iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.70e-60	196.7	343	381
UBD/Beta-Prp	2.10e-90	303.3	44	284

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+++++ ++f +  ++l++Gs D+t ++WD+ tg +l+
   Q: 343  GHEGEISKISFnPQgNRLLTGSSDKTARIWDVQTGQCLQ 381
           8**********9667**********************98 PP

UBD/Beta-Prp

   S: 15   cvkfspdksllatgsrdgtikvwdvttgkl...........lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
            v  +++ + l+t+sr++ +++   + + +           ++ l  h  + t v +++ g+ ++tgs Drt kvwd  +g+ +htl+g
   Q: 44   LVGEIQKVEPLITASRTKQVRLLVQRLQEKlrqhcdhnfylFKVLRAHILPLTNVALNKAGSCFITGSYDRTCKVWDTASGEELHTLEG 132
           444467778899********9998888777466666666666666666666************************************** PP
   S: 93   hedsvlslsfsp.sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           h + v++++f+  +gdk+++Gs d+t ++w  etg+c++ t++gh++ + c++++p++ ++++Gs D+t +lWd+++g+ + tltg h 
   Q: 133  HRNVVYAIAFNNpYGDKIATGSFDKTCKLWSAETGKCYH-TFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWDIQSGEEVVTLTG-HL 219
           **********998**************************.*********************************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgs 245
             + slsfd +g ++++gs d tv +wd +tg+ v+tl+gh + ++s  fs +  ++++gs+D++
   Q: 220  AEIISLSFDTSGDRIITGSFDHTVVVWDASTGRKVHTLIGHCAEISSALFSWDCSLILTGSMDKT 284
           ***************************************************************96 PP

Organism

Rattus norvegicus

Functional Description
(View)

May play a role in axonemal outer row dynein assembly.

Protein Sequence
(Fasta)

MKLKSLLLRY YPPGIMLEYE KGGELKTKSI DLLELSPSTD VNTLVGEIQK VEPLITASRT 60
KQVRLLVQRL QEKLRQHCDH NFYLFKVLRA HILPLTNVAL NKAGSCFITG SYDRTCKVWD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCATGGCTA CGAAGCCCAT CAGGGTACGA GAGTAAGAAA ATGAAGCTTA AGAGCCTCTT 60
GCTTCGCTAT TACCCACCAG GTACGGGGTT CCCACGAGTG GGCCCTGGAT TCTCTTTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0966--Cell projection
KW-0969--Cilium
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005929--C:cilium
GO:0005737--C:cytoplasm
GO:0007368--P:determination of left/right symmetry
GO:0007507--P:heart development

KEGG

rno:363267

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002244	Ailuropoda melanoleuca	91.08	0.00e+00	756.00
IUUC-Apl-003764	Anas platyrhynchos	78.29	0.00e+00	653.00
IUUC-Aca-005354	Anolis carolinensis	80.72	0.00e+00	711.00
IUUC-Afl-008745	Aspergillus flavus	34.24	3.00e-59	223.00
IUUC-Afu-008962	Aspergillus fumigatus	38.05	1.00e-61	231.00
IUUC-Aor-010048	Aspergillus oryzae	38.64	1.00e-60	226.00
IUUC-Ame-010648	Astyanax mexicanus	67.94	4.00e-173	600.00
IUUC-Bta-013294	Bos taurus	87.95	0.00e+00	763.00
IUUC-Bci-013681	Botrytis cinerea	35.78	2.00e-57	218.00
IUUC-Cja-018728	Callithrix jacchus	89.16	0.00e+00	788.00
IUUC-Cfa-021122	Canis familiaris	90.12	0.00e+00	793.00
IUUC-Cpo-021472	Cavia porcellus	87.56	0.00e+00	729.00
IUUC-Cre-022946	Chlamydomonas reinhardtii	42.04	1.00e-63	236.00
IUUC-Csa-023349	Chlorocebus sabaeus	90.36	0.00e+00	787.00
IUUC-Cho-024337	Choloepus hoffmanni	70.26	1.00e-155	542.00
IUUC-Cin-025447	Ciona intestinalis	68.19	0.00e+00	632.00
IUUC-Csv-026024	Ciona savignyi	68.43	0.00e+00	628.00
IUUC-Cgl-026771	Colletotrichum gloeosporioides	30.20	4.00e-47	183.00
IUUC-Dre-028787	Danio rerio	70.26	0.00e+00	643.00
IUUC-Dno-029788	Dasypus novemcinctus	83.37	0.00e+00	713.00
IUUC-Dor-030679	Dipodomys ordii	88.34	9.00e-86	310.00
IUUC-Dme-031913	Drosophila melanogaster	39.32	1.00e-91	330.00
IUUC-Ete-032844	Echinops telfairi	87.88	2.00e-104	372.00
IUUC-Eca-034088	Equus caballus	89.88	0.00e+00	784.00
IUUC-Eeu-034898	Erinaceus europaeus	78.40	3.00e-148	517.00
IUUC-Fca-036058	Felis catus	80.49	0.00e+00	654.00
IUUC-Fal-036638	Ficedula albicollis	77.45	2.00e-155	541.00
IUUC-Fox-037826	Fusarium oxysporum	38.06	2.00e-48	189.00
IUUC-Fso-038216	Fusarium solani	36.60	2.00e-55	211.00
IUUC-Gmo-039010	Gadus morhua	68.82	4.00e-152	530.00
IUUC-Ggr-039928	Gaeumannomyces graminis	37.58	3.00e-61	230.00
IUUC-Gga-040984	Gallus gallus	79.71	0.00e+00	690.00
IUUC-Gac-042552	Gasterosteus aculeatus	71.01	0.00e+00	637.00
IUUC-Ggo-044596	Gorilla gorilla	78.05	0.00e+00	645.00
IUUC-Hsa-046535	Homo sapiens	89.88	0.00e+00	781.00
IUUC-Itr-048672	Ictidomys tridecemlineatus	94.40	1.00e-150	525.00
IUUC-Lch-049902	Latimeria chalumnae	81.93	0.00e+00	730.00
IUUC-Loc-051919	Lepisosteus oculatus	81.69	0.00e+00	727.00
IUUC-Laf-053877	Loxodonta africana	87.71	0.00e+00	768.00
IUUC-Mcc-055010	Macaca mulatta	90.36	0.00e+00	787.00
IUUC-Meu-055980	Macropus eugenii	71.28	1.00e-158	552.00
IUUC-Mla-058997	Melampsora laricipopulina	29.97	1.00e-37	151.00
IUUC-Mga-059883	Meleagris gallopavo	73.05	2.00e-177	614.00
IUUC-Mmr-061645	Microcebus murinus	90.42	0.00e+00	775.00
IUUC-Mdo-062166	Monodelphis domestica	87.56	0.00e+00	739.00
IUUC-Mmu-063653	Mus musculus	98.07	0.00e+00	845.00
IUUC-Mpu-066807	Mustela putorius furo	90.66	0.00e+00	781.00
IUUC-Mlu-067792	Myotis lucifugus	89.13	0.00e+00	774.00
IUUC-Nfi-068459	Neosartorya fischeri	34.04	3.00e-59	224.00
IUUC-Nle-069067	Nomascus leucogenys	89.16	0.00e+00	774.00
IUUC-Opr-070841	Ochotona princeps	74.01	2.00e-171	595.00
IUUC-Ont-072191	Oreochromis niloticus	72.22	0.00e+00	647.00
IUUC-Oan-073649	Ornithorhynchus anatinus	84.79	2.00e-107	381.00
IUUC-Ocu-074966	Oryctolagus cuniculus	76.61	0.00e+00	627.00
IUUC-Ola-087021	Oryzias latipes	60.33	4.00e-154	537.00
IUUC-Oga-088193	Otolemur garnettii	89.21	0.00e+00	774.00
IUUC-Oar-089207	Ovis aries	89.16	0.00e+00	781.00
IUUC-Ptr-091298	Pan troglodytes	90.36	0.00e+00	786.00
IUUC-Pan-092620	Papio anubis	88.92	0.00e+00	639.00
IUUC-Psi-093232	Pelodiscus sinensis	82.41	0.00e+00	719.00
IUUC-Ppa-095926	Physcomitrella patens	34.63	2.00e-50	194.00
IUUC-Pfo-096971	Poecilia formosa	71.26	0.00e+00	640.00
IUUC-Pab-098360	Pongo abelii	90.58	0.00e+00	787.00
IUUC-Pca-100384	Procavia capensis	86.75	0.00e+00	761.00
IUUC-Pva-102206	Pteropus vampyrus	89.11	0.00e+00	754.00
IUUC-Pyt-104470	Pyrenophora triticirepentis	36.70	2.00e-62	234.00
IUUC-Sha-106970	Sarcophilus harrisii	87.06	0.00e+00	737.00
IUUC-Ssl-108470	Sclerotinia sclerotiorum	42.12	7.00e-77	282.00
IUUC-Smo-109147	Selaginella moellendorffii	34.62	5.00e-49	187.00
IUUC-Ssc-115618	Sus scrofa	87.50	0.00e+00	756.00
IUUC-Tgu-117237	Taeniopygia guttata	76.96	0.00e+00	652.00
IUUC-Tsy-119604	Tarsius syrichta	86.99	1.00e-72	266.00
IUUC-Tre-122039	Trichoderma reesei	36.75	3.00e-55	210.00
IUUC-Tvi-122368	Trichoderma virens	37.16	7.00e-67	248.00
IUUC-Tbe-127358	Tupaia belangeri	74.46	1.00e-178	619.00
IUUC-Ttr-129197	Tursiops truncatus	88.43	0.00e+00	768.00
IUUC-Vpa-130692	Vicugna pacos	82.41	0.00e+00	704.00
IUUC-Xtr-132612	Xenopus tropicalis	79.62	0.00e+00	707.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence