iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046624

Ensembl Protein ID

ENSP00000263036.3

UniProt Accession

Q96CV9; B3KP00; D3DRS4; D3DRS8; Q5T672; Q5T673; Q5T674; Q5T675; Q7LDL9; Q8N562; Q9UET9; Q9UEV4; Q9Y218; OPTN_HUMAN

Genbank Protein ID

AAC16046.1; AAC16047.1; AAL76327.1; AAL76328.1; AAL76329.1; AAG00497.1; AAG00497.1; AAG00497.1; AAG00497.1; AAG00497.1; AAG00497.1; AAG00497.1; AAG00497.1; BAG51512.1; CAI16549.1; CAI16550.1; CAI16551.1; CAI16552.1; EAW86301.1; EAW86302.1; EAW86303.1; EAW86304.1; EAW86306.1; EAW86308.1; EAW86309.1; AAH13876.1; AAH32762.1; AAC26850.1

Protein Name

Optineurin; E3-14.7K-interacting protein; FIP-2; Huntingtin yeast partner L; Huntingtin-interacting protein 7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Transcription factor IIIA-interacting protein

Genbank Nucleotide ID

AF061034; AF061034; AF420371; AF420372; AF420373; AF283527; AF283520; AF283521; AF283522; AF283523; AF283524; AF283525; AF283526; AK055403; AL355355; AL355355; AL355355; AL355355; CH471072; CH471072; CH471072; CH471072; CH471072; CH471072; CH471072; BC013876; BC032762; AF049614

Gene Name

OPTN; FIP2; GLC1E; HIP7; HYPL; NRP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000123240.16	ENST00000263036.9	ENSP00000263036.3
ENSG00000123240.16	ENST00000378764.6	ENSP00000368040.1
ENSG00000123240.16	ENST00000482140.5	ENSP00000484961.1
ENSG00000123240.16	ENST00000430081.5	ENSP00000414747.2
ENSG00000123240.16	ENST00000486862.1	ENSP00000481473.1
ENSG00000123240.16	ENST00000424614.1	ENSP00000400356.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBAN	UBAN	21617041; 23279185

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBAN	1.30e-25	90.7	454	513

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkas 60
           +ee+let+++L++Q+e+Y++DF+aERa+RE+++eeke+L+ q+++l+k++++++d++++s
   Q: 454  QEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQS 513
           79********************************************************98 PP

Organism

Homo sapiens

Functional Description
(View)

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Protein Sequence
(Fasta)

MSHQPLSCLT EKEDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL 60
NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCCTGCAG CGCTACCCGG GTACTCTGGA TGCACATAGG GCGGCTCTCG CTCCTACCTT 60
GTCATCCTGC TGTCTAATCC GGGGGCAGCT TCCCTCCTCC ACACCAGCAG AGGCTATTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0036--Amyotrophic lateral sclerosis
KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0225--Disease mutation
KW-0967--Endosome
KW-0955--Glaucoma
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-0523--Neurodegeneration
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0055038--C:recycling endosome membrane
GO:0005802--C:trans-Golgi network
GO:0042802--F:identical protein binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0031593--F:polyubiquitin binding
GO:0030674--F:protein binding, bridging
GO:0008022--F:protein C-terminus binding
GO:0017137--F:Rab GTPase binding
GO:0008219--P:cell death
GO:0050829--P:defense response to Gram-negative bacterium
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0007030--P:Golgi organization
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0061024--P:membrane organization
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0007165--P:signal transduction

KEGG

hsa:10133

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	80.77	0.00e+00	785.00
IUUC-Apl-003812	Anas platyrhynchos	56.48	1.00e-151	530.00
IUUC-Aca-004625	Anolis carolinensis	57.72	5.00e-149	521.00
IUUC-Aly-005781	Arabidopsis lyrata	55.00	2.20e-02	33.50
IUUC-Ame-011116	Astyanax mexicanus	37.65	1.00e-71	264.00
IUUC-Bta-013240	Bos taurus	83.25	0.00e+00	901.00
IUUC-Cja-019911	Callithrix jacchus	93.93	0.00e+00	979.00
IUUC-Cfa-020330	Canis familiaris	84.14	0.00e+00	837.00
IUUC-Cpo-021753	Cavia porcellus	80.41	0.00e+00	818.00
IUUC-Csa-023662	Chlorocebus sabaeus	96.53	0.00e+00	996.00
IUUC-Cho-024574	Choloepus hoffmanni	67.42	2.00e-129	455.00
IUUC-Cme-027299	Cyanidioschyzon merolae	35.96	2.00e-03	37.00
IUUC-Dre-027720	Danio rerio	40.64	2.00e-91	329.00
IUUC-Dno-029079	Dasypus novemcinctus	79.31	0.00e+00	773.00
IUUC-Dor-030890	Dipodomys ordii	80.66	0.00e+00	833.00
IUUC-Ete-032568	Echinops telfairi	81.11	0.00e+00	749.00
IUUC-Eca-033528	Equus caballus	83.59	0.00e+00	850.00
IUUC-Eeu-035219	Erinaceus europaeus	74.61	0.00e+00	815.00
IUUC-Fca-035852	Felis catus	83.95	0.00e+00	843.00
IUUC-Fal-036862	Ficedula albicollis	57.97	4.00e-151	528.00
IUUC-Gmo-038735	Gadus morhua	39.50	4.00e-78	285.00
IUUC-Gga-040939	Gallus gallus	59.17	4.00e-153	534.00
IUUC-Gac-041580	Gasterosteus aculeatus	42.66	3.00e-95	342.00
IUUC-Ggo-045034	Gorilla gorilla	88.39	0.00e+00	946.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	78.01	0.00e+00	815.00
IUUC-Lch-049720	Latimeria chalumnae	50.13	1.00e-82	300.00
IUUC-Loc-052185	Lepisosteus oculatus	46.22	5.00e-106	378.00
IUUC-Laf-054079	Loxodonta africana	81.99	0.00e+00	822.00
IUUC-Mcc-055674	Macaca mulatta	95.84	0.00e+00	970.00
IUUC-Meu-056769	Macropus eugenii	83.33	2.00e-73	270.00
IUUC-Mga-060203	Meleagris gallopavo	59.78	6.00e-146	510.00
IUUC-Mmr-061492	Microcebus murinus	85.69	0.00e+00	843.00
IUUC-Mdo-063051	Monodelphis domestica	75.38	0.00e+00	798.00
IUUC-Mmu-063409	Mus musculus	76.99	0.00e+00	860.00
IUUC-Mpu-065907	Mustela putorius furo	78.11	0.00e+00	825.00
IUUC-Mlu-066957	Myotis lucifugus	82.07	0.00e+00	780.00
IUUC-Ncr-068766	Neurospora crassa	32.69	3.10e-01	30.40
IUUC-Nle-069973	Nomascus leucogenys	96.71	0.00e+00	1026.00
IUUC-Opr-071049	Ochotona princeps	78.41	0.00e+00	743.00
IUUC-Ont-071915	Oreochromis niloticus	42.99	1.00e-92	334.00
IUUC-Oan-072965	Ornithorhynchus anatinus	72.43	0.00e+00	766.00
IUUC-Ocu-074029	Oryctolagus cuniculus	75.70	0.00e+00	692.00
IUUC-Ola-087019	Oryzias latipes	41.76	9.00e-92	330.00
IUUC-Oga-088613	Otolemur garnettii	87.26	0.00e+00	894.00
IUUC-Oar-090386	Ovis aries	82.90	0.00e+00	892.00
IUUC-Ptr-091619	Pan troglodytes	99.13	0.00e+00	1059.00
IUUC-Pan-092178	Papio anubis	95.52	0.00e+00	972.00
IUUC-Psi-093214	Pelodiscus sinensis	63.56	5.00e-170	590.00
IUUC-Pfo-096901	Poecilia formosa	41.39	1.00e-84	307.00
IUUC-Pab-097560	Pongo abelii	96.64	0.00e+00	690.00
IUUC-Pca-100853	Procavia capensis	75.90	5.00e-128	451.00
IUUC-Pva-102255	Pteropus vampyrus	83.42	0.00e+00	789.00
IUUC-Rno-105812	Rattus norvegicus	79.05	0.00e+00	853.00
IUUC-Sha-107225	Sarcophilus harrisii	79.41	3.00e-158	551.00
IUUC-Sit-110549	Setaria italica	30.56	1.10e+00	27.70
IUUC-Sar-113736	Sorex araneus	74.04	2.00e-131	462.00
IUUC-Ssc-115422	Sus scrofa	83.10	0.00e+00	877.00
IUUC-Tgu-116924	Taeniopygia guttata	59.49	3.00e-152	531.00
IUUC-Tru-117695	Takifugu rubripes	39.55	2.00e-89	323.00
IUUC-Tsy-119090	Tarsius syrichta	85.75	3.00e-159	555.00
IUUC-Tni-120645	Tetraodon nigroviridis	41.53	2.00e-94	339.00
IUUC-Tbe-127970	Tupaia belangeri	69.08	0.00e+00	673.00
IUUC-Ttr-129244	Tursiops truncatus	83.07	0.00e+00	827.00
IUUC-Vpa-130313	Vicugna pacos	81.52	0.00e+00	793.00
IUUC-Xtr-132115	Xenopus tropicalis	45.15	2.00e-101	363.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence