2.00e-119	422.00
IUUC-Sar-113736	Sorex araneus	62.02	1.00e-99	357.00
IUUC-Ssc-115422	Sus scrofa	75.44	0.00e+00	752.00
IUUC-Tgu-116924	Taeniopygia guttata	53.38	7.00e-128	450.00
IUUC-Tru-117695	Takifugu rubripes	35.68	2.00e-71	263.00
IUUC-Tsy-119090	Tarsius syrichta	81.23	2.00e-142	498.00
IUUC-Tni-120645	Tetraodon nigroviridis	39.05	5.00e-76	278.00
IUUC-Tbe-127970	Tupaia belangeri	63.26	4.00e-175	607.00
IUUC-Ttr-129244	Tursiops truncatus	74.96	0.00e+00	719.00
IUUC-Vpa-130313	Vicugna pacos	74.61	0.00e+00	668.00
IUUC-Xtr-132115	Xenopus tropicalis	40.77	7.00e-76	278.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence