iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115422

Ensembl Protein ID

ENSSSCP00000025164.1

UniProt Accession

Q7YS99; OPTN_PIG

Genbank Protein ID

AAP47176.1

Protein Name

Optineurin

Genbank Nucleotide ID

AF513722

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000023247.1	ENSSSCT00000023307.1	ENSSSCP00000025164.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	4.90e-22	77.9	448	503

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklnds 56
           +e++let+ vL++Q+e+Y++DF+aERa+RE+++eeke+L+ q+++l+k+ ++++++
   Q: 448  QEKDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKDDNAFEEG 503
           6899***********************************************99976 PP

Organism

Sus scrofa

Functional Description
(View)

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52 (By similarity).

Protein Sequence
(Fasta)

MSHQPLSCLT EKGDSPTETT GNGPPTLAHP NLDTFTPHEL LQQMRELLIE NHQLKEAMKL 60
NNQAMKGRFE ELSAWTEKQK EERLFFETQS KEAKERLTAL SLENEKLKQE LGKLKGKTER 120

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Nucleotide Sequence
(Fasta)

TTCCCCCGCG GAGGTGGGGA GGCCAGCGGG ACTGTCAGCT GAGCACCGCT GGGCGGGGTC 60
GCGAGGGCGC ACGTCAGCCC CAGGCTTCCG AGCCCCCGCC ACCGCCCCCG GCCGGTGCCC 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0005776--C:autophagosome
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0055037--C:recycling endosome
GO:0005802--C:trans-Golgi network
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling

KEGG

ssc:397011

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	83.11	0.00e+00	838.00
IUUC-Apl-003812	Anas platyrhynchos	55.08	5.00e-145	507.00
IUUC-Aca-004625	Anolis carolinensis	53.86	5.00e-144	504.00
IUUC-Ame-011116	Astyanax mexicanus	36.41	4.00e-63	235.00
IUUC-Bta-013240	Bos taurus	92.16	0.00e+00	1006.00
IUUC-Cja-019911	Callithrix jacchus	83.45	0.00e+00	848.00
IUUC-Cfa-020330	Canis familiaris	86.59	0.00e+00	882.00
IUUC-Cpo-021753	Cavia porcellus	80.73	0.00e+00	824.00
IUUC-Csa-023662	Chlorocebus sabaeus	84.48	0.00e+00	857.00
IUUC-Cho-024574	Choloepus hoffmanni	66.41	1.00e-125	442.00
IUUC-Cme-027299	Cyanidioschyzon merolae	36.99	1.70e-02	33.90
IUUC-Dre-027720	Danio rerio	41.07	6.00e-91	327.00
IUUC-Dno-029079	Dasypus novemcinctus	81.18	0.00e+00	786.00
IUUC-Dor-030890	Dipodomys ordii	79.79	0.00e+00	822.00
IUUC-Ete-032568	Echinops telfairi	78.14	0.00e+00	695.00
IUUC-Eca-033528	Equus caballus	87.69	0.00e+00	894.00
IUUC-Eeu-035219	Erinaceus europaeus	76.08	0.00e+00	815.00
IUUC-Fca-035852	Felis catus	83.79	0.00e+00	884.00
IUUC-Fal-036862	Ficedula albicollis	57.94	2.00e-139	488.00
IUUC-Gmo-038735	Gadus morhua	38.63	4.00e-73	268.00
IUUC-Gga-040939	Gallus gallus	56.00	1.00e-142	499.00
IUUC-Gac-041580	Gasterosteus aculeatus	42.98	2.00e-92	332.00
IUUC-Ggo-045034	Gorilla gorilla	75.44	0.00e+00	764.00
IUUC-Hsa-046624	Homo sapiens	83.10	0.00e+00	850.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	76.63	0.00e+00	813.00
IUUC-Lch-049720	Latimeria chalumnae	49.38	2.00e-79	288.00
IUUC-Loc-052185	Lepisosteus oculatus	45.88	3.00e-105	375.00
IUUC-Laf-054079	Loxodonta africana	82.48	0.00e+00	833.00
IUUC-Mcc-055674	Macaca mulatta	85.54	0.00e+00	855.00
IUUC-Meu-056769	Macropus eugenii	79.29	6.00e-67	248.00
IUUC-Mga-060203	Meleagris gallopavo	56.67	9.00e-136	476.00
IUUC-Mmr-061492	Microcebus murinus	83.80	0.00e+00	836.00
IUUC-Mdo-063051	Monodelphis domestica	74.02	0.00e+00	780.00
IUUC-Mmu-063409	Mus musculus	77.44	0.00e+00	862.00
IUUC-Mpu-065907	Mustela putorius furo	79.42	0.00e+00	853.00
IUUC-Mlu-066957	Myotis lucifugus	84.32	0.00e+00	810.00
IUUC-Ncr-068766	Neurospora crassa	32.05	2.60e-02	33.50
IUUC-Nle-069973	Nomascus leucogenys	83.62	0.00e+00	850.00
IUUC-Opr-071049	Ochotona princeps	77.55	0.00e+00	733.00
IUUC-Ont-071915	Oreochromis niloticus	41.83	2.00e-88	319.00
IUUC-Oan-072965	Ornithorhynchus anatinus	72.10	0.00e+00	751.00
IUUC-Ocu-074029	Oryctolagus cuniculus	74.67	0.00e+00	661.00
IUUC-Ola-087019	Oryzias latipes	41.94	4.00e-83	301.00
IUUC-Oga-088613	Otolemur garnettii	85.20	0.00e+00	868.00
IUUC-Oar-090386	Ovis aries	91.81	0.00e+00	1003.00
IUUC-Ptr-091619	Pan troglodytes	82.93	0.00e+00	846.00
IUUC-Pan-092178	Papio anubis	83.53	0.00e+00	839.00
IUUC-Psi-093214	Pelodiscus sinensis	62.22	4.00e-159	554.00
IUUC-Pfo-096901	Poecilia formosa	41.80	7.00e-81	294.00
IUUC-Pab-097560	Pongo abelii	75.47	0.00e+00	727.00
IUUC-Pca-100853	Procavia capensis	74.10	9.00e-122	430.00
IUUC-Pva-102255	Pteropus vampyrus	84.38	0.00e+00	805.00
IUUC-Rno-105812	Rattus norvegicus	77.82	0.00e+00	832.00
IUUC-Sha-107225	Sarcophilus harrisii	77.75	9.00e-151	526.00
IUUC-Sit-110549	Setaria italica	29.79	4.80e-01	28.50
IUUC-Sar-113736	Sorex araneus	70.48	6.00e-128	451.00
IUUC-Tgu-116924	Taeniopygia guttata	57.27	2.00e-141	495.00
IUUC-Tru-117695	Takifugu rubripes	40.00	3.00e-85	309.00
IUUC-Tsy-119090	Tarsius syrichta	82.07	2.00e-152	531.00
IUUC-Tni-120645	Tetraodon nigroviridis	41.79	5.00e-85	308.00
IUUC-Tbe-127970	Tupaia belangeri	67.36	0.00e+00	650.00
IUUC-Ttr-129244	Tursiops truncatus	90.80	0.00e+00	919.00
IUUC-Vpa-130313	Vicugna pacos	90.45	0.00e+00	878.00
IUUC-Xtr-132115	Xenopus tropicalis	44.53	4.00e-95	341.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence