iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.50e-17	62.2	51	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H++ vt++++ ++ +++v+++ D + +vW 
   Q: 51   HNGQVTGIDWaPEsNRIVTCGTDRNAYVWT 80
           9**********888***************6 PP

Organism

Rattus norvegicus

Functional Description
(View)

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Protein Sequence
(Fasta)

MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWNKVHELKE HNGQVTGIDW 60
APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR CVRWAPNENK FAVGSGSRVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGAAGTGG CTGCGGCGCT GCGCGGGTCT CAGAGCCGGT TCGGCGCGTC GACTGTCCAG 60
AGTCCGCGGC CGAGGAGACC CGAGGTGAGG GACGTGGGGT GGTCACGAGG TGTGTGTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR030141--ARC1B
IPR017383--ARPC1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005885--C:Arp2/3 protein complex
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0036284--C:tubulobulbar complex
GO:0051015--F:actin filament binding
GO:0032403--F:protein complex binding
GO:0005200--F:structural constituent of cytoskeleton
GO:0034314--P:Arp2/3 complex-mediated actin nucleation
GO:0032355--P:response to estradiol
GO:0043627--P:response to estrogen

KEGG

rno:54227

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000669	Aegilops tauschii	45.91	3.00e-65	242.00
IUUC-Aml-001709	Ailuropoda melanoleuca	94.95	0.00e+00	721.00
IUUC-Aly-006568	Arabidopsis lyrata	41.35	2.00e-80	292.00
IUUC-Ath-006683	Arabidopsis thaliana	42.20	5.00e-81	294.00
IUUC-Ago-007966	Ashbya gossypii	38.10	2.00e-65	242.00
IUUC-Acl-008334	Aspergillus clavatus	43.21	8.00e-87	313.00
IUUC-Ame-011512	Astyanax mexicanus	79.78	0.00e+00	648.00
IUUC-Bgr-012192	Blumeria graminis	41.21	6.00e-79	287.00
IUUC-Bta-012442	Bos taurus	95.42	0.00e+00	719.00
IUUC-Bci-013616	Botrytis cinerea	42.50	4.00e-82	298.00
IUUC-Bdi-014632	Brachypodium distachyon	42.12	1.00e-78	286.00
IUUC-Bol-016274	Brassica oleracea	41.24	6.00e-83	301.00
IUUC-Bra-016790	Brassica rapa	40.97	2.00e-81	296.00
IUUC-Cja-019899	Callithrix jacchus	95.71	0.00e+00	744.00
IUUC-Cfa-020067	Canis familiaris	95.16	0.00e+00	723.00
IUUC-Cpo-022461	Cavia porcellus	96.77	0.00e+00	729.00
IUUC-Cre-022590	Chlamydomonas reinhardtii	34.69	8.00e-35	139.00
IUUC-Csa-023277	Chlorocebus sabaeus	87.63	0.00e+00	679.00
IUUC-Csv-026275	Ciona savignyi	52.49	5.00e-107	380.00
IUUC-Cne-026926	Cryptococcus neoformans	44.42	4.00e-94	338.00
IUUC-Dre-028141	Danio rerio	80.32	0.00e+00	646.00
IUUC-Dor-030559	Dipodomys ordii	95.16	0.00e+00	728.00
IUUC-Dse-031574	Dothistroma septosporum	41.53	5.00e-82	297.00
IUUC-Ete-032299	Echinops telfairi	93.55	0.00e+00	735.00
IUUC-Eca-033593	Equus caballus	95.71	0.00e+00	723.00
IUUC-Fca-036254	Felis catus	96.77	0.00e+00	731.00
IUUC-Fal-037453	Ficedula albicollis	87.43	0.00e+00	691.00
IUUC-Fso-038276	Fusarium solani	42.15	9.00e-82	296.00
IUUC-Gmo-038471	Gadus morhua	70.32	1.00e-162	565.00
IUUC-Gga-040898	Gallus gallus	87.10	0.00e+00	694.00
IUUC-Gac-042236	Gasterosteus aculeatus	74.28	6.00e-176	610.00
IUUC-Gma-042803	Glycine max	41.33	3.00e-80	291.00
IUUC-Ggo-045355	Gorilla gorilla	80.97	1.00e-167	582.00
IUUC-Hsa-046623	Homo sapiens	96.77	0.00e+00	731.00
IUUC-Hvu-047456	Hordeum vulgare	29.21	7.00e-14	70.10
IUUC-Itr-048596	Ictidomys tridecemlineatus	96.51	0.00e+00	737.00
IUUC-Kpa-049288	Komagataella pastoris	41.64	2.00e-76	278.00
IUUC-Lch-049679	Latimeria chalumnae	79.51	0.00e+00	640.00
IUUC-Lpe-050869	Leersia perrieri	41.50	9.00e-79	287.00
IUUC-Loc-052140	Lepisosteus oculatus	80.59	0.00e+00	632.00
IUUC-Laf-054287	Loxodonta africana	93.09	0.00e+00	691.00
IUUC-Meu-056302	Macropus eugenii	90.05	0.00e+00	709.00
IUUC-Mor-057167	Magnaporthe oryzae	40.66	3.00e-79	288.00
IUUC-Mtr-057659	Medicago truncatula	40.75	6.00e-83	300.00
IUUC-Mla-058886	Melampsora laricipopulina	43.23	1.00e-88	320.00
IUUC-Mga-059279	Meleagris gallopavo	87.10	0.00e+00	695.00
IUUC-Mvi-060302	Microbotryum violaceum	45.24	1.00e-89	323.00
IUUC-Mmr-060752	Microcebus murinus	96.95	0.00e+00	720.00
IUUC-Mdo-062836	Monodelphis domestica	86.56	0.00e+00	671.00
IUUC-Mmu-064099	Mus musculus	97.07	0.00e+00	732.00
IUUC-Mac-064632	Musa acuminata	42.23	4.00e-80	291.00
IUUC-Mpu-066247	Mustela putorius furo	95.43	0.00e+00	708.00
IUUC-Mlu-067571	Myotis lucifugus	96.51	0.00e+00	745.00
IUUC-Nle-069492	Nomascus leucogenys	83.06	4.00e-171	593.00
IUUC-Opr-070519	Ochotona princeps	98.24	2.00e-134	471.00
IUUC-Ont-071316	Oreochromis niloticus	76.12	6.00e-175	606.00
IUUC-Oan-072692	Ornithorhynchus anatinus	87.90	0.00e+00	697.00
IUUC-Ocu-074187	Oryctolagus cuniculus	91.94	0.00e+00	707.00
IUUC-Oba-075379	Oryza barthii	41.64	3.00e-79	288.00
IUUC-Obr-076404	Oryza brachyantha	42.31	4.00e-80	291.00
IUUC-Ogl-077409	Oryza glaberrima	39.24	4.00e-73	268.00
IUUC-Ogu-078759	Oryza glumaepatula	41.64	4.00e-79	288.00
IUUC-Oin-079118	Oryza indica	41.69	6.00e-80	290.00
IUUC-Olo-081055	Oryza longistaminata	41.03	7.00e-70	257.00
IUUC-Ome-081281	Oryza meridionalis	41.64	5.00e-79	288.00
IUUC-Oni-083043	Oryza nivara	41.64	3.00e-79	288.00
IUUC-Opu-083392	Oryza punctata	33.70	8.00e-53	201.00
IUUC-Oru-084839	Oryza rufipogon	41.64	3.00e-79	288.00
IUUC-Osa-085377	Oryza sativa	41.69	9.00e-80	290.00
IUUC-Oga-088610	Otolemur garnettii	96.77	0.00e+00	730.00
IUUC-Oar-089639	Ovis aries	94.07	0.00e+00	702.00
IUUC-Ptr-091023	Pan troglodytes	96.51	0.00e+00	728.00
IUUC-Pan-091727	Papio anubis	96.24	0.00e+00	738.00
IUUC-Pma-094124	Petromyzon marinus	67.65	2.00e-160	558.00
IUUC-Pno-095031	Phaeosphaeria nodorum	42.08	3.00e-82	298.00
IUUC-Ppa-095858	Physcomitrella patens	44.69	2.00e-84	306.00
IUUC-Pfo-097058	Poecilia formosa	74.02	3.00e-175	607.00
IUUC-Pab-098238	Pongo abelii	96.51	0.00e+00	733.00
IUUC-Pop-098954	Populus trichocarpa	36.50	1.00e-41	163.00
IUUC-Pca-100580	Procavia capensis	93.28	0.00e+00	705.00
IUUC-Ppe-101681	Prunus persica	41.96	2.00e-81	296.00
IUUC-Pva-102928	Pteropus vampyrus	93.55	0.00e+00	692.00
IUUC-Pgr-103309	Puccinia graminis	42.86	5.00e-91	328.00
IUUC-Ptt-103959	Puccinia triticina	44.44	3.00e-91	328.00
IUUC-Ssl-108606	Sclerotinia sclerotiorum	42.50	1.00e-81	296.00
IUUC-Smo-108836	Selaginella moellendorffii	44.68	3.00e-83	301.00
IUUC-Sit-110150	Setaria italica	41.03	1.00e-79	290.00
IUUC-Sly-111048	Solanum lycopersicum	42.32	2.00e-78	285.00
IUUC-Sar-113404	Sorex araneus	78.00	5.00e-157	546.00
IUUC-Sbi-114685	Sorghum bicolor	41.80	6.00e-79	287.00
IUUC-Tru-118106	Takifugu rubripes	74.21	2.00e-177	614.00
IUUC-Tni-120079	Tetraodon nigroviridis	75.53	2.00e-179	621.00
IUUC-Tca-121645	Theobroma cacao	42.55	3.00e-80	291.00
IUUC-Tae-125810	Triticum aestivum	38.05	9.00e-71	260.00
IUUC-Tur-126640	Triticum urartu	40.06	1.00e-69	256.00
IUUC-Tme-127018	Tuber melanosporum	41.48	5.00e-79	287.00
IUUC-Ttr-128698	Tursiops truncatus	95.43	0.00e+00	727.00
IUUC-Vvi-131647	Vitis vinifera	41.76	8.00e-81	293.00
IUUC-Xtr-131893	Xenopus tropicalis	82.80	0.00e+00	660.00
IUUC-Xma-134089	Xiphophorus maculatus	74.28	1.00e-175	608.00
IUUC-Zma-135615	Zea mays	40.36	2.00e-79	289.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence